For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTELRPFYEESQSIYDVSDEFFALFLDPTMAYTCAYFERDDMTLEEASNAKFDLALGKLNLEPGMTLLDI GCGWGGALQRAVEKYDVNVIGITLSRNQFEYSKAKMAKIPTERTVEVRLQGWEEFEDKVDRIVTIGAFEA FKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEMGVKVTMSDVRFMRFIGQEIFPGGQLPAQEDI FNFAQAAGFSVERAQLLQQHYARTLNIWAANLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNVG QFTLVK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0794 | umaA | - | 100% (286) | mycolic acid synthase UmaA |
| M. marinum M | MMAR_0980 | mmaA1 | e-114 | 65.03% (286) | methoxy mycolic acid synthase 1 Mma1 |
| M. marinum M | MMAR_0979 | mmaA5_1 | 3e-94 | 57.04% (284) | methoxy mycolic acid synthase 5 MmaA5_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0478 | umaA1 | 1e-152 | 89.86% (286) | mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_3304 | - | 1e-97 | 59.15% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0469 | umaA | 1e-152 | 89.86% (286) | mycolic acid synthase |
| M. leprae Br4923 | MLBr_01900 | mmaA1 | 1e-118 | 68.53% (286) | methyl mycolic acid synthase 1 |
| M. abscessus ATCC 19977 | MAB_4088c | - | 1e-122 | 70.93% (289) | mycolic acid synthase UmaA1 |
| M. avium 104 | MAV_4680 | - | 1e-148 | 86.71% (286) | methoxy mycolic acid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_0913 | - | 1e-126 | 73.68% (285) | methoxy mycolic acid synthase 1 |
| M. thermoresistible (build 8) | TH_3763 | - | 1e-126 | 75.00% (284) | PUTATIVE Cyclopropane-fatty-acyl-phospholipid synthase |
| M. ulcerans Agy99 | MUL_4538 | umaA | 1e-166 | 99.65% (286) | mycolic acid synthase UmaA |
| M. vanbaalenii PYR-1 | Mvan_0803 | - | 1e-126 | 75.35% (284) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0794|M.marinum_M -------MTELRPFYEESQSIYDVSDEFFALFLD-PTMAYTCAYFERDDM
MUL_4538|M.ulcerans_Agy99 -------MTELRPFYEESQSIYDVSDEFFALFLD-PTMAYTCAYFERDDM
Mb0478|M.bovis_AF2122/97 -------MTELRPFYEESQSIYDVSDEFFSLFLD-PTMAYTCAYFEREDM
Rv0469|M.tuberculosis_H37Rv -------MTELRPFYEESQSIYDVSDEFFSLFLD-PTMAYTCAYFEREDM
MAV_4680|M.avium_104 ----MPRMTGLEPYYEESQSIYDVSDEFFALFLD-PTMAYTCAFFERDDM
MSMEG_0913|M.smegmatis_MC2_155 ---MSNVESELAPYYEESQSIYDISNEFFALFLG-PTMGYTCGYYEREDM
Mvan_0803|M.vanbaalenii_PYR-1 ---MSNAVPDLSPYYEESQSIYDVSNEFFALFLG-PTMGYTCSYFEREDM
MAB_4088c|M.abscessus_ATCC_199 ---MS----DLKPYYEESQSIYDISDEFYGLFLDEETMGYTCAYFERDDL
TH_3763|M.thermoresistible__bu ---MTNTSAELEPFFEESQSIYDVSDDFFALFLG-PTMGYTCAYFERDDM
MLBr_01900|M.leprae_Br4923 -------MAKLRPYYEESQSAYDISDDFFALFLD-PTWVYTCAYFERDDM
Mflv_3304|M.gilvum_PYR-GCK MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLD-PTQTYSCAYFERDDM
* *.::: ** **:*::*: ***. * *:*.::**:*:
MMAR_0794|M.marinum_M TLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGALQRAVEKYDVNVIGI
MUL_4538|M.ulcerans_Agy99 TLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGALQRAVEKYDVNVIGI
Mb0478|M.bovis_AF2122/97 TLEEAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGLQRAIENYDVNVIGI
Rv0469|M.tuberculosis_H37Rv TLEEAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGLQRAIENYDVNVIGI
MAV_4680|M.avium_104 TLEEAQTAKFDLALGKLNLEPGMTLLDIGCGWGGALKRALEKYDVNVIGI
MSMEG_0913|M.smegmatis_MC2_155 TLDESQNAKFDLALGKLDLKPGMTLLDVGCGWGGALERAVTKYDVNVIGI
Mvan_0803|M.vanbaalenii_PYR-1 TLDEAQIAKFDLALGKLNLEPGMTLLDVGCGWGGALRRAVEKYDVNVIGI
MAB_4088c|M.abscessus_ATCC_199 TLAEAQIAKFDLALGKLNLEPGMTVLDIGCGWGACLDRAMRKFDVNVIGI
TH_3763|M.thermoresistible__bu TLDEAQIAKFDLALGKLNLEPGMTLLDIGCGWGGALQLALEKYDVNVIGI
MLBr_01900|M.leprae_Br4923 TLEEAQLAKLDLALDKLNLAPGMTLLDVGCGWGGALVRAVEKYDVNVIGL
Mflv_3304|M.gilvum_PYR-GCK TLEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVNVIGL
** *:. **:****.** * ****:**:*****. * *: ::******:
MMAR_0794|M.marinum_M TLSRNQFEYSKAKMAKIP--TERTVEVRLQGWEEFEDKVDRIVTIGAFEA
MUL_4538|M.ulcerans_Agy99 TLSRNQFDYSKAKMAKIP--TERTVEVRLQGWEEFEDKVDRIVTIGAFEA
Mb0478|M.bovis_AF2122/97 TLSRNQFEYSKAKLAKIP--TERSVQVRLQGWDEFTDKVDRIVSIGAFEA
Rv0469|M.tuberculosis_H37Rv TLSRNQFEYSKAKLAKIP--TERSVQVRLQGWDEFTDKVDRIVSIGAFEA
MAV_4680|M.avium_104 TLSRNQFEYSKKLLAGFP--TDRNIEVRLQGWEEFDDKVDRIVTIGAFEA
MSMEG_0913|M.smegmatis_MC2_155 TLSKAQSDYARERLAKI--ETNRSVEVRLQGWEEFNEPVDRIVSIGAFEA
Mvan_0803|M.vanbaalenii_PYR-1 TLSRKQFEYSKALMAGL--DTERKAEVRLQGWEEFDEPVDRIVSIGAFEA
MAB_4088c|M.abscessus_ATCC_199 TLSKNQSEYSRKRLAQVAAETGRSAEIRMQGWEEFNDKVDRIVTIGAFEA
TH_3763|M.thermoresistible__bu TLSRNQYEYSKARLAQI--DTARTAEVRLQGWEQFDEPVDRIVSIGAFEA
MLBr_01900|M.leprae_Br4923 TLSRNHCARSKARLAEIL--TKRHAEARLQGWEEFEEKVDRIVSFEALDA
Mflv_3304|M.gilvum_PYR-GCK TLSRNQQAHVQKVLDEHD--SPRSKTVLLQGWEQFDQPVDRIVSIGAFEH
***: : : : : * :***::* : *****:: *::
MMAR_0794|M.marinum_M FKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEMGVKVTMSDVRF
MUL_4538|M.ulcerans_Agy99 FKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEMGVKVTMSDVRF
Mb0478|M.bovis_AF2122/97 FKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQMHEMGVKVTMSDVRF
Rv0469|M.tuberculosis_H37Rv FKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQMHEMGVKVTMSDVRF
MAV_4680|M.avium_104 FKMERYSAFFDRAYDILPDDGRMLLHTILTYTQKQQHERGVSITMSDLRF
MSMEG_0913|M.smegmatis_MC2_155 FKAERYPVFFERAYSILPDDGRMLLHTILAHTQKFFRENGIKLTISDLKF
Mvan_0803|M.vanbaalenii_PYR-1 FKAERYPLFFERAYDILPADGRMLLHTILAHTQKFFRDNGIKLTISDLKF
MAB_4088c|M.abscessus_ATCC_199 FKQERYPIFFERAYDILPNDGRMLLHTILAHTQQFFRENGIAITISDLKF
TH_3763|M.thermoresistible__bu FKKPRYAAFFEMAHKALPADGRMLLHTILAHPQTYFREAGIKITISDLKF
MLBr_01900|M.leprae_Br4923 FKKERYPAFFERSYNILPDDGRMLLHSLFTYDRRWLHEQGIPLTMGDLRF
Mflv_3304|M.gilvum_PYR-GCK FGSDRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKF
* ** ** ::. ** ** ****::. : : :*: .::*
MMAR_0794|M.marinum_M MRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQLLQQHYARTLNIWAA
MUL_4538|M.ulcerans_Agy99 MRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQLLQQHYARTLNIWAA
Mb0478|M.bovis_AF2122/97 MKFIGEEIFPGGQLPAQEDIFKFAQAADFSVEKVQLLQQHYARTLNIWAA
Rv0469|M.tuberculosis_H37Rv MKFIGEEIFPGGQLPAQEDIFKFAQAADFSVEKVQLLQQHYARTLNIWAA
MAV_4680|M.avium_104 MRFIGQEIFPGGQLPAQEDIFKFGEAAGFSVERVQLLREHYARTLNIWAA
MSMEG_0913|M.smegmatis_MC2_155 MKFIGEEIFPGGQLPAVEDIEKLAADSGFKLERIHLLQPHYARTLDMWAA
Mvan_0803|M.vanbaalenii_PYR-1 MRFIGTEIFPGGQLPAVEDIEKLAADSGFTLERAHLLRPHYARTLDMWAA
MAB_4088c|M.abscessus_ATCC_199 MKFIGEEIFPGGQLPAVEDIEKLAADSGFNLERVHLLQPHYAKTLDIWAQ
TH_3763|M.thermoresistible__bu MQFIGREIFPGGELPAEGDVVEFATGAGFSVERIQLLRPHYARTLDIWAE
MLBr_01900|M.leprae_Br4923 LKFLRESIFPGGELPSQPDIVDNAEAAGFSVEQIQLMQPHYARTLDMWAT
Mflv_3304|M.gilvum_PYR-GCK FKFIMDEIFPGGMLPKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAA
::*: .***** ** *: . . :.*.::: : :: ***:**::**
MMAR_0794|M.marinum_M NLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNVGQFTLVK-
MUL_4538|M.ulcerans_Agy99 NLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNVGQFTLVK-
Mb0478|M.bovis_AF2122/97 NLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGISNVGQFTLTK-
Rv0469|M.tuberculosis_H37Rv NLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGISNVGQFTLTK-
MAV_4680|M.avium_104 NLEANKDKAIAIQSQAVYDRYMHYLTGCENFFRKGISNVGQFTLVK-
MSMEG_0913|M.smegmatis_MC2_155 NLEAKKDEAIAMQGQEVYDRYMKYLTGCADFFRRGITNVGQFTLVK-
Mvan_0803|M.vanbaalenii_PYR-1 NLEANRQEATRITSPEVYERYMHYLTGCADFFRRGITNVGQFTLVKG
MAB_4088c|M.abscessus_ATCC_199 NLEQRREEAIAIQSQEVYDRFMKYLTGCADFFRRGVTNVGQFTLVK-
TH_3763|M.thermoresistible__bu NLAANREPAIAMQSEEVYDRYYRYLTGCADFFRRGITNVGQFTLTKG
MLBr_01900|M.leprae_Br4923 NLAAARDHALAIQPEEIYDNFMHYLTGCADRFRRGLINVAQFTLTK-
Mflv_3304|M.gilvum_PYR-GCK SLESRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGYTDVCQFTLAK-
.* :: * : :*:.: :***** . * .* :* ****.*