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TRTDGDTWDLATSVGSTATGVAAMRALATRQPDPLIDDPYADALVKAVGLEHCIALADGETCVEGDPMLD LNRMCEQIAVRTRYFDELFIAAGADGVRQAVILASGLDTRAYRLDWPAGTVVFEVDQPQVIEFKTRTLAD LGAQPTAERRTVAVDLRDDWPAALRDAGFDPAEPTAWIAEGLLIYLPAEAQDRLLDNITALSAPGSRLAT EHMDHRILAEGAGKRIGEWSRRVGSSLDIADLFYTGERNTAGDYLRGLGWQVTVRPSKEAYADHGFELPE EMAELSGDSGYLSAHLK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1480 | - | - | 100% (298) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1481 | - | 3e-94 | 60.34% (290) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1482 | - | 2e-82 | 54.28% (304) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3432 | - | 1e-83 | 54.58% (306) | hypothetical protein Mb3432 |
| M. gilvum PYR-GCK | Mflv_5024 | - | 1e-101 | 61.41% (298) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv3399 | - | 1e-83 | 54.58% (306) | hypothetical protein Rv3399 |
| M. leprae Br4923 | MLBr_02640 | - | 6e-61 | 47.69% (281) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 3e-79 | 54.95% (293) | hypothetical protein MAB_3787 |
| M. marinum M | MMAR_1058 | - | 3e-92 | 58.16% (294) | O-methyltransferase |
| M. avium 104 | MAV_4442 | - | 1e-100 | 62.29% (297) | methyltransferase, putative, family protein |
| M. thermoresistible (build 8) | TH_2706 | - | 7e-86 | 57.59% (290) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_0817 | - | 1e-90 | 57.48% (294) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1345 | - | 1e-101 | 60.98% (305) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5024|M.gilvum_PYR-GCK ------------------------------------------MAR--TDG
Mvan_1345|M.vanbaalenii_PYR-1 ------------------------------------------MAR--TEG
MSMEG_1480|M.smegmatis_MC2_155 ------------------------------------------MTR--TDG
MMAR_1058|M.marinum_M ------------------------------------------MNR-RTDA
MUL_0817|M.ulcerans_Agy99 ------------------------------------------MNR-RTDA
MAV_4442|M.avium_104 ------------------------------------------MSEGRTDG
Mb3432|M.bovis_AF2122/97 MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMTR--TDN
Rv3399|M.tuberculosis_H37Rv MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMTR--TDN
MAB_3787|M.abscessus_ATCC_1997 ------------------------------------------MAR--TDD
TH_2706|M.thermoresistible__bu ------------------------------------------MAR--SES
MLBr_02640|M.leprae_Br4923 -------------------------------------------MR--THD
. :.
Mflv_5024|M.gilvum_PYR-GCK DTWDLASSVGATATSVAASRAFASR----GPDALIDDPYARLLVEAVGL-
Mvan_1345|M.vanbaalenii_PYR-1 DTWDLGSSVGATATSVAANRAFASRSTAGGPEPLLNDPYADLLVEAVGL-
MSMEG_1480|M.smegmatis_MC2_155 DTWDLATSVGSTATGVAAMRALATR----QPDPLIDDPYADALVKAVGL-
MMAR_1058|M.marinum_M DSWDPASSVGATATMVAASRARASR----GPDALLDDRLAEPLVRAVGL-
MUL_0817|M.ulcerans_Agy99 DSWDPASSVGATATMVAASRARASR----GPDALLDDRLAGPLVRAVGL-
MAV_4442|M.avium_104 DTWGPAQSVGATATMVAAARAVASQ----GPDALLDDPLAEPLVRAVGL-
Mb3432|M.bovis_AF2122/97 DTWDLASSVGATATMIATARALASR----AENPLINDPFAEPLVRAVGI-
Rv3399|M.tuberculosis_H37Rv DTWDLASSVGATATMIATARALASR----AENPLINDPFAEPLVRAVGI-
MAB_3787|M.abscessus_ATCC_1997 DSWDLASSVGATATMVAAQRALASH----VPNPLINDPYAEPLVRAVGI-
TH_2706|M.thermoresistible__bu DTWDLTSGVGVTATMVAAARALASR----EPEPLIDDPFAAPLVRAVGV-
MLBr_02640|M.leprae_Br4923 DTWDIKTSVGTTAVMVAAARAAETD----RPDALIRDPYAKLLVTNTGAG
*:*. .** **. :*: ** : :.*: * * ** .*
Mflv_5024|M.gilvum_PYR-GCK PHFVKVARGEIDFDGDPLF-----GAQQAINQIVVRTRIFDDFLTDAGQR
Mvan_1345|M.vanbaalenii_PYR-1 PHFIRVARGEIDFDDDPLF-----GARQMLEQITVRTRHFDDFFAGAMAA
MSMEG_1480|M.smegmatis_MC2_155 EHCIALADGETCVEGDPML-----DLNRMCEQIAVRTRYFDELFIAAGAD
MMAR_1058|M.marinum_M QPLVRMIDGDTAV-DDPPS-----SPRSLNEQIAVRTRYFDDFFTAAGAG
MUL_0817|M.ulcerans_Agy99 QPLVRMIDGDTAV-DDPPS-----SPRSLNEQIAVRTRYFDDFFTAAGAG
MAV_4442|M.avium_104 DPFIRIVDGKLDFPDDPLF-----NRRARAEQITVRTRFFDDFFIDATEG
Mb3432|M.bovis_AF2122/97 DLFTRLASGELRLEDIG---DHATGGRWMIDNIAIRTKFYDDFFGDATTA
Rv3399|M.tuberculosis_H37Rv DLFTRLASGELRLEDIG---DHATGGRWMIDNIAIRTKFYDDFFGDATTA
MAB_3787|M.abscessus_ATCC_1997 EYFTKLASGAFDPEQMAGLVQLGITADGMANGMASRTWYYDTAFESSTAA
TH_2706|M.thermoresistible__bu EFFTRLVDGDLELPADTAEER--AAAQVLTEVMAVRTRFFDDFFTDATRV
MLBr_02640|M.leprae_Br4923 ALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTYFNNAVID
: . . ** :* : :
Mflv_5024|M.gilvum_PYR-GCK -EPQIRQAVILASGLDTRAYRLDWPAGTVVYEIDQPEVIDFKTAVLTDAG
Mvan_1345|M.vanbaalenii_PYR-1 GPPKIRQAVILASGLDTRAYRLPWPAGTVVYEIDQPTVIEFKTAVLADAG
MSMEG_1480|M.smegmatis_MC2_155 ---GVRQAVILASGLDTRAYRLDWPAGTVVFEVDQPQVIEFKTRTLADLG
MMAR_1058|M.marinum_M ---GIRQAVILASGLDTRAYRLNWPSGMTVYEIDQPQVIEFKTRTLAEFG
MUL_0817|M.ulcerans_Agy99 ---GIRQAVILASGLDTRAYRLNWPSGMTVYEIDQPQVIEFKTRTLAEFG
MAV_4442|M.avium_104 ---GLRQAVILASGLDTRAYRLAWPAGTVVYEIDQPQVIAFKTDTLANLG
Mb3432|M.bovis_AF2122/97 ---GIRQVVILAAGLDTRAYRLPWPPGTVVYEIDQPAVIKFKTRALANLN
Rv3399|M.tuberculosis_H37Rv ---GIRQVVILAAGLDTRAYRLPWPPGTVVYEIDQPAVIKFKTRALANLN
MAB_3787|M.abscessus_ATCC_1997 ---GVRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTDTLAELG
TH_2706|M.thermoresistible__bu ---GARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIAFKTRTLAELG
MLBr_02640|M.leprae_Br4923 ---GIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKSTTLAEHG
** ****:***:***** ** * .*:*:*** *: :*: .*:: .
Mflv_5024|M.gilvum_PYR-GCK VAPAADRRTVGIDLREDWPTALRDAGFDPDRPTAWIAEGLLPYLPPDAQD
Mvan_1345|M.vanbaalenii_PYR-1 VAPTAERRTVGIDLREDWPAALRGAGFDPTRPTAWIAEGLLIYLPPDAQD
MSMEG_1480|M.smegmatis_MC2_155 AQPTAERRTVAVDLRDDWPAALRDAGFDPAEPTAWIAEGLLIYLPAEAQD
MMAR_1058|M.marinum_M ALPCPDHRPIGIDLREDWPSALRQRGFDAGQPTAWIAEGLLVYLPPEAQD
MUL_0817|M.ulcerans_Agy99 ALPCPDHRPIGIDLREDWPSALRQRGFDAGQPTAWIAEGLLVYLPPEAQD
MAV_4442|M.avium_104 AAPTAERRTISIDLRDDWPAALREGGFDVTRPTAWSAEGLLPYLPPEAQD
Mb3432|M.bovis_AF2122/97 AEPNAERHAVAVDLRNDWPTALKNAGFDPARPTAFSAEGLLSYLPPQGQD
Rv3399|M.tuberculosis_H37Rv AEPNAERHAVAVDLRNDWPTALKNAGFDPARPTAFSAEGLLSYLPPQGQD
MAB_3787|M.abscessus_ATCC_1997 ASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYLPPEAQD
TH_2706|M.thermoresistible__bu APPTAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGLLRYLPPDAQD
MLBr_02640|M.leprae_Br4923 VTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYLPATAQD
. * . :: : :***:***.** *** *.: ***** ***. .**
Mflv_5024|M.gilvum_PYR-GCK RLLDSITALSAPGSRLATEHM-DAKALTGD----WAKAMTERARRHGSDI
Mvan_1345|M.vanbaalenii_PYR-1 RLLDHITALSAPGSRLATEHM-DAKALTGE----WARAMTERARRHGSDV
MSMEG_1480|M.smegmatis_MC2_155 RLLDNITALSAPGSRLATEHM-DHRILAEG----AGKRIGEWSRRVGSSL
MMAR_1058|M.marinum_M RLFDNIAELSTPGSQVATEHFPDPNGFSGP----RAQRLSERWRRMGLDL
MUL_0817|M.ulcerans_Agy99 RLFDNIAELSTPRSQVATEHFPDPNGFSGP----RAQRLSERWHRMGMDL
MAV_4442|M.avium_104 RLFDNITALSAPGSRLATEHVPDPNAFSDE----RLARISERWQRLGLNL
Mb3432|M.bovis_AF2122/97 RLLDAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSAAEAWRERGFDL
Rv3399|M.tuberculosis_H37Rv RLLDAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSAAEAWRERGFDL
MAB_3787|M.abscessus_ATCC_1997 RLFASITELSAPGSRLVCEQVPGLETADFS----KARELTRQFAGETLDL
TH_2706|M.thermoresistible__bu RLFDHITDLSAPGSRLATEDHPGPGAGLGE----KADELGRRWREHGFEV
MLBr_02640|M.leprae_Br4923 GLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALG-FEQAV
*: * **: *::. : :
Mflv_5024|M.gilvum_PYR-GCK DLTKLFYNGE-RRSATEHLGAVGWQTSVQTSNDAYIANGFGPIRDDLLAM
Mvan_1345|M.vanbaalenii_PYR-1 NLSELFYSGP-RTSATEHLRAQGWQTEVLSSNDAYQAQGFAPVADHLVAM
MSMEG_1480|M.smegmatis_MC2_155 DIADLFYTGE-RNTAGDYLRGLGWQVTVRPSKEAYADHGFE-LPEEMAEL
MMAR_1058|M.marinum_M DMAELIYHGD-RNTVIDYLADHGWRVRARTFEEMHAHNGFEPPDDEMMAL
MUL_0817|M.ulcerans_Agy99 DMAELIYHGD-RNTVIDYLADHGWRVRARTFEEMHAHNGFEPPDDEMMAL
MAV_4442|M.avium_104 NAADLFYRGE-RNVVADYLTGKGWRVTPHPARQLYARNGFEFPEDEMRAT
Mb3432|M.bovis_AF2122/97 DLTELIYFDQ-RNDVADYLAGSGWQVTTSTGKELFAAQGLPPFEDDHITR
Rv3399|M.tuberculosis_H37Rv DLTELIYFDQ-RNDVADYLAGSGWQVTTSTGKELFAAQGLPPFADDHITR
MAB_3787|M.abscessus_ATCC_1997 DLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLNLDPPNPLLRSI
TH_2706|M.thermoresistible__bu QLSELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYGREFPDSAALAA
MLBr_02640|M.leprae_Br4923 DVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDGVPMADD
: .*.: * . : * ** . : .
Mflv_5024|M.gilvum_PYR-GCK I-GDSGYLTAWRP-------
Mvan_1345|M.vanbaalenii_PYR-1 I-GDSGYLTARLD-------
MSMEG_1480|M.smegmatis_MC2_155 S-GDSGYLSAHLK-------
MMAR_1058|M.marinum_M F-GGMSYVTGIRK-------
MUL_0817|M.ulcerans_Agy99 F-GGMSYVTGIRK-------
MAV_4442|M.avium_104 F-GEMSYVDATLTGGRG---
Mb3432|M.bovis_AF2122/97 F-ADRRYISAVLK-------
Rv3399|M.tuberculosis_H37Rv F-ADRRYISAVLK-------
MAB_3787|M.abscessus_ATCC_1997 F-PNIVYVDATLG-------
TH_2706|M.thermoresistible__bu M-RDSSAVTAVRPVVRAGMR
MLBr_02640|M.leprae_Br4923 KDAFAEFVTAHRL-------
: .