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MSAPHKPDSLRASGSSQPDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKPQIGVGSSWNEITPCNMS LQRLAHSVKDGVHEAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLAGC DKSIPGMLMAAARLDLASVFLYNGSIMPGKAKLTDGTEKEVTIIDAFEAVGACARGLMSREDVDIIERAI CPGEGACGGMYTANTMASAAEALGMSLPGSASPVAIDKRREEYARKSGEAVVEMLRRGITARDILTKEAF ENAIAVVMAFGGSTNAVLHLLAIAKEAEVELSLADFTRIGNKVPHLADVKPFGRHVMKDVDEIGGVPVVM RALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVLRAMNDPIHPTGGITILHGSLAPEGAVVKSAGF ESDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLMTD GRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGKLDLLVDEAEIAERRKGFEPLPPRYKTGV LAKYTKLVQSAAVGAVCG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_4545 | - | - | 100% (578) | dihydroxy-acid dehydratase |
M. abscessus ATCC 19977 | MAB_4640c | - | e-114 | 40.47% (593) | dihydroxy-acid dehydratase (IlvD) |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0195c | ilvD | 0.0 | 85.19% (567) | dihydroxy-acid dehydratase |
M. gilvum PYR-GCK | Mflv_0486 | - | 0.0 | 92.37% (577) | dihydroxy-acid dehydratase |
M. tuberculosis H37Rv | Rv0189c | ilvD | 0.0 | 85.19% (567) | dihydroxy-acid dehydratase |
M. leprae Br4923 | MLBr_02608 | ilvD | 0.0 | 83.60% (561) | dihydroxy-acid dehydratase |
M. marinum M | MMAR_0432 | ilvD | 0.0 | 85.05% (562) | dihydroxy-acid dehydratase IlvD |
M. avium 104 | MAV_4989 | ilvD | 0.0 | 86.51% (571) | dihydroxy-acid dehydratase |
M. smegmatis MC2 155 | MSMEG_0229 | ilvD | 0.0 | 93.39% (560) | dihydroxy-acid dehydratase |
M. thermoresistible (build 8) | TH_0983 | ilvD | 0.0 | 88.26% (562) | PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) |
M. ulcerans Agy99 | MUL_1082 | ilvD | 0.0 | 84.70% (562) | dihydroxy-acid dehydratase |
M. vanbaalenii PYR-1 | Mvan_0173 | - | 0.0 | 88.08% (562) | dihydroxy-acid dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_0432|M.marinum_M --------------------------MPEADIKPRSRDVTDGLEKAAARG MUL_1082|M.ulcerans_Agy99 --------------------------MPEADIKPRSRDVTDGLEKAAARG Mb0195c|M.bovis_AF2122/97 ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG Rv0189c|M.tuberculosis_H37Rv ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG MLBr_02608|M.leprae_Br4923 --------------------------MMPPDIKPRSRDVTDGLEKAAARG MAV_4989|M.avium_104 ---------------MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARG TH_0983|M.thermoresistible__bu ------------------------MAQNQPDIKPRSRDVTDGLEKAAARG Mvan_0173|M.vanbaalenii_PYR-1 -------------------------MPSSPDIKPRSRDVTDGLEKAAARG MAB_4545|M.abscessus_ATCC_1997 ------------MSAPHKPDSLRASGSSQPDIKPRSRDVTDGLEKTAARG Mflv_0486|M.gilvum_PYR-GCK MWPMNRRAHNHPMPSDSRSHSLRASGSS-VDIKPRSRDVTDGLERTAARG MSMEG_0229|M.smegmatis_MC2_155 ------------MPSDDKS-------TETPDIKPRSRDVTDGLEKAAARG **************::**** MMAR_0432|M.marinum_M MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY MUL_1082|M.ulcerans_Agy99 MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY Mb0195c|M.bovis_AF2122/97 MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY Rv0189c|M.tuberculosis_H37Rv MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY MLBr_02608|M.leprae_Br4923 MLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGY MAV_4989|M.avium_104 MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVFAAGGY TH_0983|M.thermoresistible__bu MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKDGVHAAGGY Mvan_0173|M.vanbaalenii_PYR-1 MLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKEGVFEAGGF MAB_4545|M.abscessus_ATCC_1997 MLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAHSVKDGVHEAGGY Mflv_0486|M.gilvum_PYR-GCK MLRAVGMTDDDWVKPQIGVGSSWNEITPCNMSLQRLAQAVKGGVHEAGGY MSMEG_0229|M.smegmatis_MC2_155 MLRAVGMGDADWAKPQIGVGSSWNEITPCNMSLQRLAKSVKDGVHEAGGY ******* * *:.*.****.**********:**:***::** **. ***: MMAR_0432|M.marinum_M PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA MUL_1082|M.ulcerans_Agy99 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA Mb0195c|M.bovis_AF2122/97 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA Rv0189c|M.tuberculosis_H37Rv PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA MLBr_02608|M.leprae_Br4923 PLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLA MAV_4989|M.avium_104 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA TH_0983|M.thermoresistible__bu PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA Mvan_0173|M.vanbaalenii_PYR-1 PMEFGTISVSDGISMGHEGMHFSLVSREIIADSVETVMQAERLDGSVLLA MAB_4545|M.abscessus_ATCC_1997 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA Mflv_0486|M.gilvum_PYR-GCK PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA MSMEG_0229|M.smegmatis_MC2_155 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA *:***************:**********:******.*:*******:**** MMAR_0432|M.marinum_M GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE MUL_1082|M.ulcerans_Agy99 GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE Mb0195c|M.bovis_AF2122/97 GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE Rv0189c|M.tuberculosis_H37Rv GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE MLBr_02608|M.leprae_Br4923 GCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFE MAV_4989|M.avium_104 GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE TH_0983|M.thermoresistible__bu GCDKSLPGMLMAAARLDLAAVFLYAGSILPGIAKLSDGTEREVTIIDAFE Mvan_0173|M.vanbaalenii_PYR-1 GCDKSLPGMLMAAARLDLASVFLYAGSILPGRVKLSDGSEKDVTIIDAFE MAB_4545|M.abscessus_ATCC_1997 GCDKSIPGMLMAAARLDLASVFLYNGSIMPGKAKLTDGTEKEVTIIDAFE Mflv_0486|M.gilvum_PYR-GCK GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGSEKEVTIIDAFE MSMEG_0229|M.smegmatis_MC2_155 GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGTEKEVTIIDAFE *****:*************:**:* ***:** .**:**:*::**:***** MMAR_0432|M.marinum_M AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MUL_1082|M.ulcerans_Agy99 AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Mb0195c|M.bovis_AF2122/97 AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Rv0189c|M.tuberculosis_H37Rv AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MLBr_02608|M.leprae_Br4923 AVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MAV_4989|M.avium_104 AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP TH_0983|M.thermoresistible__bu AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Mvan_0173|M.vanbaalenii_PYR-1 AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MAB_4545|M.abscessus_ATCC_1997 AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP Mflv_0486|M.gilvum_PYR-GCK AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP MSMEG_0229|M.smegmatis_MC2_155 AVGACVRGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGLSLP ***** ****.* *** *****************************:*** MMAR_0432|M.marinum_M GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM MUL_1082|M.ulcerans_Agy99 GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM Mb0195c|M.bovis_AF2122/97 GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM Rv0189c|M.tuberculosis_H37Rv GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM MLBr_02608|M.leprae_Br4923 GSAAPPATDRRRDGFARRSGQAVIELLRRGITARDILTKEAFENAIAVVM MAV_4989|M.avium_104 GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM TH_0983|M.thermoresistible__bu GSAAPPATDRRRDGFARKSGQAVVELLRRGITARDILTKEAFENAIAVVM Mvan_0173|M.vanbaalenii_PYR-1 GSAAPPATDRRRDGFARKSGMAVVELLRRGITARDILTKEAFENAIAVVM MAB_4545|M.abscessus_ATCC_1997 GSASPVAIDKRREEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVM Mflv_0486|M.gilvum_PYR-GCK GSASPVAIDKRRDDFARRSGEAVVEMLRRGITARDILTKEAFENAIAVVM MSMEG_0229|M.smegmatis_MC2_155 GSASPVAIDKRRDEFARRSGEAVVDMLRRGITARDILTKEAFENAIAVVM ***:* * *:**: :**:** **:::**:*******:*:*********** MMAR_0432|M.marinum_M AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS MUL_1082|M.ulcerans_Agy99 AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS Mb0195c|M.bovis_AF2122/97 AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS Rv0189c|M.tuberculosis_H37Rv AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS MLBr_02608|M.leprae_Br4923 AFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGRHVMF MAV_4989|M.avium_104 AFGGSTNAVLHLLAIAHEADVALSLDDFSRIGSKVPHLADVKPFGRHVMT TH_0983|M.thermoresistible__bu AFGGSTNAVLHLLAIAHEANVKLTLEDFTRIGNKVPHLADVKPFGAHVMF Mvan_0173|M.vanbaalenii_PYR-1 AFGGSTNAVLHLLAIAYEANVKLTLEDFTRVGAKVPHLADVKPFGAYVMN MAB_4545|M.abscessus_ATCC_1997 AFGGSTNAVLHLLAIAKEAEVELSLADFTRIGNKVPHLADVKPFGRHVMK Mflv_0486|M.gilvum_PYR-GCK AFGGSTNAVLHLLAIAWEAQVELTLADFTRIGQKVPHLADVKPFGAYVMK MSMEG_0229|M.smegmatis_MC2_155 AFGGSTNAVLHLLAIAREAEVELTLDDFTRVGSKVPHLADVKPFGRHVMK ********:******* **:* *:* **:*:* ***:******* :** MMAR_0432|M.marinum_M HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL MUL_1082|M.ulcerans_Agy99 HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL Mb0195c|M.bovis_AF2122/97 DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL Rv0189c|M.tuberculosis_H37Rv DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL MLBr_02608|M.leprae_Br4923 DVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVI MAV_4989|M.avium_104 DVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKVL TH_0983|M.thermoresistible__bu DVDHIGGVPVIMKTLLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL Mvan_0173|M.vanbaalenii_PYR-1 DVDRIGGVPVVMKALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL MAB_4545|M.abscessus_ATCC_1997 DVDEIGGVPVVMRALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL Mflv_0486|M.gilvum_PYR-GCK HVDEIGGVPVVMRALLDAGLLHGDCLTVTGQTMAENLAHIEPPDPDGKVL MSMEG_0229|M.smegmatis_MC2_155 HVDEIGGVPVVMRALLDAGLLNGECLTVTGKTMAENLAHIAPPDPDGKVL .**.******:*::*******:*:****** *:*:** * ******:*: MMAR_0432|M.marinum_M RALNNPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA MUL_1082|M.ulcerans_Agy99 RALINPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA Mb0195c|M.bovis_AF2122/97 RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA Rv0189c|M.tuberculosis_H37Rv RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA MLBr_02608|M.leprae_Br4923 RTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDVFEGTARVFDGERAA MAV_4989|M.avium_104 RALSDPLHPTGGITILRGSLAPEGAVVKSAGFDSDVFEGTARVFDGERAA TH_0983|M.thermoresistible__bu RALSNPIHPTGGITILHGSLAPEGAVVKSAGFDTSVFEGTARVFDRERAA Mvan_0173|M.vanbaalenii_PYR-1 RALSRPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA MAB_4545|M.abscessus_ATCC_1997 RAMNDPIHPTGGITILHGSLAPEGAVVKSAGFESDVFEGTARVFERERAA Mflv_0486|M.gilvum_PYR-GCK RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA MSMEG_0229|M.smegmatis_MC2_155 RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFDRERAA *:: *:*.:******:*****:*****:**:::.*********: **** MMAR_0432|M.marinum_M LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL MUL_1082|M.ulcerans_Agy99 LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL Mb0195c|M.bovis_AF2122/97 LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL Rv0189c|M.tuberculosis_H37Rv LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL MLBr_02608|M.leprae_Br4923 LDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL MAV_4989|M.avium_104 LDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL TH_0983|M.thermoresistible__bu MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL Mvan_0173|M.vanbaalenii_PYR-1 LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM MAB_4545|M.abscessus_ATCC_1997 LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM Mflv_0486|M.gilvum_PYR-GCK LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM MSMEG_0229|M.smegmatis_MC2_155 MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM :***:**** **.***********************************: MMAR_0432|M.marinum_M TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD MUL_1082|M.ulcerans_Agy99 TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD Mb0195c|M.bovis_AF2122/97 TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD Rv0189c|M.tuberculosis_H37Rv TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD MLBr_02608|M.leprae_Br4923 TDGRFSGGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVD MAV_4989|M.avium_104 TDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVD TH_0983|M.thermoresistible__bu TDGRFSGGTTGLCVGHVAPEAVDGGPIAFLRDGDRIRLDVAKGTLDVLVD Mvan_0173|M.vanbaalenii_PYR-1 TDGRFSGGTTGLCVGHIAPEAVDGGPIAFIKDGDKIRLDVAKGTLDVVVD MAB_4545|M.abscessus_ATCC_1997 TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGKLDLLVD Mflv_0486|M.gilvum_PYR-GCK TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGTLDILVD MSMEG_0229|M.smegmatis_MC2_155 TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDVLVD ***********:****:*****:.****::::**:: ***. **::.* MMAR_0432|M.marinum_M PAEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG MUL_1082|M.ulcerans_Agy99 PPEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG Mb0195c|M.bovis_AF2122/97 PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG Rv0189c|M.tuberculosis_H37Rv PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG MLBr_02608|M.leprae_Br4923 PVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVGAVCG MAV_4989|M.avium_104 PAEFDSRRTAFTPPPPRYKTGVLAKYVKLVGSAAIGAVCG TH_0983|M.thermoresistible__bu PAEFEARKKDWEPLPPRYTTGVLAKYTKLVGSAATGAVCT Mvan_0173|M.vanbaalenii_PYR-1 KDEFEARKVGFEPLPPVYTTGVLAKYTKLVGSAATGAVCT MAB_4545|M.abscessus_ATCC_1997 EAEIAERRKGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCG Mflv_0486|M.gilvum_PYR-GCK EAEFESRKAGFEPLPPVYTTGVLAKYTKLVGSAAVGAVCS MSMEG_0229|M.smegmatis_MC2_155 EEEFEARKAGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCT *: *: : * .* *.****:**.*** **: ****