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MTETAPDQTESARSIFEVGNYAPVPDELTTFDLPVEGTIPAELDGWYLRNGPNPREATGHWFTGDGMIHG VRIENGRAAWYRNRWVRTDSFIDPFPLYREDGTRDLRASVANTHVVNHAGKTLALVESSLPYEITNDLRA VGAYDFGGKLADAMTAHPKICPTTGELHFFGYGNIFTPHVTYHRADAHGELVINRPLDVPALTMMHDFAL TQNHVVFMDLPIVFDLDIAMRGEGDMPYRWDDGYGARFGLLRRDDPFGDVRWFDIGPCYIFHVANAYETT SADGDRLVLQAVRYPELWRDNGGFDAEGVMWTWTVDLRTGAVSESQLDDRSVEFPRIDDRLATLPARYAV SVGDKNLIRHDLTTGAAEVHRFGSGGPGEAVFVPSTSGPADESSGWYLGYVYDPERNGSDLVVIDASDFS GPPVARVHLPQRVPYGFHGNWISA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1332 | - | - | 100% (444) | carotenoid oxygenase |
| M. gilvum PYR-GCK | Mflv_2111 | - | 3e-95 | 42.53% (475) | carotenoid oxygenase |
| M. gilvum PYR-GCK | Mflv_1807 | - | 8e-48 | 30.95% (475) | carotenoid oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0673 | - | 5e-84 | 39.00% (500) | dioxygenase |
| M. tuberculosis H37Rv | Rv0654 | - | 5e-84 | 39.00% (500) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 6e-78 | 35.52% (504) | putative dioxygenase |
| M. marinum M | MMAR_0993 | - | 3e-82 | 39.39% (490) | dioxygenase |
| M. avium 104 | MAV_4505 | - | 1e-85 | 41.09% (494) | Sim14 protein |
| M. smegmatis MC2 155 | MSMEG_6224 | - | 0.0 | 75.68% (444) | retinal pigment epithelial membrane protein |
| M. thermoresistible (build 8) | TH_3959 | - | 1e-88 | 41.54% (479) | PUTATIVE Carotenoid oxygenase |
| M. ulcerans Agy99 | MUL_0744 | - | 3e-82 | 39.18% (490) | dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_5460 | - | 0.0 | 82.51% (463) | carotenoid oxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0993|M.marinum_M -MTTMRSAQPR-----------------NPYLEGFLAPVRAEVTATDLEV
MUL_0744|M.ulcerans_Agy99 -MTTMRSAQPR-----------------NPYLEGFLAPVRAEVTATDLEV
MAV_4505|M.avium_104 -MTTTRTVA-------------------NPYLDGFLAPVRAEVTAFDLPV
Mb0673|M.bovis_AF2122/97 -MTTAQAAESQ-----------------NPYLEGFLAPVSTEVTATDLPV
Rv0654|M.tuberculosis_H37Rv -MTTAQAAESQ-----------------NPYLEGFLAPVSTEVTATDLPV
MAB_3874c|M.abscessus_ATCC_199 MTATAQPAAST-----------------SPYLSGIWEPVQQEMDSVDLEV
TH_3959|M.thermoresistible__bu ---------VS-----------------NRYLTGAFAPLTEEYTLTDLEV
Mflv_1332|M.gilvum_PYR-GCK MTETAPDQTES---------------ARSIFEVGNYAPVPDELTTFDLPV
Mvan_5460|M.vanbaalenii_PYR-1 MTETTSDQADSTFVDSSRERSSALFGAGEFFRVGNYAPVADELTAFDLPV
MSMEG_6224|M.smegmatis_MC2_155 MTDTDLTNLPG---------------TGEFFRRGNYAPVPDELTDYDLPV
. : * *: * ** *
MMAR_0993|M.marinum_M TGRIPDYLDGRYLRNGPNPVAEVNPATYHWFTGDGMVHGVALRDGRASWY
MUL_0744|M.ulcerans_Agy99 TGRIPDYLDGRYLRNGPNPVAEVNPATYHWFTGDGMVHGVALRDGRASWY
MAV_4505|M.avium_104 TGRIPDHLDGRYLRNGPNPVAEVDPATYHWFSGDGMVHGVALRDGRARWY
Mb0673|M.bovis_AF2122/97 TGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWY
Rv0654|M.tuberculosis_H37Rv TGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWY
MAB_3874c|M.abscessus_ATCC_199 TGTLPAHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKAQWY
TH_3959|M.thermoresistible__bu TGTIPDYLDGRYLRNGPNPVGEIDPELYHWFVGDGMVHGIRLRDGRAEWY
Mflv_1332|M.gilvum_PYR-GCK EGTIPAELDGWYLRNGPNPR----EATGHWFTGDGMIHGVRIENGRAAWY
Mvan_5460|M.vanbaalenii_PYR-1 EGAIPSELDGWYLRNGPNPR----QPTGHWFTGDGMIHGVRIENGRAAWY
MSMEG_6224|M.smegmatis_MC2_155 TGAIPPELDGWYLRNGPNPR----QATAHWFTGDGMIHGVRIENGAAKWY
* :* *** ******** * * **.*:**: :.:* * **
MMAR_0993|M.marinum_M RNRWVRSMPVCAALGESPPSRLDPRAGMLGLGANTNVLSHAGRTLALVEG
MUL_0744|M.ulcerans_Agy99 RNRWVRSMPVCAALGESPPARRDPRAGMLGLGANTNVLSHAGRTLALVEG
MAV_4505|M.avium_104 RNRWVRTAHVCAALGEPAPGGLDPRAGMLSVGPNTNVLSHAGQTLALVEG
Mb0673|M.bovis_AF2122/97 RNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEA
Rv0654|M.tuberculosis_H37Rv RNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEA
MAB_3874c|M.abscessus_ATCC_199 RNRWVRTPSVSKTLGETRPAAISANAGMGVIGPNTNVLGHAGRTLALVEG
TH_3959|M.thermoresistible__bu RNRWVRGPLTARALGERPPSE---ECSVSGIGANTNVIGHAGKTIALVES
Mflv_1332|M.gilvum_PYR-GCK RNRWVRTDSFIDPFPLYREDG---TRDLRASVANTHVVNHAGKTLALVES
Mvan_5460|M.vanbaalenii_PYR-1 RNRWVRTDSFVDPFPLYNADG---TRNLRASVANTHVVNHAGKTLALVES
MSMEG_6224|M.smegmatis_MC2_155 RNRWVRTDSFIESFPVYNADG---TRNLRASVANTHIVNHAGKTLALVES
****** .: .: .**::: ***:*:****.
MMAR_0993|M.marinum_M GVANYELTDDLDTVGTCDFDGTLPGGYTAHPHRDPQTGELHAVSYSFTRG
MUL_0744|M.ulcerans_Agy99 GVANYELTDDLDTVGTCDFDGTLPGGYTAHPHRDPQTGELHAVSYSFTRG
MAV_4505|M.avium_104 GGANYRLTEDLDTVGTCDFDGTLFGGYTAHPHRDPRTGELHAVSYSFGRG
Mb0673|M.bovis_AF2122/97 GVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARG
Rv0654|M.tuberculosis_H37Rv GVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARG
MAB_3874c|M.abscessus_ATCC_199 GIANYELTEDLDTIGTCDFDGTLPGGYTAHPHTDPDTGEMHAVSYSFARG
TH_3959|M.thermoresistible__bu GVTNYELTEELDTVGPCDFDGTLTGGYTAHPKRDPETGELHAVSYSMYRG
Mflv_1332|M.gilvum_PYR-GCK SLP-YEITNDLRAVGAYDFGGKLADAMTAHPKICPTTGELHFFGYGNIFT
Mvan_5460|M.vanbaalenii_PYR-1 SLP-YEITNDLETVGAYDFGGKLVDAMTAHPKICPTTGELHFFGYGNIFT
MSMEG_6224|M.smegmatis_MC2_155 SLP-YEITGDLETVGAYDFGGKLVDSMTAHPKICPTTGEMHFFGYGSLFE
. *.:* :* ::*. **.*.* .. ****: * ***:* ..*.
MMAR_0993|M.marinum_M HTVQYSVIDTQGRARRTVDIEVTGSPMMHDFSLTDKYVVIYDLPVTFDSA
MUL_0744|M.ulcerans_Agy99 HMVQYSVIDTQGRARRTVDIEVTGSPMMHDFSLTDKYVVIYDLPVTFDSA
MAV_4505|M.avium_104 RRVQYSVIDTAGRARRTVDIEVSGSPMMHDFSLTDEYVVIYDLPVTFDPV
Mb0673|M.bovis_AF2122/97 HRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPM
Rv0654|M.tuberculosis_H37Rv HRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPM
MAB_3874c|M.abscessus_ATCC_199 STVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMS
TH_3959|M.thermoresistible__bu NTVQYSVIGTDGRARRTVDIEVTGSPMMHDFSLTERHIVLYDLPVTFDAR
Mflv_1332|M.gilvum_PYR-GCK PHVTYHRADAHGELVINRPLDVPALTMMHDFALTQNHVVFMDLPIVFDLD
Mvan_5460|M.vanbaalenii_PYR-1 PHVTYHRADANGELVIDRPLDVPALTMMHDFALTANYVVFMDLPIVFNVD
MSMEG_6224|M.smegmatis_MC2_155 PYVTYHRADADGELTINRPVDVKAHTMMHDFAMTSGHVIFMDLPVVFDLD
* * .: *. : * . .***.*::* :::: ***:.::
MMAR_0993|M.marinum_M QVMP-VKMPSWLGVPARLVMASLIGNVRVPSPIAAMMNRNPKPSNRLPYA
MUL_0744|M.ulcerans_Agy99 QVMP-VKMPSWLGVPARLVMASLIGNVRVPSLIAAMLNRNPKPSNRLPYA
MAV_4505|M.avium_104 QVMP-ADVPRWLSAPARLVVQSLLGRVQLPGPMATAMNRNRQPLHRMPYR
Mb0673|M.bovis_AF2122/97 QVVP-ASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYA
Rv0654|M.tuberculosis_H37Rv QVVP-ASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYA
MAB_3874c|M.abscessus_ATCC_199 MISQSVPVPRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYS
TH_3959|M.thermoresistible__bu QAVS-MTVPRGLRLPARLVLSALIGRVRVPDPIAARQPRGNSSDRRFPYS
Mflv_1332|M.gilvum_PYR-GCK IAMR--------------------------------------GEGDMPYR
Mvan_5460|M.vanbaalenii_PYR-1 IAVS--------------------------------------GRGDMPYR
MSMEG_6224|M.smegmatis_MC2_155 IALK--------------------------------------GTGDMPYR
:**
MMAR_0993|M.marinum_M WNPAYPARIGVMPREGGNRD----VRWFDIEPCYVYHPLNAYSEHRDGAE
MUL_0744|M.ulcerans_Agy99 WNPAYPARIGVMPREGGNRD----VRWFDIEPCYVYHPLNAYSEHRDGAE
MAV_4505|M.avium_104 WNDAYPARLGVMPRDGGNDE----VRWFDIEPCYVYHPLNAYSEIRDGAK
Mb0673|M.bovis_AF2122/97 WNPSYPARVGVMPREGGNED----VRWFDIEPCYVYHPLNAYSECRNGAE
Rv0654|M.tuberculosis_H37Rv WNPSYPARVGVMPREGGNED----VRWFDIEPCYVYHPLNAYSECRNGAE
MAB_3874c|M.abscessus_ATCC_199 WNPKYPARIGVMPREGDDASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAE
TH_3959|M.thermoresistible__bu WNPRYPARIGVMPRDGSNKD----VRWFDVEPCYVFHPMNAY----DDGD
Mflv_1332|M.gilvum_PYR-GCK WDDGYGARFGLLRRDDPFGD----VRWFDIGPCYIFHVANAYETTSADGD
Mvan_5460|M.vanbaalenii_PYR-1 WDDGYGARFGVLRRDDPFGQ----VRWFDIDPCYIFHVANAHD----DGR
MSMEG_6224|M.smegmatis_MC2_155 WSDTYGARFGLLRRDDPFGE----IRWFDIDPCYIFHVVNAYE----HGN
*. * **.*:: *:. . :***:: ***::* *.: .
MMAR_0993|M.marinum_M VLILDVVRYRRMFDRDRRGPG-DTTPSLDRWVINLTTGAVSTECRDDRSQ
MUL_0744|M.ulcerans_Agy99 VLILDVVRYRRMFDRDRRGPG-DTSPSLDRWVINLTTGAVSTECRDDRSQ
MAV_4505|M.avium_104 VLVLDVVRYSRMFDRDLRGPG-DTRPTLDRWTVNLATGAVGSELRDDRPQ
Mb0673|M.bovis_AF2122/97 VLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQ
Rv0654|M.tuberculosis_H37Rv VLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQ
MAB_3874c|M.abscessus_ATCC_199 VIVIDLVRYDSMFSQDVLGPS-DAKGQLDRWTIDLAKGTVHMERKDDRHL
TH_3959|M.thermoresistible__bu TIVLDVIRHPKMFDTDNLGPN-EGPPTLDRWTVDLADGKVRESRIDDRGQ
Mflv_1332|M.gilvum_PYR-GCK RLVLQAVRYPELWRDN---GGFDAEGVMWTWTVDLRTGAVSESQLDDRSV
Mvan_5460|M.vanbaalenii_PYR-1 TLVLQAVRYPELWREN---GGFDADGVMWTWTIDLQNGTVRESQLDDRVV
MSMEG_6224|M.smegmatis_MC2_155 TVVVQAVRYPELWRDN---GSFDAQAVLWSWTIDLQTGAVTERQLDDLAV
:::: :*: :: : . : : *.::* * * **
MMAR_0993|M.marinum_M EFPRINETLLGKRHRFGYTLGVDGGYLTGGTSDMSTSLYKQDYATGSSQV
MUL_0744|M.ulcerans_Agy99 EFPRINETLLGKRHRFGYTLGVDGGYLTGGTSDMSTSLYKQDYATGSSQV
MAV_4505|M.avium_104 EFPRINEALLGRRHRFGYTVGTDGGYLSDGASEMSTGLYKHDYATGSRRV
Mb0673|M.bovis_AF2122/97 EFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTV
Rv0654|M.tuberculosis_H37Rv EFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTV
MAB_3874c|M.abscessus_ATCC_199 EFPRINETFTGKKHRYGYLPDVEN--FFGSGEAAGASIVKYDYETGSTLS
TH_3959|M.thermoresistible__bu EFPRVDERLVGRRHRYGYAP------TVGEGTSGGNVLLKHDFVGGNTQS
Mflv_1332|M.gilvum_PYR-GCK EFPRIDDRLATLPARYAVSVG-------------DKNLIRHDLTTGAAEV
Mvan_5460|M.vanbaalenii_PYR-1 EFPRIDDRLATLPARYAVSVG-------------DAGLIRHDLVTGAAVE
MSMEG_6224|M.smegmatis_MC2_155 EFPRIDDRLAGLHARYSVAAG-------------DHGWVRYDMTTGDAQR
****::: : *:. . : * *
MMAR_0993|M.marinum_M APLDS---DLLLGEMAFVPSPT---AAAEDDGVLMGYGYHRGSDEGQLVL
MUL_0744|M.ulcerans_Agy99 APLDP---DLLLGEMAFVPSPT---AAAEDHGVLMGYGYHRGSDEGQLVL
MAV_4505|M.avium_104 APLDP---DLLIGEMCFVPNPAGGQDGTEDDGILMGFGYHRGRDENQLVL
Mb0673|M.bovis_AF2122/97 ASLDP---DLLIGEMVFVPNPS---ARAEDDGILMGYGWHRGRDEGQLLL
Rv0654|M.tuberculosis_H37Rv ASLDP---DLLIGEMVFVPNPS---ARAEDDGILMGYGWHRGRDEGQLLL
MAB_3874c|M.abscessus_ATCC_199 SRLDP---AIVLGEMSFVPNPT---CAAEDDGVLIGFAVDRRSDEGQLLL
TH_3959|M.thermoresistible__bu RVFEP---YHELGEFVFQPSSA---DAAEDDGVVMGYVYDRTTDRSELAI
Mflv_1332|M.gilvum_PYR-GCK HRFGS----GGPGEAVFVPSTSG--PADESSGWYLGYVYDPERNGSDLVV
Mvan_5460|M.vanbaalenii_PYR-1 HRFGTDSAPGGPGEAVFVPSTSG--PADESSGWYLGYVYDPERDGSDLVI
MSMEG_6224|M.smegmatis_MC2_155 HDLGT----GGPGEAVFVPG-AG--PADESNGWYLGYVYDPERDGSDLVI
: . ** * *. : *. * :*: . : .:* :
MMAR_0993|M.marinum_M LDAQTLEL--AACVHLPQRVPLGFHGNWSAST-
MUL_0744|M.ulcerans_Agy99 LDAQTLEL--AACVHLPQRVPLGFHGNWSAST-
MAV_4505|M.avium_104 LDAQSLEQ--VAAVHLPQRVPMGFHGNWVPAG-
Mb0673|M.bovis_AF2122/97 LDAQTLES--IATVHLPQRVPMGFHGNWAPTT-
Rv0654|M.tuberculosis_H37Rv LDAQTLES--IATVHLPQRVPMGFHGNWAPTT-
MAB_3874c|M.abscessus_ATCC_199 LDATSLDL--MATVHLPQRVPAGFHGNWAPR--
TH_3959|M.thermoresistible__bu LDAQTLED--VARIRLPHRVPAGFHGNWVPSDG
Mflv_1332|M.gilvum_PYR-GCK IDASDFSGPPVARVHLPQRVPYGFHGNWISA--
Mvan_5460|M.vanbaalenii_PYR-1 IDASDFGAPPVAKIKLPQRVPYGFHGNWISA--
MSMEG_6224|M.smegmatis_MC2_155 LDASDFGGKPVARIELPRRVPYGFHGNWISA--
:** : * :.**:*** ****** .