For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDHEWECVVVGGGAAGLSAALVLARARRRTLLIDAGEPSNGVAPAIGGLLGHDRRPPHELYAQGRRELAA YPTFTFREGCVVRGAPTAGGSVLDLDDGSQVTAKRVLLATGMQYCPPSLPGMDKLWGTTVFQCPFCHAWE LRDQRLATLAAGAEGVNTALMLRGWSDDVVLLTDGPSDLSSGDRSLLDNAKVTIDERRIAELLGQDGQLT AIAFSDGTRLERDGLLVEAPLRQRSELASQLGAQCAAGELASDAIDVDEMHRTTVHSVFAAGDTCTEEPS VASAIAAGSQAAKIIVQSLFADEFGLPYPPGSN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0670 | - | - | 100% (313) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4303 | - | 7e-89 | 54.90% (306) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_1516 | - | 3e-07 | 23.72% (333) | thioredoxin reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 5e-11 | 23.98% (342) | reductase |
| M. gilvum PYR-GCK | Mflv_5165 | - | 1e-114 | 63.75% (309) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1869c | - | 5e-11 | 23.98% (342) | reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3177 | - | 9e-38 | 32.37% (312) | putative FAD-dependent pyridine nucleotide-disulphide |
| M. marinum M | MMAR_1902 | trxB2_2 | 5e-45 | 33.78% (299) | thioredoxin reductase TrxB2_2 |
| M. avium 104 | MAV_2849 | - | 4e-09 | 23.63% (292) | anthranilate dioxygenase reductase |
| M. thermoresistible (build 8) | TH_1468 | - | 6e-91 | 56.17% (308) | methyltransferase |
| M. ulcerans Agy99 | MUL_0769 | - | 6e-09 | 25.34% (296) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1165 | - | 1e-115 | 64.61% (308) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5165|M.gilvum_PYR-GCK --------MPNRADSGNRPS---------VDYECAVVGAGAAGLSAALVL
Mvan_1165|M.vanbaalenii_PYR-1 MHWSPIRKTAGRSGEGPRSAARIRGTERFVEFECAVVGAGAAGLSAALVL
MSMEG_0670|M.smegmatis_MC2_155 ------------MDH---------------EWECVVVGGGAAGLSAALVL
TH_1468|M.thermoresistible__bu ----------------------------VAMWDCIVIGGGAAGLSATLVL
MAB_3177|M.abscessus_ATCC_1997 ---------------------------MNKLWDVAIIGGGAAGLSAAITL
MMAR_1902|M.marinum_M ---------------------------MTDPHDVVVIGSGPAGLSSALTL
Mb1900c|M.bovis_AF2122/97 ---------------------------MASSTTFVIVGGGLAGAKAVEAL
Rv1869c|M.tuberculosis_H37Rv ---------------------------MASSTTFVIVGGGLAGAKAVEAL
MAV_2849|M.avium_104 ---------------------------MASATGFVIIGGGLAAAKAVEAL
MUL_0769|M.ulcerans_Agy99 ----------MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQL
::*.* *. :. *
Mflv_5165|M.gilvum_PYR-GCK GRA---RRSTVVVDTADPSNRAAPVIGGLLGFDQRPPDELYETGRAQLRA
Mvan_1165|M.vanbaalenii_PYR-1 GRA---RRTTIVIDADDPSNRASPVIGGLLGYDRRPPDELYAAGRAELGE
MSMEG_0670|M.smegmatis_MC2_155 ARA---RRRTLLIDAGEPSNGVAPAIGGLLGHDRRPPHELYAQGRRELAA
TH_1468|M.thermoresistible__bu GRA---KRQTLMIDAGRQSNLAARQVGGLLGQDGRAPADFYAAGRAEVAS
MAB_3177|M.abscessus_ATCC_1997 ARS---RRSTVVIDDHHPRNAPADRVHNYLGRESTPPAELFGIGRDEAAQ
MMAR_1902|M.marinum_M ARA---RRSVLVIDGGQPRNARSAGVHDFLTRDGCAPADLISAGHTEIAG
Mb1900c|M.bovis_AF2122/97 RRSDFGGRIILFGDEEHLPYDRPPLSKEFLAGKKSLSD--FTIQTSDWYR
Rv1869c|M.tuberculosis_H37Rv RRSDFGGRIILFGDEEHLPYDRPPLSKEFLAGKKSLSD--FTIQTSDWYR
MAV_2849|M.avium_104 RDNNFDGRIIVFADEEHLPYERPPLSKEFLAGKKSLTD--FTVQNSDWYR
MUL_0769|M.ulcerans_Agy99 RRAGYEGQLTIVSDEVHLPYDRPPLSKEVLR--SEVDD--VSLKPREWYD
: :. * . * :
Mflv_5165|M.gilvum_PYR-GCK YPSVEYRHG-EVLAGRASDHGFELDIDDGRQIRAKRVLLATGMSYCPPQL
Mvan_1165|M.vanbaalenii_PYR-1 YPSVEFRRG-EVRDGRRIDRGFLLDVD-GAQIRARRVLLATGMSYCPPQL
MSMEG_0670|M.smegmatis_MC2_155 YPTFTFREG-CVVRGAPTAGGSVLDLDDGSQVTAKRVLLATGMQYCPPSL
TH_1468|M.thermoresistible__bu YPGVVVRHGAEVVDGERTADGHRVTLADGTSECARRLLLATGMQYRPPEL
MAB_3177|M.abscessus_ATCC_1997 YG-ATFLDG-RATAVSHAENHFDVSLDGGPALRARRVLVATGVEDELPDI
MMAR_1902|M.marinum_M YG-GQLRQG-QVVAAHRNGSMFEVSITDGSTIRARKLLIASGLVDHLPDI
Mb1900c|M.bovis_AF2122/97 DHDVDVRLG--VRVSSLDRSAHTVELPDGAAVRYDKLLLATGSAPRRPPI
Rv1869c|M.tuberculosis_H37Rv DHDVDVRLG--VRVSSLDRSAHTVELPDGAAVRYDKLLLATGSAPRRPPI
MAV_2849|M.avium_104 DNDVDLRLN--TRVCALDAAGHTVGLPDGTTVAYDKLLLATGSAARRPPI
MUL_0769|M.ulcerans_Agy99 EKGITLRLG--SAATGLDTAAQTVTLADGTVLGYDELVIATGLVPRRIPA
. : : * .:::*:*
Mflv_5165|M.gilvum_PYR-GCK PG---LAELWGTAVFHCPFCHGWEMRDRKLAALAAGNAGLHAALMLRGWT
Mvan_1165|M.vanbaalenii_PYR-1 PG---LAELWGRSVFQCPFCHGWEMRDGKLAALASGEQGLHTALMLRGWT
MSMEG_0670|M.smegmatis_MC2_155 PG---MDKLWGTTVFQCPFCHAWELRDQRLATLAAGAEGVNTALMLRGWS
TH_1468|M.thermoresistible__bu PG---VAELWGKTVFHCPFCDGWEMRDRPLAVLARGEKALAESLMLRGWS
MAB_3177|M.abscessus_ATCC_1997 EG---LAERWGRDVLHCVYCHGWEVRDRTIAVLGTGPLAVHHALIFRQLS
MMAR_1902|M.marinum_M TG---LAELWGTDVLYCPYCHGWEVRDQPIGVLATGPESVHQALMFRQWS
Mb1900c|M.bovis_AF2122/97 PGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLEVAASARQRG
Rv1869c|M.tuberculosis_H37Rv PGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLEVAASARQRG
MAV_2849|M.avium_104 PGSDCAGVHYLRTYEVAVALNSFLGEGKSLAVVGAGWIGLEVAAAARQRG
MUL_0769|M.ulcerans_Agy99 FP-ELEGIRVLRSFDECMALRSHASAAKRAVVIGAGFIGCEVAASLRGLG
. . .:. * . : *
Mflv_5165|M.gilvum_PYR-GCK DDVVLLTDGKTDLTPDDERVLTAAGVRIDDRR---------VVELHGDDG
Mvan_1165|M.vanbaalenii_PYR-1 DDVVLLTDGSSGLSADDKQVLHRAGVTVDDRR---------VVELTGTDG
MSMEG_0670|M.smegmatis_MC2_155 DDVVLLTDGPSDLSSGDRSLLDNAKVTIDERR---------IAELLGQDG
TH_1468|M.thermoresistible__bu DDVVLLTDGPSELDGPACERLNAAGVRIDQRP---------VARLIGADG
MAB_3177|M.abscessus_ATCC_1997 DNVTLLRHNDFPMSIDEAAQLARRNIRIIDGP---------VSRLHVTQD
MMAR_1902|M.marinum_M PRITLFLNGAVDPSEPERARLHARQIEVIISP---------VTEVVSNDG
Mb1900c|M.bovis_AF2122/97 VDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEITAADG
Rv1869c|M.tuberculosis_H37Rv VDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEITAADG
MAV_2849|M.avium_104 VEVTVVEAARQPLTAALGETVGEVFATLHREHGVDLRLETQVREITRADG
MUL_0769|M.ulcerans_Agy99 VEVVLVEPQPTPLAAVLGEQIGELVARLHRSEGVDVRTGVGVAEVR-GDG
:.:. : : : .: :.
Mflv_5165|M.gilvum_PYR-GCK ELESIAFADGDTLARDGLLVEAPVRQRSALAEQLGATCTPG-PLGTEPLS
Mvan_1165|M.vanbaalenii_PYR-1 RLESIAFADGTRLARDGLLVEAPVRQRSALAAQLGATCTPG-PLGTEPLA
MSMEG_0670|M.smegmatis_MC2_155 QLTAIAFSDGTRLERDGLLVEAPLRQRSELASQLGAQCAAG-ELASDAID
TH_1468|M.thermoresistible__bu QLSGIEFADGDRLDRCGLLAETTLHQRSDLADRLGARSGESTPLAQHPID
MAB_3177|M.abscessus_ATCC_1997 SLRGVQLETGATIACEALVVATVVSARVDMLAPV--QLAPQEMRLGEHLL
MMAR_1902|M.marinum_M RLEAVALADGNRVALAALALLPRMVANTDFLDPLGLRLVAHPSGFGENLQ
Mb1900c|M.bovis_AF2122/97 KATGLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLVDASLR
Rv1869c|M.tuberculosis_H37Rv KATGLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLVDASLR
MAV_2849|M.avium_104 SATGLRTTDGSAIPADAVLVAVGARPNIELAEAAGLSLADGGVLVDASLR
MUL_0769|M.ulcerans_Agy99 HVDTVVLADGTQLDADLVVVGIGSHPATGWLDGSGIAVDNG-VVCDAAGR
: * : :
Mflv_5165|M.gilvum_PYR-GCK VD----EMARTSTGGVFAAGDVCTEQPHISGAIAAGSEAAMIIVQSLLAD
Mvan_1165|M.vanbaalenii_PYR-1 VD----TMARTSAGGVFAAGDVCTEQPHIAGAVASGSQAAMIVVQSLLAD
MSMEG_0670|M.smegmatis_MC2_155 VD----EMHRTTVHSVFAAGDTCTEEPSVASAIAAGSQAAKIIVQSLFAD
TH_1468|M.thermoresistible__bu VD----GMGRTAAPGVFAAGDVSAQVPQVAAAMSAGLIAATSTVQSLLAE
MAB_3177|M.abscessus_ATCC_1997 GTYLPVTRGATAVPGIYAAGNVTDIKAQVITSAAAGTEVAVAINADLAVA
MMAR_1902|M.marinum_M TD----GSGRTSVPGVYAAGNAADISAHVVNSASSGLLAAMAINADLVDE
Mb1900c|M.bovis_AF2122/97 TS----DPDIYAVGDIAAAEHPLLGTRVRTEHWANALKQPAVAAAGMLGR
Rv1869c|M.tuberculosis_H37Rv TS----DPDIYAVGDIAAAEHPLLGTRVRTEHWANALKQPAVAAAGMLGR
MAV_2849|M.avium_104 TS----DPDIYAVGDIAAAEHPLLRTRIRTEHWANALKQPAIAVAGMLGR
MUL_0769|M.ulcerans_Agy99 TS----APNVWAFGDVASWRD-QMGHQVRVEHWSNVADQARVVVPAMLGR
: .: : . : . :
Mflv_5165|M.gilvum_PYR-GCK DFG----LPYPPGS------------------------------------
Mvan_1165|M.vanbaalenii_PYR-1 EYG----LPFPPG-------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 EFG----LPYPPGSN-----------------------------------
TH_1468|M.thermoresistible__bu DSG----LPFPPWRDDAGE-------------------------------
MAB_3177|M.abscessus_ATCC_1997 DAQ----ELQYA--------------------------------------
MMAR_1902|M.marinum_M DTE----QALLAVADR----------------------------------
Mb1900c|M.bovis_AF2122/97 PGE-YAELPYLFTDQYDLGMEYVGHAPSCDRVVFRGNVAGREFLSFWLDG
Rv1869c|M.tuberculosis_H37Rv PGE-YAELPYLFTDQYDLGMEYVGHAPSCDRVVFRGNVAGREFLSFWLDG
MAV_2849|M.avium_104 PGE-YDELPYFFTDQYDLGMEYVGHAPRFERVVFRGDVAAREFVAFWLDA
MUL_0769|M.ulcerans_Agy99 EVSSNVVVPYFWSDQYDVKIQCLG-EPHSTDVVHLVEDDGRKLLAYYQRD
Mflv_5165|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1165|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb1900c|M.bovis_AF2122/97 ----------------DSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRL
Rv1869c|M.tuberculosis_H37Rv ----------------DSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRL
MAV_2849|M.avium_104 ----------------DDRVLAGMNVNIWDVLDDVKALIRSRAPIDADRL
MUL_0769|M.ulcerans_Agy99 GVLVGVVGGGVPGKVMKVRAKIAAAVPISEMLDESQGQTSARIPARGAGP
Mflv_5165|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1165|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb1900c|M.bovis_AF2122/97 VDPQWPLADLTTN-------------------------------------
Rv1869c|M.tuberculosis_H37Rv VDPQWPLADLTTN-------------------------------------
MAV_2849|M.avium_104 GDPGAPLGELLG--------------------------------------
MUL_0769|M.ulcerans_Agy99 GGPLVRWPTLTKSGRWRAEKATASSPVARVDGIGLEPGPRRTASWPDVPG
Mflv_5165|M.gilvum_PYR-GCK -
Mvan_1165|M.vanbaalenii_PYR-1 -
MSMEG_0670|M.smegmatis_MC2_155 -
TH_1468|M.thermoresistible__bu -
MAB_3177|M.abscessus_ATCC_1997 -
MMAR_1902|M.marinum_M -
Mb1900c|M.bovis_AF2122/97 -
Rv1869c|M.tuberculosis_H37Rv -
MAV_2849|M.avium_104 -
MUL_0769|M.ulcerans_Agy99 T