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MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDR LANAVKEGVFSAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKS LPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPG EGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENA IAVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMSDVDHIGGVPVVMKAL LDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPIHPSGGITILHGSLAPEGAVVKTAGFDSD VFEGTARVFDGERAALDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRF SGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSK YVKLVSSAAVGAVCG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0195c | ilvD | - | 100% (575) | dihydroxy-acid dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0486 | - | 0.0 | 85.34% (566) | dihydroxy-acid dehydratase |
M. tuberculosis H37Rv | Rv0189c | ilvD | 0.0 | 100.00% (575) | dihydroxy-acid dehydratase |
M. leprae Br4923 | MLBr_02608 | ilvD | 0.0 | 90.00% (560) | dihydroxy-acid dehydratase |
M. abscessus ATCC 19977 | MAB_4545 | - | 0.0 | 85.19% (567) | dihydroxy-acid dehydratase |
M. marinum M | MMAR_0432 | ilvD | 0.0 | 91.62% (561) | dihydroxy-acid dehydratase IlvD |
M. avium 104 | MAV_4989 | ilvD | 0.0 | 90.96% (575) | dihydroxy-acid dehydratase |
M. smegmatis MC2 155 | MSMEG_0229 | ilvD | 0.0 | 85.15% (559) | dihydroxy-acid dehydratase |
M. thermoresistible (build 8) | TH_0983 | ilvD | 0.0 | 90.34% (559) | PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) |
M. ulcerans Agy99 | MUL_1082 | ilvD | 0.0 | 91.44% (561) | dihydroxy-acid dehydratase |
M. vanbaalenii PYR-1 | Mvan_0173 | - | 0.0 | 88.55% (559) | dihydroxy-acid dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment Mb0195c|M.bovis_AF2122/97 ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG Rv0189c|M.tuberculosis_H37Rv ---------------MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARG MLBr_02608|M.leprae_Br4923 --------------------------MMPPDIKPRSRDVTDGLEKAAARG MMAR_0432|M.marinum_M --------------------------MPEADIKPRSRDVTDGLEKAAARG MUL_1082|M.ulcerans_Agy99 --------------------------MPEADIKPRSRDVTDGLEKAAARG MAV_4989|M.avium_104 ---------------MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARG TH_0983|M.thermoresistible__bu ------------------------MAQNQPDIKPRSRDVTDGLEKAAARG Mvan_0173|M.vanbaalenii_PYR-1 -------------------------MPSSPDIKPRSRDVTDGLEKAAARG Mflv_0486|M.gilvum_PYR-GCK MWPMNRRAHNHPMPSDSRSHSLRASGSS-VDIKPRSRDVTDGLERTAARG MAB_4545|M.abscessus_ATCC_1997 ------------MSAPHKPDSLRASGSSQPDIKPRSRDVTDGLEKTAARG MSMEG_0229|M.smegmatis_MC2_155 ------------MPSDDKS-------TETPDIKPRSRDVTDGLEKAAARG **************::**** Mb0195c|M.bovis_AF2122/97 MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY Rv0189c|M.tuberculosis_H37Rv MLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGY MLBr_02608|M.leprae_Br4923 MLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGY MMAR_0432|M.marinum_M MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY MUL_1082|M.ulcerans_Agy99 MLRAVGMVDEDFAKAQIGVASSWNEITPCNLSLDRLAKSVKEGVFAAGGY MAV_4989|M.avium_104 MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVFAAGGY TH_0983|M.thermoresistible__bu MLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKDGVHAAGGY Mvan_0173|M.vanbaalenii_PYR-1 MLRAVGMGDEDFAKPQIGVGSSWNEITPCNLSLDRLAKAVKEGVFEAGGF Mflv_0486|M.gilvum_PYR-GCK MLRAVGMTDDDWVKPQIGVGSSWNEITPCNMSLQRLAQAVKGGVHEAGGY MAB_4545|M.abscessus_ATCC_1997 MLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAHSVKDGVHEAGGY MSMEG_0229|M.smegmatis_MC2_155 MLRAVGMGDADWAKPQIGVGSSWNEITPCNMSLQRLAKSVKDGVHEAGGY ******* * *:.*.****.**********:**:***::** **. ***: Mb0195c|M.bovis_AF2122/97 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA Rv0189c|M.tuberculosis_H37Rv PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLA MLBr_02608|M.leprae_Br4923 PLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLA MMAR_0432|M.marinum_M PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA MUL_1082|M.ulcerans_Agy99 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA MAV_4989|M.avium_104 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA TH_0983|M.thermoresistible__bu PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA Mvan_0173|M.vanbaalenii_PYR-1 PMEFGTISVSDGISMGHEGMHFSLVSREIIADSVETVMQAERLDGSVLLA Mflv_0486|M.gilvum_PYR-GCK PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA MAB_4545|M.abscessus_ATCC_1997 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLA MSMEG_0229|M.smegmatis_MC2_155 PLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLA *:***************:**********:******.*:*******:**** Mb0195c|M.bovis_AF2122/97 GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE Rv0189c|M.tuberculosis_H37Rv GCDKSLPGMLMAAARLDLAAVFLYAGSILPGRAKLSDGSERDVTIIDAFE MLBr_02608|M.leprae_Br4923 GCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFE MMAR_0432|M.marinum_M GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE MUL_1082|M.ulcerans_Agy99 GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE MAV_4989|M.avium_104 GCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTIIDAFE TH_0983|M.thermoresistible__bu GCDKSLPGMLMAAARLDLAAVFLYAGSILPGIAKLSDGTEREVTIIDAFE Mvan_0173|M.vanbaalenii_PYR-1 GCDKSLPGMLMAAARLDLASVFLYAGSILPGRVKLSDGSEKDVTIIDAFE Mflv_0486|M.gilvum_PYR-GCK GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGSEKEVTIIDAFE MAB_4545|M.abscessus_ATCC_1997 GCDKSIPGMLMAAARLDLASVFLYNGSIMPGKAKLTDGTEKEVTIIDAFE MSMEG_0229|M.smegmatis_MC2_155 GCDKSIPGMLMAAARLDLASVFFYNGSIMPGVAKLTDGTEKEVTIIDAFE *****:*************:**:* ***:** .**:**:*::**:***** Mb0195c|M.bovis_AF2122/97 AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Rv0189c|M.tuberculosis_H37Rv AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MLBr_02608|M.leprae_Br4923 AVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MMAR_0432|M.marinum_M AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MUL_1082|M.ulcerans_Agy99 AVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP MAV_4989|M.avium_104 AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP TH_0983|M.thermoresistible__bu AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Mvan_0173|M.vanbaalenii_PYR-1 AVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLP Mflv_0486|M.gilvum_PYR-GCK AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP MAB_4545|M.abscessus_ATCC_1997 AVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP MSMEG_0229|M.smegmatis_MC2_155 AVGACVRGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGLSLP ***** ****.* *** *****************************:*** Mb0195c|M.bovis_AF2122/97 GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM Rv0189c|M.tuberculosis_H37Rv GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM MLBr_02608|M.leprae_Br4923 GSAAPPATDRRRDGFARRSGQAVIELLRRGITARDILTKEAFENAIAVVM MMAR_0432|M.marinum_M GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM MUL_1082|M.ulcerans_Agy99 GSAAPPATDRRRDGFARQSGQAVIELLRQGITARDIMTREAFENAIAVVM MAV_4989|M.avium_104 GSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVM TH_0983|M.thermoresistible__bu GSAAPPATDRRRDGFARKSGQAVVELLRRGITARDILTKEAFENAIAVVM Mvan_0173|M.vanbaalenii_PYR-1 GSAAPPATDRRRDGFARKSGMAVVELLRRGITARDILTKEAFENAIAVVM Mflv_0486|M.gilvum_PYR-GCK GSASPVAIDKRRDDFARRSGEAVVEMLRRGITARDILTKEAFENAIAVVM MAB_4545|M.abscessus_ATCC_1997 GSASPVAIDKRREEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVM MSMEG_0229|M.smegmatis_MC2_155 GSASPVAIDKRRDEFARRSGEAVVDMLRRGITARDILTKEAFENAIAVVM ***:* * *:**: :**:** **:::**:*******:*:*********** Mb0195c|M.bovis_AF2122/97 AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS Rv0189c|M.tuberculosis_H37Rv AFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVMS MLBr_02608|M.leprae_Br4923 AFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGRHVMF MMAR_0432|M.marinum_M AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS MUL_1082|M.ulcerans_Agy99 AFGGSTNAVLHLLAIAHEANVELTLDDFSRIGSKVPHLADVKPFGRHVMS MAV_4989|M.avium_104 AFGGSTNAVLHLLAIAHEADVALSLDDFSRIGSKVPHLADVKPFGRHVMT TH_0983|M.thermoresistible__bu AFGGSTNAVLHLLAIAHEANVKLTLEDFTRIGNKVPHLADVKPFGAHVMF Mvan_0173|M.vanbaalenii_PYR-1 AFGGSTNAVLHLLAIAYEANVKLTLEDFTRVGAKVPHLADVKPFGAYVMN Mflv_0486|M.gilvum_PYR-GCK AFGGSTNAVLHLLAIAWEAQVELTLADFTRIGQKVPHLADVKPFGAYVMK MAB_4545|M.abscessus_ATCC_1997 AFGGSTNAVLHLLAIAKEAEVELSLADFTRIGNKVPHLADVKPFGRHVMK MSMEG_0229|M.smegmatis_MC2_155 AFGGSTNAVLHLLAIAREAEVELTLDDFTRVGSKVPHLADVKPFGRHVMK ********:******* **:* *:* **:*:* ***:******* :** Mb0195c|M.bovis_AF2122/97 DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL Rv0189c|M.tuberculosis_H37Rv DVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVL MLBr_02608|M.leprae_Br4923 DVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVI MMAR_0432|M.marinum_M HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL MUL_1082|M.ulcerans_Agy99 HVDHIGGVPVVMKTLLDAGLLHGDCLTVTGRTVAENLEAIAPPDPDGKVL MAV_4989|M.avium_104 DVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKVL TH_0983|M.thermoresistible__bu DVDHIGGVPVIMKTLLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL Mvan_0173|M.vanbaalenii_PYR-1 DVDRIGGVPVVMKALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL Mflv_0486|M.gilvum_PYR-GCK HVDEIGGVPVVMRALLDAGLLHGDCLTVTGQTMAENLAHIEPPDPDGKVL MAB_4545|M.abscessus_ATCC_1997 DVDEIGGVPVVMRALLDAGLLHGDCLTVTGKTMAENLAHIAPPDPDGKVL MSMEG_0229|M.smegmatis_MC2_155 HVDEIGGVPVVMRALLDAGLLNGECLTVTGKTMAENLAHIAPPDPDGKVL .**.******:*::*******:*:****** *:*:** * ******:*: Mb0195c|M.bovis_AF2122/97 RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA Rv0189c|M.tuberculosis_H37Rv RALANPIHPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAA MLBr_02608|M.leprae_Br4923 RTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDVFEGTARVFDGERAA MMAR_0432|M.marinum_M RALNNPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA MUL_1082|M.ulcerans_Agy99 RALINPIHATGGITILRGSLAPEGAVVKTAGLDTDVFEGTARVFDGERAA MAV_4989|M.avium_104 RALSDPLHPTGGITILRGSLAPEGAVVKSAGFDSDVFEGTARVFDGERAA TH_0983|M.thermoresistible__bu RALSNPIHPTGGITILHGSLAPEGAVVKSAGFDTSVFEGTARVFDRERAA Mvan_0173|M.vanbaalenii_PYR-1 RALSRPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA Mflv_0486|M.gilvum_PYR-GCK RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAA MAB_4545|M.abscessus_ATCC_1997 RAMNDPIHPTGGITILHGSLAPEGAVVKSAGFESDVFEGTARVFERERAA MSMEG_0229|M.smegmatis_MC2_155 RAMNNPIHPTGGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFDRERAA *:: *:*.:******:*****:*****:**:::.*********: **** Mb0195c|M.bovis_AF2122/97 LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL Rv0189c|M.tuberculosis_H37Rv LDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL MLBr_02608|M.leprae_Br4923 LDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL MMAR_0432|M.marinum_M LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL MUL_1082|M.ulcerans_Agy99 LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL MAV_4989|M.avium_104 LDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL TH_0983|M.thermoresistible__bu MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLL Mvan_0173|M.vanbaalenii_PYR-1 LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM Mflv_0486|M.gilvum_PYR-GCK LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM MAB_4545|M.abscessus_ATCC_1997 LDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM MSMEG_0229|M.smegmatis_MC2_155 MDALEDGTIQAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLM :***:**** **.***********************************: Mb0195c|M.bovis_AF2122/97 TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD Rv0189c|M.tuberculosis_H37Rv TDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLAD MLBr_02608|M.leprae_Br4923 TDGRFSGGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVD MMAR_0432|M.marinum_M TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD MUL_1082|M.ulcerans_Agy99 TDGRFSGGTTGFCVGHIAPEAVDAGPIAFVRDGDRIRLDVAGRTLDVLTD MAV_4989|M.avium_104 TDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVD TH_0983|M.thermoresistible__bu TDGRFSGGTTGLCVGHVAPEAVDGGPIAFLRDGDRIRLDVAKGTLDVLVD Mvan_0173|M.vanbaalenii_PYR-1 TDGRFSGGTTGLCVGHIAPEAVDGGPIAFIKDGDKIRLDVAKGTLDVVVD Mflv_0486|M.gilvum_PYR-GCK TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGTLDILVD MAB_4545|M.abscessus_ATCC_1997 TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVANGKLDLLVD MSMEG_0229|M.smegmatis_MC2_155 TDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDVLVD ***********:****:*****:.****::::**:: ***. **::.* Mb0195c|M.bovis_AF2122/97 PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG Rv0189c|M.tuberculosis_H37Rv PAEFASRQQDFSPPPPRYTTGVLSKYVKLVSSAAVGAVCG MLBr_02608|M.leprae_Br4923 PVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVGAVCG MMAR_0432|M.marinum_M PAEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG MUL_1082|M.ulcerans_Agy99 PPEFAARQQNFTPPAPRYKTGVLAKYVKLVGSAAIGAVCG MAV_4989|M.avium_104 PAEFDSRRTAFTPPPPRYKTGVLAKYVKLVGSAAIGAVCG TH_0983|M.thermoresistible__bu PAEFEARKKDWEPLPPRYTTGVLAKYTKLVGSAATGAVCT Mvan_0173|M.vanbaalenii_PYR-1 KDEFEARKVGFEPLPPVYTTGVLAKYTKLVGSAATGAVCT Mflv_0486|M.gilvum_PYR-GCK EAEFESRKAGFEPLPPVYTTGVLAKYTKLVGSAAVGAVCS MAB_4545|M.abscessus_ATCC_1997 EAEIAERRKGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCG MSMEG_0229|M.smegmatis_MC2_155 EEEFEARKAGFEPLPPRYKTGVLAKYTKLVQSAAVGAVCT *: *: : * .* *.****:**.*** **: ****