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VTDNFERAGAPGELRSNFTPGSTRWAVRRAQWSAMGIDWRDQEKPKIAIVNTSSKLSVCFAHLDDVAVRV AEAVRAAGGLPFEIRTTAPSDFVTSAGRKARYLMPTRDLIVNDVEAAVEGAVLDGVVFLSSCDKTTPAHL MAAARLDLPAIVVIGGYQRGGTWSGCSVDIDTVYESVGALTAGTMTVDQLGELADQAIEGPGVCAGLATA NTMHCLAEALGMTVAGSAPVRANSDRMLDNAAAAGHHIVKMVEQNLTARQVITEKSIENAIEVALALGGS VNCIRHLAAICAEADLDLDVVGMFEKHGGDAVQLAAIRPNGAHQVWDLDGVGGIQTVMRTLLPRLHGDAL TVDGRTVSERAADAQPADGDVLHPLDDPINDEPGLIILRGSLAPDGSIVKVAGVGKATRRQFNGPAKVFV GEDDAIAALGDGRIQRGDVIVLRGMGPRGGPGTVFAASFVAALNGAGLGGHVAVVTDGELSGLNHGLVVG QVMPEAADGGPLAGLQNGDTVAIDLDARRIDSHPIRDGEPVRATGEHPERGWLGQYAALVGPVQRGAVLR RPRN
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_0482 | - | - | 100% (564) | dihydroxy-acid dehydratase |
M. smegmatis MC2 155 | MSMEG_0229 | ilvD | 5e-93 | 37.06% (572) | dihydroxy-acid dehydratase |
M. smegmatis MC2 155 | MSMEG_1290 | ilvD | 2e-73 | 32.29% (607) | dihydroxy-acid dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0195c | ilvD | 3e-97 | 38.46% (572) | dihydroxy-acid dehydratase |
M. gilvum PYR-GCK | Mflv_0486 | - | 4e-94 | 37.94% (572) | dihydroxy-acid dehydratase |
M. tuberculosis H37Rv | Rv0189c | ilvD | 3e-97 | 38.46% (572) | dihydroxy-acid dehydratase |
M. leprae Br4923 | MLBr_02608 | ilvD | 2e-94 | 38.11% (530) | dihydroxy-acid dehydratase |
M. abscessus ATCC 19977 | MAB_4545 | - | 1e-94 | 37.41% (572) | dihydroxy-acid dehydratase |
M. marinum M | MMAR_0432 | ilvD | 1e-95 | 37.94% (572) | dihydroxy-acid dehydratase IlvD |
M. avium 104 | MAV_4989 | ilvD | 2e-96 | 38.29% (572) | dihydroxy-acid dehydratase |
M. thermoresistible (build 8) | TH_0983 | ilvD | 1e-98 | 38.38% (581) | PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) |
M. ulcerans Agy99 | MUL_1082 | ilvD | 1e-95 | 38.11% (572) | dihydroxy-acid dehydratase |
M. vanbaalenii PYR-1 | Mvan_0173 | - | 9e-96 | 38.11% (572) | dihydroxy-acid dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_0432|M.marinum_M --------------------------MPEADIKPRSRDVTDGLEKAAARG MUL_1082|M.ulcerans_Agy99 --------------------------MPEADIKPRSRDVTDGLEKAAARG Mb0195c|M.bovis_AF2122/97 ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG Rv0189c|M.tuberculosis_H37Rv ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG MLBr_02608|M.leprae_Br4923 --------------------------MMPPDIKPRSRDVTDGLEKAAARG MAV_4989|M.avium_104 ---------------MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARG TH_0983|M.thermoresistible__bu ------------------------MAQNQPDIKPRSRDVTDGLEKAAARG Mvan_0173|M.vanbaalenii_PYR-1 -------------------------MPSSPDIKPRSRDVTDGLEKAAARG Mflv_0486|M.gilvum_PYR-GCK MWPMNRRAHNHPMPSDSRSHSLRASGSS-VDIKPRSRDVTDGLERTAARG MAB_4545|M.abscessus_ATCC_1997 ------------MSAPHKPDSLRASGSSQPDIKPRSRDVTDGLEKTAARG MSMEG_0482|M.smegmatis_MC2_155 --------------------MTDNFERAGAPGELRSNFTPGSTRWAVRRA : **. .... . :. *. MMAR_0432|M.marinum_M MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY MUL_1082|M.ulcerans_Agy99 MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY Mb0195c|M.bovis_AF2122/97 MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY Rv0189c|M.tuberculosis_H37Rv MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY MLBr_02608|M.leprae_Br4923 MLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGY MAV_4989|M.avium_104 MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVFAAGGY TH_0983|M.thermoresistible__bu MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKDGVHAAGGY Mvan_0173|M.vanbaalenii_PYR-1 MLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKEGVFEAGGF Mflv_0486|M.gilvum_PYR-GCK MLRAVGMTDDDWVKPQIGVGSSWNEITPCNMSLQRLAQAVKGGVHEAGGY MAB_4545|M.abscessus_ATCC_1997 MLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAHSVKDGVHEAGGY MSMEG_0482|M.smegmatis_MC2_155 QWSAMGIDWRDQEKPKIAIVNTSSKLSVCFAHLDDVAVRVAEAVRAAGGL *:*: * *.:*.: .: .::: * *: :* * .* *** MMAR_0432|M.marinum_M PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA MUL_1082|M.ulcerans_Agy99 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA Mb0195c|M.bovis_AF2122/97 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA Rv0189c|M.tuberculosis_H37Rv PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA MLBr_02608|M.leprae_Br4923 PLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLA MAV_4989|M.avium_104 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA TH_0983|M.thermoresistible__bu PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA Mvan_0173|M.vanbaalenii_PYR-1 PMEFGTISVSDGISMGHEGMHFSLVSREIIADSVETVMQAERLDGSVLLA Mflv_0486|M.gilvum_PYR-GCK PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA MAB_4545|M.abscessus_ATCC_1997 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA MSMEG_0482|M.smegmatis_MC2_155 PFEIRTTAPSDFVTSAGRKARYLMPTRDLIVNDVEAAVEGAVLDGVVFLS *:*: * : ** :: . . :: : :*::*.:.**..::. *** *:*: MMAR_0432|M.marinum_M GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE MUL_1082|M.ulcerans_Agy99 GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE Mb0195c|M.bovis_AF2122/97 GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE Rv0189c|M.tuberculosis_H37Rv GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE MLBr_02608|M.leprae_Br4923 GCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFE MAV_4989|M.avium_104 GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE TH_0983|M.thermoresistible__bu GCDKSLPGMLMAAARLDLAAVFLYAGSILPGIAKLSDGTEREVTIIDAFE Mvan_0173|M.vanbaalenii_PYR-1 GCDKSLPGMLMAAARLDLASVFLYAGSILPGRVKLSDGSEKDVTIIDAFE Mflv_0486|M.gilvum_PYR-GCK GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGSEKEVTIIDAFE MAB_4545|M.abscessus_ATCC_1997 GCDKSIPGMLMAAARLDLASVFLYNGSIMPGKAKLTDGTEKEVTIIDAFE MSMEG_0482|M.smegmatis_MC2_155 SCDKTTPAHLMAAARLDLPAIVVIG-----GYQRGGTWSGCSVDIDTVYE .***: *. *********.::.. * : : .* : .:* MMAR_0432|M.marinum_M AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MUL_1082|M.ulcerans_Agy99 AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Mb0195c|M.bovis_AF2122/97 AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Rv0189c|M.tuberculosis_H37Rv AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MLBr_02608|M.leprae_Br4923 AVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MAV_4989|M.avium_104 AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP TH_0983|M.thermoresistible__bu AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Mvan_0173|M.vanbaalenii_PYR-1 AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Mflv_0486|M.gilvum_PYR-GCK AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP MAB_4545|M.abscessus_ATCC_1997 AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP MSMEG_0482|M.smegmatis_MC2_155 SVGALTAGTMTVDQLGELADQAIEGPGVCAGLATANTMHCLAEALGMTVA :*** : * *. ::. : * *.*.*: ***** . ******::. MMAR_0432|M.marinum_M GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM MUL_1082|M.ulcerans_Agy99 GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM Mb0195c|M.bovis_AF2122/97 GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM Rv0189c|M.tuberculosis_H37Rv GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM MLBr_02608|M.leprae_Br4923 GSAAPPATDRRRDGFARRSGQAVIELLRRGITARDILTKEAFENAIAVVM MAV_4989|M.avium_104 GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM TH_0983|M.thermoresistible__bu GSAAPPATDRRRDGFARKSGQAVVELLRRGITARDILTKEAFENAIAVVM Mvan_0173|M.vanbaalenii_PYR-1 GSAAPPATDRRRDGFARKSGMAVVELLRRGITARDILTKEAFENAIAVVM Mflv_0486|M.gilvum_PYR-GCK GSASPVAIDKRRDDFARRSGEAVVEMLRRGITARDILTKEAFENAIAVVM MAB_4545|M.abscessus_ATCC_1997 GSASPVAIDKRREEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVM MSMEG_0482|M.smegmatis_MC2_155 GSAPVRANSDRMLDNAAAAGHHIVKMVEQNLTARQVITEKSIENAIEVAL ***. * . * * :* :::::.:.:***:::*.:::**** *.: MMAR_0432|M.marinum_M AFGGSTNAVLHLLAIAHEANVELTLD-DFSRIGSKVPHLADVKPFGRHVM MUL_1082|M.ulcerans_Agy99 AFGGSTNAVLHLLAIAHEANVELTLD-DFSRIGSKVPHLADVKPFGRHVM Mb0195c|M.bovis_AF2122/97 AFGGSTNAVLHLLAIAHEANVALSLQ-DFSRIGSGVPHLADVKPFGRHVM Rv0189c|M.tuberculosis_H37Rv AFGGSTNAVLHLLAIAHEANVALSLQ-DFSRIGSGVPHLADVKPFGRHVM MLBr_02608|M.leprae_Br4923 AFGGSTNAILHLLAIAHEADVTLSLE-DFSRIGFKVPHIADVKPFGRHVM MAV_4989|M.avium_104 AFGGSTNAVLHLLAIAHEADVALSLD-DFSRIGSKVPHLADVKPFGRHVM TH_0983|M.thermoresistible__bu AFGGSTNAVLHLLAIAHEANVKLTLE-DFTRIGNKVPHLADVKPFGAHVM Mvan_0173|M.vanbaalenii_PYR-1 AFGGSTNAVLHLLAIAYEANVKLTLE-DFTRVGAKVPHLADVKPFGAYVM Mflv_0486|M.gilvum_PYR-GCK AFGGSTNAVLHLLAIAWEAQVELTLA-DFTRIGQKVPHLADVKPFGAYVM MAB_4545|M.abscessus_ATCC_1997 AFGGSTNAVLHLLAIAKEAEVELSLA-DFTRIGNKVPHLADVKPFGRHVM MSMEG_0482|M.smegmatis_MC2_155 ALGGSVNCIRHLAAICAEADLDLDVVGMFEKHGGDAVQLAAIRPNGAHQV *:***.*.: ** **. **:: * : * : * . ::* ::* * : : MMAR_0432|M.marinum_M SHVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKV MUL_1082|M.ulcerans_Agy99 SHVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKV Mb0195c|M.bovis_AF2122/97 SDVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKV Rv0189c|M.tuberculosis_H37Rv SDVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKV MLBr_02608|M.leprae_Br4923 FDVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQV MAV_4989|M.avium_104 TDVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKV TH_0983|M.thermoresistible__bu FDVDHIGGVPVIMKTLLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKV Mvan_0173|M.vanbaalenii_PYR-1 NDVDRIGGVPVVMKALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKV Mflv_0486|M.gilvum_PYR-GCK KHVDEIGGVPVVMRALLDAGLLHGDCLTVTGQTMAENLAHIEPPDPDGKV MAB_4545|M.abscessus_ATCC_1997 KDVDEIGGVPVVMRALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKV MSMEG_0482|M.smegmatis_MC2_155 WDLDGVGGIQTVMRTLLPR--LHGDALTVDGRTVSERAADAQP--ADGDV .:* :**: .:*::** *:**.*** * *:::. * .**.* MMAR_0432|M.marinum_M LRALNNPIHATGGITILRGSLAPEGAVVKTAGLDTDV---FEGTARVFDG MUL_1082|M.ulcerans_Agy99 LRALINPIHATGGITILRGSLAPEGAVVKTAGLDTDV---FEGTARVFDG Mb0195c|M.bovis_AF2122/97 LRALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDV---FEGTARVFDG Rv0189c|M.tuberculosis_H37Rv LRALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDV---FEGTARVFDG MLBr_02608|M.leprae_Br4923 IRTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDV---FEGTARVFDG MAV_4989|M.avium_104 LRALSDPLHPTGGITILRGSLAPEGAVVKSAGFDSDV---FEGTARVFDG TH_0983|M.thermoresistible__bu LRALSNPIHPTGGITILHGSLAPEGAVVKSAGFDTSV---FEGTARVFDR Mvan_0173|M.vanbaalenii_PYR-1 LRALSRPIHPTGGITILHGSLAPEGAVVKSAGFDSDV---FEGTARVFER Mflv_0486|M.gilvum_PYR-GCK LRAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDV---FEGTARVFER MAB_4545|M.abscessus_ATCC_1997 LRAMNDPIHPTGGITILHGSLAPEGAVVKSAGFESDV---FEGTARVFER MSMEG_0482|M.smegmatis_MC2_155 LHPLDDPINDEPGLIILRGSLAPDGSIVKVAGVGKATRRQFNGPAKVFVG ::.: *:: *: **:*****:*::** **. . . *:*.*:** MMAR_0432|M.marinum_M ERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD MUL_1082|M.ulcerans_Agy99 ERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD Mb0195c|M.bovis_AF2122/97 ERAALDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD Rv0189c|M.tuberculosis_H37Rv ERAALDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD MLBr_02608|M.leprae_Br4923 ERAALDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD MAV_4989|M.avium_104 ERAALDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD TH_0983|M.thermoresistible__bu ERAAMDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD Mvan_0173|M.vanbaalenii_PYR-1 ERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD Mflv_0486|M.gilvum_PYR-GCK ERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD MAB_4545|M.abscessus_ATCC_1997 ERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD MSMEG_0482|M.smegmatis_MC2_155 EDDAIAALGDGRIQRGDVIVLRGMGPRGGPGTVFAASFVAALNGAGLGGH * *: ** ** * **.:*:* **:**** ::..*::***** . MMAR_0432|M.marinum_M VLLLTDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLD MUL_1082|M.ulcerans_Agy99 VLLLTDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLD Mb0195c|M.bovis_AF2122/97 VLLLTDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLD Rv0189c|M.tuberculosis_H37Rv VLLLTDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLD MLBr_02608|M.leprae_Br4923 VLLLTDGRFSGGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLD MAV_4989|M.avium_104 VLLLTDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLD TH_0983|M.thermoresistible__bu VLLLTDGRFSGGTTGLCVGHVAPEAVDGGPIAFLRDGDRIRLDVAKGTLD Mvan_0173|M.vanbaalenii_PYR-1 VLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFIKDGDKIRLDVAKGTLD Mflv_0486|M.gilvum_PYR-GCK VLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGTLD MAB_4545|M.abscessus_ATCC_1997 VLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGKLD MSMEG_0482|M.smegmatis_MC2_155 VAVVTDGELSGLNHGLVVGQVMPEAADGGPLAGLQNGDTVAIDLDARRID * ::***.:** . *: **:: ***.:.**:* :::** : :*: :* MMAR_0432|M.marinum_M VLTDPAEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG---- MUL_1082|M.ulcerans_Agy99 VLTDPPEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG---- Mb0195c|M.bovis_AF2122/97 VLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG---- Rv0189c|M.tuberculosis_H37Rv VLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG---- MLBr_02608|M.leprae_Br4923 VLVDPVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVGAVCG---- MAV_4989|M.avium_104 VLVDPAEFDSRRTAFTPPPPRYKTGVLAKYVKLVGSAAIGAVCG---- TH_0983|M.thermoresistible__bu VLVDPAEFEARKKDWEPLPPRYTTGVLAKYTKLVGSAATGAVCT---- Mvan_0173|M.vanbaalenii_PYR-1 VVVDKDEFEARKVGFEPLPPVYTTGVLAKYTKLVGSAATGAVCT---- Mflv_0486|M.gilvum_PYR-GCK ILVDEAEFESRKAGFEPLPPVYTTGVLAKYTKLVGSAAVGAVCS---- MAB_4545|M.abscessus_ATCC_1997 LLVDEAEIAERRKGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCG---- MSMEG_0482|M.smegmatis_MC2_155 SHPIRDGEPVRATGEHP-----ERGWLGQYAALVGPVQRGAVLRRPRN * * * *.:*. ** .. ***