For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SYVITAPEMLTTAATDLDGIGSAIKAASAAVAGPTTGVAAAAADEVSGAIAKLFGMFGQEYQSVVAQASA FQTEFTRLLATAGDSYAITEASNALGALNTQAQTLLGGAFGTAAGTSATGPLAAGTHVAFVMGGTAIPWP DATYVTAVQDLFIDPHFPGFTTQVLFTPEQLWPFTSNLGSLTFGQSVAQGVAILRDALSAQLSDPANTAV VFGYSQSATIATNQIRAFMSQLNPPSPSQLSFVLTGNPNNPDGGVLERFNGLYLPIVDVLFNGATPPDSP YPTAIYTAQYDGIANFPRYPLNVVSDVNAIMGFLYDEHYYAGLTSDPNAIGSGPTVANAVQLPTSPGYTG NTEYYMVLGQHLPLTDPLRQIPYVGTPIADLIQPSLRVIVDLGYSDYGPGQNYADIPTPASLFSLPNPLA VSYYLGKGAVQGVQAFMVDEGWLPQSYLPDTYPYVASLSPGLNVYLGQPSVTGLSLLTGALGTAARDLGW IPSWD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0383 | - | - | 100% (496) | PE family protein |
| M. marinum M | MMAR_0384 | - | e-154 | 56.04% (505) | PE family protein, PE4 |
| M. marinum M | MMAR_0382 | - | e-128 | 49.30% (503) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0165c | PE4 | 1e-144 | 54.09% (501) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 2e-32 | 35.58% (312) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv0160c | PE4 | 1e-145 | 54.00% (500) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 1e-11 | 23.36% (321) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 6e-29 | 35.00% (240) | PE/PPE family protein |
| M. avium 104 | MAV_1346 | - | 3e-19 | 43.26% (141) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 9e-31 | 32.55% (298) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 1e-40 | 36.50% (337) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 1e-152 | 55.64% (505) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 4e-43 | 34.81% (385) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1918|M.gilvum_PYR-GCK -----MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLYRHDGLGVG
MSMEG_5455|M.smegmatis_MC2_155 -----MGRLLHSLSTAFLVFVAVVVLCVSTS-------------------
TH_3724|M.thermoresistible__bu ---------VVAVGALTWGGXGVASPAGQPE-------------------
Mb0165c|M.bovis_AF2122/97 MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGDEVSAA
Rv0160c|M.tuberculosis_H37Rv MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGDEVSAA
MUL_1034|M.ulcerans_Agy99 MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDEVSAA
MMAR_0383|M.marinum_M MSYVITAPEMLTTAATDLDGIGSAIKAASAAVAGPTTGVAAAAADEVSGA
Mvan_4726|M.vanbaalenii_PYR-1 -----MRRRLRSAAWGLLSLVIAVLFAWG---------------------
MAV_1346|M.avium_104 MSFVTTRPEALLAVASMLEGLGSSMDAQN---------------------
MAB_4141|M.abscessus_ATCC_1997 ----MAGQYSVPGKRHSLRRYVATITAVAAT-------------------
MLBr_01232|M.leprae_Br4923 -MKRLLATTLAALTVGTVSGFGSTVASSEPGEP-----------------
Mflv_1918|M.gilvum_PYR-GCK TWAWVFARSSRSFPRSRRCWRYP---------------------------
MSMEG_5455|M.smegmatis_MC2_155 --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
Mb0165c|M.bovis_AF2122/97 TAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANA----A
Rv0160c|M.tuberculosis_H37Rv TAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANA----A
MUL_1034|M.ulcerans_Agy99 IAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAEAANASLITA
MMAR_0383|M.marinum_M IAKLFGMFGQEYQSVVAQASAFQTEFTRLLATAGDSYAITEASNA-----
Mvan_4726|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK ------RGVPTPVAVLVA-------------------------NTTALVM
MSMEG_5455|M.smegmatis_MC2_155 --------MPTAAHLLLN-------------------------HPHALVI
TH_3724|M.thermoresistible__bu ---------RAAALRLTA-------------------------TADAIIM
Mb0165c|M.bovis_AF2122/97 RVSHALDTINAPIRTLLGRTPLSPNGSSGAGGLPAIAQLAAESPITALIM
Rv0160c|M.tuberculosis_H37Rv RVSHALDTINAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPITALIM
MUL_1034|M.ulcerans_Agy99 GVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPVVALIM
MMAR_0383|M.marinum_M -----LGALNTQAQTLLGGAFGTAAGTSATG-------PLAAGTHVAFVM
Mvan_4726|M.vanbaalenii_PYR-1 ---------SVVTSTSAG-------------------------AGTALVM
MAV_1346|M.avium_104 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 ------------CTVLAP------------------------LAMESRTI
MLBr_01232|M.leprae_Br4923 ------WLPPSPVPVREN-----------------------SPAKIVYAL
Mflv_1918|M.gilvum_PYR-GCK GGTFHPLTGPRDSPEFVTAYLDNAVDNQISAAYGYAVTNAVAVYTPEEFF
MSMEG_5455|M.smegmatis_MC2_155 GGTGTPVP----PPEYVNGQTDNYIGAEFPGEYRYAVH------TPQNFW
TH_3724|M.thermoresistible__bu PGTKIGYIP---SQDEFTAYATAVIGATAGAPGAVDYLG-----VPGEFW
Mb0165c|M.bovis_AF2122/97 GGTNNPLPD----PEYVTDINKAFIQTLFPGAVSQGLFT------PEQFW
Rv0160c|M.tuberculosis_H37Rv GGTNNPLPD----PEYVTDINKAFIQTLFPGAVSQGLFT------PEQFW
MUL_1034|M.ulcerans_Agy99 GGTSVPLPG----PGYVSDINNNYIQPLFSGAIPQALFT------PEQFW
MMAR_0383|M.marinum_M GGTAIPWPD----ATYVTAVQDLFIDPHFPGFTTQVLFT------PEQLW
Mvan_4726|M.vanbaalenii_PYR-1 GGNGHPLSVPQDTPDYINKYVTAADDAFIAPSGLCGPQCSLVATYTPAQI
MAV_1346|M.avium_104 AAAAAPTTS---IAPAAADEVSALQAAQFSAYG-----------------
MAB_4141|M.abscessus_ATCC_1997 ASTLASYVIG---IGGNNDGASANIPRKLGGAYSVDYHP---VSYPGAIW
MLBr_01232|M.leprae_Br4923 GGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPARAPFR------YVPTF
.
Mflv_1918|M.gilvum_PYR-GCK PLGG----LTFDDSVAEGLANLGRCLRAEPGCVFNADPAVAARVGTVAPR
MSMEG_5455|M.smegmatis_MC2_155 PVYGS---MSFDESTVAGLAALQAEMAKEG-------------------H
TH_3724|M.thermoresistible__bu PATGLD-SLTFDASVAXGQAMLTPMVDGAIES------------------
Mb0165c|M.bovis_AF2122/97 PVTPDLGNLTFNQSVTEGVALLNTTVNNQLA-------------------
Rv0160c|M.tuberculosis_H37Rv PVTPDLGNLTFNQSVTEGVALLNTAVNNQLA-------------------
MUL_1034|M.ulcerans_Agy99 PVTPGLGNLTFNQSVAQGVTLLNDAINTQLA-------------------
MMAR_0383|M.marinum_M PFTSNLGSLTFGQSVAQGVAILRDALSAQLSD------------------
Mvan_4726|M.vanbaalenii_PYR-1 RFVNGIFDMTYDESVAVGQANLNDCIQGSDCTATLAPYSETG----PHTV
MAV_1346|M.avium_104 ---------TWYQQVSAQAKAIHQTLVQNLD-------------------
MAB_4141|M.abscessus_ATCC_1997 PVSG-LTAPTFKTSVAQGRTNLNDEIVTAGN-------------------
MLBr_01232|M.leprae_Br4923 LVPGPRDEVTIGEAIAVATKNLNQAIHRGTEP------------------
: : :
Mflv_1918|M.gilvum_PYR-GCK HDDTFVVFGYSQSAAVASLLKRQLIDAP--GPEPAATTFMLAANPMRPNG
MSMEG_5455|M.smegmatis_MC2_155 FGSPLVILGYSSSTRILTADKNRRIAD---GDYAVDINYVLVSDVAKGNG
TH_3724|M.thermoresistible__bu -DTPIVVFGHSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNG
Mb0165c|M.bovis_AF2122/97 LDNKVVAFGYSQSATIINNYINSLMAMGS--PNPDDISFVMIGSGNNPVG
Rv0160c|M.tuberculosis_H37Rv LDNKVVAFGYSQSATIINNYINSLMAMGS--PNPDDISFVMIGSGNNPVG
MUL_1034|M.ulcerans_Agy99 LGNKVVAFGYSQSATIVNNEILALMAMGTGAPDPGDLSFIMVGAPNNPDG
MMAR_0383|M.marinum_M PANTAVVFGYSQSATIATNQIRAFMSQLN-PPSPSQLSFVLTGNPNNPDG
Mvan_4726|M.vanbaalenii_PYR-1 ADSTYVIYAYSQSATVAANQKLQLIAH----PVASTVSFLLVANPNRPDG
MAV_1346|M.avium_104 --TNADSYGATEAANRVN---------------TSAAALQGLAPNVIPNA
MAB_4141|M.abscessus_ATCC_1997 --QPITIVGYSLGAVVVSKSHSDLLQRYP--GGNPNIQFVLMGSANTPNG
MLBr_01232|M.leprae_Br4923 ----AAVVGLSQGSLALDTEQEQLATDPT-APPPDQLTFNTFGDPSGYHG
. : .: . .
Mflv_1918|M.gilvum_PYR-GCK G----VLGRF-PALTIPILGITFHGATPTAG-VDGAYRTVDVVRQYDGLG
MSMEG_5455|M.smegmatis_MC2_155 G----VMARF-PGWHIPILGVTFDGATRTDS-DGYAFDTKSISFVHDGWS
TH_3724|M.thermoresistible__bu G----LLARF-PGLYIPILGVTFNGATPAPA-DG-PFDSYDVAREFDGWA
Mb0165c|M.bovis_AF2122/97 G----LLARF-PGFYIPFLDVPFNGATPA----NSPYPTHIYTAQYDGIA
Rv0160c|M.tuberculosis_H37Rv G----LLARF-PGFYIPFLDVPFNGATPA----NSPYPTHIYTAQYDGIA
MUL_1034|M.ulcerans_Agy99 G----LLARF-PGFYIPFLDVSFNGATPA----ANPYPTSIFTAQYDGIA
MMAR_0383|M.marinum_M G----VLERF-NGLYLPIVDVLFNGATPP----DSPYPTAIYTAQYDGIA
Mvan_4726|M.vanbaalenii_PYR-1 G----ILERF-VGAYIPLLGITFNGSTPTFSPQPRPLTTVDVARQYDGWA
MAV_1346|M.avium_104 A----PAADP-PPAGTTSLGTSIG-----------------WAQNVGAAA
MAB_4141|M.abscessus_ATCC_1997 G----IFARF-PWLKIPLADIESNGAWEP-----DQFKTKVINTEYDTYG
MLBr_01232|M.leprae_Br4923 FGKSVLASIFRPGDYIPLIDYTMPQRMDS------QYDSNRVVAAYDGLS
. . . .
Mflv_1918|M.gilvum_PYR-GCK GDFPVRPLNLLATVNALLGYGIMHGETVDVPF---------------AQA
MSMEG_5455|M.smegmatis_MC2_155 -DFPVYPLNVLALANAVAGIAVLHPTYPELDR---------------PDL
TH_3724|M.thermoresistible__bu -DFPRYPLNLVATANAILGIYYLHGGYYELLTEN-------PDILDDPER
Mb0165c|M.bovis_AF2122/97 -HAPQFPLRILSDINAFMGYFYVHNTYPELMAT--------QVDNAVPLP
Rv0160c|M.tuberculosis_H37Rv -HAPQFPLRILSDINAFMGYFYVHNTYPELMAT--------QVDNAVPLP
MUL_1034|M.ulcerans_Agy99 -HAPQYRLNILSDINAIMGYFYVHGNYPDLMS-----------GQAIQLP
MMAR_0383|M.marinum_M -NFPRYPLNVVSDVNAIMGFLYDEHYYAGLTSDPNAIGSGPTVANAVQLP
Mvan_4726|M.vanbaalenii_PYR-1 -DFPTNPLNLLADLNAIMGTILLHPNYSDAGT-----------------P
MAV_1346|M.avium_104 SDFITLGEGQFAPVPGAAGIPNFNPGLTAATTAG------------PPAP
MAB_4141|M.abscessus_ATCC_1997 -DFPAY-FNPLALANSIAAIQYAHPDAYYDRIDP------AALDDPDNPN
MLBr_01232|M.leprae_Br4923 -EFPDRADNLLAQLNCFAGGAISHTPSGFFNPED--------VPPQNIRT
. .: . .
Mflv_1918|M.gilvum_PYR-GCK RFQGREGDTDYYLIGTDLLPLLQPLLLF----VPRPILSALDAPLRVLVE
MSMEG_5455|M.smegmatis_MC2_155 VPVGSTGDTEYFVIGTDIMPLLMPLETIG---VPRPILLAVDEPLRVLVE
TH_3724|M.thermoresistible__bu TIVQQYGDTTYYLIRTEQLPLLRPLRDLG---VPEEFVDALEPYVRRIVD
Mb0165c|M.bovis_AF2122/97 TSPGYTGNTQYYMFLTQDLPLLQPIRDIPY--AGPPIADLFQPQLRVLVD
Rv0160c|M.tuberculosis_H37Rv TSPGYTGNTQYYMFLTQDLPLLQPIRDIPY--AGPPIADLFQPQLRVLVD
MUL_1034|M.ulcerans_Agy99 TSPGYTGNTDYYMYLTQDLPLVQPIRDIPY--AGPPLADLIQPQLRVLVD
MMAR_0383|M.marinum_M TSPGYTGNTEYYMVLGQHLPLTDPLRQIPY--VGTPIADLIQPSLRVIVD
Mvan_4726|M.vanbaalenii_PYR-1 QLQGQYQDSTYYLIPAPITPVLVPLTWVPI--VGKPLAIALDPAVRVLVE
MAV_1346|M.avium_104 AAPAAAAGAPVLASMGRGPSIGGLSVPPSW--APGGVAPAANATPAQLVG
MAB_4141|M.abscessus_ATCC_1997 VVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFVLDAIEPTLRVFID
MLBr_01232|M.leprae_Br4923 TVNSRGAKTTTYLIPVNHLPLTLPLRYLG---WSDALVDQIDAVLQPKID
: .: . : :
Mflv_1918|M.gilvum_PYR-GCK DAYDRDAG----PGDPTTARWWP-VKDFAGTAAKLIASVPVAVDNLTEGF
MSMEG_5455|M.smegmatis_MC2_155 AGYRRDIA----PGAPTPARLIP-IVNPITLTRNFIAAIPVGVDDAMEEL
TH_3724|M.thermoresistible__bu LGYDRNTP----YGEPAPVRVLP-PLTPAPG--------PATQHNAGQGI
Mb0165c|M.bovis_AF2122/97 LGYADYGPGGNYADIPTPAGLFS-IPNPFAVTYYLIKGSLQAPYGAIVEI
Rv0160c|M.tuberculosis_H37Rv LGYADYGPGGNYADIPTPAGLFS-IPNPFAVTYYLIKGSLQAPYGAIVEI
MUL_1034|M.ulcerans_Agy99 LGYSDYGPGLSYADVPTPAGLLS-VPNPFAVSYYLLKGSLQAPYGAAVEI
MMAR_0383|M.marinum_M LGYSDYGPGQNYADIPTPASLFS-LPNPLAVSYYLGKGAVQG----VQAF
Mvan_4726|M.vanbaalenii_PYR-1 MGYDRTVN----PGQPTPARYLY-VPNLIKAALNFAMAIPTGWDDAISYL
MAV_1346|M.avium_104 AGFTSAAP----DTAPVTAVPGG-VPSMATAGR-----------------
MAB_4141|M.abscessus_ATCC_1997 MAYDRDTG----PGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNVENGL
MLBr_01232|M.leprae_Br4923 AAYAYNDNP---LNKPISVDPVN---------------------------
.: .
Mflv_1918|M.gilvum_PYR-GCK GLGRVLGTPVPGVFGVGG-----------------PDLPDVDEGGAVTSD
MSMEG_5455|M.smegmatis_MC2_155 GHGRPLGTQPSGVFGVGGEDTELKGLPAGVISLAKPTLPVSSHTTVVEKT
TH_3724|M.thermoresistible__bu TVASATSTP-------------------------------DKRTPVVEAP
Mb0165c|M.bovis_AF2122/97 GVEAGLIGP-------------------------------------EWFP
Rv0160c|M.tuberculosis_H37Rv GVEAGLIGP-------------------------------------EWFP
MUL_1034|M.ulcerans_Agy99 GVEAGLLGP-------------------------------------ESFP
MMAR_0383|M.marinum_M MVDEGWLPQ-------------------------------------SYLP
Mvan_4726|M.vanbaalenii_PYR-1 TGDPDCRPFHTTVPASPFG---VGGPPVYTGAIDPYGEPTPYLAPPVETH
MAV_1346|M.avium_104 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 AGATPKQSASPEKPASPPVP------QPGPTNPGSATTQIPAPEAPTPSV
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK IDEDAVAQRDSASSTERSAPAEESRSAVGGADSDGRDDV-----VDPEPA
MSMEG_5455|M.smegmatis_MC2_155 ERKDLAKPAAEPEPVVEDEPAVEDETPVADTKKASPKPL-----RPKVRG
TH_3724|M.thermoresistible__bu VEE---PPVQTGRSTLKREKPVSARHLVRNSLRAVPGLR-----RGEPAA
Mb0165c|M.bovis_AF2122/97 DSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLG-NILHL-----IPPPVF
Rv0160c|M.tuberculosis_H37Rv DSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLG-NILHL-----IPPPVF
MUL_1034|M.ulcerans_Agy99 DTYPWVPSLNPGLNFYLGQPSVTLLSLLSGGLG-DIFHL-----IPPPVF
MMAR_0383|M.marinum_M DTYPYVASLSPGLNVYLGQPSVTGLSLLTGALGTAARDL-----GWIPSW
Mvan_4726|M.vanbaalenii_PYR-1 GEAAPGSGSPAAHPAGTEPPETVTFSPTTESTPSTLLPE-----TPAESE
MAV_1346|M.avium_104 ------GGYGLGAPRYGVKPTVMPKPAI----------------------
MAB_4141|M.abscessus_ATCC_1997 VSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKSTP
MLBr_01232|M.leprae_Br4923 -----GMDPIAGIDAELRDSILNVFAQLRSILPPPPG-------------
Mflv_1918|M.gilvum_PYR-GCK APEAETSEAETVTETEADD---------ADDADDGADADDEDIDADGADA
MSMEG_5455|M.smegmatis_MC2_155 PISFDAPKLPTIRKATGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDT
TH_3724|M.thermoresistible__bu TPTPDVTPDVTPDAPAGQP--------------EPAEPNESAAPPAAAEA
Mb0165c|M.bovis_AF2122/97 T-------------------------------------------------
Rv0160c|M.tuberculosis_H37Rv T-------------------------------------------------
MUL_1034|M.ulcerans_Agy99 P-------------------------------------------------
MMAR_0383|M.marinum_M D-------------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 DMPPDFVENDTPDSDEVSPTEDDALKDTETINESQDGPTESASGVSGEDA
MAV_1346|M.avium_104 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 PPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSV
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_1918|M.gilvum_PYR-GCK DGEDTAGNTAEAA------------------------------
MSMEG_5455|M.smegmatis_MC2_155 DNADKPAARADDAA-----------------------------
TH_3724|M.thermoresistible__bu DDASE--------------------------------------
Mb0165c|M.bovis_AF2122/97 -------------------------------------------
Rv0160c|M.tuberculosis_H37Rv -------------------------------------------
MUL_1034|M.ulcerans_Agy99 -------------------------------------------
MMAR_0383|M.marinum_M -------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 ADADSRSADADSLSADAGDSAPADAAAADTAA-----------
MAV_1346|M.avium_104 -------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 PGLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA
MLBr_01232|M.leprae_Br4923 -------------------------------------------