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AKLRPYYEESQSAYDISDDFFALFLDPTWVYTCAYFERDDMTLEEAQLAKVDLALDKLNLEPGMTLLDVG CGWGGALVRAVEKYDVNVIGLTLSRNHYERSKDRLAAIGTQRRAEARLQGWEEFEENVDRIVSFEAFDAF KKERYLTFFERSYDILPDDGRMLLHSLFTYDRRWLHEQGIALTMSDLRFLKFLRESIFPGGELPSEPDIV DNAQAAGFTIEHVQLLQQHYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINVAQ FTMTK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0645c | mmaA1 | - | 100% (286) | METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) |
| M. tuberculosis H37Rv | Rv0469 | umaA | e-120 | 69.58% (286) | mycolic acid synthase |
| M. tuberculosis H37Rv | Rv3392c | cmaA1 | 4e-91 | 57.04% (284) | cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0664c | mmaA1 | 1e-167 | 100.00% (286) | methoxy mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_3304 | - | 2e-92 | 56.84% (285) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. leprae Br4923 | MLBr_01900 | mmaA1 | 1e-148 | 87.41% (286) | methyl mycolic acid synthase 1 |
| M. abscessus ATCC 19977 | MAB_4088c | - | 1e-106 | 63.67% (289) | mycolic acid synthase UmaA1 |
| M. marinum M | MMAR_0980 | mmaA1 | 1e-146 | 85.66% (286) | methoxy mycolic acid synthase 1 Mma1 |
| M. avium 104 | MAV_4516 | - | 1e-124 | 73.43% (286) | methoxy mycolic acid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_0913 | - | 1e-107 | 64.21% (285) | methoxy mycolic acid synthase 1 |
| M. thermoresistible (build 8) | TH_3763 | - | 1e-112 | 67.37% (285) | PUTATIVE Cyclopropane-fatty-acyl-phospholipid synthase |
| M. ulcerans Agy99 | MUL_4538 | umaA | 1e-120 | 69.23% (286) | mycolic acid synthase UmaA |
| M. vanbaalenii PYR-1 | Mvan_0803 | - | 1e-109 | 65.72% (283) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0645c|M.tuberculosis_H37Rv MA-------KLRPYYEESQSAYDISDDFFALFLD-PTWVYTCAYFERDDM
Mb0664c|M.bovis_AF2122/97 MA-------KLRPYYEESQSAYDISDDFFALFLD-PTWVYTCAYFERDDM
MMAR_0980|M.marinum_M MA-------ELKPYFEDSQATYDISDEFFGLFLD-PTWVYTCAYFERDDM
MLBr_01900|M.leprae_Br4923 MA-------KLRPYYEESQSAYDISDDFFALFLD-PTWVYTCAYFERDDM
MAV_4516|M.avium_104 MA-------KLKPYYEESQATYDISDDFFALFLD-PNMVYTCAYFENDDM
MSMEG_0913|M.smegmatis_MC2_155 MSNV---ESELAPYYEESQSIYDISNEFFALFLG-PTMGYTCGYYEREDM
Mvan_0803|M.vanbaalenii_PYR-1 MSNA---VPDLSPYYEESQSIYDVSNEFFALFLG-PTMGYTCSYFEREDM
MAB_4088c|M.abscessus_ATCC_199 MS-------DLKPYYEESQSIYDISDEFYGLFLDEETMGYTCAYFERDDL
MUL_4538|M.ulcerans_Agy99 MT-------ELRPFYEESQSIYDVSDEFFALFLD-PTMAYTCAYFERDDM
TH_3763|M.thermoresistible__bu MTNT---SAELEPFFEESQSIYDVSDDFFALFLG-PTMGYTCAYFERDDM
Mflv_3304|M.gilvum_PYR-GCK MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLD-PTQTYSCAYFERDDM
*: .* *.::: *: **:*::*: ***. . *:*.*:*.:*:
Rv0645c|M.tuberculosis_H37Rv TLEEAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGL
Mb0664c|M.bovis_AF2122/97 TLEEAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGL
MMAR_0980|M.marinum_M TLEEAQLAKLDLALDKLHLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGL
MLBr_01900|M.leprae_Br4923 TLEEAQLAKLDLALDKLNLAPGMTLLDVGCGWGGALVRAVEKYDVNVIGL
MAV_4516|M.avium_104 TLEQAQLAKLDLGLDKLNLEPGMTLLDVGCGWGGAVVRALEKYDVNVIGI
MSMEG_0913|M.smegmatis_MC2_155 TLDESQNAKFDLALGKLDLKPGMTLLDVGCGWGGALERAVTKYDVNVIGI
Mvan_0803|M.vanbaalenii_PYR-1 TLDEAQIAKFDLALGKLNLEPGMTLLDVGCGWGGALRRAVEKYDVNVIGI
MAB_4088c|M.abscessus_ATCC_199 TLAEAQIAKFDLALGKLNLEPGMTVLDIGCGWGACLDRAMRKFDVNVIGI
MUL_4538|M.ulcerans_Agy99 TLEEASNAKFDLALGKLNLEPGMTLLDIGCGWGGALQRAVEKYDVNVIGI
TH_3763|M.thermoresistible__bu TLDEAQIAKFDLALGKLNLEPGMTLLDIGCGWGGALQLALEKYDVNVIGI
Mflv_3304|M.gilvum_PYR-GCK TLEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVNVIGL
** ::. **.**.*.** * ****:**:*****. : *: *:******:
Rv0645c|M.tuberculosis_H37Rv TLSRNHYERSKDRLAAIG--TQRRAEARLQGWEEFEENVDRIVSFEAFDA
Mb0664c|M.bovis_AF2122/97 TLSRNHYERSKDRLAAIG--TQRRAEARLQGWEEFEENVDRIVSFEAFDA
MMAR_0980|M.marinum_M TLSRNHCQRSQDRLAALG--TKRRAEARLQGWEEFDEQVDRIVSFEAFDA
MLBr_01900|M.leprae_Br4923 TLSRNHCARSKARLAEIL--TKRHAEARLQGWEEFEEKVDRIVSFEALDA
MAV_4516|M.avium_104 TLSRNHYARTKERLAAIP--TTRRAEARLQGWEEFDEPVDRIISFEAFDA
MSMEG_0913|M.smegmatis_MC2_155 TLSKAQSDYARERLAKI--ETNRSVEVRLQGWEEFNEPVDRIVSIGAFEA
Mvan_0803|M.vanbaalenii_PYR-1 TLSRKQFEYSKALMAGL--DTERKAEVRLQGWEEFDEPVDRIVSIGAFEA
MAB_4088c|M.abscessus_ATCC_199 TLSKNQSEYSRKRLAQVAAETGRSAEIRMQGWEEFNDKVDRIVTIGAFEA
MUL_4538|M.ulcerans_Agy99 TLSRNQFDYSKAKMAKIP--TERTVEVRLQGWEEFEDKVDRIVTIGAFEA
TH_3763|M.thermoresistible__bu TLSRNQYEYSKARLAQID--TARTAEVRLQGWEQFDEPVDRIVSIGAFEA
Mflv_3304|M.gilvum_PYR-GCK TLSRNQQAHVQKVLDEHD--SPRSKTVLLQGWEQFDQPVDRIVSIGAFEH
***: : : : : * :****:*:: ****::: *::
Rv0645c|M.tuberculosis_H37Rv FKKERYLTFFERSYDILPDDGRMLLHSLFTYDRRWLHEQGIALTMSDLRF
Mb0664c|M.bovis_AF2122/97 FKKERYLTFFERSYDILPDDGRMLLHSLFTYDRRWLHEQGIALTMSDLRF
MMAR_0980|M.marinum_M FRKERYGAFFQRSYDILPAGGSLLLHSLFTYDRRWLHEQGIALTMSDLRF
MLBr_01900|M.leprae_Br4923 FKKERYPAFFERSYNILPDDGRMLLHSLFTYDRRWLHEQGIPLTMGDLRF
MAV_4516|M.avium_104 FKKERWPAFWDWAYKSLPNDSRMLMHSIFTYPQSQWKERGIPITMSDLRF
MSMEG_0913|M.smegmatis_MC2_155 FKAERYPVFFERAYSILPDDGRMLLHTILAHTQKFFRENGIKLTISDLKF
Mvan_0803|M.vanbaalenii_PYR-1 FKAERYPLFFERAYDILPADGRMLLHTILAHTQKFFRDNGIKLTISDLKF
MAB_4088c|M.abscessus_ATCC_199 FKQERYPIFFERAYDILPNDGRMLLHTILAHTQQFFRENGIAITISDLKF
MUL_4538|M.ulcerans_Agy99 FKMERYAAFFERSYDILPDDGRMLLHTILTYTQKQFHEMGVKVTMSDVRF
TH_3763|M.thermoresistible__bu FKKPRYAAFFEMAHKALPADGRMLLHTILAHPQTYFREAGIKITISDLKF
Mflv_3304|M.gilvum_PYR-GCK FGSDRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKF
* *: *: ::. ** .. :*:*::. : : :*: .::*
Rv0645c|M.tuberculosis_H37Rv LKFLRESIFPGGELPSEPDIVDNAQAAGFTIEHVQLLQQHYARTLDAWAA
Mb0664c|M.bovis_AF2122/97 LKFLRESIFPGGELPSEPDIVDNAQAAGFTIEHVQLLQQHYARTLDAWAA
MMAR_0980|M.marinum_M LKFLRESIFPGGEVPSESDIVDNAQAAGFAVEQIQLMQQHYAHTLDIWAA
MLBr_01900|M.leprae_Br4923 LKFLRESIFPGGELPSQPDIVDNAEAAGFSVEQIQLMQPHYARTLDMWAT
MAV_4516|M.avium_104 FHFLGKEIFPGGQMCGEADIVDLSQASGFSLEQVQYLRPHYARTLDTWAA
MSMEG_0913|M.smegmatis_MC2_155 MKFIGEEIFPGGQLPAVEDIEKLAADSGFKLERIHLLQPHYARTLDMWAA
Mvan_0803|M.vanbaalenii_PYR-1 MRFIGTEIFPGGQLPAVEDIEKLAADSGFTLERAHLLRPHYARTLDMWAA
MAB_4088c|M.abscessus_ATCC_199 MKFIGEEIFPGGQLPAVEDIEKLAADSGFNLERVHLLQPHYAKTLDIWAQ
MUL_4538|M.ulcerans_Agy99 MRFIGQEIFPGGQLPAQEDIFNFAQAAGFSVERAQLLQQHYARTLNIWAA
TH_3763|M.thermoresistible__bu MQFIGREIFPGGELPAEGDVVEFATGAGFSVERIQLLRPHYARTLDIWAE
Mflv_3304|M.gilvum_PYR-GCK FKFIMDEIFPGGMLPKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAA
::*: .***** : *: . : :.* ::: : :: ***:**: **
Rv0645c|M.tuberculosis_H37Rv NLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINVAQFTMTK-
Mb0664c|M.bovis_AF2122/97 NLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINVAQFTMTK-
MMAR_0980|M.marinum_M NLAAARDRAIAVQSEQVYDNFMHYLTGCAERFRRGLVNVGQFTLTK-
MLBr_01900|M.leprae_Br4923 NLAAARDHALAIQPEEIYDNFMHYLTGCADRFRRGLINVAQFTLTK-
MAV_4516|M.avium_104 NLEANREQAIAIQSQEVYDRFMRYLTGCAELFRKGISNVAQYTLTK-
MSMEG_0913|M.smegmatis_MC2_155 NLEAKKDEAIAMQGQEVYDRYMKYLTGCADFFRRGITNVGQFTLVK-
Mvan_0803|M.vanbaalenii_PYR-1 NLEANRQEATRITSPEVYERYMHYLTGCADFFRRGITNVGQFTLVKG
MAB_4088c|M.abscessus_ATCC_199 NLEQRREEAIAIQSQEVYDRFMKYLTGCADFFRRGVTNVGQFTLVK-
MUL_4538|M.ulcerans_Agy99 NLEARKEEAIAMQSQEIYDKYMHYLTGCENFFRKGISNVGQFTLVK-
TH_3763|M.thermoresistible__bu NLAANREPAIAMQSEEVYDRYYRYLTGCADFFRRGITNVGQFTLTKG
Mflv_3304|M.gilvum_PYR-GCK SLESRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGYTDVCQFTLAK-
.* :: * : ::*:.: :***** : * .* :* *:*:.*