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TDPHDVVVIGSGPAGLSSALTLARARRSVLVIDGGQPRNARSAGVHDFLTRDGCAPADLISAGHTEIAGY GGQLRQGQVVAAHRNGSMFEVSITDGSTIRARKLLIASGLVDHLPDITGLAELWGTDVLYCPYCHGWEVR DQPIGVLATGPESVHQALMFRQWSPRITLFLNGAVDPSEPERARLHARQIEVIISPVTEVVSNDGRLEAV ALADGNRVALAALALLPRMVANTDFLDPLGLRLVAHPSGFGENLQTDGSGRTSVPGVYAAGNAADISAHV VNSASSGLLAAMAINADLVDEDTEQALLAVADR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1902 | trxB2_2 | - | 100% (314) | thioredoxin reductase TrxB2_2 |
| M. marinum M | MMAR_5477 | trxB2 | 3e-20 | 28.57% (308) | thioredoxin reductase TrxB2 |
| M. marinum M | MMAR_4486 | - | 4e-06 | 26.73% (318) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3944 | trxB2 | 9e-21 | 28.39% (317) | thioredoxin reductase TRXB2 |
| M. gilvum PYR-GCK | Mflv_2894 | - | 2e-51 | 36.18% (304) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv3913 | trxB2 | 6e-20 | 28.08% (317) | thioredoxin reductase TRXB2 |
| M. leprae Br4923 | MLBr_02703 | trx | 1e-16 | 27.12% (306) | bifunctional thioredoxin reductase/thioredoxin |
| M. abscessus ATCC 19977 | MAB_3177 | - | 1e-66 | 44.92% (305) | putative FAD-dependent pyridine nucleotide-disulphide |
| M. avium 104 | MAV_5301 | trxB | 4e-22 | 28.20% (305) | thioredoxin-disulfide reductase |
| M. smegmatis MC2 155 | MSMEG_4303 | - | 4e-55 | 38.87% (301) | methyltransferase |
| M. thermoresistible (build 8) | TH_1468 | - | 4e-55 | 38.11% (307) | methyltransferase |
| M. ulcerans Agy99 | MUL_5066 | trxB2 | 9e-21 | 29.41% (306) | thioredoxin reductase TrxB2 |
| M. vanbaalenii PYR-1 | Mvan_3616 | - | 2e-53 | 37.25% (298) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1902|M.marinum_M --------------------------------MTDPHDVVVIGSGPAGLS
MAB_3177|M.abscessus_ATCC_1997 --------------------------------MNKLWDVAIIGGGAAGLS
Mflv_2894|M.gilvum_PYR-GCK --------------------------------MEDIWDCVIVGGGAAGLS
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------MDKLWDCVIIGGGAAGLS
MSMEG_4303|M.smegmatis_MC2_155 -------------------------------MENKPWDSIIVGGGAAGLS
TH_1468|M.thermoresistible__bu ---------------------------------VAMWDCIVIGGGAAGLS
Mb3944|M.bovis_AF2122/97 MTAPPVHDRAH----------------------HPVRDVIVIGSGPAGYT
Rv3913|M.tuberculosis_H37Rv MTAPPVHDRAH----------------------HPVRDVIVIGSGPAGYT
MUL_5066|M.ulcerans_Agy99 MTT---DSSAD----------------------ATIHDVIVIGSGPAGYT
MLBr_02703|M.leprae_Br4923 MNT---TPSAH----------------------ETIHEVIVIGSGPAGYT
MAV_5301|M.avium_104 MPAVLFATAGNSHPYPGVYTDPETIARKVFMTADTVHDVIIIGSGPAGYT
: ::*.*.** :
MMAR_1902|M.marinum_M SALTLARARRSVLVIDGGQP--RNARSAGVHDFLTR-DGCAPADLISAGH
MAB_3177|M.abscessus_ATCC_1997 AAITLARSRRSTVVIDDHHP--RNAPADRVHNYLGR-ESTPPAELFGIGR
Mflv_2894|M.gilvum_PYR-GCK AALVLGRARRRTLLVDAGAQ--SNLAAHGIGGLLGF-DGVPPAQLYAQGR
Mvan_3616|M.vanbaalenii_PYR-1 AALVLGRARRRTLVVDAGAQ--SNLAATGIGGLLGF-DGVPPGQLYAQGR
MSMEG_4303|M.smegmatis_MC2_155 AALVLGRARRRVLLVDAGEQ--SNLPAHGIGGLLGS-DGRAPADLYAAGH
TH_1468|M.thermoresistible__bu ATLVLGRAKRQTLMIDAGRQ--SNLAARQVGGLLGQ-DGRAPADFYAAGR
Mb3944|M.bovis_AF2122/97 AALYAARAQLAPLVFEGTSFGGALMTTTGVENYPGFRNGITGPELMDEMR
Rv3913|M.tuberculosis_H37Rv AALYAARAQLAPLVFEGTSFGGALMTTTDVENYPGFRNGITGPELMDEMR
MUL_5066|M.ulcerans_Agy99 AALYTARAQLAPLVFEGTSFGGALMTTTEVENYPGFREGITGPELMDEMR
MLBr_02703|M.leprae_Br4923 AALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMR
MAV_5301|M.avium_104 AALYTARAQLAPVVFEGTSFGGALMTTTEVENYPGFRDGITGPELMDQMR
::: .*:: ::.: : : . :. . :: :
MMAR_1902|M.marinum_M TEIAGY-GGQLRQG-QVVAAHRNGSMFEVSITDGSTIRARKLLIASGLVD
MAB_3177|M.abscessus_ATCC_1997 DEAAQY-GATFLDG-RATAVSHAENHFDVSLDGGPALRARRVLVATGVED
Mflv_2894|M.gilvum_PYR-GCK RELTRYPDVAVCDG-DVTGAVAVEGGFTVELAGRSDVRTRRILLAMGMRY
Mvan_3616|M.vanbaalenii_PYR-1 SQLAAYPSVEVRDG-EVVTGAASDGGFTLELADGGVVQARRVLLAMGMRY
MSMEG_4303|M.smegmatis_MC2_155 AELAAYPSVQVRRG-EVIAGRR---GFALDLADGGHEHARTVLLAAGMDY
TH_1468|M.thermoresistible__bu AEVASYPGVVVRHGAEVVDGERTADGHRVTLADGTSECARRLLLATGMQY
Mb3944|M.bovis_AF2122/97 EQALRFGADLRMED--VESVSLHGPLKSVVTADGQTHRARAVILAMGAAA
Rv3913|M.tuberculosis_H37Rv EQALRFGADLRMED--VESVSLHGPLKSVVTADGQTHRARAVILAMGAAA
MUL_5066|M.ulcerans_Agy99 EQALRFGADLRMED--VQSVSLDGPIKSVVTSDGETHRARAVILAMGAAA
MLBr_02703|M.leprae_Br4923 EQALRFGAELRTED--VESVSLRGPIKSVVTAEGQTYQARAVILAMGTSV
MAV_5301|M.avium_104 EQALRFGADLRMED--VESVSLAGPVKSVTTAEGETVRARAVILAMGAAA
: : . . : :* :::* *
MMAR_1902|M.marinum_M HLPDITGLAELWGTDVLYCPYCHGWEVRDQPIGVLATGPESVHQALMFRQ
MAB_3177|M.abscessus_ATCC_1997 ELPDIEGLAERWGRDVLHCVYCHGWEVRDRTIAVLGTGPLAVHHALIFRQ
Mflv_2894|M.gilvum_PYR-GCK DMPALPGLAELWGDSVFHCPFCHGWEARDRPLAVLADGDRGVHMATLLSG
Mvan_3616|M.vanbaalenii_PYR-1 EAPSLPGLAELWGRSVFHCPFCHGWEVRDRPLAVLANGERATHMATLLRG
MSMEG_4303|M.smegmatis_MC2_155 LPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARGERAVHSALLLRA
TH_1468|M.thermoresistible__bu RPPELPGVAELWGKTVFHCPFCDGWEMRDRPLAVLARGEKALAESLMLRG
Mb3944|M.bovis_AF2122/97 RYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
Rv3913|M.tuberculosis_H37Rv RYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
MUL_5066|M.ulcerans_Agy99 RYLHVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
MLBr_02703|M.leprae_Br4923 RYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALFLTR
MAV_5301|M.avium_104 RYLGVPGEQDLLGRGVSSCATCDGFFFKDQDIAVIGGGDSAMEEATFLTR
: * : * * * *.* :. :.*:. * . : ::
MMAR_1902|M.marinum_M WSPRITLFLNGAVDPSEPERARLHARQIEVIISPVTEVVSNDG--RLEAV
MAB_3177|M.abscessus_ATCC_1997 LSDNVTLLRHNDFPMSIDEAAQLARRNIRIIDGPVSRLHVTQD--SLRGV
Mflv_2894|M.gilvum_PYR-GCK WSDDVVLLTSGPADLTDAQRDRLAEAGIAIDERAVAELVSADG--QLAQV
Mvan_3616|M.vanbaalenii_PYR-1 WSDDVVLLTGGPAELTDTDRSRLADAGAAVDERAVSHLVSAGG--ELAAV
MSMEG_4303|M.smegmatis_MC2_155 WSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARLVAHDG--ELVAV
TH_1468|M.thermoresistible__bu WSDDVVLLTDGPSELDGPACERLNAAGVRIDQRPVARLIGADG--QLSGI
Mb3944|M.bovis_AF2122/97 FARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGL
Rv3913|M.tuberculosis_H37Rv FARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGL
MUL_5066|M.ulcerans_Agy99 FARSVTLVHRRDEFRASKIMTNRAQANDKIRILTNKIVLAVDGETTVTGL
MLBr_02703|M.leprae_Br4923 FARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGL
MAV_5301|M.avium_104 FARSVTLLHRREEFRASRIMLERARANDKITIVTNKAVEAVEGSETVTGL
: :.:. : . : . : :
MMAR_1902|M.marinum_M ALADGNRVALAALALLPRMVANTDFLDPLGLRLVAHPSGFGENLQTD---
MAB_3177|M.abscessus_ATCC_1997 QLETGATIACEALVVATVVSARVDMLAPV--QLAPQEMRLGEHLLGTYLP
Mflv_2894|M.gilvum_PYR-GCK VFADGSGIARSGLLIATTLHQRSSLAAELGVAFAAPSPVTAEAVDVD---
Mvan_3616|M.vanbaalenii_PYR-1 VFADGTSLGRRGLLVAVTLHQRSALAAKLGVSFAAPGPVSVEAIEID---
MSMEG_4303|M.smegmatis_MC2_155 EFTDGTRLSRRGALVATTLHQRSPLAAQLG-AIGAPTPLAGDAVVVD---
TH_1468|M.thermoresistible__bu EFADGDRLDRCGLLAETTLHQRSDLADRLGARSGESTPLAQHPIDVD---
Mb3944|M.bovis_AF2122/97 RVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQG---
Rv3913|M.tuberculosis_H37Rv RVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQG---
MUL_5066|M.ulcerans_Agy99 QLRDTVTGEETTLPVTGVFVAIGHEPRSSLVRDAVDVDPDGYVLVNG---
MLBr_02703|M.leprae_Br4923 RLRNTTTGEETTLVVTGVFVAIGHEPRSSLVSDVVDIDPDGYVLVKG---
MAV_5301|M.avium_104 RLRDTVTGETSTLAVTGVFVAIGHDPRSELVRDVLDTDPDGYVLVQG---
. . :
MMAR_1902|M.marinum_M -GSGRTSVPGVYAAGNAADISAHVVNSASSGLLAAMAINADLVDEDTEQA
MAB_3177|M.abscessus_ATCC_1997 VTRGATAVPGIYAAGNVTDIKAQVITSAAAGTEVAVAINADLAVADAQEL
Mflv_2894|M.gilvum_PYR-GCK -AMYRTTVPGVFAAGDVSARMPQVAAAIAAGSGAAASVVASFLEEEK---
Mvan_3616|M.vanbaalenii_PYR-1 -ATHRTSVPGVFAAGDACVQMPQVAAAIAAGSAAAASIVASFQEER----
MSMEG_4303|M.smegmatis_MC2_155 -TFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAEDIGLP
TH_1468|M.thermoresistible__bu -GMGRTAAPGVFAAGDVSAQVPQVAAAMSAGLIAATSTVQSLLAEDSGLP
Mb3944|M.bovis_AF2122/97 -RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA---
Rv3913|M.tuberculosis_H37Rv -RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA---
MUL_5066|M.ulcerans_Agy99 -RTTGTSLEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHE---
MLBr_02703|M.leprae_Br4923 -RTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSK
MAV_5301|M.avium_104 -RTTATSIPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAES-
*: *::***: : : :.. .*
MMAR_1902|M.marinum_M -----LLAVADR--------------------------------------
MAB_3177|M.abscessus_ATCC_1997 -----QYA------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 -----TPPWPTEGLSPAEYWERHYGEREQIWSGRVNPQLEKVASDLPAGH
TH_1468|M.thermoresistible__bu -----FPPWRDDAGE-----------------------------------
Mb3944|M.bovis_AF2122/97 ------ATGEADSTD------ALIGAQR----------------------
Rv3913|M.tuberculosis_H37Rv ------ATGEADSTD------ALIGAQR----------------------
MUL_5066|M.ulcerans_Agy99 ------ATGDADSTD------TLIGAQQ----------------------
MLBr_02703|M.leprae_Br4923 ANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKP
MAV_5301|M.avium_104 -----SAAAQGDATEFPGSTDTLIGAPQ----------------------
MMAR_1902|M.marinum_M --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ALDLGCGEGGDAVWLAERGWRVTAVDISHTALSRAAAEAGRRGVADRITF
TH_1468|M.thermoresistible__bu --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 VLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQV
MAV_5301|M.avium_104 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ERHDLSESFPDGEFDLVSAQFLHSTVRLERPRILSTAARAIRPGGHLVIV
TH_1468|M.thermoresistible__bu --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 VSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN-----------
MAV_5301|M.avium_104 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2894|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 DHGKMPPNATRVPHDHPFPSAEEVLAGLDLPASEWERVRVEAVHREATGP
TH_1468|M.thermoresistible__bu --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
MAV_5301|M.avium_104 --------------------------------------------------
MMAR_1902|M.marinum_M ------------------
MAB_3177|M.abscessus_ATCC_1997 ------------------
Mflv_2894|M.gilvum_PYR-GCK ------------------
Mvan_3616|M.vanbaalenii_PYR-1 ------------------
MSMEG_4303|M.smegmatis_MC2_155 DGQPMPMVDNVMVLRRTS
TH_1468|M.thermoresistible__bu ------------------
Mb3944|M.bovis_AF2122/97 ------------------
Rv3913|M.tuberculosis_H37Rv ------------------
MUL_5066|M.ulcerans_Agy99 ------------------
MLBr_02703|M.leprae_Br4923 ------------------
MAV_5301|M.avium_104 ------------------