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M. thermoresistible (build 8) TH_1468 (-)

annotation: methyltransferase
coordinates: 2773628 - 2774584
length: 319

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1468--100% (319)methyltransferase
M. thermoresistible (build 8)TH_2413trxB21e-1126.02% (319) PROBABLE THIOREDOXIN REDUCTASE TRXB2 (TRXR) (TR)
M. thermoresistible (build 8)TH_1141-2e-0527.10% (321) dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3944trxB28e-1427.85% (316) thioredoxin reductase TRXB2
M. gilvum PYR-GCKMflv_2894-7e-9356.95% (302) FAD-dependent pyridine nucleotide-disulphide oxidoreductase
M. tuberculosis H37RvRv3913trxB28e-1427.11% (332) thioredoxin reductase TRXB2
M. leprae Br4923MLBr_02703trx4e-1326.30% (346) bifunctional thioredoxin reductase/thioredoxin
M. abscessus ATCC 19977MAB_3177-4e-4435.78% (313) putative FAD-dependent pyridine nucleotide-disulphide
M. marinum MMMAR_1902trxB2_27e-5538.11% (307) thioredoxin reductase TrxB2_2
M. avium 104MAV_5301trxB1e-1225.72% (311) thioredoxin-disulfide reductase
M. smegmatis MC2 155MSMEG_4303-1e-10259.55% (309) methyltransferase
M. ulcerans Agy99MUL_5066trxB21e-1225.07% (335) thioredoxin reductase TrxB2
M. vanbaalenii PYR-1Mvan_3616-9e-9457.48% (301) FAD-dependent pyridine nucleotide-disulphide oxidoreductase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2894|M.gilvum_PYR-GCK          --------------------------------MEDIWDCVIVGGGAAGLS
Mvan_3616|M.vanbaalenii_PYR-1       --------------------------------MDKLWDCVIIGGGAAGLS
MSMEG_4303|M.smegmatis_MC2_155      -------------------------------MENKPWDSIIVGGGAAGLS
TH_1468|M.thermoresistible__bu      ---------------------------------VAMWDCIVIGGGAAGLS
MAB_3177|M.abscessus_ATCC_1997      --------------------------------MNKLWDVAIIGGGAAGLS
MMAR_1902|M.marinum_M               --------------------------------MTDPHDVVVIGSGPAGLS
Mb3944|M.bovis_AF2122/97            MTAPPVHDRAH----------------------HPVRDVIVIGSGPAGYT
Rv3913|M.tuberculosis_H37Rv         MTAPPVHDRAH----------------------HPVRDVIVIGSGPAGYT
MUL_5066|M.ulcerans_Agy99           MTT---DSSAD----------------------ATIHDVIVIGSGPAGYT
MLBr_02703|M.leprae_Br4923          MNT---TPSAH----------------------ETIHEVIVIGSGPAGYT
MAV_5301|M.avium_104                MPAVLFATAGNSHPYPGVYTDPETIARKVFMTADTVHDVIIIGSGPAGYT
                                                                         :  ::*.*.** :

Mflv_2894|M.gilvum_PYR-GCK          AALVLGRARRRTLLVDAGAQ--SNLAAHGIGGLLGF-DGVPPAQLYAQGR
Mvan_3616|M.vanbaalenii_PYR-1       AALVLGRARRRTLVVDAGAQ--SNLAATGIGGLLGF-DGVPPGQLYAQGR
MSMEG_4303|M.smegmatis_MC2_155      AALVLGRARRRVLLVDAGEQ--SNLPAHGIGGLLGS-DGRAPADLYAAGH
TH_1468|M.thermoresistible__bu      ATLVLGRAKRQTLMIDAGRQ--SNLAARQVGGLLGQ-DGRAPADFYAAGR
MAB_3177|M.abscessus_ATCC_1997      AAITLARSRRSTVVIDDHHP--RNAPADRVHNYLGR-ESTPPAELFGIGR
MMAR_1902|M.marinum_M               SALTLARARRSVLVIDGGQP--RNARSAGVHDFLTR-DGCAPADLISAGH
Mb3944|M.bovis_AF2122/97            AALYAARAQLAPLVFEGTSFGGALMTTTGVENYPGFRNGITGPELMDEMR
Rv3913|M.tuberculosis_H37Rv         AALYAARAQLAPLVFEGTSFGGALMTTTDVENYPGFRNGITGPELMDEMR
MUL_5066|M.ulcerans_Agy99           AALYTARAQLAPLVFEGTSFGGALMTTTEVENYPGFREGITGPELMDEMR
MLBr_02703|M.leprae_Br4923          AALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMR
MAV_5301|M.avium_104                AALYTARAQLAPVVFEGTSFGGALMTTTEVENYPGFRDGITGPELMDQMR
                                    :::  .*::   ::.:          :  : .     :. .  ::    :

Mflv_2894|M.gilvum_PYR-GCK          RELTRYPDVAVCDG-DVTGAVAVEGGFTVELAGRSDVRTRRILLAMGMRY
Mvan_3616|M.vanbaalenii_PYR-1       SQLAAYPSVEVRDG-EVVTGAASDGGFTLELADGGVVQARRVLLAMGMRY
MSMEG_4303|M.smegmatis_MC2_155      AELAAYPSVQVRRG-EVIAGRR---GFALDLADGGHEHARTVLLAAGMDY
TH_1468|M.thermoresistible__bu      AEVASYPGVVVRHGAEVVDGERTADGHRVTLADGTSECARRLLLATGMQY
MAB_3177|M.abscessus_ATCC_1997      DEAAQY-GATFLDG-RATAVSHAENHFDVSLDGGPALRARRVLVATGVED
MMAR_1902|M.marinum_M               TEIAGY-GGQLRQG-QVVAAHRNGSMFEVSITDGSTIRARKLLIASGLVD
Mb3944|M.bovis_AF2122/97            EQALRFGADLRMED--VESVSLHGPLKSVVTADGQTHRARAVILAMGAAA
Rv3913|M.tuberculosis_H37Rv         EQALRFGADLRMED--VESVSLHGPLKSVVTADGQTHRARAVILAMGAAA
MUL_5066|M.ulcerans_Agy99           EQALRFGADLRMED--VQSVSLDGPIKSVVTSDGETHRARAVILAMGAAA
MLBr_02703|M.leprae_Br4923          EQALRFGAELRTED--VESVSLRGPIKSVVTAEGQTYQARAVILAMGTSV
MAV_5301|M.avium_104                EQALRFGADLRMED--VESVSLAGPVKSVTTAEGETVRARAVILAMGAAA
                                     :   :       .  .           :         :* :::* *   

Mflv_2894|M.gilvum_PYR-GCK          DMPALPGLAELWGDSVFHCPFCHGWEARDRPLAVLADGDRGVHMATLLSG
Mvan_3616|M.vanbaalenii_PYR-1       EAPSLPGLAELWGRSVFHCPFCHGWEVRDRPLAVLANGERATHMATLLRG
MSMEG_4303|M.smegmatis_MC2_155      LPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARGERAVHSALLLRA
TH_1468|M.thermoresistible__bu      RPPELPGVAELWGKTVFHCPFCDGWEMRDRPLAVLARGEKALAESLMLRG
MAB_3177|M.abscessus_ATCC_1997      ELPDIEGLAERWGRDVLHCVYCHGWEVRDRTIAVLGTGPLAVHHALIFRQ
MMAR_1902|M.marinum_M               HLPDITGLAELWGTDVLYCPYCHGWEVRDQPIGVLATGPESVHQALMFRQ
Mb3944|M.bovis_AF2122/97            RYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
Rv3913|M.tuberculosis_H37Rv         RYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
MUL_5066|M.ulcerans_Agy99           RYLHVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
MLBr_02703|M.leprae_Br4923          RYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALFLTR
MAV_5301|M.avium_104                RYLGVPGEQDLLGRGVSSCATCDGFFFKDQDIAVIGGGDSAMEEATFLTR
                                        : *  :  *  *  *  *.*   :.  :.*:. *  .   : ::  

Mflv_2894|M.gilvum_PYR-GCK          WSDDVVLLTSGPADLTDAQRDRLAEAGIAIDERAVAELVSADG--QLAQV
Mvan_3616|M.vanbaalenii_PYR-1       WSDDVVLLTGGPAELTDTDRSRLADAGAAVDERAVSHLVSAGG--ELAAV
MSMEG_4303|M.smegmatis_MC2_155      WSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARLVAHDG--ELVAV
TH_1468|M.thermoresistible__bu      WSDDVVLLTDGPSELDGPACERLNAAGVRIDQRPVARLIGADG--QLSGI
MAB_3177|M.abscessus_ATCC_1997      LSDNVTLLRHNDFPMSIDEAAQLARRNIRIIDGPVSRLHVTQD--SLRGV
MMAR_1902|M.marinum_M               WSPRITLFLNGAVDPSEPERARLHARQIEVIISPVTEVVSNDG--RLEAV
Mb3944|M.bovis_AF2122/97            FARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGL
Rv3913|M.tuberculosis_H37Rv         FARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGL
MUL_5066|M.ulcerans_Agy99           FARSVTLVHRRDEFRASKIMTNRAQANDKIRILTNKIVLAVDGETTVTGL
MLBr_02703|M.leprae_Br4923          FARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGL
MAV_5301|M.avium_104                FARSVTLLHRREEFRASRIMLERARANDKITIVTNKAVEAVEGSETVTGL
                                     :  :.:.                     :   .   :    .   :  :

Mflv_2894|M.gilvum_PYR-GCK          VFADGSGIARSGLLIATTLHQRSSLAAELGVAFAAPSPVTAEAVDVD---
Mvan_3616|M.vanbaalenii_PYR-1       VFADGTSLGRRGLLVAVTLHQRSALAAKLGVSFAAPGPVSVEAIEID---
MSMEG_4303|M.smegmatis_MC2_155      EFTDGTRLSRRGALVATTLHQRSPLAAQLG-AIGAPTPLAGDAVVVD---
TH_1468|M.thermoresistible__bu      EFADGDRLDRCGLLAETTLHQRSDLADRLGARSGESTPLAQHPIDVD---
MAB_3177|M.abscessus_ATCC_1997      QLETGATIACEALVVATVVSARVDMLAPV--QLAPQEMRLGEHLLGTYLP
MMAR_1902|M.marinum_M               ALADGNRVALAALALLPRMVANTDFLDPLGLRLVAHPSGFGENLQTD---
Mb3944|M.bovis_AF2122/97            RVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQG---
Rv3913|M.tuberculosis_H37Rv         RVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQG---
MUL_5066|M.ulcerans_Agy99           QLRDTVTGEETTLPVTGVFVAIGHEPRSSLVRDAVDVDPDGYVLVNG---
MLBr_02703|M.leprae_Br4923          RLRNTTTGEETTLVVTGVFVAIGHEPRSSLVSDVVDIDPDGYVLVKG---
MAV_5301|M.avium_104                RLRDTVTGETSTLAVTGVFVAIGHDPRSELVRDVLDTDPDGYVLVQG---
                                     .                .                        :      

Mflv_2894|M.gilvum_PYR-GCK          -AMYRTTVPGVFAAGDVSARMPQVAAAIAAGSGAAASVVASFLEEEK---
Mvan_3616|M.vanbaalenii_PYR-1       -ATHRTSVPGVFAAGDACVQMPQVAAAIAAGSAAAASIVASFQEER----
MSMEG_4303|M.smegmatis_MC2_155      -TFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAEDIGLP
TH_1468|M.thermoresistible__bu      -GMGRTAAPGVFAAGDVSAQVPQVAAAMSAGLIAATSTVQSLLAEDSGLP
MAB_3177|M.abscessus_ATCC_1997      VTRGATAVPGIYAAGNVTDIKAQVITSAAAGTEVAVAINADLAVADAQEL
MMAR_1902|M.marinum_M               -GSGRTSVPGVYAAGNAADISAHVVNSASSGLLAAMAINADLVDEDTEQA
Mb3944|M.bovis_AF2122/97            -RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA---
Rv3913|M.tuberculosis_H37Rv         -RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA---
MUL_5066|M.ulcerans_Agy99           -RTTGTSLEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHE---
MLBr_02703|M.leprae_Br4923          -RTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSK
MAV_5301|M.avium_104                -RTTATSIPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAES-
                                         *:  *::***:      :   : :..  .*               

Mflv_2894|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155      -----TPPWPTEGLSPAEYWERHYGEREQIWSGRVNPQLEKVASDLPAGH
TH_1468|M.thermoresistible__bu      -----FPPWRDDAGE-----------------------------------
MAB_3177|M.abscessus_ATCC_1997      -----QYA------------------------------------------
MMAR_1902|M.marinum_M               -----LLAVADR--------------------------------------
Mb3944|M.bovis_AF2122/97            ------ATGEADSTD------ALIGAQR----------------------
Rv3913|M.tuberculosis_H37Rv         ------ATGEADSTD------ALIGAQR----------------------
MUL_5066|M.ulcerans_Agy99           ------ATGDADSTD------TLIGAQQ----------------------
MLBr_02703|M.leprae_Br4923          ANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKP
MAV_5301|M.avium_104                -----SAAAQGDATEFPGSTDTLIGAPQ----------------------
                                                                                      

Mflv_2894|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155      ALDLGCGEGGDAVWLAERGWRVTAVDISHTALSRAAAEAGRRGVADRITF
TH_1468|M.thermoresistible__bu      --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_1902|M.marinum_M               --------------------------------------------------
Mb3944|M.bovis_AF2122/97            --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_5066|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02703|M.leprae_Br4923          VLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQV
MAV_5301|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_2894|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155      ERHDLSESFPDGEFDLVSAQFLHSTVRLERPRILSTAARAIRPGGHLVIV
TH_1468|M.thermoresistible__bu      --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_1902|M.marinum_M               --------------------------------------------------
Mb3944|M.bovis_AF2122/97            --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_5066|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02703|M.leprae_Br4923          VSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN-----------
MAV_5301|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_2894|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3616|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155      DHGKMPPNATRVPHDHPFPSAEEVLAGLDLPASEWERVRVEAVHREATGP
TH_1468|M.thermoresistible__bu      --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997      --------------------------------------------------
MMAR_1902|M.marinum_M               --------------------------------------------------
Mb3944|M.bovis_AF2122/97            --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv         --------------------------------------------------
MUL_5066|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02703|M.leprae_Br4923          --------------------------------------------------
MAV_5301|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_2894|M.gilvum_PYR-GCK          ------------------
Mvan_3616|M.vanbaalenii_PYR-1       ------------------
MSMEG_4303|M.smegmatis_MC2_155      DGQPMPMVDNVMVLRRTS
TH_1468|M.thermoresistible__bu      ------------------
MAB_3177|M.abscessus_ATCC_1997      ------------------
MMAR_1902|M.marinum_M               ------------------
Mb3944|M.bovis_AF2122/97            ------------------
Rv3913|M.tuberculosis_H37Rv         ------------------
MUL_5066|M.ulcerans_Agy99           ------------------
MLBr_02703|M.leprae_Br4923          ------------------
MAV_5301|M.avium_104                ------------------