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MGDHRLPVVADVDVAVVGAGAAGVAAATVAAEAGLSVVVVEKYGFAGGAAVAGMSGTICGMYLASDSASR PERVVHGFTERFAGELTVRGGLTAPQRYGKTFTVAHDPLVWREVADDLMTAAGVRILYHTQVIDVLIEGD DYQGLVLASNAGVGVVRAARIIDASGDGAVVARAGGGYRFGDHGRIQNPTMFFRLGNVDLHAFWSAWGPN TISPQWVSDAIEQARTAGLDLPRNKIWIFDTTRPGELLVNATRLTAPDGRMLNVIDPADFTIAEVEGRRQ VRAYARFLAENVPGCGHAFVVDTGVEAGIRQTRTVDCIETLRDGDVVDGAKRDDSICRSPWPIELHDGEK PKLHWLLDDYYDVPYGALVPQRGENIIVAGRCLSAEHQALASARVTAQCFEYGHAAAVATALSLDRGTAY RDLDPAGIQARMIASGSALRTPQRQDVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0481 | - | - | 100% (448) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3987 | - | e-160 | 64.75% (434) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_1153 | - | 8e-41 | 27.95% (458) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 1e-06 | 54.17% (48) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1519 | - | 2e-05 | 50.00% (46) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv3537 | - | 2e-06 | 54.17% (48) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1646c | - | 4e-05 | 28.41% (176) | hypothetical protein MAB_1646c |
| M. marinum M | MMAR_5024 | - | 5e-06 | 32.46% (114) | dehydrogenase |
| M. avium 104 | MAV_2953 | - | 1e-05 | 27.73% (119) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_2036 | - | 4e-05 | 39.24% (79) | POSSIBLE ALANINE RICH DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_4098 | - | 3e-06 | 32.46% (114) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1580 | - | 3e-06 | 43.48% (69) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5024|M.marinum_M ---MFYMTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGST
MUL_4098|M.ulcerans_Agy99 ------MTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGST
Mb3567|M.bovis_AF2122/97 ------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGST
Rv3537|M.tuberculosis_H37Rv ------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGST
Mflv_1519|M.gilvum_PYR-GCK ------MAQQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGST
MAV_2953|M.avium_104 -----MTWDRSVDMLIAGSGGGGMVAGLAALDSGLEPLIVEKQSLVGGST
MSMEG_0481|M.smegmatis_MC2_155 MGDHRLPVVADVDVAVVGAGAAGVAAATVAAEAGLSVVVVEKYGFAGGAA
MAB_1646c|M.abscessus_ATCC_199 --MIKPELPQGTTCAIAGGGPAGMMLALLLARAGIDVTVLEKHPDFLRDF
TH_2036|M.thermoresistible__bu -----------MDVTVVGSGPNGLAAAVTCARAGLSVQVLEAQPTAGGGA
Mvan_1580|M.vanbaalenii_PYR-1 -------------MVVVGGGIAGLAAATGLAERGVAVEVIEKHGYLGGRV
:.*.* *: . *: ::*
MMAR_5024|M.marinum_M ARSGG----GVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPE
MUL_4098|M.ulcerans_Agy99 ARSGG----GVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPE
Mb3567|M.bovis_AF2122/97 ARSGG----GVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPE
Rv3537|M.tuberculosis_H37Rv ARSGG----GVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPE
Mflv_1519|M.gilvum_PYR-GCK ARSGG----GVWIPNNEVLKRDGVKDTTEAARTYLHSIVG----DAVPAE
MAV_2953|M.avium_104 GLSGG----IVWLPNNPLMRAEGVADSHQDGLAYLADVVGDIG-AASSPE
MSMEG_0481|M.smegmatis_MC2_155 VAGMSGTICGMYLASDSASRPERVVHGFTERFAGELTVRG----GLTAPQ
MAB_1646c|M.abscessus_ATCC_199 RGDT------VHASTLNLIDELGLGPRFAAMPHNLVEQVTVDLGEQTFRL
TH_2036|M.thermoresistible__bu RTTADPEFEGIVHDVCSAVHPMALASPFMAEFDLPARGVR----LQVPAI
Mvan_1580|M.vanbaalenii_PYR-1 GGWSD-----TLADGTPVAMNRGFHAFFRQYYNLRALLRRSDPGLSALTP
.
MMAR_5024|M.marinum_M RIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYPEAPGGRSGGRSIEPK
MUL_4098|M.ulcerans_Agy99 RIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDYYSEAPGGRSGGRSIEPK
Mb3567|M.bovis_AF2122/97 RIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPK
Rv3537|M.tuberculosis_H37Rv RIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPK
Mflv_1519|M.gilvum_PYR-GCK KIDTYLDRGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPK
MAV_2953|M.avium_104 RREMFLTAGHEMLNFLTRRG-VALIRCAGWSDYYPNHKGGNASGRAVEAV
MSMEG_0481|M.smegmatis_MC2_155 RYGKTFTVAHDPLVWR----------------------------------
MAB_1646c|M.abscessus_ATCC_199 GDLNRLPGPHKHIAMAP---------------------------------
TH_2036|M.thermoresistible__bu SYANPLLDRPAAVAYRDLDR---------TCAELVNGHSWRRLFGPLTAR
Mvan_1580|M.vanbaalenii_PYR-1 VEDYPLIDGAGRRDTFRG--------------------------------
:
MMAR_5024|M.marinum_M PFDARKLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMK
MUL_4098|M.ulcerans_Agy99 PFDARKLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMK
Mb3567|M.bovis_AF2122/97 PFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMK
Rv3537|M.tuberculosis_H37Rv PFNARKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMK
Mflv_1519|M.gilvum_PYR-GCK PFNAKKLGPDEKGLEPPYGKVPLNMVVMQQDYVRLNQLKRHPRGVLRSLK
MAV_2953|M.avium_104 PFDAAKLGSWSGRVQPPLARN-YGYVVLTNELRSVQYFNRSARTFAVAAR
MSMEG_0481|M.smegmatis_MC2_155 --EVADDLMTAAGVRILYHTQVIDVLIEGDDYQGLVLASNAGVGVVRAAR
MAB_1646c|M.abscessus_ATCC_199 QWDFLEMLATAAETEPTFRLR------RSTEVTGLLRSGDRITGIEYRTA
TH_2036|M.thermoresistible__bu DDGVLDLVMGDKRSIPSDPIAALQLGMRMLAQGSAAWGSLSGSDARALFS
Mvan_1580|M.vanbaalenii_PYR-1 --LPQTPPLNALAFALRSPTFRLRDLVRLDAKAAAPLAAVSVPETYDLLD
MMAR_5024|M.marinum_M VGARTMWAKATGKNLVGMGRALIGPLR---IGLQRKGVPVQLNTALTDLY
MUL_4098|M.ulcerans_Agy99 VGARTMWAKATGKNLVGMGRALIGPLR---IGLQRKGVPVQLNTALTDLY
Mb3567|M.bovis_AF2122/97 VGARTMWAKATGKNLVGMGRALIGPLR---IGLQRAGVPVELNTAFTDLF
Rv3537|M.tuberculosis_H37Rv VGARTMWAKATGKNLVGMGRALIGPLR---IGLQRAGVPVELNTAFTDLF
Mflv_1519|M.gilvum_PYR-GCK VGVRSVWANATGKNLVGMGRALIAPLR---IGLQKAGVPVLLNTALTDLH
MAV_2953|M.avium_104 VFARTAAARMRRRQLLTNGASLIAHMLKALLDLSDGQPPLWTDAALTELV
MSMEG_0481|M.smegmatis_MC2_155 IIDASGDGAVVAR--AGGGYRFGDHGR-----IQN---------------
MAB_1646c|M.abscessus_ATCC_199 SGETGALKADLTVACDGRGSALRAAAG-----------------------
TH_2036|M.thermoresistible__bu GVAGHAISRMPSLISAGAGLLLATLAHTVGWPIPIGGSQRITDALIADLT
Mvan_1580|M.vanbaalenii_PYR-1 GRDAETFLRDINFPEAARHLAFEVFAR-----------------------
:
MMAR_5024|M.marinum_M LEDGMVRGIYVRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRVKYQR
MUL_4098|M.ulcerans_Agy99 LEDGVVRGIYVRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRVKYQR
Mb3567|M.bovis_AF2122/97 VENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQR
Rv3537|M.tuberculosis_H37Rv VENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQR
Mflv_1519|M.gilvum_PYR-GCK VEDGVVTGIYVVATGDSVNAEPQLIRARRAVILGSGGFEHNEQMRVKYQR
MAV_2953|M.avium_104 VEDGRVVGACIVRDGRACAVE-----ARKGVLLAAGGFGHNKQMRRRYSG
MSMEG_0481|M.smegmatis_MC2_155 ----------------------------PTMFFRLGNVDLHAFWSAWGPN
MAB_1646c|M.abscessus_ATCC_199 ----------------------------------MRPRQFGVPIDIWWFR
TH_2036|M.thermoresistible__bu AHGG----------------------ELRVGEPVTRPPEGVVIYDTAPTA
Mvan_1580|M.vanbaalenii_PYR-1 --------------------------SFFARPETLSAGELVTMFHIYFLG
MMAR_5024|M.marinum_M -APITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWF
MUL_4098|M.ulcerans_Agy99 -APITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWF
Mb3567|M.bovis_AF2122/97 -APITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWF
Rv3537|M.tuberculosis_H37Rv -APITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWF
Mflv_1519|M.gilvum_PYR-GCK -APITTEWTVGAVANTGDGILAAEKLGAALEIMEDAWWGPTVPLEGAPWF
MAV_2953|M.avium_104 DQPNEGQWSIANAGDTGEVLEAAMRLGAKTDLMDEAWWLPSVFIANGGAV
MSMEG_0481|M.smegmatis_MC2_155 --TISPQWVSDAIEQART---------AGLDLPRNKIWIFDTTRPGELLV
MAB_1646c|M.abscessus_ATCC_199 -LPKHPDDPQGPRARVGAN--------RFMVLLDRGDYFQCGYLIGKGTD
TH_2036|M.thermoresistible__bu LLDIYGDALPARYARALRRYRFGPGVAKVDFVLSDEIPWQDPRLANAPTL
Mvan_1580|M.vanbaalenii_PYR-1 SSEGLIFDVANANFDVALWNPLRRYLEGRGVVFHTGAEVDSVTVADEVTV
. : .
MMAR_5024|M.marinum_M ALSE---RNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGE
MUL_4098|M.ulcerans_Agy99 ALSE---RNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGE
Mb3567|M.bovis_AF2122/97 ALSE---RNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGE
Rv3537|M.tuberculosis_H37Rv ALSE---RNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGE
Mflv_1519|M.gilvum_PYR-GCK ALSE---RNSPGSIIVNMAGKRFMNESMPYVEACHHMYGGQYGQGPGPGE
MAV_2953|M.avium_104 AASLGSGRQRPGAIYVDSTGRRFCNESNSYVEVGKAMY---------ANK
MSMEG_0481|M.smegmatis_MC2_155 NATR---LTAPDGRMLNVIDP--ADFTIAEVEGRRQVR------------
MAB_1646c|M.abscessus_ATCC_199 SQMR--------SGDVQVLRDRVAEMAPWLAARTNAIAS-----------
TH_2036|M.thermoresistible__bu HLGGS--REQMAHAEREIFADRHAEWPMTLASLPHLVDP-------GRVD
Mvan_1580|M.vanbaalenii_PYR-1 TGSR----AQVWSADAAVLATDPGSLRRVVAASPGLGDPS----WRERVA
. .
MMAR_5024|M.marinum_M NIPAWLVFDQRYRDRYIFAG-----LQPGQRIPRKWLDSGVIVMADTLEE
MUL_4098|M.ulcerans_Agy99 NIPAWLVFDQRYRDRYIFAG-----LQPGQRIPRKWLDSGVIVMADTLEE
Mb3567|M.bovis_AF2122/97 NIPAWLVFDQRYRDRYIFAG-----LQPGQRIPSRWLDSGVIVQADTLAE
Rv3537|M.tuberculosis_H37Rv NIPAWLVFDQRYRDRYIFAG-----LQPGQRIPSRWLDSGVIVQADTLAE
Mflv_1519|M.gilvum_PYR-GCK NIPAWLIFDQQYRDRYIFAG-----LQPGQRIPSKWLESGVIVKADTLDE
MAV_2953|M.avium_104 AVPCWMIFDDGYVRRYVTSANPLKTLRRHQPLPAELIESGAVKRAATIAG
MSMEG_0481|M.smegmatis_MC2_155 ------AYARFLAENVPGCG------------HAFVVDTGVEAGIRQTRT
MAB_1646c|M.abscessus_ATCC_199 -------WDDVKLLDIQLNR------------LRKWYRDGLLFIGDAAHA
TH_2036|M.thermoresistible__bu GQGRRPLWSYVHVPAHSPVD-----------QTESVIKIFERFAPGFRDI
Mvan_1580|M.vanbaalenii_PYR-1 AIGTAPPFVVLRLWLDRPVR----------HDRAAFVGTGGRDPLDNISV
:
MMAR_5024|M.marinum_M LAAKAGLPVDELTST-VSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKP
MUL_4098|M.ulcerans_Agy99 LAAKAGLPVDELTST-VSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKP
Mb3567|M.bovis_AF2122/97 LAGKAGLPADELTAT-VQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKP
Rv3537|M.tuberculosis_H37Rv LAGKAGLPADELTAT-VQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKP
Mflv_1519|M.gilvum_PYR-GCK LAARTGLPTDAFKAT-VDRFNGFARSGRDEDFKRGESAYDRYYGDPTNKP
MAV_2953|M.avium_104 LAGETDLPADELARS-VERFNRFAAKGLDPDFGRGQSAYNDCLGDPGYRP
MSMEG_0481|M.smegmatis_MC2_155 VDCIETLRDGDVVDG-AKRDDSICRSPWPIELHDGE----------KPKL
MAB_1646c|M.abscessus_ATCC_199 MSPVGGVGINLAIAD-AVATARILAEPLR----------------TGTLT
TH_2036|M.thermoresistible__bu VVAARCVPAARLADDNANYVGGDIAVGGNDTWRALAGPTPRLNPWSTPIP
Mvan_1580|M.vanbaalenii_PYR-1 LERYEREAAQWCSRTGGSVVELHAYSVRDEDADVRDRLIARMHELYPETA
:
MMAR_5024|M.marinum_M NP-NLGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYA
MUL_4098|M.ulcerans_Agy99 NP-NLGEINHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYA
Mb3567|M.bovis_AF2122/97 NP-NLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYA
Rv3537|M.tuberculosis_H37Rv NP-NLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYA
Mflv_1519|M.gilvum_PYR-GCK NP-NLGEITQGPFYAAKMVPGDLGTKGGIRTDVHGRALRDDGSVIEGLYA
MAV_2953|M.avium_104 NA-AIGPLDTAPYYATRVFPADVGTCGGVITNEYAQVLDQHDRVIEGLYA
MSMEG_0481|M.smegmatis_MC2_155 HW-LLDDYYDVPYGALVPQRGENIIVAGRCLSAEHQALAS-ARVTAQCFE
MAB_1646c|M.abscessus_ATCC_199 TA-DLRKVQLRRWVPTALIQR-------IQRAVHRRVFSAVDSSTTAASN
TH_2036|M.thermoresistible__bu RA-YQCSSATPPGPGVHGLAGYYAARTVLRREFGXXXGTATSSRTPTTYS
Mvan_1580|M.vanbaalenii_PYR-1 TASIVAERLLRRDDCPRFAPGDFADRPTVSTPDPRLKLAGDGIRIDLPVA
MMAR_5024|M.marinum_M AG-NVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIAGDR-----------
MUL_4098|M.ulcerans_Agy99 AG-NVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIAGDR-----------
Mb3567|M.bovis_AF2122/97 AG-NVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR--------
Rv3537|M.tuberculosis_H37Rv AG-NVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR--------
Mflv_1519|M.gilvum_PYR-GCK AG-NVSSPVMGHTYPGPGGTIGPAMTFGYLAALHIAGAAPAATSSSGKG-
MAV_2953|M.avium_104 TG-NTTATVMGRTYPGAGASIANSMVFGYVAARHAAGRRIAGTPPRAIAG
MSMEG_0481|M.smegmatis_MC2_155 YG-HAAAVATALSLDR-GTAYRDLDPAGIQARMIASGSALRTPQRQDVP-
MAB_1646c|M.abscessus_ATCC_199 AK-IASVLSIATKYPWLQAVPAYGVAIGPLPEHAPDFARRSPID------
TH_2036|M.thermoresistible__bu ARRSEFGASYRRRFFALASFLRRGLLIAPTNSLVCNIEGRDRRELDR---
Mvan_1580|M.vanbaalenii_PYR-1 LMERAATTGWTAANELLTGFGLAGHTLHTVPNRGRSAVLRRLATSAGGVR
MMAR_5024|M.marinum_M --------
MUL_4098|M.ulcerans_Agy99 --------
Mb3567|M.bovis_AF2122/97 --------
Rv3537|M.tuberculosis_H37Rv --------
Mflv_1519|M.gilvum_PYR-GCK --------
MAV_2953|M.avium_104 VPPRRVCD
MSMEG_0481|M.smegmatis_MC2_155 --------
MAB_1646c|M.abscessus_ATCC_199 --------
TH_2036|M.thermoresistible__bu --------
Mvan_1580|M.vanbaalenii_PYR-1 --------