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M. gilvum PYR-GCK Mflv_0486 (-)

annotation: dihydroxy-acid dehydratase
coordinates: 510996 - 512765
length: 589

MWPMNRRAHNHPMPSDSRSHSLRASGSSVDIKPRSRDVTDGLERTAARGMLRAVGMTDDDWVKPQIGVGS
SWNEITPCNMSLQRLAQAVKGGVHEAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAE
RLDGTVLLAGCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGSEKEVTIIDAFEAVGACARGLMS
REDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLPGSASPVAIDKRRDDFARRSGEAVVEMLRRGI
TARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAWEAQVELTLADFTRIGQKVPHLADVKPFGAYVMKH
VDEIGGVPVVMRALLDAGLLHGDCLTVTGQTMAENLAHIEPPDPDGKVLRAMNNPIHPTGGITILHGSLA
PEGAVVKSAGFDSDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGA
GLGKDVLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGTLDILVDEAEFESRKAGF
EPLPPVYTTGVLAKYTKLVGSAAVGAVCS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0486--100% (589)dihydroxy-acid dehydratase
M. gilvum PYR-GCKMflv_5171-e-11139.87% (607) dihydroxy-acid dehydratase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0195cilvD0.085.34% (566) dihydroxy-acid dehydratase
M. tuberculosis H37RvRv0189cilvD0.085.34% (566) dihydroxy-acid dehydratase
M. leprae Br4923MLBr_02608ilvD0.083.36% (559) dihydroxy-acid dehydratase
M. abscessus ATCC 19977MAB_4545-0.092.37% (577) dihydroxy-acid dehydratase
M. marinum MMMAR_0432ilvD0.085.33% (559) dihydroxy-acid dehydratase IlvD
M. avium 104MAV_4989ilvD0.086.40% (559) dihydroxy-acid dehydratase
M. smegmatis MC2 155MSMEG_0229ilvD0.091.68% (577) dihydroxy-acid dehydratase
M. thermoresistible (build 8)TH_0983ilvD0.087.86% (560) PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD)
M. ulcerans Agy99MUL_1082ilvD0.084.97% (559) dihydroxy-acid dehydratase
M. vanbaalenii PYR-1Mvan_0173-0.088.99% (563) dihydroxy-acid dehydratase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0432|M.marinum_M               --------------------------MPEADIKPRSRDVTDGLEKAAARG
MUL_1082|M.ulcerans_Agy99           --------------------------MPEADIKPRSRDVTDGLEKAAARG
Mb0195c|M.bovis_AF2122/97           ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG
Rv0189c|M.tuberculosis_H37Rv        ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG
MLBr_02608|M.leprae_Br4923          --------------------------MMPPDIKPRSRDVTDGLEKAAARG
MAV_4989|M.avium_104                ---------------MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARG
TH_0983|M.thermoresistible__bu      ------------------------MAQNQPDIKPRSRDVTDGLEKAAARG
Mvan_0173|M.vanbaalenii_PYR-1       -------------------------MPSSPDIKPRSRDVTDGLEKAAARG
Mflv_0486|M.gilvum_PYR-GCK          MWPMNRRAHNHPMPSDSRSHSLRASGSS-VDIKPRSRDVTDGLERTAARG
MAB_4545|M.abscessus_ATCC_1997      ------------MSAPHKPDSLRASGSSQPDIKPRSRDVTDGLEKTAARG
MSMEG_0229|M.smegmatis_MC2_155      ------------MPSDDKS-------TETPDIKPRSRDVTDGLEKAAARG
                                                                  **************::****

MMAR_0432|M.marinum_M               MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY
MUL_1082|M.ulcerans_Agy99           MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY
Mb0195c|M.bovis_AF2122/97           MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY
Rv0189c|M.tuberculosis_H37Rv        MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY
MLBr_02608|M.leprae_Br4923          MLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGY
MAV_4989|M.avium_104                MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVFAAGGY
TH_0983|M.thermoresistible__bu      MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKDGVHAAGGY
Mvan_0173|M.vanbaalenii_PYR-1       MLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKEGVFEAGGF
Mflv_0486|M.gilvum_PYR-GCK          MLRAVGMTDDDWVKPQIGVGSSWNEITPCNMSLQRLAQAVKGGVHEAGGY
MAB_4545|M.abscessus_ATCC_1997      MLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAHSVKDGVHEAGGY
MSMEG_0229|M.smegmatis_MC2_155      MLRAVGMGDADWAKPQIGVGSSWNEITPCNMSLQRLAKSVKDGVHEAGGY
                                    ******* * *:.*.****.**********:**:***::** **. ***:

MMAR_0432|M.marinum_M               PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
MUL_1082|M.ulcerans_Agy99           PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
Mb0195c|M.bovis_AF2122/97           PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA
Rv0189c|M.tuberculosis_H37Rv        PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA
MLBr_02608|M.leprae_Br4923          PLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLA
MAV_4989|M.avium_104                PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
TH_0983|M.thermoresistible__bu      PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
Mvan_0173|M.vanbaalenii_PYR-1       PMEFGTISVSDGISMGHEGMHFSLVSREIIADSVETVMQAERLDGSVLLA
Mflv_0486|M.gilvum_PYR-GCK          PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA
MAB_4545|M.abscessus_ATCC_1997      PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
MSMEG_0229|M.smegmatis_MC2_155      PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA
                                    *:***************:**********:******.*:*******:****

MMAR_0432|M.marinum_M               GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE
MUL_1082|M.ulcerans_Agy99           GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE
Mb0195c|M.bovis_AF2122/97           GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE
Rv0189c|M.tuberculosis_H37Rv        GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE
MLBr_02608|M.leprae_Br4923          GCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFE
MAV_4989|M.avium_104                GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE
TH_0983|M.thermoresistible__bu      GCDKSLPGMLMAAARLDLAAVFLYAGSILPGIAKLSDGTEREVTIIDAFE
Mvan_0173|M.vanbaalenii_PYR-1       GCDKSLPGMLMAAARLDLASVFLYAGSILPGRVKLSDGSEKDVTIIDAFE
Mflv_0486|M.gilvum_PYR-GCK          GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGSEKEVTIIDAFE
MAB_4545|M.abscessus_ATCC_1997      GCDKSIPGMLMAAARLDLASVFLYNGSIMPGKAKLTDGTEKEVTIIDAFE
MSMEG_0229|M.smegmatis_MC2_155      GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGTEKEVTIIDAFE
                                    *****:*************:**:* ***:** .**:**:*::**:*****

MMAR_0432|M.marinum_M               AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
MUL_1082|M.ulcerans_Agy99           AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
Mb0195c|M.bovis_AF2122/97           AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
Rv0189c|M.tuberculosis_H37Rv        AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
MLBr_02608|M.leprae_Br4923          AVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
MAV_4989|M.avium_104                AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
TH_0983|M.thermoresistible__bu      AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
Mvan_0173|M.vanbaalenii_PYR-1       AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
Mflv_0486|M.gilvum_PYR-GCK          AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
MAB_4545|M.abscessus_ATCC_1997      AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
MSMEG_0229|M.smegmatis_MC2_155      AVGACVRGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGLSLP
                                    ***** ****.* *** *****************************:***

MMAR_0432|M.marinum_M               GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM
MUL_1082|M.ulcerans_Agy99           GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM
Mb0195c|M.bovis_AF2122/97           GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM
Rv0189c|M.tuberculosis_H37Rv        GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM
MLBr_02608|M.leprae_Br4923          GSAAPPATDRRRDGFARRSGQAVIELLRRGITARDILTKEAFENAIAVVM
MAV_4989|M.avium_104                GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM
TH_0983|M.thermoresistible__bu      GSAAPPATDRRRDGFARKSGQAVVELLRRGITARDILTKEAFENAIAVVM
Mvan_0173|M.vanbaalenii_PYR-1       GSAAPPATDRRRDGFARKSGMAVVELLRRGITARDILTKEAFENAIAVVM
Mflv_0486|M.gilvum_PYR-GCK          GSASPVAIDKRRDDFARRSGEAVVEMLRRGITARDILTKEAFENAIAVVM
MAB_4545|M.abscessus_ATCC_1997      GSASPVAIDKRREEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVM
MSMEG_0229|M.smegmatis_MC2_155      GSASPVAIDKRRDEFARRSGEAVVDMLRRGITARDILTKEAFENAIAVVM
                                    ***:* * *:**: :**:** **:::**:*******:*:***********

MMAR_0432|M.marinum_M               AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS
MUL_1082|M.ulcerans_Agy99           AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS
Mb0195c|M.bovis_AF2122/97           AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS
Rv0189c|M.tuberculosis_H37Rv        AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS
MLBr_02608|M.leprae_Br4923          AFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGRHVMF
MAV_4989|M.avium_104                AFGGSTNAVLHLLAIAHEADVALSLDDFSRIGSKVPHLADVKPFGRHVMT
TH_0983|M.thermoresistible__bu      AFGGSTNAVLHLLAIAHEANVKLTLEDFTRIGNKVPHLADVKPFGAHVMF
Mvan_0173|M.vanbaalenii_PYR-1       AFGGSTNAVLHLLAIAYEANVKLTLEDFTRVGAKVPHLADVKPFGAYVMN
Mflv_0486|M.gilvum_PYR-GCK          AFGGSTNAVLHLLAIAWEAQVELTLADFTRIGQKVPHLADVKPFGAYVMK
MAB_4545|M.abscessus_ATCC_1997      AFGGSTNAVLHLLAIAKEAEVELSLADFTRIGNKVPHLADVKPFGRHVMK
MSMEG_0229|M.smegmatis_MC2_155      AFGGSTNAVLHLLAIAREAEVELTLDDFTRVGSKVPHLADVKPFGRHVMK
                                    ********:******* **:* *:* **:*:*  ***:******* :** 

MMAR_0432|M.marinum_M               HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL
MUL_1082|M.ulcerans_Agy99           HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL
Mb0195c|M.bovis_AF2122/97           DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL
Rv0189c|M.tuberculosis_H37Rv        DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL
MLBr_02608|M.leprae_Br4923          DVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVI
MAV_4989|M.avium_104                DVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKVL
TH_0983|M.thermoresistible__bu      DVDHIGGVPVIMKTLLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL
Mvan_0173|M.vanbaalenii_PYR-1       DVDRIGGVPVVMKALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL
Mflv_0486|M.gilvum_PYR-GCK          HVDEIGGVPVVMRALLDAGLLHGDCLTVTGQTMAENLAHIEPPDPDGKVL
MAB_4545|M.abscessus_ATCC_1997      DVDEIGGVPVVMRALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL
MSMEG_0229|M.smegmatis_MC2_155      HVDEIGGVPVVMRALLDAGLLNGECLTVTGKTMAENLAHIAPPDPDGKVL
                                    .**.******:*::*******:*:****** *:*:**  * ******:*:

MMAR_0432|M.marinum_M               RALNNPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA
MUL_1082|M.ulcerans_Agy99           RALINPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA
Mb0195c|M.bovis_AF2122/97           RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA
Rv0189c|M.tuberculosis_H37Rv        RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA
MLBr_02608|M.leprae_Br4923          RTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDVFEGTARVFDGERAA
MAV_4989|M.avium_104                RALSDPLHPTGGITILRGSLAPEGAVVKSAGFDSDVFEGTARVFDGERAA
TH_0983|M.thermoresistible__bu      RALSNPIHPTGGITILHGSLAPEGAVVKSAGFDTSVFEGTARVFDRERAA
Mvan_0173|M.vanbaalenii_PYR-1       RALSRPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA
Mflv_0486|M.gilvum_PYR-GCK          RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA
MAB_4545|M.abscessus_ATCC_1997      RAMNDPIHPTGGITILHGSLAPEGAVVKSAGFESDVFEGTARVFERERAA
MSMEG_0229|M.smegmatis_MC2_155      RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFDRERAA
                                    *::  *:*.:******:*****:*****:**:::.*********: ****

MMAR_0432|M.marinum_M               LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
MUL_1082|M.ulcerans_Agy99           LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
Mb0195c|M.bovis_AF2122/97           LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
Rv0189c|M.tuberculosis_H37Rv        LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
MLBr_02608|M.leprae_Br4923          LDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
MAV_4989|M.avium_104                LDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
TH_0983|M.thermoresistible__bu      MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
Mvan_0173|M.vanbaalenii_PYR-1       LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
Mflv_0486|M.gilvum_PYR-GCK          LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
MAB_4545|M.abscessus_ATCC_1997      LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
MSMEG_0229|M.smegmatis_MC2_155      MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
                                    :***:****  **.***********************************:

MMAR_0432|M.marinum_M               TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD
MUL_1082|M.ulcerans_Agy99           TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD
Mb0195c|M.bovis_AF2122/97           TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD
Rv0189c|M.tuberculosis_H37Rv        TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD
MLBr_02608|M.leprae_Br4923          TDGRFSGGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVD
MAV_4989|M.avium_104                TDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVD
TH_0983|M.thermoresistible__bu      TDGRFSGGTTGLCVGHVAPEAVDGGPIAFLRDGDRIRLDVAKGTLDVLVD
Mvan_0173|M.vanbaalenii_PYR-1       TDGRFSGGTTGLCVGHIAPEAVDGGPIAFIKDGDKIRLDVAKGTLDVVVD
Mflv_0486|M.gilvum_PYR-GCK          TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGTLDILVD
MAB_4545|M.abscessus_ATCC_1997      TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGKLDLLVD
MSMEG_0229|M.smegmatis_MC2_155      TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDVLVD
                                    ***********:****:*****:.****::::**:: ***.   **::.*

MMAR_0432|M.marinum_M               PAEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG
MUL_1082|M.ulcerans_Agy99           PPEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG
Mb0195c|M.bovis_AF2122/97           PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG
Rv0189c|M.tuberculosis_H37Rv        PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG
MLBr_02608|M.leprae_Br4923          PVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVGAVCG
MAV_4989|M.avium_104                PAEFDSRRTAFTPPPPRYKTGVLAKYVKLVGSAAIGAVCG
TH_0983|M.thermoresistible__bu      PAEFEARKKDWEPLPPRYTTGVLAKYTKLVGSAATGAVCT
Mvan_0173|M.vanbaalenii_PYR-1       KDEFEARKVGFEPLPPVYTTGVLAKYTKLVGSAATGAVCT
Mflv_0486|M.gilvum_PYR-GCK          EAEFESRKAGFEPLPPVYTTGVLAKYTKLVGSAAVGAVCS
MAB_4545|M.abscessus_ATCC_1997      EAEIAERRKGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCG
MSMEG_0229|M.smegmatis_MC2_155      EEEFEARKAGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCT
                                      *:  *:  : * .* *.****:**.*** **: ****