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M. abscessus ATCC 19977 MAB_4545 (-)

annotation: dihydroxy-acid dehydratase
coordinates: 4628544 - 4630280
length: 578

MSAPHKPDSLRASGSSQPDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKPQIGVGSSWNEITPCNMS
LQRLAHSVKDGVHEAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLAGC
DKSIPGMLMAAARLDLASVFLYNGSIMPGKAKLTDGTEKEVTIIDAFEAVGACARGLMSREDVDIIERAI
CPGEGACGGMYTANTMASAAEALGMSLPGSASPVAIDKRREEYARKSGEAVVEMLRRGITARDILTKEAF
ENAIAVVMAFGGSTNAVLHLLAIAKEAEVELSLADFTRIGNKVPHLADVKPFGRHVMKDVDEIGGVPVVM
RALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVLRAMNDPIHPTGGITILHGSLAPEGAVVKSAGF
ESDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLMTD
GRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGKLDLLVDEAEIAERRKGFEPLPPRYKTGV
LAKYTKLVQSAAVGAVCG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. abscessus ATCC 19977MAB_4545--100% (578)dihydroxy-acid dehydratase
M. abscessus ATCC 19977MAB_4640c-e-11440.47% (593) dihydroxy-acid dehydratase (IlvD)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0195cilvD0.085.19% (567) dihydroxy-acid dehydratase
M. gilvum PYR-GCKMflv_0486-0.092.37% (577) dihydroxy-acid dehydratase
M. tuberculosis H37RvRv0189cilvD0.085.19% (567) dihydroxy-acid dehydratase
M. leprae Br4923MLBr_02608ilvD0.083.60% (561) dihydroxy-acid dehydratase
M. marinum MMMAR_0432ilvD0.085.05% (562) dihydroxy-acid dehydratase IlvD
M. avium 104MAV_4989ilvD0.086.51% (571) dihydroxy-acid dehydratase
M. smegmatis MC2 155MSMEG_0229ilvD0.093.39% (560) dihydroxy-acid dehydratase
M. thermoresistible (build 8)TH_0983ilvD0.088.26% (562) PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD)
M. ulcerans Agy99MUL_1082ilvD0.084.70% (562) dihydroxy-acid dehydratase
M. vanbaalenii PYR-1Mvan_0173-0.088.08% (562) dihydroxy-acid dehydratase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0432|M.marinum_M               --------------------------MPEADIKPRSRDVTDGLEKAAARG
MUL_1082|M.ulcerans_Agy99           --------------------------MPEADIKPRSRDVTDGLEKAAARG
Mb0195c|M.bovis_AF2122/97           ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG
Rv0189c|M.tuberculosis_H37Rv        ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG
MLBr_02608|M.leprae_Br4923          --------------------------MMPPDIKPRSRDVTDGLEKAAARG
MAV_4989|M.avium_104                ---------------MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARG
TH_0983|M.thermoresistible__bu      ------------------------MAQNQPDIKPRSRDVTDGLEKAAARG
Mvan_0173|M.vanbaalenii_PYR-1       -------------------------MPSSPDIKPRSRDVTDGLEKAAARG
MAB_4545|M.abscessus_ATCC_1997      ------------MSAPHKPDSLRASGSSQPDIKPRSRDVTDGLEKTAARG
Mflv_0486|M.gilvum_PYR-GCK          MWPMNRRAHNHPMPSDSRSHSLRASGSS-VDIKPRSRDVTDGLERTAARG
MSMEG_0229|M.smegmatis_MC2_155      ------------MPSDDKS-------TETPDIKPRSRDVTDGLEKAAARG
                                                                  **************::****

MMAR_0432|M.marinum_M               MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY
MUL_1082|M.ulcerans_Agy99           MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY
Mb0195c|M.bovis_AF2122/97           MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY
Rv0189c|M.tuberculosis_H37Rv        MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY
MLBr_02608|M.leprae_Br4923          MLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGY
MAV_4989|M.avium_104                MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVFAAGGY
TH_0983|M.thermoresistible__bu      MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKDGVHAAGGY
Mvan_0173|M.vanbaalenii_PYR-1       MLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKEGVFEAGGF
MAB_4545|M.abscessus_ATCC_1997      MLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAHSVKDGVHEAGGY
Mflv_0486|M.gilvum_PYR-GCK          MLRAVGMTDDDWVKPQIGVGSSWNEITPCNMSLQRLAQAVKGGVHEAGGY
MSMEG_0229|M.smegmatis_MC2_155      MLRAVGMGDADWAKPQIGVGSSWNEITPCNMSLQRLAKSVKDGVHEAGGY
                                    ******* * *:.*.****.**********:**:***::** **. ***:

MMAR_0432|M.marinum_M               PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
MUL_1082|M.ulcerans_Agy99           PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
Mb0195c|M.bovis_AF2122/97           PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA
Rv0189c|M.tuberculosis_H37Rv        PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA
MLBr_02608|M.leprae_Br4923          PLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLA
MAV_4989|M.avium_104                PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
TH_0983|M.thermoresistible__bu      PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
Mvan_0173|M.vanbaalenii_PYR-1       PMEFGTISVSDGISMGHEGMHFSLVSREIIADSVETVMQAERLDGSVLLA
MAB_4545|M.abscessus_ATCC_1997      PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA
Mflv_0486|M.gilvum_PYR-GCK          PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA
MSMEG_0229|M.smegmatis_MC2_155      PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA
                                    *:***************:**********:******.*:*******:****

MMAR_0432|M.marinum_M               GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE
MUL_1082|M.ulcerans_Agy99           GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE
Mb0195c|M.bovis_AF2122/97           GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE
Rv0189c|M.tuberculosis_H37Rv        GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE
MLBr_02608|M.leprae_Br4923          GCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFE
MAV_4989|M.avium_104                GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE
TH_0983|M.thermoresistible__bu      GCDKSLPGMLMAAARLDLAAVFLYAGSILPGIAKLSDGTEREVTIIDAFE
Mvan_0173|M.vanbaalenii_PYR-1       GCDKSLPGMLMAAARLDLASVFLYAGSILPGRVKLSDGSEKDVTIIDAFE
MAB_4545|M.abscessus_ATCC_1997      GCDKSIPGMLMAAARLDLASVFLYNGSIMPGKAKLTDGTEKEVTIIDAFE
Mflv_0486|M.gilvum_PYR-GCK          GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGSEKEVTIIDAFE
MSMEG_0229|M.smegmatis_MC2_155      GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGTEKEVTIIDAFE
                                    *****:*************:**:* ***:** .**:**:*::**:*****

MMAR_0432|M.marinum_M               AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
MUL_1082|M.ulcerans_Agy99           AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
Mb0195c|M.bovis_AF2122/97           AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
Rv0189c|M.tuberculosis_H37Rv        AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
MLBr_02608|M.leprae_Br4923          AVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
MAV_4989|M.avium_104                AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
TH_0983|M.thermoresistible__bu      AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
Mvan_0173|M.vanbaalenii_PYR-1       AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP
MAB_4545|M.abscessus_ATCC_1997      AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
Mflv_0486|M.gilvum_PYR-GCK          AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
MSMEG_0229|M.smegmatis_MC2_155      AVGACVRGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGLSLP
                                    ***** ****.* *** *****************************:***

MMAR_0432|M.marinum_M               GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM
MUL_1082|M.ulcerans_Agy99           GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM
Mb0195c|M.bovis_AF2122/97           GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM
Rv0189c|M.tuberculosis_H37Rv        GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM
MLBr_02608|M.leprae_Br4923          GSAAPPATDRRRDGFARRSGQAVIELLRRGITARDILTKEAFENAIAVVM
MAV_4989|M.avium_104                GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM
TH_0983|M.thermoresistible__bu      GSAAPPATDRRRDGFARKSGQAVVELLRRGITARDILTKEAFENAIAVVM
Mvan_0173|M.vanbaalenii_PYR-1       GSAAPPATDRRRDGFARKSGMAVVELLRRGITARDILTKEAFENAIAVVM
MAB_4545|M.abscessus_ATCC_1997      GSASPVAIDKRREEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVM
Mflv_0486|M.gilvum_PYR-GCK          GSASPVAIDKRRDDFARRSGEAVVEMLRRGITARDILTKEAFENAIAVVM
MSMEG_0229|M.smegmatis_MC2_155      GSASPVAIDKRRDEFARRSGEAVVDMLRRGITARDILTKEAFENAIAVVM
                                    ***:* * *:**: :**:** **:::**:*******:*:***********

MMAR_0432|M.marinum_M               AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS
MUL_1082|M.ulcerans_Agy99           AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS
Mb0195c|M.bovis_AF2122/97           AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS
Rv0189c|M.tuberculosis_H37Rv        AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS
MLBr_02608|M.leprae_Br4923          AFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGRHVMF
MAV_4989|M.avium_104                AFGGSTNAVLHLLAIAHEADVALSLDDFSRIGSKVPHLADVKPFGRHVMT
TH_0983|M.thermoresistible__bu      AFGGSTNAVLHLLAIAHEANVKLTLEDFTRIGNKVPHLADVKPFGAHVMF
Mvan_0173|M.vanbaalenii_PYR-1       AFGGSTNAVLHLLAIAYEANVKLTLEDFTRVGAKVPHLADVKPFGAYVMN
MAB_4545|M.abscessus_ATCC_1997      AFGGSTNAVLHLLAIAKEAEVELSLADFTRIGNKVPHLADVKPFGRHVMK
Mflv_0486|M.gilvum_PYR-GCK          AFGGSTNAVLHLLAIAWEAQVELTLADFTRIGQKVPHLADVKPFGAYVMK
MSMEG_0229|M.smegmatis_MC2_155      AFGGSTNAVLHLLAIAREAEVELTLDDFTRVGSKVPHLADVKPFGRHVMK
                                    ********:******* **:* *:* **:*:*  ***:******* :** 

MMAR_0432|M.marinum_M               HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL
MUL_1082|M.ulcerans_Agy99           HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL
Mb0195c|M.bovis_AF2122/97           DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL
Rv0189c|M.tuberculosis_H37Rv        DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL
MLBr_02608|M.leprae_Br4923          DVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVI
MAV_4989|M.avium_104                DVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKVL
TH_0983|M.thermoresistible__bu      DVDHIGGVPVIMKTLLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL
Mvan_0173|M.vanbaalenii_PYR-1       DVDRIGGVPVVMKALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL
MAB_4545|M.abscessus_ATCC_1997      DVDEIGGVPVVMRALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL
Mflv_0486|M.gilvum_PYR-GCK          HVDEIGGVPVVMRALLDAGLLHGDCLTVTGQTMAENLAHIEPPDPDGKVL
MSMEG_0229|M.smegmatis_MC2_155      HVDEIGGVPVVMRALLDAGLLNGECLTVTGKTMAENLAHIAPPDPDGKVL
                                    .**.******:*::*******:*:****** *:*:**  * ******:*:

MMAR_0432|M.marinum_M               RALNNPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA
MUL_1082|M.ulcerans_Agy99           RALINPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA
Mb0195c|M.bovis_AF2122/97           RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA
Rv0189c|M.tuberculosis_H37Rv        RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA
MLBr_02608|M.leprae_Br4923          RTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDVFEGTARVFDGERAA
MAV_4989|M.avium_104                RALSDPLHPTGGITILRGSLAPEGAVVKSAGFDSDVFEGTARVFDGERAA
TH_0983|M.thermoresistible__bu      RALSNPIHPTGGITILHGSLAPEGAVVKSAGFDTSVFEGTARVFDRERAA
Mvan_0173|M.vanbaalenii_PYR-1       RALSRPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA
MAB_4545|M.abscessus_ATCC_1997      RAMNDPIHPTGGITILHGSLAPEGAVVKSAGFESDVFEGTARVFERERAA
Mflv_0486|M.gilvum_PYR-GCK          RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA
MSMEG_0229|M.smegmatis_MC2_155      RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFDRERAA
                                    *::  *:*.:******:*****:*****:**:::.*********: ****

MMAR_0432|M.marinum_M               LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
MUL_1082|M.ulcerans_Agy99           LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
Mb0195c|M.bovis_AF2122/97           LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
Rv0189c|M.tuberculosis_H37Rv        LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
MLBr_02608|M.leprae_Br4923          LDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
MAV_4989|M.avium_104                LDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
TH_0983|M.thermoresistible__bu      MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL
Mvan_0173|M.vanbaalenii_PYR-1       LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
MAB_4545|M.abscessus_ATCC_1997      LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
Mflv_0486|M.gilvum_PYR-GCK          LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
MSMEG_0229|M.smegmatis_MC2_155      MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM
                                    :***:****  **.***********************************:

MMAR_0432|M.marinum_M               TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD
MUL_1082|M.ulcerans_Agy99           TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD
Mb0195c|M.bovis_AF2122/97           TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD
Rv0189c|M.tuberculosis_H37Rv        TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD
MLBr_02608|M.leprae_Br4923          TDGRFSGGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVD
MAV_4989|M.avium_104                TDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVD
TH_0983|M.thermoresistible__bu      TDGRFSGGTTGLCVGHVAPEAVDGGPIAFLRDGDRIRLDVAKGTLDVLVD
Mvan_0173|M.vanbaalenii_PYR-1       TDGRFSGGTTGLCVGHIAPEAVDGGPIAFIKDGDKIRLDVAKGTLDVVVD
MAB_4545|M.abscessus_ATCC_1997      TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGKLDLLVD
Mflv_0486|M.gilvum_PYR-GCK          TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGTLDILVD
MSMEG_0229|M.smegmatis_MC2_155      TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDVLVD
                                    ***********:****:*****:.****::::**:: ***.   **::.*

MMAR_0432|M.marinum_M               PAEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG
MUL_1082|M.ulcerans_Agy99           PPEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG
Mb0195c|M.bovis_AF2122/97           PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG
Rv0189c|M.tuberculosis_H37Rv        PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG
MLBr_02608|M.leprae_Br4923          PVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVGAVCG
MAV_4989|M.avium_104                PAEFDSRRTAFTPPPPRYKTGVLAKYVKLVGSAAIGAVCG
TH_0983|M.thermoresistible__bu      PAEFEARKKDWEPLPPRYTTGVLAKYTKLVGSAATGAVCT
Mvan_0173|M.vanbaalenii_PYR-1       KDEFEARKVGFEPLPPVYTTGVLAKYTKLVGSAATGAVCT
MAB_4545|M.abscessus_ATCC_1997      EAEIAERRKGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCG
Mflv_0486|M.gilvum_PYR-GCK          EAEFESRKAGFEPLPPVYTTGVLAKYTKLVGSAAVGAVCS
MSMEG_0229|M.smegmatis_MC2_155      EEEFEARKAGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCT
                                      *:  *:  : * .* *.****:**.*** **: ****