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MDSSREVAMSVATAVTPVVQRTRTPAFCLTVAASLAMTVGASAPSPFYPVLQQHLGYSAATSTTIFAVYA GALLVTLLVVGSLSDHIGRRPIISFGFVVLAASMVTFWHADSVTALIVARIVQGTATGFLMSTLSAAVVD LEPSNRPGLAATLNSVFPLGGLALGAPISGVLIDHSSSAPAMVFGGLTSLYVAIAAAACLLPETSPRHEG LLRSFVPRVGVPAAARPPFWRGAPGLVAGWATTGLYLSLGAPLVAQELGGTDHAEQGLVVAALAGVGSVT SYVCRGKSSRALTTYGTTALAAGTAFSLVGLAVGSLWVFIAAAVLAGAGVGASFLGILRSITPLAAPHER GELFAAVFVVSYLAFGGPAVLAGVAVPHIGLAQTTYLYGGLVVVLSVGACLLRALATEQQSAPDTIGRTN EAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3373 | - | - | 100% (423) | major facilitator superfamily protein MFS_1 |
| M. smegmatis MC2 155 | MSMEG_5167 | - | 1e-49 | 32.14% (392) | major facilitator superfamily protein MFS_1 |
| M. smegmatis MC2 155 | MSMEG_2137 | - | 4e-19 | 25.57% (395) | permease of the major facilitator superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1282 | - | 9e-09 | 24.41% (295) | drug-transport integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1450 | - | 2e-36 | 29.07% (375) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1877 | - | 3e-08 | 25.30% (336) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1299c | - | 2e-46 | 30.33% (399) | multidrug ABC transporter |
| M. marinum M | MMAR_0690 | - | 5e-18 | 26.53% (377) | putative transport protein |
| M. avium 104 | MAV_3974 | - | 1e-14 | 22.04% (372) | permease of the major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_0476 | - | 1e-52 | 34.29% (385) | major facilitator superfamily protein MFS_1 |
| M. ulcerans Agy99 | MUL_0911 | - | 3e-09 | 26.19% (252) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5329 | - | 2e-36 | 28.94% (387) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1299c|M.abscessus_ATCC_199 -------------------MIARLRRSAAFVLLAFSFSAVMIGTTMPTPM
TH_0476|M.thermoresistible__bu -----------------------VRR-FAFPLLAYAFAAVMVGTTVPTPM
MSMEG_3373|M.smegmatis_MC2_155 ---MDSSREVAMSVATAVTPVVQRTRTPAFCLTVAASLAMTVGASAPSPF
Mflv_1450|M.gilvum_PYR-GCK --------------MVAIDRSIGETQRWAYPLLLVLSGVALGVSGLPAPL
Mvan_5329|M.vanbaalenii_PYR-1 --------------MVAFDRSIPDTQRWAYPLLLVLSGVALGVSGLPAPL
MAV_3974|M.avium_104 --------------------------------------MVALGYGVISPA
MMAR_0690|M.marinum_M --------------------MTDSSRRVVLAAVGFTFFIDMLVYGIVVPV
Rv1877|M.tuberculosis_H37Rv MAGPTAPTTAPTAIRAGGPLLSPVRRNIIFTALVFGVLVAATGQTIVVPA
Mb1282|M.bovis_AF2122/97 ---------MTTAIRRAAGSSYFRNPWPALWAMMVGFFMIMLDSTVVAIA
MUL_0911|M.ulcerans_Agy99 ---------------MRIQPVFRDHPILALAVICLSVFVISVDATIVNVA
MAB_1299c|M.abscessus_ATCC_199 YALYSQQMHFSVLTTTVVYATYAAGVLFALLMFGGWSDVLGRRPLLLTGA
TH_0476|M.thermoresistible__bu YAVYAERLGFGVLTTTVVFAGYTAGVLFALVVFGRWSDALGRRPMLLAGV
MSMEG_3373|M.smegmatis_MC2_155 YPVLQQHLGYSAATSTTIFAVYAGALLVTLLVVGSLSDHIGRRPIISFGF
Mflv_1450|M.gilvum_PYR-GCK YGIYETNWHLSPLATTIVFAVYAVAALAAVLVSGRISDVVGRKPVLLGAL
Mvan_5329|M.vanbaalenii_PYR-1 YGIYETNWHLSPLATTVVFAVYAVAALAAVLVSGRISDVVGRKPVLVGAL
MAV_3974|M.avium_104 LPTFARSFGVSIKAVTFLVTVFSLSRLCFAPISGLLTERLGERRIYIGGL
MMAR_0690|M.marinum_M LPRLAKPAGLEFLGVGVVFACYGLAYFVLTPVAGWLIDRRGSRSVFLSGA
Rv1877|M.tuberculosis_H37Rv LPTIVAELG-STVDQSWAVTSYLLGGTVVVVVAGKLGDLLGRNRVLLGSV
Mb1282|M.bovis_AF2122/97 NPTIMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYLIGL
MUL_0911|M.ulcerans_Agy99 LPTLSRELGADTAQLQWIVDAYTLVMSGLLLSAGSLSDRYGRRGWLSAGL
: * : * . .
MAB_1299c|M.abscessus_ATCC_199 GFAILSSVIFLFVDSVPLLLVARIVSGLSAGFFTGAATVAVIESAP-ETW
TH_0476|M.thermoresistible__bu GCAIVSALVFLIAGSVPQLIAARFVSGMSAGIFTGTATAAVIEAAP-ERR
MSMEG_3373|M.smegmatis_MC2_155 VVLAASMVTFWHADSVTALIVARIVQGTATGFLMSTLSAAVVDLEP-SNR
Mflv_1450|M.gilvum_PYR-GCK VALLIGLGVFLIADSMAMLLLARAIHGVAVGSIVVAGAAALLDLRP-DHG
Mvan_5329|M.vanbaalenii_PYR-1 VALLIGLGVFLIADSMAMLLLARTIHGAAVGSIVVAGAAALLDLRP-DHG
MAV_3974|M.avium_104 LIVAVSTAACAFSQAYWQLMLCRVFSGVGSTMFYVSALGLMIHISP-ADA
MMAR_0690|M.marinum_M IILMLATLAFGYASSPVGLVTCRVLQGGAAAATWVAGYATLVEIFP-REQ
Rv1877|M.tuberculosis_H37Rv VVFVVGSVLCGLSQTMTMLAISRALQGVGAGAISVTAYALAAEVVP-LRD
Mb1282|M.bovis_AF2122/97 GVFTVASLGCGLSSGAGMLIAARVVQGVGAGLLTPQTLSTITRIFP-AHR
MUL_0911|M.ulcerans_Agy99 ILFALTSALAAQVNSADTLVAARAAMGVGAAVIFPTTLGLITNIFTDPVP
* .* * . .
MAB_1299c|M.abscessus_ATCC_199 RGRAAAVATVANTGGLGLGPLLAGVLVQYA--------------------
TH_0476|M.thermoresistible__bu RSRAAAVATVANIGGLGAGPLLAGILVQYA--------------------
MSMEG_3373|M.smegmatis_MC2_155 PGLAATLNSVFPLGGLALGAPISGVLIDHS--------------------
Mflv_1450|M.gilvum_PYR-GCK -VRVGQLSGVAFNIGMTIAIFGSALLAQYA--------------------
Mvan_5329|M.vanbaalenii_PYR-1 -VRAGQLSGVSFNIGMTVAILGSALLAQYA--------------------
MAV_3974|M.avium_104 RGRIAGLFTTSFMVGAVGGPAVGGLAAGWG--------------------
MMAR_0690|M.marinum_M RGRAVGLASIGTALGALLGPALGGLAYEASG-------------------
Rv1877|M.tuberculosis_H37Rv RGRYQGVLGAVFGVNTVTGPLLGGWLTDYLSWRWAFWINVPVSIAVLTVA
Mb1282|M.bovis_AF2122/97 RGVALGAWGTVASVASLVGPLAGGALVDSMGWEWIFFVNVPVG--VIGLI
MUL_0911|M.ulcerans_Agy99 RAKAIGLWTAMVGVGVAVGPITGGWLLEHFSWGSIFLVNVPIAVAAMAGA
. ..
MAB_1299c|M.abscessus_ATCC_199 ---------PWPTHLAFVVHIGLVSIAVAALLFVPETAPKHG---KLGRQ
TH_0476|M.thermoresistible__bu ---------PWPLHLTFWVHIVLMVLAAAAIAVAPETSPRTG---RLGVQ
MSMEG_3373|M.smegmatis_MC2_155 ---------SSAPAMVFGGLTSLYVAIAAAACLLPETSPRHEGLLRSFVP
Mflv_1450|M.gilvum_PYR-GCK ---------PHPLRTPYAVVAVICLIVGVGVLALREPHTARTRG-PIRIA
Mvan_5329|M.vanbaalenii_PYR-1 ---------PHPLRTPYAVVAVICLVVGVGVLALREPHTARTRG-PIRIA
MAV_3974|M.avium_104 ---------LTAPFVVYG--VAMLGVALVLFLGLRNSALAAPPPPTRSTV
MMAR_0690|M.marinum_M ---------PHAPFLGAAGLSALAVAALAASLPQAAGGQASGPG-----M
Rv1877|M.tuberculosis_H37Rv ATAVPALARPPKPVIDYLGILVIAVATTALIMATSWGGTTYAWG-SATIV
Mb1282|M.bovis_AF2122/97 LAAYLIPALPHHPHRFDWFGVGLSGAGMFLIVFGLQQGQSANWQPWIWAV
MUL_0911|M.ulcerans_Agy99 ILFVPTSRDPAAPRVDVPG-LMLSAVGITALVYTIIEAPNWGWTSTRASG
:
MAB_1299c|M.abscessus_ATCC_199 RLSLPPQVRATFAAAATA------------------------GFAGFAAL
TH_0476|M.thermoresistible__bu RLSLPPQVRKVFAIASLA------------------------AFAGFAVT
MSMEG_3373|M.smegmatis_MC2_155 RVGVPAAARPPFWRGAPG------------------------LVAGWATT
Mflv_1450|M.gilvum_PYR-GCK RPAVPAEIRADFWFSALG------------------------AMASWSVL
Mvan_5329|M.vanbaalenii_PYR-1 RPAVPAEIRADFWFSALG------------------------AMASWSVL
MAV_3974|M.avium_104 TMREALRVRAYQSALLSN------------------------FATGWSAF
MMAR_0690|M.marinum_M WSGERAFPGLAVPWLVAG------------------------LAVGLALG
Rv1877|M.tuberculosis_H37Rv GLLIGAAVALGFFVWLEGRAAAAILPPRLFGSPVFAVCCVLSFVVGFAML
Mb1282|M.bovis_AF2122/97 IVGGIGFMSLFVYWQARN------AREPLIPLEVFNDRNFSLSNLGIAII
MUL_0911|M.ulcerans_Agy99 GFIAAAIVLVGFALWERR--SSHPMLDVSVFANRRFSGGSLAVTAGFLTL
.
MAB_1299c|M.abscessus_ATCC_199 G---SFTAVAPGFLSGVLGIDNHAVAGASVFLTFGSSCVAQILTRRVAAA
TH_0476|M.thermoresistible__bu G---LFTAVAPSFLAEVIGVRNHAVAGAVAASIFAASAVTQVLGASVSPR
MSMEG_3373|M.smegmatis_MC2_155 G---LYLSLGAPLVAQELGGTDHAEQGLVVAALAGVGSVTSYVCRGKSSR
Mflv_1450|M.gilvum_PYR-GCK G---VLLSLYPSLAAHHTHIDNLVFGGAVVATTAFAAALAQLAATRVPAR
Mvan_5329|M.vanbaalenii_PYR-1 G---VLLSLYPSLAARQTHIDNLVFGGAVVGTTAFAAALAQLAATRVPAR
MAV_3974|M.avium_104 G---LRMALVPLFVSDVMGRG-IGTIGVVLAAFAGGNALAVVPSGYLSDR
MMAR_0690|M.marinum_M A---VEATLPIDLVARFDASG--VTVGLLFALTTVAFIVTSQYAGRLSDA
Rv1877|M.tuberculosis_H37Rv GAL-TFVPIYLGYVDGASATASGLRTLPMVIGLLIASTGTGVLVGRTGRY
Mb1282|M.bovis_AF2122/97 AFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAPFVGMIIDR
MUL_0911|M.ulcerans_Agy99 FGFIFVITQYFQFIKDYTALQTGVRLLPVAFSIALAAILGPRLVERVGTT
MAB_1299c|M.abscessus_ATCC_199 K-ALLIGCTILLTGMLLVVLALHTSSLPWYLASAVVVGIGQGISFSRGLA
TH_0476|M.thermoresistible__bu R-AVAVGCALLIVGMVFLAAALVWSSLPALIATAVVAGAGQGLSFSRGLA
MSMEG_3373|M.smegmatis_MC2_155 A-LTTYGTTALAAGTAFSLVGLAVGSLWVFIAAAVLAGAGVGASFLGILR
Mflv_1450|M.gilvum_PYR-GCK Y-AAIIGDAGMAAALLLTIPVLLTHQWQLVFVAAALLGATFGLGFGGSLR
Mvan_5329|M.vanbaalenii_PYR-1 Y-SAILGDAGMAAALLLTIPVLLTHQWQLVFVAAALLGATFGLGFGGSLR
MAV_3974|M.avium_104 MGRRTLLIVGLVTSGAATVWLGFVASLPVFLVAAGVVGVVTGIYMSPLQA
MMAR_0690|M.marinum_M GRRAPVLAAGWVTLGVALAVMGVPSAVGIQAAALVLLGAGLGAMIATIMP
Rv1877|M.tuberculosis_H37Rv KIFPVAGMALMAVAFLLMSQMDEWTPPLLQSLYLVVLGAGIGLSMQVLVL
Mb1282|M.bovis_AF2122/97 SHPLCVLGFGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAFVWS
MUL_0911|M.ulcerans_Agy99 A-VVAAGLAVFAAALAWASTADATTPYTQITLQMLLLGGGLGLTTAPATE
. : *
MAB_1299c|M.abscessus_ATCC_199 AIADRTPED----------------------------------------N
TH_0476|M.thermoresistible__bu AVSARTPSD----------------------------------------Q
MSMEG_3373|M.smegmatis_MC2_155 SITPLAAPH----------------------------------------E
Mflv_1450|M.gilvum_PYR-GCK HLSNVVPPA----------------------------------------R
Mvan_5329|M.vanbaalenii_PYR-1 HLSDVVPAG----------------------------------------R
MAV_3974|M.avium_104 AVADILGNE----------------------------------------A
MMAR_0690|M.marinum_M ALADAMESAGG-------------------------------------AQ
Rv1877|M.tuberculosis_H37Rv IVQNTSSFEDLGVATSGVTFFRVVGASFGTATFGALFVNFLDRRLGSALT
Mb1282|M.bovis_AF2122/97 PLTVTATRN----------------------------------------L
MUL_0911|M.ulcerans_Agy99 AIMGSLPAD-----------------------------------------
:
MAB_1299c|M.abscessus_ATCC_199 RA-EVTSSYFVVAYIGIALPVIGEGLAAQAWGLRTAGVTFALAVAALAA-
TH_0476|M.thermoresistible__bu RG-EVSSTYFVVAYVALLVPVIGEGWAAHHWGLRTAGISFAVGVAVLAI-
MSMEG_3373|M.smegmatis_MC2_155 RG-ELFAAVFVVSYLAFGGPAVLAGVAVPHIGLAQTTYLYGGLVVVLSVG
Mflv_1450|M.gilvum_PYR-GCK RG-ETMSAFYLLAYSAMAVPTLVAGWAATRWELASVFPWFAGIVSAACLG
Mvan_5329|M.vanbaalenii_PYR-1 RG-ETMSAFYLLAYSAMAVPTLIAGWAATRWDLAAVFPWFAGVVAAACMG
MAV_3974|M.avium_104 RAGLPVATVQMMSDLGAIVGSMAVGWAAEQIGYGWGFFISGVVLLIAAVG
MMAR_0690|M.marinum_M RPGTAAAAYNLAFSAGTVAGGPLAGWMADLRSFQDAAMLIAVVTLTCGVL
Rv1877|M.tuberculosis_H37Rv SGAVPVPAVPSPAVLHQLPQSMAAPIVRAYAESLTQVFLCAVSVTVVGFI
Mb1282|M.bovis_AF2122/97 RPHLAGASSGVFNAVRQLGAVLGSASMAAFMTSRIAAEMPGGVDALTGPA
MUL_0911|M.ulcerans_Agy99 RAGVGSAVNDTTRELGGTLGVAIAGSVFASVYSGQLGSASALATLPSDVR
. .
MAB_1299c|M.abscessus_ATCC_199 LCLIAVIWQERPSRTEALAPVSTG--------------------------
TH_0476|M.thermoresistible__bu GCLIAILIQE-SRDPQAI--------------------------------
MSMEG_3373|M.smegmatis_MC2_155 ACLLRALATEQQSAPDTIGRTNEAT-------------------------
Mflv_1450|M.gilvum_PYR-GCK AAVAGLRSIRVARAA-----------------------------------
Mvan_5329|M.vanbaalenii_PYR-1 AAIAGVRSVRLAQ-------------------------------------
MAV_3974|M.avium_104 WVMAPETRTATELEADLMAASRTSSRCEQQL-------------------
MMAR_0690|M.marinum_M AALVHAAVVRRAVSDA----------------------------------
Rv1877|M.tuberculosis_H37Rv LALLLREVPLTDIHDDADDLGDGFGVPRAESPEDVLEIAVRRMLPNGVRL
Mb1282|M.bovis_AF2122/97 GQDATVLQLPEFVREPFAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAV
MUL_0911|M.ulcerans_Agy99 SAMKGSMAVAHKVIDQLPAGPAAGVRDAVNHAFLDGLQVATLVCAG----
MAB_1299c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0476|M.thermoresistible__bu --------------------------------------------------
MSMEG_3373|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1450|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5329|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3974|M.avium_104 --------------------------------------------------
MMAR_0690|M.marinum_M --------------------------------------------------
Rv1877|M.tuberculosis_H37Rv RDIATQPGCGLGVAELWALLRIYQYQRLFEAVRLTDIGRHLHVPYQVFEP
Mb1282|M.bovis_AF2122/97 AKEPLPESDGDADDDDYVEYILRREP-------------EEDCDTQPLRA
MUL_0911|M.ulcerans_Agy99 --------------------------------------------------
MAB_1299c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0476|M.thermoresistible__bu --------------------------------------------------
MSMEG_3373|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1450|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5329|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3974|M.avium_104 --------------------------------------------------
MMAR_0690|M.marinum_M --------------------------------------------------
Rv1877|M.tuberculosis_H37Rv VFDRLVQTGYAARDGDILTLTPSGHRQVDSLAVLIRQWLLDHLAVAPGLK
Mb1282|M.bovis_AF2122/97 SRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTESTAPSAL
MUL_0911|M.ulcerans_Agy99 ----------IALAAAIVVGWLLPARAGQPTPAQTEPALAQV--------
MAB_1299c|M.abscessus_ATCC_199 -----------------------------------------
TH_0476|M.thermoresistible__bu -----------------------------------------
MSMEG_3373|M.smegmatis_MC2_155 -----------------------------------------
Mflv_1450|M.gilvum_PYR-GCK -----------------------------------------
Mvan_5329|M.vanbaalenii_PYR-1 -----------------------------------------
MAV_3974|M.avium_104 -----------------------------------------
MMAR_0690|M.marinum_M -----------------------------------------
Rv1877|M.tuberculosis_H37Rv RQPDHQFEAALQHVTDAVLVQRDWYEDLGDLSESRQLAATT
Mb1282|M.bovis_AF2122/97 -----------------------------------------
MUL_0911|M.ulcerans_Agy99 -----------------------------------------