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SEKVWFITGASRGFGREWAIAALDRGDKVAATARDTATLADLADKYGDALLPLQLDVDDRAADFAAVKQA HEHFGRLDIVVNNAGYGQFGFIEELSEAEARAQIETNLFGALWVTQAALPILRAQRSGHIIQVSSIGGIS AFPLVGMYHASKWALEGFSQSLAQEVEGFGINVTLIEPGGFSTDWAGSSAKHATPIADYDELRDATNTAR SQRNSKPGDPKASASAVLKIVDAEKPPLRVFFGERPLEIAKADYERRIKLWEEWQPVAVEAQG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1114 | - | - | 100% (274) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3302 | - | 6e-54 | 45.75% (247) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_3426 | - | 1e-52 | 43.61% (266) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1277c | - | 1e-23 | 33.82% (204) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0295 | - | 7e-51 | 41.95% (267) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1245c | - | 1e-23 | 33.82% (204) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01094 | - | 2e-21 | 29.83% (238) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3919c | - | 2e-30 | 34.55% (246) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1614 | - | 2e-43 | 39.78% (269) | short chain dehydrogenase |
| M. avium 104 | MAV_4982 | - | 6e-64 | 48.11% (264) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3670 | - | 1e-116 | 73.43% (271) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3423 | - | 8e-44 | 39.78% (269) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0982 | - | 1e-123 | 77.74% (274) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1114|M.smegmatis_MC2_155 -----------MSEKVWFITGASRGFGREWAIAALDRGDKVAATARDTAT
Mvan_0982|M.vanbaalenii_PYR-1 MPGHPTGIDPGMTEKVWFITGASRGFGREWAIAALDRGDKVAATARDLST
TH_3670|M.thermoresistible__bu MGSN------VWGSKVWFITGASRGFGREWAIAALDRGDRVAATARDVST
MMAR_1614|M.marinum_M ------------MS-TWLITGCSTGLGRALAEAVIDAGHHTVATARSVGG
MUL_3423|M.ulcerans_Agy99 ------------MS-TWLITGCSTGLGRALAEAVIDAGHHTVATARSVGG
Mflv_0295|M.gilvum_PYR-GCK ------------MSKVLLISGASRGLGRAITESALAAGHLVVAGVRATSS
MAV_4982|M.avium_104 ------------MPKTWFITGSSRGLGRALTTAVLDHGDHVVATARRPAQ
Mb1277c|M.bovis_AF2122/97 --------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDG
Rv1245c|M.tuberculosis_H37Rv --------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDG
MLBr_01094|M.leprae_Br4923 --------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEG
MAB_3919c|M.abscessus_ATCC_199 --------MKNFDNKVAVITGAGSGIGRSLALALAQRGARLALSDIDTAG
. .::*.. *:*: : * .
MSMEG_1114|M.smegmatis_MC2_155 LADLADKYGDA---LLPLQLDVDDRAADFAAVKQAHEHFGRLDIVVNNAG
Mvan_0982|M.vanbaalenii_PYR-1 LDDLTAKYGDA---LLPLTLDVTDRDADFAAVTQAHDHFGRLDIVVNNAG
TH_3670|M.thermoresistible__bu LDDLRDRFGDA---VLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAG
MMAR_1614|M.marinum_M VADLVQRSPER---VLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAG
MUL_3423|M.ulcerans_Agy99 VADLAQRSPER---VLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAG
Mflv_0295|M.gilvum_PYR-GCK LSDLATREPDR---LAVVELDVTDDRHARAAVATAVERFGRLDVLVNNAG
MAV_4982|M.avium_104 LDELVDRYGPR---IRACELDVTDRAAARRAIAAAVTAFGRIDVVVNNAG
Mb1277c|M.bovis_AF2122/97 LADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAG
Rv1245c|M.tuberculosis_H37Rv LADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAG
MLBr_01094|M.leprae_Br4923 LAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAG
MAB_3919c|M.abscessus_ATCC_199 VADTAGRCEKAGATAIPFELDVADRAAVYAHAADVKNEFGQVNLVFNNAG
: : : **: : . ** :: : ****
MSMEG_1114|M.smegmatis_MC2_155 YGQFGFIEELSEAEARAQIETNLFGALWVTQAALPILRAQRSGHIIQVSS
Mvan_0982|M.vanbaalenii_PYR-1 YGQFGFVEELSEQEARAQIDTNVFGALWITQAALPYLRAQRSGHLIQVSS
TH_3670|M.thermoresistible__bu YGHFGFVEELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSS
MMAR_1614|M.marinum_M YGYRAAVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISS
MUL_3423|M.ulcerans_Agy99 YGYRAAVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISS
Mflv_0295|M.gilvum_PYR-GCK YANMSAIEDVDVDDFRAQIETNFFGVVNLTRAALPAMRRQRDGHIVQISS
MAV_4982|M.avium_104 YANSAPVEEVSDDDFRAQVETNFFGVVNVTKAALPVLHRQRAGHIVQISS
Mb1277c|M.bovis_AF2122/97 IAFTGDIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISS
Rv1245c|M.tuberculosis_H37Rv IAFTGDIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISS
MLBr_01094|M.leprae_Br4923 IAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISS
MAB_3919c|M.abscessus_ATCC_199 VALSADVKDMEWDDFDWLMNINFWGVAHGTKAFLPHLIESGDGHIVNVSS
. . :: : .: . :*. :* ** : * ::::**
MSMEG_1114|M.smegmatis_MC2_155 IGG-ISAFPLVGMYHASKWALEGFSQSLAQEVEGFG--INVTLIEPGGFS
Mvan_0982|M.vanbaalenii_PYR-1 IGG-IVAFPNLGIYHASKWALEGFSQALAQEVAEFG--IHVTLIEPGGYS
TH_3670|M.thermoresistible__bu IGG-VSAFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYA
MMAR_1614|M.marinum_M IAVALTP-VGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFR
MUL_3423|M.ulcerans_Agy99 IAVALTP-VGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFR
Mflv_0295|M.gilvum_PYR-GCK VGGRLVR-PGLAAYQSAKWAVTGFSGVLAVEVAPLG--IKVTVLEPGGMR
MAV_4982|M.avium_104 VGGRVGGSPGIAAYQASKFAVAGFSEALAAEVAPLG--IKVTIAEPGALR
Mb1277c|M.bovis_AF2122/97 VFG-LFSAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVK
Rv1245c|M.tuberculosis_H37Rv VFG-LFSAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVK
MLBr_01094|M.leprae_Br4923 VFG-LFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIK
MAB_3919c|M.abscessus_ATCC_199 VFG-LMGIPSQSAYNAAKFAVRGFTESLRQEIRAAKFPVGVTCVHPGGIK
: : . * ::* *: *:: * *: : ** **.
MSMEG_1114|M.smegmatis_MC2_155 TDWAGSSAKHAT-PIADYDELRDATNTARSQRNS-KPGDPKASASAVLKI
Mvan_0982|M.vanbaalenii_PYR-1 TDWAGASAKRAT-ALPAYAEAHAATERTRQARTA-RPGDPQASARALLTV
TH_3670|M.thermoresistible__bu TDWGGSSARRSA-TMPEYAESRAEADRVRSQRVA-RPGDPKASAAALLKV
MMAR_1614|M.marinum_M TDFAGRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITA
MUL_3423|M.ulcerans_Agy99 TDFAGRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIITA
Mflv_0295|M.gilvum_PYR-GCK TDWAGSSMRIAP-VREEYAATVGAAAS-LSDPNVLGASDPAKVAGLLLDV
MAV_4982|M.avium_104 TEWAGSSMAVAT-VSPDYESTVGAMNRRRAGFNRNAPGDPARAAHAIIEV
Mb1277c|M.bovis_AF2122/97 TAIAR--------NAT-AAEGLDQAELAETFDKRVAHLSPQRAAQIILTG
Rv1245c|M.tuberculosis_H37Rv TAIAR--------NAT-AAEGLDQAELAETFDKRVAHLSPQRAAQIILTG
MLBr_01094|M.leprae_Br4923 TAIAR--------NAT-AAEGLDVSKIASRFDTWVAHTSPQHAARIILKA
MAB_3919c|M.abscessus_ATCC_199 TNIAS--------SARGIPDGVDRETVRKGFQ-LMAITRPDSAARIILRG
* . * * ::
MSMEG_1114|M.smegmatis_MC2_155 VDAEKPPLRVFFGERPLEIAKADYERRIKLWEEWQPVAVEAQG-------
Mvan_0982|M.vanbaalenii_PYR-1 VDAPEPPLRVFFGELPLELARADYESRLANWEKWQPVAIEAQG-------
TH_3670|M.thermoresistible__bu VDAEKPPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVLAQG-------
MMAR_1614|M.marinum_M VESPAPPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP-----
MUL_3423|M.ulcerans_Agy99 VESPAPPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP-----
Mflv_0295|M.gilvum_PYR-GCK IGMPDPPRRLLVGPDAYRYATAAGRDLLAVDERWRTLSMSTAADDVSPEQ
MAV_4982|M.avium_104 VIADDPPLRLLLGSDALSAALAKSHQQIAEANRWAELSKSIDYPPVATPH
Mb1277c|M.bovis_AF2122/97 VAKNKA--RVLVGVDAKVLDLVVRLTG-SGYQRIFP------------II
Rv1245c|M.tuberculosis_H37Rv VAKNKA--RVLVGVDAKVLDLVVRLTG-SGYQRIFP------------II
MLBr_01094|M.leprae_Br4923 VRKKKA--RVLVGPDAKVANVVVRFSGGAGYQRLFA------------QV
MAB_3919c|M.abscessus_ATCC_199 VEKNRP--RVLIGPDARVFDAIPRIIG-PRYEDLMAPFYGMGRYGIGKKI
: . ::.* .
MSMEG_1114|M.smegmatis_MC2_155 ---------
Mvan_0982|M.vanbaalenii_PYR-1 ---------
TH_3670|M.thermoresistible__bu ---------
MMAR_1614|M.marinum_M ---------
MUL_3423|M.ulcerans_Agy99 ---------
Mflv_0295|M.gilvum_PYR-GCK LDPLGSASR
MAV_4982|M.avium_104 R---AARSR
Mb1277c|M.bovis_AF2122/97 TGRLIPRPR
Rv1245c|M.tuberculosis_H37Rv TGRLIPRPR
MLBr_01094|M.leprae_Br4923 ASRLILNQR
MAB_3919c|M.abscessus_ATCC_199 AGRFGIEL-