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PNRADSGNRPSVDYECAVVGAGAAGLSAALVLGRARRSTVVVDTADPSNRAAPVIGGLLGFDQRPPDELY ETGRAQLRAYPSVEYRHGEVLAGRASDHGFELDIDDGRQIRAKRVLLATGMSYCPPQLPGLAELWGTAVF HCPFCHGWEMRDRKLAALAAGNAGLHAALMLRGWTDDVVLLTDGKTDLTPDDERVLTAAGVRIDDRRVVE LHGDDGELESIAFADGDTLARDGLLVEAPVRQRSALAEQLGATCTPGPLGTEPLSVDEMARTSTGGVFAA GDVCTEQPHISGAIAAGSEAAMIIVQSLLADDFGLPYPPGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5165 | - | - | 100% (322) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2894 | - | 3e-85 | 53.33% (300) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3013 | - | 1e-10 | 26.63% (323) | nitrite reductase (NAD(P)H), large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3944 | trxB2 | 2e-09 | 26.47% (306) | thioredoxin reductase TRXB2 |
| M. tuberculosis H37Rv | Rv3913 | trxB2 | 3e-09 | 26.62% (308) | thioredoxin reductase TRXB2 |
| M. leprae Br4923 | MLBr_02703 | trx | 5e-10 | 25.94% (320) | bifunctional thioredoxin reductase/thioredoxin |
| M. abscessus ATCC 19977 | MAB_3177 | - | 7e-46 | 35.58% (312) | putative FAD-dependent pyridine nucleotide-disulphide |
| M. marinum M | MMAR_1902 | trxB2_2 | 3e-50 | 36.00% (300) | thioredoxin reductase TrxB2_2 |
| M. avium 104 | MAV_5301 | trxB | 1e-10 | 25.17% (302) | thioredoxin-disulfide reductase |
| M. smegmatis MC2 155 | MSMEG_0670 | - | 1e-114 | 63.75% (309) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_1468 | - | 9e-90 | 55.52% (308) | methyltransferase |
| M. ulcerans Agy99 | MUL_5066 | trxB2 | 2e-09 | 25.41% (303) | thioredoxin reductase TrxB2 |
| M. vanbaalenii PYR-1 | Mvan_1165 | - | 1e-143 | 78.66% (314) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3944|M.bovis_AF2122/97 MTAPPVHDRAH----------------------HPVRDVIVIGSGPAGYT
Rv3913|M.tuberculosis_H37Rv MTAPPVHDRAH----------------------HPVRDVIVIGSGPAGYT
MUL_5066|M.ulcerans_Agy99 MTT---DSSAD----------------------ATIHDVIVIGSGPAGYT
MLBr_02703|M.leprae_Br4923 MNT---TPSAH----------------------ETIHEVIVIGSGPAGYT
MAV_5301|M.avium_104 MPAVLFATAGNSHPYPGVYTDPETIARKVFMTADTVHDVIIIGSGPAGYT
Mflv_5165|M.gilvum_PYR-GCK -------------MPNRADSGNRPS---------VDYECAVVGAGAAGLS
Mvan_1165|M.vanbaalenii_PYR-1 -----MHWSPIRKTAGRSGEGPRSAARIRGTERFVEFECAVVGAGAAGLS
MSMEG_0670|M.smegmatis_MC2_155 -----------------MDH---------------EWECVVVGGGAAGLS
TH_1468|M.thermoresistible__bu ---------------------------------VAMWDCIVIGGGAAGLS
MAB_3177|M.abscessus_ATCC_1997 --------------------------------MNKLWDVAIIGGGAAGLS
MMAR_1902|M.marinum_M --------------------------------MTDPHDVVVIGSGPAGLS
: ::*.*.** :
Mb3944|M.bovis_AF2122/97 AALYAARAQLAPLVFEGTSFGGALMTTTGVENYPGFRNGITGPELMDEMR
Rv3913|M.tuberculosis_H37Rv AALYAARAQLAPLVFEGTSFGGALMTTTDVENYPGFRNGITGPELMDEMR
MUL_5066|M.ulcerans_Agy99 AALYTARAQLAPLVFEGTSFGGALMTTTEVENYPGFREGITGPELMDEMR
MLBr_02703|M.leprae_Br4923 AALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMR
MAV_5301|M.avium_104 AALYTARAQLAPVVFEGTSFGGALMTTTEVENYPGFRDGITGPELMDQMR
Mflv_5165|M.gilvum_PYR-GCK AALVLGRARRSTVVVDTADP--SNRAAPVIGGLLGF-DQRPPDELYETGR
Mvan_1165|M.vanbaalenii_PYR-1 AALVLGRARRTTIVIDADDP--SNRASPVIGGLLGY-DRRPPDELYAAGR
MSMEG_0670|M.smegmatis_MC2_155 AALVLARARRRTLLIDAGEP--SNGVAPAIGGLLGH-DRRPPHELYAQGR
TH_1468|M.thermoresistible__bu ATLVLGRAKRQTLMIDAGRQ--SNLAARQVGGLLGQ-DGRAPADFYAAGR
MAB_3177|M.abscessus_ATCC_1997 AAITLARSRRSTVVIDDHHP--RNAPADRVHNYLGR-ESTPPAELFGIGR
MMAR_1902|M.marinum_M SALTLARARRSVLVIDGGQP--RNARSAGVHDFLTR-DGCAPADLISAGH
::: .*:: ::.: : : . : . :: :
Mb3944|M.bovis_AF2122/97 EQALRFGADLRMED--VESVSLHGPLKSVVTADGQTHRARAVILAMGAAA
Rv3913|M.tuberculosis_H37Rv EQALRFGADLRMED--VESVSLHGPLKSVVTADGQTHRARAVILAMGAAA
MUL_5066|M.ulcerans_Agy99 EQALRFGADLRMED--VQSVSLDGPIKSVVTSDGETHRARAVILAMGAAA
MLBr_02703|M.leprae_Br4923 EQALRFGAELRTED--VESVSLRGPIKSVVTAEGQTYQARAVILAMGTSV
MAV_5301|M.avium_104 EQALRFGADLRMED--VESVSLAGPVKSVTTAEGETVRARAVILAMGAAA
Mflv_5165|M.gilvum_PYR-GCK AQLRAYPSVEYRHG-EVLAGRASDHGFELDIDDGRQIRAKRVLLATGMSY
Mvan_1165|M.vanbaalenii_PYR-1 AELGEYPSVEFRRG-EVRDGRRIDRGFLLDVD-GAQIRARRVLLATGMSY
MSMEG_0670|M.smegmatis_MC2_155 RELAAYPTFTFREG-CVVRGAPTAGGSVLDLDDGSQVTAKRVLLATGMQY
TH_1468|M.thermoresistible__bu AEVASYPGVVVRHGAEVVDGERTADGHRVTLADGTSECARRLLLATGMQY
MAB_3177|M.abscessus_ATCC_1997 DEAAQYG-ATFLDG-RATAVSHAENHFDVSLDGGPALRARRVLVATGVED
MMAR_1902|M.marinum_M TEIAGYG-GQLRQG-QVVAAHRNGSMFEVSITDGSTIRARKLLIASGLVD
: : . . : * *: :::* *
Mb3944|M.bovis_AF2122/97 RYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
Rv3913|M.tuberculosis_H37Rv RYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
MUL_5066|M.ulcerans_Agy99 RYLHVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTR
MLBr_02703|M.leprae_Br4923 RYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALFLTR
MAV_5301|M.avium_104 RYLGVPGEQDLLGRGVSSCATCDGFFFKDQDIAVIGGGDSAMEEATFLTR
Mflv_5165|M.gilvum_PYR-GCK CPPQLPGLAELWGTAVFHCPFCHGWEMRDRKLAALAAGNAGLHAALMLRG
Mvan_1165|M.vanbaalenii_PYR-1 CPPQLPGLAELWGRSVFQCPFCHGWEMRDGKLAALASGEQGLHTALMLRG
MSMEG_0670|M.smegmatis_MC2_155 CPPSLPGMDKLWGTTVFQCPFCHAWELRDQRLATLAAGAEGVNTALMLRG
TH_1468|M.thermoresistible__bu RPPELPGVAELWGKTVFHCPFCDGWEMRDRPLAVLARGEKALAESLMLRG
MAB_3177|M.abscessus_ATCC_1997 ELPDIEGLAERWGRDVLHCVYCHGWEVRDRTIAVLGTGPLAVHHALIFRQ
MMAR_1902|M.marinum_M HLPDITGLAELWGTDVLYCPYCHGWEVRDQPIGVLATGPESVHQALMFRQ
: * . * * * *.. .:. :..:. * .: : ::
Mb3944|M.bovis_AF2122/97 FARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGL
Rv3913|M.tuberculosis_H37Rv FARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGL
MUL_5066|M.ulcerans_Agy99 FARSVTLVHRRDEFRASKIMTNRAQANDKIRILTNKIVLAVDGETTVTGL
MLBr_02703|M.leprae_Br4923 FARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGL
MAV_5301|M.avium_104 FARSVTLLHRREEFRASRIMLERARANDKITIVTNKAVEAVEGSETVTGL
Mflv_5165|M.gilvum_PYR-GCK WTDDVVLLTDGK--TDLTPDDERVLTAAGVRIDDRRVVELHGDDGELESI
Mvan_1165|M.vanbaalenii_PYR-1 WTDDVVLLTDGS--SGLSADDKQVLHRAGVTVDDRRVVELTGTDGRLESI
MSMEG_0670|M.smegmatis_MC2_155 WSDDVVLLTDGP--SDLSSGDRSLLDNAKVTIDERRIAELLGQDGQLTAI
TH_1468|M.thermoresistible__bu WSDDVVLLTDGP--SELDGPACERLNAAGVRIDQRPVARLIGADGQLSGI
MAB_3177|M.abscessus_ATCC_1997 LSDNVTLLRHND--FPMSIDEAAQLARRNIRIIDGPVSRLHVTQDSLRGV
MMAR_1902|M.marinum_M WSPRITLFLNGA--VDPSEPERARLHARQIEVIISPVTEVVSNDGRLEAV
: :.*. : . : .:
Mb3944|M.bovis_AF2122/97 RVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQG---
Rv3913|M.tuberculosis_H37Rv RVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQG---
MUL_5066|M.ulcerans_Agy99 QLRDTVTGEETTLPVTGVFVAIGHEPRSSLVRDAVDVDPDGYVLVNG---
MLBr_02703|M.leprae_Br4923 RLRNTTTGEETTLVVTGVFVAIGHEPRSSLVSDVVDIDPDGYVLVKG---
MAV_5301|M.avium_104 RLRDTVTGETSTLAVTGVFVAIGHDPRSELVRDVLDTDPDGYVLVQG---
Mflv_5165|M.gilvum_PYR-GCK AFADGDTLARDGLLVEAPVRQRSALAEQLGATCTPG-PLGTEPLSVD---
Mvan_1165|M.vanbaalenii_PYR-1 AFADGTRLARDGLLVEAPVRQRSALAAQLGATCTPG-PLGTEPLAVD---
MSMEG_0670|M.smegmatis_MC2_155 AFSDGTRLERDGLLVEAPLRQRSELASQLGAQCAAG-ELASDAIDVD---
TH_1468|M.thermoresistible__bu EFADGDRLDRCGLLAETTLHQRSDLADRLGARSGESTPLAQHPIDVD---
MAB_3177|M.abscessus_ATCC_1997 QLETGATIACEALVVATVVSARVDMLAPV--QLAPQEMRLGEHLLGTYLP
MMAR_1902|M.marinum_M ALADGNRVALAALALLPRMVANTDFLDPLGLRLVAHPSGFGENLQTD---
. * . :
Mb3944|M.bovis_AF2122/97 -RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA---
Rv3913|M.tuberculosis_H37Rv -RTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA---
MUL_5066|M.ulcerans_Agy99 -RTTGTSLEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHE---
MLBr_02703|M.leprae_Br4923 -RTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSK
MAV_5301|M.avium_104 -RTTATSIPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAES-
Mflv_5165|M.gilvum_PYR-GCK -EMARTSTGGVFAAGDVCTEQPHISGAIAAGSEAAMIIVQSLLADDF---
Mvan_1165|M.vanbaalenii_PYR-1 -TMARTSAGGVFAAGDVCTEQPHIAGAVASGSQAAMIVVQSLLADEY---
MSMEG_0670|M.smegmatis_MC2_155 -EMHRTTVHSVFAAGDTCTEEPSVASAIAAGSQAAKIIVQSLFADEF---
TH_1468|M.thermoresistible__bu -GMGRTAAPGVFAAGDVSAQVPQVAAAMSAGLIAATSTVQSLLAEDS---
MAB_3177|M.abscessus_ATCC_1997 VTRGATAVPGIYAAGNVTDIKAQVITSAAAGTEVAVAINADLAVADA---
MMAR_1902|M.marinum_M -GSGRTSVPGVYAAGNAADISAHVVNSASSGLLAAMAINADLVDEDT---
*: .::***: : :.. .* .
Mb3944|M.bovis_AF2122/97 ------ATGEADSTD------ALIGAQR----------------------
Rv3913|M.tuberculosis_H37Rv ------ATGEADSTD------ALIGAQR----------------------
MUL_5066|M.ulcerans_Agy99 ------ATGDADSTD------TLIGAQQ----------------------
MLBr_02703|M.leprae_Br4923 ANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKP
MAV_5301|M.avium_104 -----SAAAQGDATEFPGSTDTLIGAPQ----------------------
Mflv_5165|M.gilvum_PYR-GCK ------GLPYPPGS------------------------------------
Mvan_1165|M.vanbaalenii_PYR-1 ------GLPFPPG-------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 ------GLPYPPGSN-----------------------------------
TH_1468|M.thermoresistible__bu ------GLPFPPWRDDAGE-------------------------------
MAB_3177|M.abscessus_ATCC_1997 ------QELQYA--------------------------------------
MMAR_1902|M.marinum_M ------EQALLAVADR----------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02703|M.leprae_Br4923 VLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQV
MAV_5301|M.avium_104 --------------------------------------------------
Mflv_5165|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1165|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 --------------------------------------------------
TH_1468|M.thermoresistible__bu --------------------------------------------------
MAB_3177|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1902|M.marinum_M --------------------------------------------------
Mb3944|M.bovis_AF2122/97 ---------------------------------------
Rv3913|M.tuberculosis_H37Rv ---------------------------------------
MUL_5066|M.ulcerans_Agy99 ---------------------------------------
MLBr_02703|M.leprae_Br4923 VSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
MAV_5301|M.avium_104 ---------------------------------------
Mflv_5165|M.gilvum_PYR-GCK ---------------------------------------
Mvan_1165|M.vanbaalenii_PYR-1 ---------------------------------------
MSMEG_0670|M.smegmatis_MC2_155 ---------------------------------------
TH_1468|M.thermoresistible__bu ---------------------------------------
MAB_3177|M.abscessus_ATCC_1997 ---------------------------------------
MMAR_1902|M.marinum_M ---------------------------------------