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MAKSSVNPPAAGKNMEPHFEEVQAHYDLSDDFFGLFQDPSRTYSCAFYERDDVTLAEAQMAKIDLALGKL ELKPGMTLLDIGCGWGSVLQRAVEKHDVNVVGLTLSRNQCRFAQELLDGLDTERSRRILLRGWEQFDEPV DRIVSIEAIEAFPQERYAPFFQMCSRALPRGGRMLLQAILGHPLKKWPEMGIPIVMSDLKFMRFIAKEIF PGGSVPSEENIVELSADAGFTLERTQFLNQDYVRTLDTWAQALEAHHDEAVAATSEEVYQRYMKYLTGCS DFFNRGISELGQFTLVKT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4949 | - | - | 100% (298) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. vanbaalenii PYR-1 | Mvan_0803 | - | 9e-99 | 59.86% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 1e-92 | 56.69% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0662c | mmaA3 | 2e-94 | 60.07% (278) | methoxy mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_1800 | - | 1e-154 | 89.62% (289) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0644c | mmaA2 | 5e-95 | 58.45% (284) | methoxy mycolic acid synthase |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-89 | 56.18% (283) | Mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_4088c | - | 2e-93 | 56.79% (287) | mycolic acid synthase UmaA1 |
| M. marinum M | MMAR_2920 | mmaA2_1 | 1e-100 | 61.84% (283) | methoxy mycolic acid synthase 2 MmaA2 _1 |
| M. avium 104 | MAV_0130 | - | 2e-99 | 59.86% (284) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_1203 | - | 1e-107 | 63.38% (284) | methoxy mycolic acid synthase 1 |
| M. thermoresistible (build 8) | TH_2621 | - | 1e-116 | 67.49% (283) | PUTATIVE methoxy mycolic acid synthase 1 |
| M. ulcerans Agy99 | MUL_4538 | umaA | 1e-95 | 57.24% (283) | mycolic acid synthase UmaA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4949|M.vanbaalenii_PYR-1 MAKSSVNP-------PAAGKNMEPHFEEVQAHYDLSDDFFGLFQDP-SRT
Mflv_1800|M.gilvum_PYR-GCK MTGRTAEPPTGHDTTPPTAEDMKPHFEEVQAHYDLSDVFFGLFQDP-SRT
MSMEG_1203|M.smegmatis_MC2_155 -MADGVGT-----------AQMRPYFEEVQAHYDLSDDFFGLFQDP-SRT
TH_2621|M.thermoresistible__bu ---VMVES-----------TELRPNFEDVQAHYDLSNEFFGLFQDP-TRT
Rv0644c|M.tuberculosis_H37Rv -MVNDLT----------------PHFEDVQAHYDLSDDFFRLFLDP-TQT
MMAR_2920|M.marinum_M -MAQRLV----------------PHFDDVQAHYDLSDDFFRLFLDP-TQT
MLBr_02459|M.leprae_Br4923 -MSVQLT----------------PHFRNVQAHYDLSDDFFRLFLDP-TLT
Mb0662c|M.bovis_AF2122/97 -MSDNSTG----------TTKSRSNVDDVQAHYDLSDAFFALFQDP-TRT
MAV_0130|M.avium_104 -MSENTGD----------AVNLQPHFDDVQAHYDLSDEFFALFLDP-TRT
MAB_4088c|M.abscessus_ATCC_199 -MS-----------------DLKPYYEESQSIYDISDEFYGLFLDEETMG
MUL_4538|M.ulcerans_Agy99 -MT-----------------ELRPFYEESQSIYDVSDEFFALFLDP-TMA
. : *: **:*: *: ** * :
Mvan_4949|M.vanbaalenii_PYR-1 YSCAFYERDDVTLAEAQMAKIDLALGKLELKPGMTLLDIGCGWGSVLQRA
Mflv_1800|M.gilvum_PYR-GCK YSCAYYERDDMTLAEAQIAKIDLALGKLNLEPGMTLLDIGCGWGSVLQRA
MSMEG_1203|M.smegmatis_MC2_155 YSCAYYERDDMTLEQAQMAKIDLALDQLALQPGMTLLDIGCGWGALMKRA
TH_2621|M.thermoresistible__bu YSCAYYARDDMTLEEAQLAKIDLALDKLGLQPGMTLLDIGCGWGSTMKRA
Rv0644c|M.tuberculosis_H37Rv YSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRA
MMAR_2920|M.marinum_M YSCAYFERDDMTLEEAQIAKIDLALGKLGLEPGMTLLDIGCGWGATMRRA
MLBr_02459|M.leprae_Br4923 YSCAYFERDDMTLEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRA
Mb0662c|M.bovis_AF2122/97 YSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRA
MAV_0130|M.avium_104 YSCAYFERDDMTLEEAQIAKVDLSLGKLGLQPGMTLLDIGCGWGTTIVRA
MAB_4088c|M.abscessus_ATCC_199 YTCAYFERDDLTLAEAQIAKFDLALGKLNLEPGMTVLDIGCGWGACLDRA
MUL_4538|M.ulcerans_Agy99 YTCAYFERDDMTLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGALQRA
*:**.: *:*:** :*. **.**:*.:* *:****:**:***** : **
Mvan_4949|M.vanbaalenii_PYR-1 VEKHDVNVVGLTLSRNQCRFAQELLDGLDTER--SRRILLRGWEQFDEPV
Mflv_1800|M.gilvum_PYR-GCK VEKYDVNVVGLTLSRNQCKFAQDLLDGLDTER--SRRILLRGWEQFDEPV
MSMEG_1203|M.smegmatis_MC2_155 IEKYDVDVIGLTLSKNQYAFCQQLLDQIDTRR--SHFVCLQGWEQFDAPV
TH_2621|M.thermoresistible__bu VERHDVNVIGLTLSRNQCAYSRDLLAGLDTDR--SRRVLLQGWEQFDEPV
Rv0644c|M.tuberculosis_H37Rv IAQYDVNVVGLTLSKNQAAHVQKSFDEMDTPR--DRRVLLAGWEQFNEPV
MMAR_2920|M.marinum_M IEKHDVNVVGLTLSNNQAAHVQKSFDQLDTAR--TRRVLLKGWEQFDEPV
MLBr_02459|M.leprae_Br4923 IEIYDVNVIGLTLSENQAAHVQKTFDELDTPR--TRRVLLEGWEKFHEPV
Mb0662c|M.bovis_AF2122/97 VERYDVNVVGLTLSKNQHAYCQQVLDKVDTNR--SHRVLLSDWANFSEPV
MAV_0130|M.avium_104 LERYDVNVVGLTLSRNQQAHVQRPLDNHPSPR--SKRVLLQGWEQFDEKV
MAB_4088c|M.abscessus_ATCC_199 MRKFDVNVIGITLSKNQSEYSRKRLAQVAAETGRSAEIRMQGWEEFNDKV
MUL_4538|M.ulcerans_Agy99 VEKYDVNVIGITLSRNQFDYSKAKMAKIPTER--TVEVRLQGWEEFEDKV
: .**:*:*:***.** . : : : : : .* :* *
Mvan_4949|M.vanbaalenii_PYR-1 DRIVSIEAIEAFPQERYAPFFQMCSRALPRGGRMLLQAILGHPLKKWPEM
Mflv_1800|M.gilvum_PYR-GCK DRIISIEAIEAFPQERYAPFFKMCSSVLPEGGRFVLQAILGHPLKKWPEL
MSMEG_1203|M.smegmatis_MC2_155 DRIVSIEAFEAFGKSRYKAFFDTTYRVMPDDGRMVIETIFTHPINYWREH
TH_2621|M.thermoresistible__bu DRIVSIEAFEAFGKPRYKPFFELTHRILPDGGRFVLETIFTHPPSYWHDH
Rv0644c|M.tuberculosis_H37Rv DRIVSIGAFEHFGHDRHADFFARAHKILPPDGVLLLHTITGLTRQQMVDH
MMAR_2920|M.marinum_M DRIVSIGAFEHFGHDRYDDFFAMAHRVLPRGGVMLLHTITGLTREQISDR
MLBr_02459|M.leprae_Br4923 DRIVSIGAFEHFGRQRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARAR
Mb0662c|M.bovis_AF2122/97 DRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIER
MAV_0130|M.avium_104 DRIVSIGAFEHFGRDRYDDFFKMAYAALPDDGVMMLHTIIKPSDEEFAER
MAB_4088c|M.abscessus_ATCC_199 DRIVTIGAFEAFKQERYPIFFERAYDILPNDGRMLLHTILAHTQQFFREN
MUL_4538|M.ulcerans_Agy99 DRIVTIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEM
***::* *:* * *: ** :* .. :::.:* .
Mvan_4949|M.vanbaalenii_PYR-1 GIPIVMSDLKFMRFIAKEIFPGGSVPSEENIVELSADAGFTLERTQFLNQ
Mflv_1800|M.gilvum_PYR-GCK GIPIVMSDLKFMRFIAKEIFPGGSVPGEENIVELSAEAGFTLEQTQFLNK
MSMEG_1203|M.smegmatis_MC2_155 GIAVTLSDMKFTRFIYKEIFPGGQLPSDDDMRDFSGAAGFHTADVTVMNP
TH_2621|M.thermoresistible__bu GIAITMSDLRFMRFVGKEIFPGGEMPSAEDVVDISTAAGFRQEDLQLMNP
Rv0644c|M.tuberculosis_H37Rv GLPLTLWLARFLKFIATEIFPGGQPPTIEMVEEQSAKTGFTLTRRQSLQP
MMAR_2920|M.marinum_M GIPISIDMIRFVKFIVTEIFPGGRLPSIDMVQQHAGRAGFTLTRRQSLQP
MLBr_02459|M.leprae_Br4923 GMTLTHEIVHFTQFILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQL
Mb0662c|M.bovis_AF2122/97 GIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQP
MAV_0130|M.avium_104 GLPITMTKLRFMKFIMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRP
MAB_4088c|M.abscessus_ATCC_199 GIAITISDLKFMKFIGEEIFPGGQLPAVEDIEKLAADSGFNLERVHLLQP
MUL_4538|M.ulcerans_Agy99 GVKVTMSDVRFMRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQLLQQ
*: : :* :*: :***** * : . :** :.
Mvan_4949|M.vanbaalenii_PYR-1 DYVRTLDTWAQALEAHHDEAVAATSEEVYQRYMKYLTGCSDFFNRGISEL
Mflv_1800|M.gilvum_PYR-GCK DYARTLDTWAEALEAHHDEAVAATSEEVYQRYMKYLTGCSDFFTRGISEL
MSMEG_1203|M.smegmatis_MC2_155 HYVRTLDTWAENLSAQRAAAIATTSEEVYDRYMHYLTGCADFFRRGISEV
TH_2621|M.thermoresistible__bu HYVRTLDTWADNLQDRRDEAIAVTSEKVYANYLRYLTGCADFFRRGITEV
Rv0644c|M.tuberculosis_H37Rv HYARTLDLWAEALQEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDV
MMAR_2920|M.marinum_M HYARTLALWAQALYAYRDEAIEIQSEEVYERYLKYLTGCADAFRRGHIDV
MLBr_02459|M.leprae_Br4923 HYAKTLDLWAARLEANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDV
Mb0662c|M.bovis_AF2122/97 HFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDC
MAV_0130|M.avium_104 HYARTLDTWAAALRARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDV
MAB_4088c|M.abscessus_ATCC_199 HYAKTLDIWAQNLEQRREEAIAIQSQEVYDRFMKYLTGCADFFRRGVTNV
MUL_4538|M.ulcerans_Agy99 HYARTLNIWAANLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNV
.:.:** ** * : *: * ::* .:::***** . * * :
Mvan_4949|M.vanbaalenii_PYR-1 GQFTLVKT-------
Mflv_1800|M.gilvum_PYR-GCK GQFTLVKA-------
MSMEG_1203|M.smegmatis_MC2_155 AQFAYTKSG------
TH_2621|M.thermoresistible__bu GQFTMVKGG------
Rv0644c|M.tuberculosis_H37Rv NQFTLAK--------
MMAR_2920|M.marinum_M NQFTLQN--------
MLBr_02459|M.leprae_Br4923 DQFTLEKQPATARRH
Mb0662c|M.bovis_AF2122/97 NQFTLAK--------
MAV_0130|M.avium_104 AQFTLTKG-------
MAB_4088c|M.abscessus_ATCC_199 GQFTLVK--------
MUL_4538|M.ulcerans_Agy99 GQFTLVK--------
**: :