For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ADGVGTAQMRPYFEEVQAHYDLSDDFFGLFQDPSRTYSCAYYERDDMTLEQAQMAKIDLALDQLALQPGM TLLDIGCGWGALMKRAIEKYDVDVIGLTLSKNQYAFCQQLLDQIDTRRSHFVCLQGWEQFDAPVDRIVSI EAFEAFGKSRYKAFFDTTYRVMPDDGRMVIETIFTHPINYWREHGIAVTLSDMKFTRFIYKEIFPGGQLP SDDDMRDFSGAAGFHTADVTVMNPHYVRTLDTWAENLSAQRAAAIATTSEEVYDRYMHYLTGCADFFRRG ISEVAQFAYTKSG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1203 | - | - | 100% (294) | methoxy mycolic acid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_0913 | - | 2e-95 | 55.79% (285) | methoxy mycolic acid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_3538 | - | 7e-93 | 55.99% (284) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0664c | mmaA1 | 1e-98 | 58.25% (285) | methoxy mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_1800 | - | 1e-106 | 63.03% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0645c | mmaA1 | 1e-98 | 58.25% (285) | methoxy mycolic acid synthase |
| M. leprae Br4923 | MLBr_01900 | mmaA1 | 2e-98 | 57.54% (285) | methyl mycolic acid synthase 1 |
| M. abscessus ATCC 19977 | MAB_4088c | - | 3e-93 | 54.51% (288) | mycolic acid synthase UmaA1 |
| M. marinum M | MMAR_0794 | umaA | 2e-96 | 56.34% (284) | mycolic acid synthase UmaA |
| M. avium 104 | MAV_4516 | - | 1e-101 | 58.95% (285) | methoxy mycolic acid synthase 1 |
| M. thermoresistible (build 8) | TH_2621 | - | 1e-123 | 69.66% (290) | PUTATIVE methoxy mycolic acid synthase 1 |
| M. ulcerans Agy99 | MUL_4538 | umaA | 2e-96 | 56.34% (284) | mycolic acid synthase UmaA |
| M. vanbaalenii PYR-1 | Mvan_4949 | - | 1e-107 | 63.38% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0794|M.marinum_M ------------------MTELRPFYEESQSIYDVSDEFFALFLDP-TMA
MUL_4538|M.ulcerans_Agy99 ------------------MTELRPFYEESQSIYDVSDEFFALFLDP-TMA
MAB_4088c|M.abscessus_ATCC_199 ------------------MSDLKPYYEESQSIYDISDEFYGLFLDEETMG
Mb0664c|M.bovis_AF2122/97 ------------------MAKLRPYYEESQSAYDISDDFFALFLDP-TWV
Rv0645c|M.tuberculosis_H37Rv ------------------MAKLRPYYEESQSAYDISDDFFALFLDP-TWV
MLBr_01900|M.leprae_Br4923 ------------------MAKLRPYYEESQSAYDISDDFFALFLDP-TWV
MAV_4516|M.avium_104 ------------------MAKLKPYYEESQATYDISDDFFALFLDP-NMV
MSMEG_1203|M.smegmatis_MC2_155 -MADGVGT-----------AQMRPYFEEVQAHYDLSDDFFGLFQDP-SRT
TH_2621|M.thermoresistible__bu ---VMVES-----------TELRPNFEDVQAHYDLSNEFFGLFQDP-TRT
Mflv_1800|M.gilvum_PYR-GCK MTGRTAEPPTGHDTTPPTAEDMKPHFEEVQAHYDLSDVFFGLFQDP-SRT
Mvan_4949|M.vanbaalenii_PYR-1 MAKSSVNP-------PAAGKNMEPHFEEVQAHYDLSDDFFGLFQDP-SRT
.:.* :*: *: **:*: *:.** * .
MMAR_0794|M.marinum_M YTCAYFERDDMTLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGALQRA
MUL_4538|M.ulcerans_Agy99 YTCAYFERDDMTLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGALQRA
MAB_4088c|M.abscessus_ATCC_199 YTCAYFERDDLTLAEAQIAKFDLALGKLNLEPGMTVLDIGCGWGACLDRA
Mb0664c|M.bovis_AF2122/97 YTCAYFERDDMTLEEAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRA
Rv0645c|M.tuberculosis_H37Rv YTCAYFERDDMTLEEAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRA
MLBr_01900|M.leprae_Br4923 YTCAYFERDDMTLEEAQLAKLDLALDKLNLAPGMTLLDVGCGWGGALVRA
MAV_4516|M.avium_104 YTCAYFENDDMTLEQAQLAKLDLGLDKLNLEPGMTLLDVGCGWGGAVVRA
MSMEG_1203|M.smegmatis_MC2_155 YSCAYYERDDMTLEQAQMAKIDLALDQLALQPGMTLLDIGCGWGALMKRA
TH_2621|M.thermoresistible__bu YSCAYYARDDMTLEEAQLAKIDLALDKLGLQPGMTLLDIGCGWGSTMKRA
Mflv_1800|M.gilvum_PYR-GCK YSCAYYERDDMTLAEAQIAKIDLALGKLNLEPGMTLLDIGCGWGSVLQRA
Mvan_4949|M.vanbaalenii_PYR-1 YSCAFYERDDVTLAEAQMAKIDLALGKLELKPGMTLLDIGCGWGSVLQRA
*:**:: .**:** :*. **.**.*.:* * ****:**:*****. : **
MMAR_0794|M.marinum_M VEKYDVNVIGITLSRNQFEYSKAKMAKIPTER--TVEVRLQGWEEFEDKV
MUL_4538|M.ulcerans_Agy99 VEKYDVNVIGITLSRNQFDYSKAKMAKIPTER--TVEVRLQGWEEFEDKV
MAB_4088c|M.abscessus_ATCC_199 MRKFDVNVIGITLSKNQSEYSRKRLAQVAAETGRSAEIRMQGWEEFNDKV
Mb0664c|M.bovis_AF2122/97 VEKYDVNVIGLTLSRNHYERSKDRLAAIGTQR--RAEARLQGWEEFEENV
Rv0645c|M.tuberculosis_H37Rv VEKYDVNVIGLTLSRNHYERSKDRLAAIGTQR--RAEARLQGWEEFEENV
MLBr_01900|M.leprae_Br4923 VEKYDVNVIGLTLSRNHCARSKARLAEILTKR--HAEARLQGWEEFEEKV
MAV_4516|M.avium_104 LEKYDVNVIGITLSRNHYARTKERLAAIPTTR--RAEARLQGWEEFDEPV
MSMEG_1203|M.smegmatis_MC2_155 IEKYDVDVIGLTLSKNQYAFCQQLLDQIDTRR--SHFVCLQGWEQFDAPV
TH_2621|M.thermoresistible__bu VERHDVNVIGLTLSRNQCAYSRDLLAGLDTDR--SRRVLLQGWEQFDEPV
Mflv_1800|M.gilvum_PYR-GCK VEKYDVNVVGLTLSRNQCKFAQDLLDGLDTER--SRRILLRGWEQFDEPV
Mvan_4949|M.vanbaalenii_PYR-1 VEKHDVNVVGLTLSRNQCRFAQELLDGLDTER--SRRILLRGWEQFDEPV
:.:.**:*:*:***:*: : : : : ::***:*: *
MMAR_0794|M.marinum_M DRIVTIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEM
MUL_4538|M.ulcerans_Agy99 DRIVTIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEM
MAB_4088c|M.abscessus_ATCC_199 DRIVTIGAFEAFKQERYPIFFERAYDILPNDGRMLLHTILAHTQQFFREN
Mb0664c|M.bovis_AF2122/97 DRIVSFEAFDAFKKERYLTFFERSYDILPDDGRMLLHSLFTYDRRWLHEQ
Rv0645c|M.tuberculosis_H37Rv DRIVSFEAFDAFKKERYLTFFERSYDILPDDGRMLLHSLFTYDRRWLHEQ
MLBr_01900|M.leprae_Br4923 DRIVSFEALDAFKKERYPAFFERSYNILPDDGRMLLHSLFTYDRRWLHEQ
MAV_4516|M.avium_104 DRIISFEAFDAFKKERWPAFWDWAYKSLPNDSRMLMHSIFTYPQSQWKER
MSMEG_1203|M.smegmatis_MC2_155 DRIVSIEAFEAFGKSRYKAFFDTTYRVMPDDGRMVIETIFTHPINYWREH
TH_2621|M.thermoresistible__bu DRIVSIEAFEAFGKPRYKPFFELTHRILPDGGRFVLETIFTHPPSYWHDH
Mflv_1800|M.gilvum_PYR-GCK DRIISIEAIEAFPQERYAPFFKMCSSVLPEGGRFVLQAILGHPLKKWPEL
Mvan_4949|M.vanbaalenii_PYR-1 DRIVSIEAIEAFPQERYAPFFQMCSRALPRGGRMLLQAILGHPLKKWPEM
***::: *::** *: *:. :* ..*:::.::: : :
MMAR_0794|M.marinum_M GVKVTMSDVRFMRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQLLQQ
MUL_4538|M.ulcerans_Agy99 GVKVTMSDVRFMRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQLLQQ
MAB_4088c|M.abscessus_ATCC_199 GIAITISDLKFMKFIGEEIFPGGQLPAVEDIEKLAADSGFNLERVHLLQP
Mb0664c|M.bovis_AF2122/97 GIALTMSDLRFLKFLRESIFPGGELPSEPDIVDNAQAAGFTIEHVQLLQQ
Rv0645c|M.tuberculosis_H37Rv GIALTMSDLRFLKFLRESIFPGGELPSEPDIVDNAQAAGFTIEHVQLLQQ
MLBr_01900|M.leprae_Br4923 GIPLTMGDLRFLKFLRESIFPGGELPSQPDIVDNAEAAGFSVEQIQLMQP
MAV_4516|M.avium_104 GIPITMSDLRFFHFLGKEIFPGGQMCGEADIVDLSQASGFSLEQVQYLRP
MSMEG_1203|M.smegmatis_MC2_155 GIAVTLSDMKFTRFIYKEIFPGGQLPSDDDMRDFSGAAGFHTADVTVMNP
TH_2621|M.thermoresistible__bu GIAITMSDLRFMRFVGKEIFPGGEMPSAEDVVDISTAAGFRQEDLQLMNP
Mflv_1800|M.gilvum_PYR-GCK GIPIVMSDLKFMRFIAKEIFPGGSVPGEENIVELSAEAGFTLEQTQFLNK
Mvan_4949|M.vanbaalenii_PYR-1 GIPIVMSDLKFMRFIAKEIFPGGSVPSEENIVELSADAGFTLERTQFLNQ
*: :.:.*::* :*: :.*****.: . :: . : :** :.
MMAR_0794|M.marinum_M HYARTLNIWAANLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNV
MUL_4538|M.ulcerans_Agy99 HYARTLNIWAANLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNV
MAB_4088c|M.abscessus_ATCC_199 HYAKTLDIWAQNLEQRREEAIAIQSQEVYDRFMKYLTGCADFFRRGVTNV
Mb0664c|M.bovis_AF2122/97 HYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINV
Rv0645c|M.tuberculosis_H37Rv HYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINV
MLBr_01900|M.leprae_Br4923 HYARTLDMWATNLAAARDHALAIQPEEIYDNFMHYLTGCADRFRRGLINV
MAV_4516|M.avium_104 HYARTLDTWAANLEANREQAIAIQSQEVYDRFMRYLTGCAELFRKGISNV
MSMEG_1203|M.smegmatis_MC2_155 HYVRTLDTWAENLSAQRAAAIATTSEEVYDRYMHYLTGCADFFRRGISEV
TH_2621|M.thermoresistible__bu HYVRTLDTWADNLQDRRDEAIAVTSEKVYANYLRYLTGCADFFRRGITEV
Mflv_1800|M.gilvum_PYR-GCK DYARTLDTWAEALEAHHDEAVAATSEEVYQRYMKYLTGCSDFFTRGISEL
Mvan_4949|M.vanbaalenii_PYR-1 DYVRTLDTWAQALEAHHDEAVAATSEEVYQRYMKYLTGCSDFFNRGISEL
.*.:**: ** * : *:* .:::* .:::***** : * :*: ::
MMAR_0794|M.marinum_M GQFTLVK--
MUL_4538|M.ulcerans_Agy99 GQFTLVK--
MAB_4088c|M.abscessus_ATCC_199 GQFTLVK--
Mb0664c|M.bovis_AF2122/97 AQFTMTK--
Rv0645c|M.tuberculosis_H37Rv AQFTMTK--
MLBr_01900|M.leprae_Br4923 AQFTLTK--
MAV_4516|M.avium_104 AQYTLTK--
MSMEG_1203|M.smegmatis_MC2_155 AQFAYTKSG
TH_2621|M.thermoresistible__bu GQFTMVKGG
Mflv_1800|M.gilvum_PYR-GCK GQFTLVKA-
Mvan_4949|M.vanbaalenii_PYR-1 GQFTLVKT-
.*:: .*