For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TGRTAEPPTGHDTTPPTAEDMKPHFEEVQAHYDLSDVFFGLFQDPSRTYSCAYYERDDMTLAEAQIAKID LALGKLNLEPGMTLLDIGCGWGSVLQRAVEKYDVNVVGLTLSRNQCKFAQDLLDGLDTERSRRILLRGWE QFDEPVDRIISIEAIEAFPQERYAPFFKMCSSVLPEGGRFVLQAILGHPLKKWPELGIPIVMSDLKFMRF IAKEIFPGGSVPGEENIVELSAEAGFTLEQTQFLNKDYARTLDTWAEALEAHHDEAVAATSEEVYQRYMK YLTGCSDFFTRGISELGQFTLVKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1800 | - | - | 100% (305) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. gilvum PYR-GCK | Mflv_3304 | - | 3e-95 | 57.24% (290) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. gilvum PYR-GCK | Mflv_5113 | - | 3e-84 | 52.63% (285) | cyclopropane-fatty-acyl-phospholipid synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0662c | mmaA3 | 1e-96 | 60.28% (282) | methoxy mycolic acid synthase |
| M. tuberculosis H37Rv | Rv0643c | mmaA3 | 1e-96 | 60.28% (282) | methoxy mycolic acid synthase |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-89 | 56.89% (283) | Mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_4088c | - | 1e-94 | 57.14% (287) | mycolic acid synthase UmaA1 |
| M. marinum M | MMAR_0979 | mmaA5_1 | 1e-100 | 59.93% (287) | methoxy mycolic acid synthase 5 MmaA5_1 |
| M. avium 104 | MAV_0130 | - | 1e-100 | 60.14% (286) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_1203 | - | 1e-106 | 63.03% (284) | methoxy mycolic acid synthase 1 |
| M. thermoresistible (build 8) | TH_2621 | - | 1e-118 | 67.25% (284) | PUTATIVE methoxy mycolic acid synthase 1 |
| M. ulcerans Agy99 | MUL_4538 | umaA | 3e-97 | 57.04% (284) | mycolic acid synthase UmaA |
| M. vanbaalenii PYR-1 | Mvan_4949 | - | 1e-154 | 89.62% (289) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1800|M.gilvum_PYR-GCK MTGRTAEPPTGHDTTPPTAEDMKPHFEEVQAHYDLSDVFFGLFQDP-SRT
Mvan_4949|M.vanbaalenii_PYR-1 MAKSSVNP-------PAAGKNMEPHFEEVQAHYDLSDDFFGLFQDP-SRT
MSMEG_1203|M.smegmatis_MC2_155 -MADGVGT-----------AQMRPYFEEVQAHYDLSDDFFGLFQDP-SRT
TH_2621|M.thermoresistible__bu ---VMVES-----------TELRPNFEDVQAHYDLSNEFFGLFQDP-TRT
MLBr_02459|M.leprae_Br4923 MS-----------------VQLTPHFRNVQAHYDLSDDFFRLFLDP-TLT
MMAR_0979|M.marinum_M MA-----------------KELKPHFDDVQAHYDLSDDFFRLFLDP-TQT
Mb0662c|M.bovis_AF2122/97 MSDNSTGT-----------TKSRSNVDDVQAHYDLSDAFFALFQDP-TRT
Rv0643c|M.tuberculosis_H37Rv MSDNSTGT-----------TKSRSNVDDVQAHYDLSDAFFALFQDP-TRT
MAV_0130|M.avium_104 MSENTGDA-----------VNLQPHFDDVQAHYDLSDEFFALFLDP-TRT
MAB_4088c|M.abscessus_ATCC_199 ------------------MSDLKPYYEESQSIYDISDEFYGLFLDEETMG
MUL_4538|M.ulcerans_Agy99 ------------------MTELRPFYEESQSIYDVSDEFFALFLDP-TMA
. . : *: **:*: *: ** * :
Mflv_1800|M.gilvum_PYR-GCK YSCAYYERDDMTLAEAQIAKIDLALGKLNLEPGMTLLDIGCGWGSVLQRA
Mvan_4949|M.vanbaalenii_PYR-1 YSCAFYERDDVTLAEAQMAKIDLALGKLELKPGMTLLDIGCGWGSVLQRA
MSMEG_1203|M.smegmatis_MC2_155 YSCAYYERDDMTLEQAQMAKIDLALDQLALQPGMTLLDIGCGWGALMKRA
TH_2621|M.thermoresistible__bu YSCAYYARDDMTLEEAQLAKIDLALDKLGLQPGMTLLDIGCGWGSTMKRA
MLBr_02459|M.leprae_Br4923 YSCAYFERDDMTLEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRA
MMAR_0979|M.marinum_M YSCAYFERDDMTLEEAQIAKIDLALGKLGLEPGMTLLDVGCGWGATMRRA
Mb0662c|M.bovis_AF2122/97 YSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRA
Rv0643c|M.tuberculosis_H37Rv YSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRA
MAV_0130|M.avium_104 YSCAYFERDDMTLEEAQIAKVDLSLGKLGLQPGMTLLDIGCGWGTTIVRA
MAB_4088c|M.abscessus_ATCC_199 YTCAYFERDDLTLAEAQIAKFDLALGKLNLEPGMTVLDIGCGWGACLDRA
MUL_4538|M.ulcerans_Agy99 YTCAYFERDDMTLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGALQRA
*:**:: ***:** :*. **.**:*.:* *:****:**:***** : **
Mflv_1800|M.gilvum_PYR-GCK VEKYDVNVVGLTLSRNQCKFAQDLLDGLDTER--SRRILLRGWEQFDEPV
Mvan_4949|M.vanbaalenii_PYR-1 VEKHDVNVVGLTLSRNQCRFAQELLDGLDTER--SRRILLRGWEQFDEPV
MSMEG_1203|M.smegmatis_MC2_155 IEKYDVDVIGLTLSKNQYAFCQQLLDQIDTRR--SHFVCLQGWEQFDAPV
TH_2621|M.thermoresistible__bu VERHDVNVIGLTLSRNQCAYSRDLLAGLDTDR--SRRVLLQGWEQFDEPV
MLBr_02459|M.leprae_Br4923 IEIYDVNVIGLTLSENQAAHVQKTFDELDTPR--TRRVLLEGWEKFHEPV
MMAR_0979|M.marinum_M IEKYDVNVVGLTLSKNQAAHVQKSFDQLDTAR--TRRVLLEGWEQFDEPV
Mb0662c|M.bovis_AF2122/97 VERYDVNVVGLTLSKNQHAYCQQVLDKVDTNR--SHRVLLSDWANFSEPV
Rv0643c|M.tuberculosis_H37Rv VERYDVNVVGLTLSKNQHAYCQQVLDKVDTNR--SHRVLLSDWANFSEPV
MAV_0130|M.avium_104 LERYDVNVVGLTLSRNQQAHVQRPLDNHPSPR--SKRVLLQGWEQFDEKV
MAB_4088c|M.abscessus_ATCC_199 MRKFDVNVIGITLSKNQSEYSRKRLAQVAAETGRSAEIRMQGWEEFNDKV
MUL_4538|M.ulcerans_Agy99 VEKYDVNVIGITLSRNQFDYSKAKMAKIPTER--TVEVRLQGWEEFEDKV
:. .**:*:*:***.** . : : : : : : .* :* *
Mflv_1800|M.gilvum_PYR-GCK DRIISIEAIEAFPQERYAPFFKMCSSVLPEGGRFVLQAILGHPLKKWPEL
Mvan_4949|M.vanbaalenii_PYR-1 DRIVSIEAIEAFPQERYAPFFQMCSRALPRGGRMLLQAILGHPLKKWPEM
MSMEG_1203|M.smegmatis_MC2_155 DRIVSIEAFEAFGKSRYKAFFDTTYRVMPDDGRMVIETIFTHPINYWREH
TH_2621|M.thermoresistible__bu DRIVSIEAFEAFGKPRYKPFFELTHRILPDGGRFVLETIFTHPPSYWHDH
MLBr_02459|M.leprae_Br4923 DRIVSIGAFEHFGRQRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARAR
MMAR_0979|M.marinum_M DRIVSIGAFEHFGHDRYDDFFTLAHNILPSDGVMLLHTITGLTFQQATDR
Mb0662c|M.bovis_AF2122/97 DRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIER
Rv0643c|M.tuberculosis_H37Rv DRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIER
MAV_0130|M.avium_104 DRIVSIGAFEHFGRDRYDDFFKMAYAALPDDGVMMLHTIIKPSDEEFAER
MAB_4088c|M.abscessus_ATCC_199 DRIVTIGAFEAFKQERYPIFFERAYDILPNDGRMLLHTILAHTQQFFREN
MUL_4538|M.ulcerans_Agy99 DRIVTIGAFEAFKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEM
***::* *:* * ** ** :* .. :::.:* .
Mflv_1800|M.gilvum_PYR-GCK GIPIVMSDLKFMRFIAKEIFPGGSVPGEENIVELSAEAGFTLEQTQFLNK
Mvan_4949|M.vanbaalenii_PYR-1 GIPIVMSDLKFMRFIAKEIFPGGSVPSEENIVELSADAGFTLERTQFLNQ
MSMEG_1203|M.smegmatis_MC2_155 GIAVTLSDMKFTRFIYKEIFPGGQLPSDDDMRDFSGAAGFHTADVTVMNP
TH_2621|M.thermoresistible__bu GIAITMSDLRFMRFVGKEIFPGGEMPSAEDVVDISTAAGFRQEDLQLMNP
MLBr_02459|M.leprae_Br4923 GMTLTHEIVHFTQFILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQL
MMAR_0979|M.marinum_M GMPLTFEIARFIKFIVTEIFPGGRLPSIEKVADHSSKAGFTLTRRQSLQP
Mb0662c|M.bovis_AF2122/97 GIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQP
Rv0643c|M.tuberculosis_H37Rv GIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQP
MAV_0130|M.avium_104 GLPITMTKLRFMKFIMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRP
MAB_4088c|M.abscessus_ATCC_199 GIAITISDLKFMKFIGEEIFPGGQLPAVEDIEKLAADSGFNLERVHLLQP
MUL_4538|M.ulcerans_Agy99 GVKVTMSDVRFMRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQLLQQ
*: :. :* :*: :***** :* : . :** :.
Mflv_1800|M.gilvum_PYR-GCK DYARTLDTWAEALEAHHDEAVAATSEEVYQRYMKYLTGCSDFFTRGISEL
Mvan_4949|M.vanbaalenii_PYR-1 DYVRTLDTWAQALEAHHDEAVAATSEEVYQRYMKYLTGCSDFFNRGISEL
MSMEG_1203|M.smegmatis_MC2_155 HYVRTLDTWAENLSAQRAAAIATTSEEVYDRYMHYLTGCADFFRRGISEV
TH_2621|M.thermoresistible__bu HYVRTLDTWADNLQDRRDEAIAVTSEKVYANYLRYLTGCADFFRRGITEV
MLBr_02459|M.leprae_Br4923 HYAKTLDLWAARLEANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDV
MMAR_0979|M.marinum_M HYARTLDLWAQALQARRDEAIEVQSEEVYERYMKYLTGCADGFRVGYIDV
Mb0662c|M.bovis_AF2122/97 HFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDC
Rv0643c|M.tuberculosis_H37Rv HFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDC
MAV_0130|M.avium_104 HYARTLDTWAAALRARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDV
MAB_4088c|M.abscessus_ATCC_199 HYAKTLDIWAQNLEQRREEAIAIQSQEVYDRFMKYLTGCADFFRRGVTNV
MUL_4538|M.ulcerans_Agy99 HYARTLNIWAANLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNV
.:.:**: ** * .: *: * ::* .:::***** . * * :
Mflv_1800|M.gilvum_PYR-GCK GQFTLVKA-------
Mvan_4949|M.vanbaalenii_PYR-1 GQFTLVKT-------
MSMEG_1203|M.smegmatis_MC2_155 AQFAYTKSG------
TH_2621|M.thermoresistible__bu GQFTMVKGG------
MLBr_02459|M.leprae_Br4923 DQFTLEKQPATARRH
MMAR_0979|M.marinum_M NQFTLEKS-------
Mb0662c|M.bovis_AF2122/97 NQFTLAK--------
Rv0643c|M.tuberculosis_H37Rv NQFTLAK--------
MAV_0130|M.avium_104 AQFTLTKG-------
MAB_4088c|M.abscessus_ATCC_199 GQFTLVK--------
MUL_4538|M.ulcerans_Agy99 GQFTLVK--------
**: *