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NRRTDADSWDPASSVGATATMVAASRARASRGPDALLDDRLAEPLVRAVGLQPLVRMIDGDTAVDDPPSS PRSLNEQIAVRTRYFDDFFTAAGAGGIRQAVILASGLDTRAYRLNWPSGMTVYEIDQPQVIEFKTRTLAE FGALPCPDHRPIGIDLREDWPSALRQRGFDAGQPTAWIAEGLLVYLPPEAQDRLFDNIAELSTPGSQVAT EHFPDPNGFSGPRAQRLSERWRRMGLDLDMAELIYHGDRNTVIDYLADHGWRVRARTFEEMHAHNGFEPP DDEMMALFGGMSYVTGIRK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1058 | - | - | 100% (300) | O-methyltransferase |
| M. marinum M | MMAR_1068 | - | 1e-88 | 55.24% (286) | O-methyltransferase |
| M. marinum M | MMAR_4850 | - | 2e-83 | 51.35% (296) | O-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0752c | - | 4e-85 | 55.48% (301) | hypothetical protein Mb0752c |
| M. gilvum PYR-GCK | Mflv_5024 | - | 3e-88 | 55.85% (299) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0731c | - | 4e-85 | 55.48% (301) | hypothetical protein Rv0731c |
| M. leprae Br4923 | MLBr_02640 | - | 3e-59 | 46.79% (280) | hypothetical protein MLBr_02640 |
| M. abscessus ATCC 19977 | MAB_3787 | - | 3e-79 | 50.50% (301) | hypothetical protein MAB_3787 |
| M. avium 104 | MAV_4442 | - | 1e-110 | 66.89% (293) | methyltransferase, putative, family protein |
| M. smegmatis MC2 155 | MSMEG_1480 | - | 3e-92 | 58.16% (294) | methyltransferase |
| M. thermoresistible (build 8) | TH_2706 | - | 2e-89 | 55.00% (300) | PUTATIVE putative methyltransferase |
| M. ulcerans Agy99 | MUL_0817 | - | 1e-175 | 98.67% (300) | O-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1344 | - | 2e-86 | 55.15% (301) | putative methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1058|M.marinum_M MNR----RTDADSWDPASSVGATATMVAASRARASRGPDALLDDRLAEPL
MUL_0817|M.ulcerans_Agy99 MNR----RTDADSWDPASSVGATATMVAASRARASRGPDALLDDRLAGPL
MAV_4442|M.avium_104 MSEG---RTDGDTWGPAQSVGATATMVAAARAVASQGPDALLDDPLAEPL
Mflv_5024|M.gilvum_PYR-GCK MAR-----TDGDTWDLASSVGATATSVAASRAFASRGPDALIDDPYARLL
MSMEG_1480|M.smegmatis_MC2_155 MTR-----TDGDTWDLATSVGSTATGVAAMRALATRQPDPLIDDPYADAL
Mb0752c|M.bovis_AF2122/97 MTQTGSARFEGDSWDLASSVGLTATMVAAARAVAGRAPGALVNDQFAEPL
Rv0731c|M.tuberculosis_H37Rv MTQTGSARFEGDSWDLASSVGLTATMVAAARAVAGRAPGALVNDQFAEPL
MAB_3787|M.abscessus_ATCC_1997 MAR-----TDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPL
Mvan_1344|M.vanbaalenii_PYR-1 MAR-----TADDSWDPASSVGATATMVAAGRAAASADPDPLINDPYAEPL
TH_2706|M.thermoresistible__bu MAR-----SESDTWDLTSGVGVTATMVAAARALASREPEPLIDDPFAAPL
MLBr_02640|M.leprae_Br4923 MR------THDDTWDIKTSVGTTAVMVAAARAAETDRPDALIRDPYAKLL
* *:*. .** **. *** ** * .*: * * *
MMAR_1058|M.marinum_M VRAVGL-QPLVRMIDGDTAV----DDPPS--SPRSLNEQIAVRTRYFDDF
MUL_0817|M.ulcerans_Agy99 VRAVGL-QPLVRMIDGDTAV----DDPPS--SPRSLNEQIAVRTRYFDDF
MAV_4442|M.avium_104 VRAVGL-DPFIRIVDGKLDFP---DDPLF--NRRARAEQITVRTRFFDDF
Mflv_5024|M.gilvum_PYR-GCK VEAVGL-PHFVKVARGEIDFD---GDPLF--GAQQAINQIVVRTRIFDDF
MSMEG_1480|M.smegmatis_MC2_155 VKAVGL-EHCIALADGETCVE---GDPML--DLNRMCEQIAVRTRYFDEL
Mb0752c|M.bovis_AF2122/97 VRAVGV-DFFVRMASGELDPDELAEDEAN--GLRRFADAMAIRTHYFDNF
Rv0731c|M.tuberculosis_H37Rv VRAVGV-DFFVRMASGELDPDELAEDEAN--GLRRFADAMAIRTHYFDNF
MAB_3787|M.abscessus_ATCC_1997 VRAVGI-EYFTKLASGAFDPEQMAGLVQLGITADGMANGMASRTWYYDTA
Mvan_1344|M.vanbaalenii_PYR-1 VRAVGL-SFFTKMLDGELDLSQFADGSPE--RVQAMIDGMAVRTRFFDDC
TH_2706|M.thermoresistible__bu VRAVGV-EFFTRLVDGDLELP--ADTAEERAAAQVLTEVMAVRTRFFDDF
MLBr_02640|M.leprae_Br4923 VTNTGAGALWEAMLDPSMVAKVEAIDAEAAAMVEHMRSYQAVRTNFFDTY
* .* : . . ** :*
MMAR_1058|M.marinum_M FTAAG--AGGIRQAVILASGLDTRAYRLNWPSGMTVYEIDQPQVIEFKTR
MUL_0817|M.ulcerans_Agy99 FTAAG--AGGIRQAVILASGLDTRAYRLNWPSGMTVYEIDQPQVIEFKTR
MAV_4442|M.avium_104 FIDAT--EGGLRQAVILASGLDTRAYRLAWPAGTVVYEIDQPQVIAFKTD
Mflv_5024|M.gilvum_PYR-GCK LTDAGQREPQIRQAVILASGLDTRAYRLDWPAGTVVYEIDQPEVIDFKTA
MSMEG_1480|M.smegmatis_MC2_155 FIAAG--ADGVRQAVILASGLDTRAYRLDWPAGTVVFEVDQPQVIEFKTR
Mb0752c|M.bovis_AF2122/97 FLDAT--RAGIRQAVILASGLDSRAYRLRWPAGTIVFEVDQPQVIDFKTT
Rv0731c|M.tuberculosis_H37Rv FLDAT--RAGIRQAVILASGLDSRAYRLRWPAGTIVFEVDQPQVIDFKTT
MAB_3787|M.abscessus_ATCC_1997 FESST--AAGVRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTD
Mvan_1344|M.vanbaalenii_PYR-1 CGTST--TAGITQVVILASGLDARAYRLGWPAGTVVYELDQPAVIEFKTR
TH_2706|M.thermoresistible__bu FTDAT--RVGARQAVILASGLDARAYRLTWPDGTVVYEIDQPEVIAFKTR
MLBr_02640|M.leprae_Br4923 FNNAV--IDGIRQFVILASGLDSRAYRLDWPTGTTVYEIDQPKVLAYKST
: * ********:***** ** * *:*:*** *: :*:
MMAR_1058|M.marinum_M TLAEFGALPCPDHRPIGIDLREDWPSALRQRGFDAGQPTAWIAEGLLVYL
MUL_0817|M.ulcerans_Agy99 TLAEFGALPCPDHRPIGIDLREDWPSALRQRGFDAGQPTAWIAEGLLVYL
MAV_4442|M.avium_104 TLANLGAAPTAERRTISIDLRDDWPAALREGGFDVTRPTAWSAEGLLPYL
Mflv_5024|M.gilvum_PYR-GCK VLTDAGVAPAADRRTVGIDLREDWPTALRDAGFDPDRPTAWIAEGLLPYL
MSMEG_1480|M.smegmatis_MC2_155 TLADLGAQPTAERRTVAVDLRDDWPAALRDAGFDPAEPTAWIAEGLLIYL
Mb0752c|M.bovis_AF2122/97 TLAGLGAAPTTDRRTVAVDLRDDWPTALQKAGFDNAQRTAWIAEGLLGYL
Rv0731c|M.tuberculosis_H37Rv TLAGLGAAPTTDRRTVAVDLRDDWPTALQKAGFDNAQRTAWIAEGLLGYL
MAB_3787|M.abscessus_ATCC_1997 TLAELGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYL
Mvan_1344|M.vanbaalenii_PYR-1 TLAGLGAHPTATHRPVPIDLREDWPAALHAAGFDASRPTAWLAEGLLIYL
TH_2706|M.thermoresistible__bu TLAELGAPPTAPHRPVAVDLRDDWPAALTAAGFDPTVATAWSAEGLLRYL
MLBr_02640|M.leprae_Br4923 TLAEHGVTPTADRREVPIDLRQDWPPALRSAGFDPSARTAWLAEGLLMYL
.*: *. * . :* : :***:***.** *** *.* ***** **
MMAR_1058|M.marinum_M PPEAQDRLFDNIAELSTPGSQVATEHFPDPNGFSGP----RAQRLSERWR
MUL_0817|M.ulcerans_Agy99 PPEAQDRLFDNIAELSTPRSQVATEHFPDPNGFSGP----RAQRLSERWH
MAV_4442|M.avium_104 PPEAQDRLFDNITALSAPGSRLATEHVPDPNAFSDE----RLARISERWQ
Mflv_5024|M.gilvum_PYR-GCK PPDAQDRLLDSITALSAPGSRLATEHM-DAKALTGD----WAKAMTERAR
MSMEG_1480|M.smegmatis_MC2_155 PAEAQDRLLDNITALSAPGSRLATEHM-DHRILAEG----AGKRIGEWSR
Mb0752c|M.bovis_AF2122/97 SAEAQDRLLDQITAQSVPGSQFATEVLRDINRLNEEELRGRMRRLAERFR
Rv0731c|M.tuberculosis_H37Rv SAEAQDRLLDQITAQSVPGSQFATEVLRDINRLNEEELRGRMRRLAERFR
MAB_3787|M.abscessus_ATCC_1997 PPEAQDRLFASITELSAPGSRLVCEQVPGLETADFS----KARELTRQFA
Mvan_1344|M.vanbaalenii_PYR-1 PPEAQDQLFDRITALSAPGSTIATEYAPGIIDFDDE----KARAMSAPMR
TH_2706|M.thermoresistible__bu PPDAQDRLFDHITDLSAPGSRLATEDHPGPGAGLGE----KADELGRRWR
MLBr_02640|M.leprae_Br4923 PATAQDGLFTEIGGLSAVGSRIAVETSPLHGDEWREQMQLRFRRVSDALG
.. *** *: * *. * .. * :
MMAR_1058|M.marinum_M RMGLDLDMAELIYHGD-RNTVIDYLADHGWRVRARTFEEMHAHNG-FEPP
MUL_0817|M.ulcerans_Agy99 RMGMDLDMAELIYHGD-RNTVIDYLADHGWRVRARTFEEMHAHNG-FEPP
MAV_4442|M.avium_104 RLGLNLNAADLFYRGE-RNVVADYLTGKGWRVTPHPARQLYARNG-FEFP
Mflv_5024|M.gilvum_PYR-GCK RHGSDIDLTKLFYNGE-RRSATEHLGAVGWQTSVQTSNDAYIANG-FGPI
MSMEG_1480|M.smegmatis_MC2_155 RVGSSLDIADLFYTGE-RNTAGDYLRGLGWQVTVRPSKEAYADHG-F-EL
Mb0752c|M.bovis_AF2122/97 RHGLDLDMSGLVYFGD-RTDARTYLADHGWRTASASTTDLLAEHG-LPPI
Rv0731c|M.tuberculosis_H37Rv RHGLDLDMSGLVYFGD-RTDARTYLADHGWRTASASTTDLLAEHG-LPPI
MAB_3787|M.abscessus_ATCC_1997 GETLDLDLESLVYTQE-RQMAADWLAEHGWTVITEENDELYARLN-LDPP
Mvan_1344|M.vanbaalenii_PYR-1 EMGLDIDMPSLVYAGT-RSHVMDYLAGQGWEVTGVPRRELFTRYGRPLPP
TH_2706|M.thermoresistible__bu EHGFEVQLSELFHPGE-RTPVVDYLRGRGWDARARPRAEVFAGYG-REFP
MLBr_02640|M.leprae_Br4923 -FEQAVDVQELIYHDENRAVVADWLNRHGWRATAQSAPDEMRRVGRWGDG
:: *.: * . * ** . : .
MMAR_1058|M.marinum_M DDEMMALFGGMSYVTGIRK-------
MUL_0817|M.ulcerans_Agy99 DDEMMALFGGMSYVTGIRK-------
MAV_4442|M.avium_104 EDEMRATFGEMSYVDATLTGGRG---
Mflv_5024|M.gilvum_PYR-GCK RDDLLAMIGDSGYLTAWRP-------
MSMEG_1480|M.smegmatis_MC2_155 PEEMAELSGDSGYLSAHLK-------
Mb0752c|M.bovis_AF2122/97 DGDD-APFGEVIYVSAELKQKHQDTR
Rv0731c|M.tuberculosis_H37Rv DGDD-APFGEVIYVSAELKQKHQDTR
MAB_3787|M.abscessus_ATCC_1997 NPLLRSIFPNIVYVDATLG-------
Mvan_1344|M.vanbaalenii_PYR-1 EAGDTDPLGEIVYVSAHRPQ------
TH_2706|M.thermoresistible__bu DSAALAAMRDSSAVTAVRPVVRAGMR
MLBr_02640|M.leprae_Br4923 VPMADDKDAFAEFVTAHRL-------
: .