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MSEGRTDGDTWGPAQSVGATATMVAAARAVASQGPDALLDDPLAEPLVRAVGLDPFIRIVDGKLDFPDDP LFNRRARAEQITVRTRFFDDFFIDATEGGLRQAVILASGLDTRAYRLAWPAGTVVYEIDQPQVIAFKTDT LANLGAAPTAERRTISIDLRDDWPAALREGGFDVTRPTAWSAEGLLPYLPPEAQDRLFDNITALSAPGSR LATEHVPDPNAFSDERLARISERWQRLGLNLNAADLFYRGERNVVADYLTGKGWRVTPHPARQLYARNGF EFPEDEMRATFGEMSYVDATLTGGRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4442 | - | - | 100% (306) | methyltransferase, putative, family protein |
| M. avium 104 | MAV_2732 | - | e-103 | 61.87% (299) | methyltransferase |
| M. avium 104 | MAV_4435 | - | 4e-96 | 59.14% (301) | methyltransferase, putative, family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0853 | - | 5e-93 | 56.57% (297) | hypothetical protein Mb0853 |
| M. gilvum PYR-GCK | Mflv_5024 | - | 2e-94 | 58.59% (297) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0830 | - | 5e-93 | 56.57% (297) | hypothetical protein Rv0830 |
| M. leprae Br4923 | MLBr_02640 | - | 9e-60 | 48.62% (290) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 1e-83 | 53.47% (303) | hypothetical protein MAB_3787 |
| M. marinum M | MMAR_1058 | - | 1e-110 | 66.89% (293) | O-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1480 | - | 1e-100 | 62.29% (297) | methyltransferase |
| M. thermoresistible (build 8) | TH_2706 | - | 9e-95 | 59.06% (298) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_0817 | - | 1e-108 | 65.87% (293) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1345 | - | 9e-94 | 59.54% (304) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1058|M.marinum_M MNR-RTDADSWDPASSVGATATMVAASRARASR----GPDALLDDRLAEP
MUL_0817|M.ulcerans_Agy99 MNR-RTDADSWDPASSVGATATMVAASRARASR----GPDALLDDRLAGP
MAV_4442|M.avium_104 MSEGRTDGDTWGPAQSVGATATMVAAARAVASQ----GPDALLDDPLAEP
Mflv_5024|M.gilvum_PYR-GCK MAR--TDGDTWDLASSVGATATSVAASRAFASR----GPDALIDDPYARL
Mvan_1345|M.vanbaalenii_PYR-1 MAR--TEGDTWDLGSSVGATATSVAANRAFASRSTAGGPEPLLNDPYADL
MSMEG_1480|M.smegmatis_MC2_155 MTR--TDGDTWDLATSVGSTATGVAAMRALATR----QPDPLIDDPYADA
TH_2706|M.thermoresistible__bu MAR--SESDTWDLTSGVGVTATMVAAARALASR----EPEPLIDDPFAAP
Mb0853|M.bovis_AF2122/97 MVR--ADRDRWDLATSVGATATMVAAQRALAAD----PRYALIDDPYAAP
Rv0830|M.tuberculosis_H37Rv MVR--ADRDRWDLATSVGATATMVAAQRALAAD----PRYALIDDPYAAP
MAB_3787|M.abscessus_ATCC_1997 MAR--TDDDSWDLASSVGATATMVAAQRALASH----VPNPLINDPYAEP
MLBr_02640|M.leprae_Br4923 -MR--THDDTWDIKTSVGTTAVMVAAARAAETD----RPDALIRDPYAKL
. :. * *. .** **. *** ** : .*: * *
MMAR_1058|M.marinum_M LVRAVGL-QPLVRMIDGDTAV-DDPPSS-----PRSLNEQIAVRTRYFDD
MUL_0817|M.ulcerans_Agy99 LVRAVGL-QPLVRMIDGDTAV-DDPPSS-----PRSLNEQIAVRTRYFDD
MAV_4442|M.avium_104 LVRAVGL-DPFIRIVDGKLDFPDDPLFN-----RRARAEQITVRTRFFDD
Mflv_5024|M.gilvum_PYR-GCK LVEAVGL-PHFVKVARGEIDFDGDPLFG-----AQQAINQIVVRTRIFDD
Mvan_1345|M.vanbaalenii_PYR-1 LVEAVGL-PHFIRVARGEIDFDDDPLFG-----ARQMLEQITVRTRHFDD
MSMEG_1480|M.smegmatis_MC2_155 LVKAVGL-EHCIALADGETCVEGDPMLD-----LNRMCEQIAVRTRYFDE
TH_2706|M.thermoresistible__bu LVRAVGV-EFFTRLVDGDLELPADTAEERA--AAQVLTEVMAVRTRFFDD
Mb0853|M.bovis_AF2122/97 LVRAVGM-DVYTRLVDWQIPVEGDSEFD-----PQRMATGMACRTRFFDQ
Rv0830|M.tuberculosis_H37Rv LVRAVGM-DVYTRLVDWQIPVEGDSEFD-----PQRMATGMACRTRFFDQ
MAB_3787|M.abscessus_ATCC_1997 LVRAVGI-EYFTKLASGAFDPEQMAGLVQLGITADGMANGMASRTWYYDT
MLBr_02640|M.leprae_Br4923 LVTNTGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDT
** .* : . . ** :*
MMAR_1058|M.marinum_M FFTAAGAG---GIRQAVILASGLDTRAYRLNWPSGMTVYEIDQPQVIEFK
MUL_0817|M.ulcerans_Agy99 FFTAAGAG---GIRQAVILASGLDTRAYRLNWPSGMTVYEIDQPQVIEFK
MAV_4442|M.avium_104 FFIDATEG---GLRQAVILASGLDTRAYRLAWPAGTVVYEIDQPQVIAFK
Mflv_5024|M.gilvum_PYR-GCK FLTDAGQR-EPQIRQAVILASGLDTRAYRLDWPAGTVVYEIDQPEVIDFK
Mvan_1345|M.vanbaalenii_PYR-1 FFAGAMAAGPPKIRQAVILASGLDTRAYRLPWPAGTVVYEIDQPTVIEFK
MSMEG_1480|M.smegmatis_MC2_155 LFIAAGAD---GVRQAVILASGLDTRAYRLDWPAGTVVFEVDQPQVIEFK
TH_2706|M.thermoresistible__bu FFTDATRV---GARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIAFK
Mb0853|M.bovis_AF2122/97 FFLDATHS---GIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFK
Rv0830|M.tuberculosis_H37Rv FFLDATHS---GIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFK
MAB_3787|M.abscessus_ATCC_1997 AFESSTAA---GVRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFK
MLBr_02640|M.leprae_Br4923 YFNNAVID---GIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYK
: : * ********:***** ** * *:*:* * *: :*
MMAR_1058|M.marinum_M TRTLAEFGALPCPDHRPIGIDLREDWPSALRQRGFDAGQPTAWIAEGLLV
MUL_0817|M.ulcerans_Agy99 TRTLAEFGALPCPDHRPIGIDLREDWPSALRQRGFDAGQPTAWIAEGLLV
MAV_4442|M.avium_104 TDTLANLGAAPTAERRTISIDLRDDWPAALREGGFDVTRPTAWSAEGLLP
Mflv_5024|M.gilvum_PYR-GCK TAVLTDAGVAPAADRRTVGIDLREDWPTALRDAGFDPDRPTAWIAEGLLP
Mvan_1345|M.vanbaalenii_PYR-1 TAVLADAGVAPTAERRTVGIDLREDWPAALRGAGFDPTRPTAWIAEGLLI
MSMEG_1480|M.smegmatis_MC2_155 TRTLADLGAQPTAERRTVAVDLRDDWPAALRDAGFDPAEPTAWIAEGLLI
TH_2706|M.thermoresistible__bu TRTLAELGAPPTAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGLLR
Mb0853|M.bovis_AF2122/97 TATLSDLGAEPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLV
Rv0830|M.tuberculosis_H37Rv TATLSDLGAEPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLV
MAB_3787|M.abscessus_ATCC_1997 TDTLAELGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLI
MLBr_02640|M.leprae_Br4923 STTLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLM
: .*:: *. * . :* : :***:**..** *** :.* *****
MMAR_1058|M.marinum_M YLPPEAQDRLFDNIAELSTPGSQVATEHFPDPNGFSGPRAQRLSERWRRM
MUL_0817|M.ulcerans_Agy99 YLPPEAQDRLFDNIAELSTPRSQVATEHFPDPNGFSGPRAQRLSERWHRM
MAV_4442|M.avium_104 YLPPEAQDRLFDNITALSAPGSRLATEHVPDPNAFSDERLARISERWQRL
Mflv_5024|M.gilvum_PYR-GCK YLPPDAQDRLLDSITALSAPGSRLATEHM-DAKALTGDWAKAMTERARRH
Mvan_1345|M.vanbaalenii_PYR-1 YLPPDAQDRLLDHITALSAPGSRLATEHM-DAKALTGEWARAMTERARRH
MSMEG_1480|M.smegmatis_MC2_155 YLPAEAQDRLLDNITALSAPGSRLATEHM-DHRILAEGAGKRIGEWSRRV
TH_2706|M.thermoresistible__bu YLPPDAQDRLFDHITDLSAPGSRLATEDHPGPGAGLGEKADELGRRWREH
Mb0853|M.bovis_AF2122/97 YLPVEAQDALFDNITALSAPGSRLAFEFVPDTAIFADERWRNYHNRMSEL
Rv0830|M.tuberculosis_H37Rv YLPVEAQDALFDNITALSAPGSRLAFEFVPDTAIFADERWRNYHNRMSEL
MAB_3787|M.abscessus_ATCC_1997 YLPPEAQDRLFASITELSAPGSRLVCEQVPGLETADFSKARELTRQFAGE
MLBr_02640|M.leprae_Br4923 YLPATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDA
*** *** *: * **: *::. * .
MMAR_1058|M.marinum_M G---LDLDMAELIYHGD-RNTVIDYLADHGWRVRARTFEEMHAHNGFEPP
MUL_0817|M.ulcerans_Agy99 G---MDLDMAELIYHGD-RNTVIDYLADHGWRVRARTFEEMHAHNGFEPP
MAV_4442|M.avium_104 G---LNLNAADLFYRGE-RNVVADYLTGKGWRVTPHPARQLYARNGFEFP
Mflv_5024|M.gilvum_PYR-GCK G---SDIDLTKLFYNGE-RRSATEHLGAVGWQTSVQTSNDAYIANGFGPI
Mvan_1345|M.vanbaalenii_PYR-1 G---SDVNLSELFYSGP-RTSATEHLRAQGWQTEVLSSNDAYQAQGFAPV
MSMEG_1480|M.smegmatis_MC2_155 G---SSLDIADLFYTGE-RNTAGDYLRGLGWQVTVRPSKEAYADHGFE-L
TH_2706|M.thermoresistible__bu G---FEVQLSELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYGREFP
Mb0853|M.bovis_AF2122/97 G---FDIDLNELVYHGQ-RGHVLDYLTRDGWQTSALTVTQLYEANGFAYP
Rv0830|M.tuberculosis_H37Rv G---FDIDLNELVYHGQ-RGHVLDYLTRDGWQTSALTVTQLYEANGFAYP
MAB_3787|M.abscessus_ATCC_1997 T---LDLDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLNLDPP
MLBr_02640|M.leprae_Br4923 LGFEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGD
:: .*.: * . : * ** . : .
MMAR_1058|M.marinum_M DDEMMALF-GGMSYVTGIRK-------
MUL_0817|M.ulcerans_Agy99 DDEMMALF-GGMSYVTGIRK-------
MAV_4442|M.avium_104 EDEMRATF-GEMSYVDATLTGGRG---
Mflv_5024|M.gilvum_PYR-GCK RDDLLAMI-GDSGYLTAWRP-------
Mvan_1345|M.vanbaalenii_PYR-1 ADHLVAMI-GDSGYLTARLD-------
MSMEG_1480|M.smegmatis_MC2_155 PEEMAELS-GDSGYLSAHLK-------
TH_2706|M.thermoresistible__bu DSAALAAM-RDSSAVTAVRPVVRAGMR
Mb0853|M.bovis_AF2122/97 DDELATAF-ADLTYSSATLMR------
Rv0830|M.tuberculosis_H37Rv DDELATAF-ADLTYSSATLMR------
MAB_3787|M.abscessus_ATCC_1997 NPLLRSIF-PNIVYVDATLG-------
MLBr_02640|M.leprae_Br4923 GVPMADDKDAFAEFVTAHRL-------
.