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VHWSPIRKTAGRSGEGPRSAARIRGTERFVEFECAVVGAGAAGLSAALVLGRARRTTIVIDADDPSNRAS PVIGGLLGYDRRPPDELYAAGRAELGEYPSVEFRRGEVRDGRRIDRGFLLDVDGAQIRARRVLLATGMSY CPPQLPGLAELWGRSVFQCPFCHGWEMRDGKLAALASGEQGLHTALMLRGWTDDVVLLTDGSSGLSADDK QVLHRAGVTVDDRRVVELTGTDGRLESIAFADGTRLARDGLLVEAPVRQRSALAAQLGATCTPGPLGTEP LAVDTMARTSAGGVFAAGDVCTEQPHIAGAVASGSQAAMIVVQSLLADEYGLPFPPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1165 | - | - | 100% (337) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3616 | - | 3e-90 | 56.95% (295) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3494 | - | 4e-08 | 25.71% (319) | nitrite reductase (NAD(P)H), large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 6e-12 | 25.44% (338) | reductase |
| M. gilvum PYR-GCK | Mflv_5165 | - | 1e-143 | 78.66% (314) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1869c | - | 6e-12 | 25.44% (338) | reductase |
| M. leprae Br4923 | MLBr_02703 | trx | 4e-13 | 27.55% (323) | bifunctional thioredoxin reductase/thioredoxin |
| M. abscessus ATCC 19977 | MAB_3177 | - | 1e-42 | 34.09% (308) | putative FAD-dependent pyridine nucleotide-disulphide |
| M. marinum M | MMAR_1902 | trxB2_2 | 1e-49 | 37.12% (299) | thioredoxin reductase TrxB2_2 |
| M. avium 104 | MAV_5301 | trxB | 5e-11 | 25.16% (314) | thioredoxin-disulfide reductase |
| M. smegmatis MC2 155 | MSMEG_0670 | - | 1e-115 | 64.61% (308) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_1468 | - | 5e-89 | 56.82% (308) | methyltransferase |
| M. ulcerans Agy99 | MUL_5066 | trxB2 | 4e-10 | 26.90% (316) | thioredoxin reductase TrxB2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1165|M.vanbaalenii_PYR-1 -----MHWSPIRKTAGRSGEGPRSAARIRGTERFVEFECAVVGAGAAGLS
Mflv_5165|M.gilvum_PYR-GCK -------------MPNRADSGNRPS---------VDYECAVVGAGAAGLS
MSMEG_0670|M.smegmatis_MC2_155 -----------------MDH---------------EWECVVVGGGAAGLS
TH_1468|M.thermoresistible__bu ---------------------------------VAMWDCIVIGGGAAGLS
MAB_3177|M.abscessus_ATCC_1997 --------------------------------MNKLWDVAIIGGGAAGLS
MMAR_1902|M.marinum_M --------------------------------MTDPHDVVVIGSGPAGLS
MAV_5301|M.avium_104 MPAVLFATAGNSHPYPGVYTDPETIARKVFMTADTVHDVIIIGSGPAGYT
MUL_5066|M.ulcerans_Agy99 -----------------MTTDSS--------ADATIHDVIVIGSGPAGYT
MLBr_02703|M.leprae_Br4923 -----------------MNTTPS--------AHETIHEVIVIGSGPAGYT
Mb1900c|M.bovis_AF2122/97 --------------------------------MASSTTFVIVGGGLAGAK
Rv1869c|M.tuberculosis_H37Rv --------------------------------MASSTTFVIVGGGLAGAK
::*.* ** .
Mvan_1165|M.vanbaalenii_PYR-1 AALVLGRARRTTIVIDADDP--SNRASPVIGGLLGY-DRRPPDELYAAGR
Mflv_5165|M.gilvum_PYR-GCK AALVLGRARRSTVVVDTADP--SNRAAPVIGGLLGF-DQRPPDELYETGR
MSMEG_0670|M.smegmatis_MC2_155 AALVLARARRRTLLIDAGEP--SNGVAPAIGGLLGH-DRRPPHELYAQGR
TH_1468|M.thermoresistible__bu ATLVLGRAKRQTLMIDAGRQ--SNLAARQVGGLLGQ-DGRAPADFYAAGR
MAB_3177|M.abscessus_ATCC_1997 AAITLARSRRSTVVIDDHHP--RNAPADRVHNYLGR-ESTPPAELFGIGR
MMAR_1902|M.marinum_M SALTLARARRSVLVIDGGQP--RNARSAGVHDFLTR-DGCAPADLISAGH
MAV_5301|M.avium_104 AALYTARAQLAPVVFEGTSFGGALMTTTEVENYPGFRDGITGPELMDQMR
MUL_5066|M.ulcerans_Agy99 AALYTARAQLAPLVFEGTSFGGALMTTTEVENYPGFREGITGPELMDEMR
MLBr_02703|M.leprae_Br4923 AALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMR
Mb1900c|M.bovis_AF2122/97 AVEALRRSDFGGRIILFGDE--EHLPYDRPPLSKEFLAGKKSLSDFTIQT
Rv1869c|M.tuberculosis_H37Rv AVEALRRSDFGGRIILFGDE--EHLPYDRPPLSKEFLAGKKSLSDFTIQT
:. *: :. .
Mvan_1165|M.vanbaalenii_PYR-1 AELGEYPSVEFRRG-EVRDGRRIDRGFLLDVD-GAQIRARRVLLATGMSY
Mflv_5165|M.gilvum_PYR-GCK AQLRAYPSVEYRHG-EVLAGRASDHGFELDIDDGRQIRAKRVLLATGMSY
MSMEG_0670|M.smegmatis_MC2_155 RELAAYPTFTFREG-CVVRGAPTAGGSVLDLDDGSQVTAKRVLLATGMQY
TH_1468|M.thermoresistible__bu AEVASYPGVVVRHGAEVVDGERTADGHRVTLADGTSECARRLLLATGMQY
MAB_3177|M.abscessus_ATCC_1997 DEAAQYG-ATFLDG-RATAVSHAENHFDVSLDGGPALRARRVLVATGVED
MMAR_1902|M.marinum_M TEIAGYG-GQLRQG-QVVAAHRNGSMFEVSITDGSTIRARKLLIASGLVD
MAV_5301|M.avium_104 EQALRFGADLRMED--VESVSLAGPVKSVTTAEGETVRARAVILAMGAAA
MUL_5066|M.ulcerans_Agy99 EQALRFGADLRMED--VQSVSLDGPIKSVVTSDGETHRARAVILAMGAAA
MLBr_02703|M.leprae_Br4923 EQALRFGAELRTED--VESVSLRGPIKSVVTAEGQTYQARAVILAMGTSV
Mb1900c|M.bovis_AF2122/97 SDWYRDHDVDVRLG--VRVSSLDRSAHTVELPDGAAVRYDKLLLATGSAP
Rv1869c|M.tuberculosis_H37Rv SDWYRDHDVDVRLG--VRVSSLDRSAHTVELPDGAAVRYDKLLLATGSAP
: . . : * :::* *
Mvan_1165|M.vanbaalenii_PYR-1 CPPQLPG---LAELWGRSVFQCPFCHGWEMRDGKLAALASGEQGLHTALM
Mflv_5165|M.gilvum_PYR-GCK CPPQLPG---LAELWGTAVFHCPFCHGWEMRDRKLAALAAGNAGLHAALM
MSMEG_0670|M.smegmatis_MC2_155 CPPSLPG---MDKLWGTTVFQCPFCHAWELRDQRLATLAAGAEGVNTALM
TH_1468|M.thermoresistible__bu RPPELPG---VAELWGKTVFHCPFCDGWEMRDRPLAVLARGEKALAESLM
MAB_3177|M.abscessus_ATCC_1997 ELPDIEG---LAERWGRDVLHCVYCHGWEVRDRTIAVLGTGPLAVHHALI
MMAR_1902|M.marinum_M HLPDITG---LAELWGTDVLYCPYCHGWEVRDQPIGVLATGPESVHQALM
MAV_5301|M.avium_104 RYLGVPG---EQDLLGRGVSSCATCDGFFFKDQDIAVIGGGDSAMEEATF
MUL_5066|M.ulcerans_Agy99 RYLHVPG---EQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATF
MLBr_02703|M.leprae_Br4923 RYLQIPG---EQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALF
Mb1900c|M.bovis_AF2122/97 RRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLEVAAS
Rv1869c|M.tuberculosis_H37Rv RRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLEVAAS
: * . .. .:. :..:. * .: :
Mvan_1165|M.vanbaalenii_PYR-1 LRGWTDDVVLLTDGS--SGLSADDKQVLHRAGVTVDD-------RRVVEL
Mflv_5165|M.gilvum_PYR-GCK LRGWTDDVVLLTDGK--TDLTPDDERVLTAAGVRIDD-------RRVVEL
MSMEG_0670|M.smegmatis_MC2_155 LRGWSDDVVLLTDGP--SDLSSGDRSLLDNAKVTIDE-------RRIAEL
TH_1468|M.thermoresistible__bu LRGWSDDVVLLTDGP--SELDGPACERLNAAGVRIDQ-------RPVARL
MAB_3177|M.abscessus_ATCC_1997 FRQLSDNVTLLRHND--FPMSIDEAAQLARRNIRIID-------GPVSRL
MMAR_1902|M.marinum_M FRQWSPRITLFLNGA--VDPSEPERARLHARQIEVII-------SPVTEV
MAV_5301|M.avium_104 LTRFARSVTLLHRREEFRASRIMLERARANDKITIVT-------NKAVEA
MUL_5066|M.ulcerans_Agy99 LTRFARSVTLVHRRDEFRASKIMTNRAQANDKIRILT-------NKIVLA
MLBr_02703|M.leprae_Br4923 LTRFARSVTLVHRRDEFRASKIMLGRARNNDKIKFIT-------NHTVVA
Mb1900c|M.bovis_AF2122/97 ARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEI
Rv1869c|M.tuberculosis_H37Rv ARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEI
:.:. :
Mvan_1165|M.vanbaalenii_PYR-1 TGTDGRLESIAFADGTRLARDGLLVEAPVRQRSALAAQLGATCTPG-PLG
Mflv_5165|M.gilvum_PYR-GCK HGDDGELESIAFADGDTLARDGLLVEAPVRQRSALAEQLGATCTPG-PLG
MSMEG_0670|M.smegmatis_MC2_155 LGQDGQLTAIAFSDGTRLERDGLLVEAPLRQRSELASQLGAQCAAG-ELA
TH_1468|M.thermoresistible__bu IGADGQLSGIEFADGDRLDRCGLLAETTLHQRSDLADRLGARSGESTPLA
MAB_3177|M.abscessus_ATCC_1997 HVTQDSLRGVQLETGATIACEALVVATVVSARVDMLAPV--QLAPQEMRL
MMAR_1902|M.marinum_M VSNDGRLEAVALADGNRVALAALALLPRMVANTDFLDPLGLRLVAHPSGF
MAV_5301|M.avium_104 VEGSETVTGLRLRDTVTGETSTLAVTGVFVAIGHDPRSELVRDVLDTDPD
MUL_5066|M.ulcerans_Agy99 VDGETTVTGLQLRDTVTGEETTLPVTGVFVAIGHEPRSSLVRDAVDVDPD
MLBr_02703|M.leprae_Br4923 VNGYTTVTGLRLRNTTTGEETTLVVTGVFVAIGHEPRSSLVSDVVDIDPD
Mb1900c|M.bovis_AF2122/97 TAADGKATGLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLV
Rv1869c|M.tuberculosis_H37Rv TAADGKATGLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLV
.: : :
Mvan_1165|M.vanbaalenii_PYR-1 TEPLAVD----TMARTSAGGVFAAGDVCTEQPHIAGAVASGSQAAMIVVQ
Mflv_5165|M.gilvum_PYR-GCK TEPLSVD----EMARTSTGGVFAAGDVCTEQPHISGAIAAGSEAAMIIVQ
MSMEG_0670|M.smegmatis_MC2_155 SDAIDVD----EMHRTTVHSVFAAGDTCTEEPSVASAIAAGSQAAKIIVQ
TH_1468|M.thermoresistible__bu QHPIDVD----GMGRTAAPGVFAAGDVSAQVPQVAAAMSAGLIAATSTVQ
MAB_3177|M.abscessus_ATCC_1997 GEHLLGTYLPVTRGATAVPGIYAAGNVTDIKAQVITSAAAGTEVAVAINA
MMAR_1902|M.marinum_M GENLQTD----GSGRTSVPGVYAAGNAADISAHVVNSASSGLLAAMAINA
MAV_5301|M.avium_104 GYVLVQG----RTTATSIPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAE
MUL_5066|M.ulcerans_Agy99 GYVLVNG----RTTGTSLEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAE
MLBr_02703|M.leprae_Br4923 GYVLVKG----RTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAE
Mb1900c|M.bovis_AF2122/97 DASLRTS----DPDIYAVGDIAAAEHPLLGTRVRTEHWANALKQPAVAAA
Rv1869c|M.tuberculosis_H37Rv DASLRTS----DPDIYAVGDIAAAEHPLLGTRVRTEHWANALKQPAVAAA
: : .: ** . : . .
Mvan_1165|M.vanbaalenii_PYR-1 SLLADEYGLPFPPG------------------------------------
Mflv_5165|M.gilvum_PYR-GCK SLLADDFGLPYPPGS-----------------------------------
MSMEG_0670|M.smegmatis_MC2_155 SLFADEFGLPYPPGSN----------------------------------
TH_1468|M.thermoresistible__bu SLLAEDSGLPFPPWRDDAGE------------------------------
MAB_3177|M.abscessus_ATCC_1997 DLAVADAQELQYA-------------------------------------
MMAR_1902|M.marinum_M DLVDEDTEQALLAVADR---------------------------------
MAV_5301|M.avium_104 RWLAEHAESSAAAQGDATEFPGSTDT------LIGAPQ------------
MUL_5066|M.ulcerans_Agy99 RWLAEHEAT-----GDA----DSTDT------LIGAQQ------------
MLBr_02703|M.leprae_Br4923 RWLAEHAGSKANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASF
Mb1900c|M.bovis_AF2122/97 GMLGRPGEYAELPYLFTDQYDLGMEYVGHAPSCDRVVFRGNVAGREFLSF
Rv1869c|M.tuberculosis_H37Rv GMLGRPGEYAELPYLFTDQYDLGMEYVGHAPSCDRVVFRGNVAGREFLSF
Mvan_1165|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5165|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
MAV_5301|M.avium_104 --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 FADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDT
Mb1900c|M.bovis_AF2122/97 WLDGDSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRLVDPQWPLADLTT
Rv1869c|M.tuberculosis_H37Rv WLDGDSRVLAGMNVNVWDVVDDVKGLIRSGNPVDVDRLVDPQWPLADLTT
Mvan_1165|M.vanbaalenii_PYR-1 -------------------------------------------------
Mflv_5165|M.gilvum_PYR-GCK -------------------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 -------------------------------------------------
TH_1468|M.thermoresistible__bu -------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 -------------------------------------------------
MMAR_1902|M.marinum_M -------------------------------------------------
MAV_5301|M.avium_104 -------------------------------------------------
MUL_5066|M.ulcerans_Agy99 -------------------------------------------------
MLBr_02703|M.leprae_Br4923 NPEMAREFQVVSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
Mb1900c|M.bovis_AF2122/97 N------------------------------------------------
Rv1869c|M.tuberculosis_H37Rv N------------------------------------------------