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MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVRALDMGQQVIRAAGGAVTRVQFG PRWLVPPLVAVFSPEGIRDVLGRNDAFAERCIVHDEVRHAAGDSLFVLPNEQWRPRKRALQPVFTKHSVR AFGGHMSRAAQTLVDEWADQWAQADSLEVDLDAVCRRVTMQSLGRSVLGIDLNERADVIVEHMHVASSYA TDRALRPLRAPRWLPTPARRRARAAVAAMRAVTAEILQACRDDADRDAPLVRALMAAEDPETGERLSDED ICNDLLIFMLAGHDTTATALTYALWALGHHPEIQDRVAAEARALGDRELTPADVPQLGYTVQVLHESLRM CPPAAGVGRLALRDIAVAGHRVEAGSLVALGIYAVHHDPQLWPDPEVFDPDRFSPENSRERDRWHFIPFA GGARACIGEHFARLETTLALATIIRSVVVGSVDAEFPVDVPFTTVAKGPIRANVAPRGPDHYTL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0968 | - | - | 100% (484) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_0822 | - | e-137 | 52.08% (457) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_2289 | - | 8e-29 | 25.45% (334) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 6e-33 | 30.49% (364) | cytochrome P450 139 CYP139 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 0.0 | 74.62% (457) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 6e-33 | 30.49% (364) | cytochrome P450 139 CYP139 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-15 | 24.19% (434) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1426 | - | 4e-44 | 29.55% (440) | putative cytochrome P450 |
| M. marinum M | MMAR_0852 | cyp185A4 | 1e-145 | 53.61% (457) | cytochrome P450 185A4 Cyp185A4 |
| M. avium 104 | MAV_3927 | - | 2e-31 | 25.54% (372) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_3255 | - | 0.0 | 68.94% (454) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 1e-141 | 52.52% (457) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0858 | - | 0.0 | 71.87% (455) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1694c|M.bovis_AF2122/97 ---------------------------------MRYPLG-----EALLAL
Rv1666c|M.tuberculosis_H37Rv ---------------------------------MRYPLG-----EALLAL
MSMEG_0968|M.smegmatis_MC2_155 MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVRAL
Mflv_0056|M.gilvum_PYR-GCK MV------------------AGTEPGVGHLPLAPKNPLPYRRLLTLVRAL
Mvan_0858|M.vanbaalenii_PYR-1 MTAR---------------DTAAAPEVGSLPLVPRNPLPLWKLVQLVRRL
TH_3255|M.thermoresistible__bu MVVT-----------------TERADVATLPPAPRNPLPYWRQVRAVRSF
MMAR_0852|M.marinum_M MVDS--------------------PDVRSLPLAPRNPLPYWQQLKALKTL
MUL_0604|M.ulcerans_Agy99 MVDP--------------------PDIRSLPLAPRNPLPYWQQLKALKTL
MAB_1426|M.abscessus_ATCC_1997 MSASALQ----PEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYL
MAV_3927|M.avium_104 -MTATISTPQYLLDQARRRFTPTLNTIPGMGAIEKRLLAHEWQTKVLAEP
MLBr_02088|M.leprae_Br4923 MRTCVPTR--------TCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLI
:
Mb1694c|M.bovis_AF2122/97 YRW---RGPLINAG-----------VGGHG--YTYLLGAEA-----NRFV
Rv1666c|M.tuberculosis_H37Rv YRW---RGPLINAG-----------VGGHG--YTYLLGAEA-----NRFV
MSMEG_0968|M.smegmatis_MC2_155 DMG---QQVIRAAGGAVTRVQFGPRWLVPP--LVAVFSPEG-----IRDV
Mflv_0056|M.gilvum_PYR-GCK DTG---QLQVRAAGGPITRVQVAPRWLFPP--FVAVFSPRG-----VRDV
Mvan_0858|M.vanbaalenii_PYR-1 DTG---QEVIRDAGGPITRIQLGPKKLMPP--IVAVMSPAG-----MRDV
TH_3255|M.thermoresistible__bu HTG---QELLRDAGGPVK-------WAIPP--IVLVTSPAG-----IRDV
MMAR_0852|M.marinum_M HVG---SEALRDAGGSVTRIWLGPKRLVPP--MVMVTSPQG-----ARDV
MUL_0604|M.ulcerans_Agy99 HVG---SEALRDAGGSVTRIWLGPKRLVPP--MVMVTSPQG-----ARDV
MAB_1426|M.abscessus_ATCC_1997 KSW---RLALGAVWSTYRHTISEYLADLPGQDDVIVARAPM-----RKAV
MAV_3927|M.avium_104 PAGSGLKPVLGDAGLPILGHIIELFRGGPD-YALFLYRNHGPLIYLDSPI
MLBr_02088|M.leprae_Br4923 DPG------TRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHP
:
Mb1694c|M.bovis_AF2122/97 FANADAF---SWS---QTFESLVPVDGPTALIVSDG---------ADHRR
Rv1666c|M.tuberculosis_H37Rv FANADAF---SWS---QTFESLVPVDGPTALIVSDG---------ADHRR
MSMEG_0968|M.smegmatis_MC2_155 LGRNDAF---AER--CIVHDEVRHAAGDSLFVLPN----------EQWRP
Mflv_0056|M.gilvum_PYR-GCK LGRNDAF---SER--CIVHEEVRDMAGDSLFVLPN----------EPWRP
Mvan_0858|M.vanbaalenii_PYR-1 LGRNDAS---SDR--CIIHEQVQEMAGDSLWVLPN----------EQWRP
TH_3255|M.thermoresistible__bu LNRRDAL---SER--CQVHHEVRHLGGDSLFVLPT----------DPWRA
MMAR_0852|M.marinum_M LGRSGAL---SDRGTLPLLKDLRRAIGESVLNLPH----------DTWLP
MUL_0604|M.ulcerans_Agy99 LGRSGAL---SDRGTLPLLKDLRRAIGESVLNLPH----------DTWLP
MAB_1426|M.abscessus_ATCC_1997 IVRNPEL---ARHVLVANQDNYIKSAEYDLLAVGFGRGLVTDLNEGLWNR
MAV_3927|M.avium_104 MPAVTALGPDATQAVFSNRNKDYSQKGWHPVIGPFFNRGLMMLDFDEHMY
MLBr_02088|M.leprae_Br4923 LSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDP----------PDHTR
: .
Mb1694c|M.bovis_AF2122/97 RRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQ------PGQRLDIYQEL
Rv1666c|M.tuberculosis_H37Rv RRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQ------PGQRLDIYQEL
MSMEG_0968|M.smegmatis_MC2_155 RKRALQPVFTKHSVRAFGGHMSRAAQTLVDEWADQWAQADSLEVDLDAVC
Mflv_0056|M.gilvum_PYR-GCK RKRALQPVFTPQNVRRFGGHMSRAAEVFVDAWR------DGGDVDLDLEC
Mvan_0858|M.vanbaalenii_PYR-1 RKRALAPVFTKTSVRAFGGHMSKAAQAFVDRWP------SGGEVDLDAEC
TH_3255|M.thermoresistible__bu RRRALAPVFTPTAVRSYGGYMSEAAQRVADGWQ------AAREVDLDAEC
MMAR_0852|M.marinum_M RRRTLQPIFTKQRVAGFAGHMSEAANHILLGWP------DGAEVDLNAAS
MUL_0604|M.ulcerans_Agy99 RRRTLQPIFTKQRVAGFAGHMSEAANHILLGWP------DGAEVDLNAAS
MAB_1426|M.abscessus_ATCC_1997 NRRLVQPIFAKRQVDLFAPQMAEAAARTISRWD--ELYAEGKPVDITAEM
MAV_3927|M.avium_104 HRRIMQEAFTRSRLTGYVEHIDRVATDIVADWP-----TNDARFLFHPAM
MLBr_02088|M.leprae_Br4923 LRKLVSKAFAPKVVQALEGDIAALVDSLLDKGA------AAGQFDVIADL
: : : : : . .
Mb1694c|M.bovis_AF2122/97 RSAVRRSTAESLFGQRLA-----------------------------VHS
Rv1666c|M.tuberculosis_H37Rv RSAVRRSTAESLFGQRLA-----------------------------VHS
MSMEG_0968|M.smegmatis_MC2_155 RRVTMQSLGRSVLGIDLN-----------------------------ERA
Mflv_0056|M.gilvum_PYR-GCK RRITMQSLGRSVLGVDLN-----------------------------ESA
Mvan_0858|M.vanbaalenii_PYR-1 RRVAMQSLGRSVLGVDLN-----------------------------ERG
TH_3255|M.thermoresistible__bu RRLTMRSLGRSVLGLDIN-----------------------------ERA
MMAR_0852|M.marinum_M HALVLRVVGHSVFGLDLQ-----------------------------DKA
MUL_0604|M.ulcerans_Agy99 HALVLRVVGHSVFGLDLQ-----------------------------DKA
MAB_1426|M.abscessus_ATCC_1997 NYLTMDIVAQTMFGIDLSGDMAERMRIYFARLLKLFGVGFIVGAAPPLRW
MAV_3927|M.avium_104 KELTLDIASLVFMGHEPG------------------------------TD
MLBr_02088|M.leprae_Br4923 AFPLAVAVICRLLGVPYE--------------------------------
.:*
Mb1694c|M.bovis_AF2122/97 DFLGEQLQPLLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQ
Rv1666c|M.tuberculosis_H37Rv DFLGEQLQPLLDLTR-RPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQ
MSMEG_0968|M.smegmatis_MC2_155 DVIVEHMHVASSYATDRALRPLRAPRWLPTPARRRARAAVAAMRAVTAEI
Mflv_0056|M.gilvum_PYR-GCK DVIAEHMHVASSYTADRALRPVRAPRWLPTPARRRAAHAVAEMRQVAADM
Mvan_0858|M.vanbaalenii_PYR-1 ETIARCMHVASSYTADRALRPVRAPRWLLTPARQRARSAVNAMRAITDEM
TH_3255|M.thermoresistible__bu DAISEPMHIASSYTADRALRPVRAPRWLPTPARRRARAAVATMRRITDEM
MMAR_0852|M.marinum_M DVITTGVTLAAKWAADRSARPVRAPHWLPTPARRRARGAYDAMYKIAADM
MUL_0604|M.ulcerans_Agy99 DVITTGVTLAAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADM
MAB_1426|M.abscessus_ATCC_1997 VVDKLAAHGPDELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTIDQL
MAV_3927|M.avium_104 HDLVTKVNQAFTTTTRAGGAIIRQP--IPPFKWWRGLRARQLLEDYFSER
MLBr_02088|M.leprae_Br4923 ---DAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
. . . . :
Mb1694c|M.bovis_AF2122/97 IADARTA-PRPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYET
Rv1666c|M.tuberculosis_H37Rv IADARTA-PRPDDHMLTTLISGCS-EEGTTLSDNEIRDSIVSLITAGYET
MSMEG_0968|M.smegmatis_MC2_155 LQACRDD-ADRDAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDT
Mflv_0056|M.gilvum_PYR-GCK LQVCRDD-PDRDAPLVRALMDARDPETGMALSDDDICNDLLIFMLAGHDT
Mvan_0858|M.vanbaalenii_PYR-1 VKACRDD-PTRDAPLVQALIAATDPETGRPLTDEEISNDLLIFMLAGHDT
TH_3255|M.thermoresistible__bu LQACRAD-PDRDAPLVHALIRATDPETGRGLSDEDICNDLLIFMLAGHDT
MMAR_0852|M.marinum_M LAACRAD-PNREAPLIRALIDATDPNTGESLSDQQICDEMVYFMILGEDT
MUL_0604|M.ulcerans_Agy99 LAACRAD-PSREAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDT
MAB_1426|M.abscessus_ATCC_1997 IADHRSGRIARQDNLLALLMAAEDPETGAKYTDLEIRDELMTFLGAGFET
MAV_3927|M.avium_104 VKERRNA----TGNDMLTVLCHTEDDDGNSFTDDDIVNHMIFLMMAAHDT
MLBr_02088|M.leprae_Br4923 VKCRRGT---PGEDLISRLIELDE--SGDQLTEEEIIATCGLLLVAGHET
: * : :: * :: :* :: . :*
Mb1694c|M.bovis_AF2122/97 TSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVV
Rv1666c|M.tuberculosis_H37Rv TSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVV
MSMEG_0968|M.smegmatis_MC2_155 TATALTYALWALGHHPEIQDRVAAEAR-ALGDRELTPADVPQLGYTVQVL
Mflv_0056|M.gilvum_PYR-GCK TATALTYALWVLGHHPDVQDRVAAEAA-ALGRRELEPGDVPHLKYTTQVL
Mvan_0858|M.vanbaalenii_PYR-1 TATALTHALWVLGHHPDIQDRVAAEAA-AIGDRELTPDDVPALGYTVQVL
TH_3255|M.thermoresistible__bu TATALTYALWALGHHPEIQDRVAAEVA-ELPDREITPHDVPRLGYTVQVL
MMAR_0852|M.marinum_M TSTVLTYALWALGRHSQLQDRVAAEAA-ELGDRPLTPADVPRLGYTIQVL
MUL_0604|M.ulcerans_Agy99 TSTVLTYALWALGQHCQLQDRLAAEAA-ELGDRPLTPADVPRLGYTIQVL
MAB_1426|M.abscessus_ATCC_1997 TAAALAWTWYLLSRNPDARAKLGQEVDRVLGGRQPTAADVDNLPWTAAVL
MAV_3927|M.avium_104 STSTTTTMVYNMAAHPEWQERAREEST-RLGDGPLDIEALEKLETLELIM
MLBr_02088|M.leprae_Br4923 TVNLIANAVLAMLRNPSQWKALSSNPQ-----------------RAPLVV
: : : : ::
Mb1694c|M.bovis_AF2122/97 HETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPE
Rv1666c|M.tuberculosis_H37Rv HETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPE
MSMEG_0968|M.smegmatis_MC2_155 HESLRMCPPAAGVGRLALRDIAVAGHRVEAGSLVALGIYAVHHDPQLWPD
Mflv_0056|M.gilvum_PYR-GCK LEALRLCPPAAGVGRMAVRDIDVDGHRVQAGTLVAVGIYALHRDPEIWPD
Mvan_0858|M.vanbaalenii_PYR-1 HESVRLCPPAAGVARLVTRDFAVDGYRVEAGSLVALGLYALHHDPALWPD
TH_3255|M.thermoresistible__bu RESLRLCPPAAGVGRLAMSDLAVDGYRVEAGTLLAVGIQAIHRDPSLWPD
MMAR_0852|M.marinum_M QEAMRLCPPGPTVARRAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDD
MUL_0604|M.ulcerans_Agy99 QEAMRLRPPGPTVARRAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDD
MAB_1426|M.abscessus_ATCC_1997 NEAMRVYPPILGLARTAKADDVLGDYPISAGTTVMVLIDSIHHNERVWDD
MAV_3927|M.avium_104 NESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWPGMNHRLPELWTD
MLBr_02088|M.leprae_Br4923 EETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSR
*::* .. * . * . : * . :: ::
Mb1694c|M.bovis_AF2122/97 PTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILAR
Rv1666c|M.tuberculosis_H37Rv PTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILAR
MSMEG_0968|M.smegmatis_MC2_155 PEVFDPDRFSPENSRERD--RWHFIPFAGGARACIGEHFARLETTLALAT
Mflv_0056|M.gilvum_PYR-GCK PDRFDPDRFSPEQTAQRD--RWHFLPFAGGARSCIGEHFARLETTLALAT
Mvan_0858|M.vanbaalenii_PYR-1 PMAFDPDRFSPENVKARD--RWQFLPFLGGGRPCIGEHFARLETTLALAT
TH_3255|M.thermoresistible__bu PMVFDPDRFAPERFKAMD--RWQFVPFIGGPRSCIGEHFAMLESTLAIAT
MMAR_0852|M.marinum_M PLAFDPDRFAPKKSKGRD--RWQYLPFGGGGRSCLGDHFAMLEASLALAT
MUL_0604|M.ulcerans_Agy99 PLAFDPDRFAPKKSKGRD--RWQYLPFGGGGRSCLGDHFAMLEASLALAT
MAB_1426|M.abscessus_ATCC_1997 AKTFDPARFLKENLQPEQ--RKAHMPFGAGKRMCVASGFANLEAIIGIAA
MAV_3927|M.avium_104 PDKFDPERFAEPRAEHKK-HRYAFAPFGGGAHKCIGMVFGQLEVKTVVHR
MLBr_02088|M.leprae_Br4923 PDEFDPDRPSS-----------RHLAFAVGSHFCLGAALARLEATVTLSA
. * * * . .* * : *:. :. * :
Mb1694c|M.bovis_AF2122/97 LVARAMLQLP-AQRTH-RIRAANFAALRPWPGLTVEIRKSAPAQ------
Rv1666c|M.tuberculosis_H37Rv LVARAMLQLP-AQRTH-RIRAANFAALRPWPGLTVEIRKSAPAQ------
MSMEG_0968|M.smegmatis_MC2_155 IIRSVVVGSV-DAEFP-VDVPFTTVAKGPIRANVAPRGPDHYTL------
Mflv_0056|M.gilvum_PYR-GCK IVRSMRVTSS-DNDFP-VDVPFTTVAHGPIPAHLTPR-------------
Mvan_0858|M.vanbaalenii_PYR-1 VVRACRIESL-DDLFE-CEVPLTTVAKGPIRARVTPRR------------
TH_3255|M.thermoresistible__bu LIRSVRIRSL-DDDFP-VEVPFTTVARGPIRAVVSARR------------
MMAR_0852|M.marinum_M IIREAEIHSL-DGDFP-VAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSD
MUL_0604|M.ulcerans_Agy99 IIREAEIHSL-DGDFP-VAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSD
MAB_1426|M.abscessus_ATCC_1997 LAQNYELDLL-PGQQPRREVTFTGGPEGEILMRLRKRHP-----------
MAV_3927|M.avium_104 LLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL-------------
MLBr_02088|M.leprae_Br4923 ISARFPQVQLAGELVYKPNVAMRGMSALPVQV------------------
: .
Mb1694c|M.bovis_AF2122/97 --------
Rv1666c|M.tuberculosis_H37Rv --------
MSMEG_0968|M.smegmatis_MC2_155 --------
Mflv_0056|M.gilvum_PYR-GCK --------
Mvan_0858|M.vanbaalenii_PYR-1 --------
TH_3255|M.thermoresistible__bu --------
MMAR_0852|M.marinum_M SSASSSAS
MUL_0604|M.ulcerans_Agy99 SSASS---
MAB_1426|M.abscessus_ATCC_1997 --------
MAV_3927|M.avium_104 --------
MLBr_02088|M.leprae_Br4923 --------