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MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARSGGGVWIPNNEVLKRRGVRDTPEA ARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNA RKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIG PLRIGLQRAGVPVELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIK YQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSIIVNMSGK RFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGVIVQAD TLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKM VPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQA GKR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3537 | - | - | 100% (563) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv1817 | - | 3e-27 | 25.66% (565) | hypothetical protein Rv1817 |
| M. tuberculosis H37Rv | Rv0785 | - | 5e-07 | 40.30% (67) | putative FAD-binding dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 0.0 | 100.00% (563) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1519 | - | 0.0 | 83.39% (560) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | MLBr_02387 | lpd | 6e-05 | 51.06% (47) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0622c | - | 0.0 | 77.92% (557) | 3-ketosteroid-delta-1-dehydrogenase |
| M. marinum M | MMAR_5024 | - | 0.0 | 87.88% (561) | dehydrogenase |
| M. avium 104 | MAV_0624 | - | 0.0 | 89.09% (559) | 3-ketosteroid-delta-1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5941 | - | 0.0 | 82.86% (560) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_0368 | - | 0.0 | 82.73% (527) | PROBABLE DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_4098 | - | 0.0 | 87.88% (561) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5237 | - | 0.0 | 83.66% (557) | 3-ketosteroid-delta-1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3537|M.tuberculosis_H37Rv ---MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARS
Mb3567|M.bovis_AF2122/97 ---MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARS
MMAR_5024|M.marinum_M MFYMTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGSTARS
MUL_4098|M.ulcerans_Agy99 ---MTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGSTARS
MAV_0624|M.avium_104 ---MSAQEYDVVVVGSGGAGMVAALTAAHRGLSTIVIEKAPHFGGSTARS
MSMEG_5941|M.smegmatis_MC2_155 ---MTGQEYDVVVVGSGAAGMVAALTAAHQGLSTVVVEKAPHYGGSTARS
Mvan_5237|M.vanbaalenii_PYR-1 ---MTEQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGSTARS
Mflv_1519|M.gilvum_PYR-GCK ---MAQQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGSTARS
TH_0368|M.thermoresistible__bu ------------------------------------VEKAPHYGGSTARS
MAB_0622c|M.abscessus_ATCC_199 ---MTEQEYDVVVVGSGGAGMVAALTAAHNGLSTVLIEKAPHFGGSTARS
MLBr_02387|M.leprae_Br4923 -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPK-YWGGICLNV
:* ::** .
Rv3537|M.tuberculosis_H37Rv GGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPERIDAYLD
Mb3567|M.bovis_AF2122/97 GGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPERIDAYLD
MMAR_5024|M.marinum_M GGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPERIDTYLE
MUL_4098|M.ulcerans_Agy99 GGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPERIDTYLE
MAV_0624|M.avium_104 GGGVWIPNNEVLKRDGVKDTPEAARTYLHGIIG----DVVEPERIDTYLE
MSMEG_5941|M.smegmatis_MC2_155 GGGVWIPNNEILKRDGVKDTPDEARKYLHAIIG----DVVPAEKIDTYLD
Mvan_5237|M.vanbaalenii_PYR-1 GGGVWIPNNEVLKRDGVKDTADAARTYLHAIIG----DVVPAEKIDTYLQ
Mflv_1519|M.gilvum_PYR-GCK GGGVWIPNNEVLKRDGVKDTTEAARTYLHSIVG----DAVPAEKIDTYLD
TH_0368|M.thermoresistible__bu GGGVWIPNNEVLKRDGVTDTPEEARRYLHAIVG----DVVPAEKIDTYLD
MAB_0622c|M.abscessus_ATCC_199 GGGVWIPNNEVLKKARQTDTPEAAREYLYSIIG----DVVPREKIDTYLD
MLBr_02387|M.leprae_Br4923 G---CIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSRKVSE
* **.: :*:. . : . : :: :
Rv3537|M.tuberculosis_H37Rv RGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKL
Mb3567|M.bovis_AF2122/97 RGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKL
MMAR_5024|M.marinum_M RGPEMLSFVLEHTPLKMCWVPGYSDYYPEAPGGRSGGRSIEPKPFDARKL
MUL_4098|M.ulcerans_Agy99 RGPEMLSFVLEHTPLKMCWVPGYSDYYSEAPGGRSGGRSIEPKPFDARKL
MAV_0624|M.avium_104 RGPEMLSFVLKHTPLKMCWVPRYSDYYPESPGGRAEGRSIEPKPFNARKL
MSMEG_5941|M.smegmatis_MC2_155 RGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPKPFDANKL
Mvan_5237|M.vanbaalenii_PYR-1 RGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKATGRSVEPKPFDAKKL
Mflv_1519|M.gilvum_PYR-GCK RGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPKPFNAKKL
TH_0368|M.thermoresistible__bu RGPEMLSFVLKHTPLKLCWVPGYSDYYPETPGGKPTGRSVEPRPFDAKKL
MAB_0622c|M.abscessus_ATCC_199 RGPEMLSFVLANSPLKLDWVPNYSDYYPEAPGGRAAGRSVEPKPFDAKKL
MLBr_02387|M.leprae_Br4923 GRVAGVHFLMKKN--KITEIHGYGRFTDANTLSVELSEGVPETPL-----
: *:: :. *: : *. : . . ...: *:
Rv3537|M.tuberculosis_H37Rv GADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
Mb3567|M.bovis_AF2122/97 GADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
MMAR_5024|M.marinum_M GADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
MUL_4098|M.ulcerans_Agy99 GADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
MAV_0624|M.avium_104 GPDEAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSLKVGARTMW
MSMEG_5941|M.smegmatis_MC2_155 GPDLKGLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLKVGIRATW
Mvan_5237|M.vanbaalenii_PYR-1 GEDLPGLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLRVGIRSVW
Mflv_1519|M.gilvum_PYR-GCK GPDEKGLEPPYGKVPLNMVVMQQDYVRLNQLKRHPRGVLRSLKVGVRSVW
TH_0368|M.thermoresistible__bu GPDMDTLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLKVGIRSMW
MAB_0622c|M.abscessus_ATCC_199 GDELPNLEPPYGKVPLNVVVRQQDYVRLNQLKRHPRGVLRSLRVGVRTFW
MLBr_02387|M.leprae_Br4923 ------------KVTFNNVIIATG--------SKTRLVPGTLLSTNVITY
*:.:* *: . :.* * :: :
Rv3537|M.tuberculosis_H37Rv AKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSGVY
Mb3567|M.bovis_AF2122/97 AKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSGVY
MMAR_5024|M.marinum_M AKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALTDLYLEDGMVRGIY
MUL_4098|M.ulcerans_Agy99 AKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALTDLYLEDGVVRGIY
MAV_0624|M.avium_104 AKATGKNLVGMGRALIGPLRIGLQRAGVPVVLNTALTDLYLEDGVVRGVY
MSMEG_5941|M.smegmatis_MC2_155 GKVSGKNLVGMGRALIAPLRIGLREAGVPVLLNTALTDLYVEDGRVLGIY
Mvan_5237|M.vanbaalenii_PYR-1 ANTTGKNLVGMGRALIAPLRIGLREAGVPVRLNTAMTDLYVEDGVVRGIY
Mflv_1519|M.gilvum_PYR-GCK ANATGKNLVGMGRALIAPLRIGLQKAGVPVLLNTALTDLHVEDGVVTGIY
TH_0368|M.thermoresistible__bu ANATGKNLVGMGRALIAPLRIGLREAGVPLLLNTAMTDLYVEDGVVRGIY
MAB_0622c|M.abscessus_ATCC_199 AQGTGKKLVGMGRALSAALRIGLRDAGVPVKLNTALTDLYIEDGTVRGVY
MLBr_02387|M.leprae_Br4923 EEQILTRELPDSIVIVGAGAIGIEFG---YVLKNYGVDVTIVEFLPRAMP
: .. : . .: .. **:. *:. .*: : : .:
Rv3537|M.tuberculosis_H37Rv VRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVG
Mb3567|M.bovis_AF2122/97 VRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVG
MMAR_5024|M.marinum_M VRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRVKYQRAPITTDWTVG
MUL_4098|M.ulcerans_Agy99 VRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRVKYQRAPITTDWTVG
MAV_0624|M.avium_104 VRDSQAAESAEPRLIRARRGVILASGGFEHNEQMRVKYQRAPITTEWTVG
MSMEG_5941|M.smegmatis_MC2_155 VRDTTAGDDAEPRLIRARHGVILGSGGFEHNEQMRVKYQRAPITTEWTVG
Mvan_5237|M.vanbaalenii_PYR-1 VRDTTAPESAEPQLIRARRGVILGSGGFEHNEQMRVKYQRAPITTEWTVG
Mflv_1519|M.gilvum_PYR-GCK VVATGDSVNAEPQLIRARRAVILGSGGFEHNEQMRVKYQRAPITTEWTVG
TH_0368|M.thermoresistible__bu VVDARDPESAEPRLIRARRGVILGSGGFEHNEQMRVKYQRPPITTEWTVG
MAB_0622c|M.abscessus_ATCC_199 VRETGAPEASEPTLIRGRRGVILASGGFEHNEQMRVKYQRAPITTEWTVG
MLBr_02387|M.leprae_Br4923 NEDAEVSKEIEKQFKKMGIKILTG----TKVESISDNGSHVLVAVSKDGQ
: * : : :: . : *.: : .: ::..
Rv3537|M.tuberculosis_H37Rv ASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSI
Mb3567|M.bovis_AF2122/97 ASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSI
MMAR_5024|M.marinum_M AKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWFALSERNSPGSI
MUL_4098|M.ulcerans_Agy99 AKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWFALSERNSPGSI
MAV_0624|M.avium_104 AKANTGDGILAAEKLGAALELMEDAWWGPTVPLVGAPWFALSERNSPGSI
MSMEG_5941|M.smegmatis_MC2_155 AVANTGDGIVAAEKLGAALELMEDAWWGPTVPLVGAPWFALSERNSPGSI
Mvan_5237|M.vanbaalenii_PYR-1 AKANTGDGILAAEKLGAALDVMEDAWWGPTVPLVDAPWFALSERNSPGSI
Mflv_1519|M.gilvum_PYR-GCK AVANTGDGILAAEKLGAALEIMEDAWWGPTVPLEGAPWFALSERNSPGSI
TH_0368|M.thermoresistible__bu AKANTGDGILAAEKLGAALEIMEDAWWGPTIPLPGAPWFALSERNSPGSI
MAB_0622c|M.abscessus_ATCC_199 AKANTGDGILAAEKLGAALEFMEDSWWGPTVPLVGRPWFALSERNSPGSI
MLBr_02387|M.leprae_Br4923 FQELKADKVLQAIGFAPNVDGYGLDKVG--VALTADKAVDIDDYMQTNVS
..* :: * :.. :: * :.* . :.: ...
Rv3537|M.tuberculosis_H37Rv IVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRD
Mb3567|M.bovis_AF2122/97 IVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRD
MMAR_5024|M.marinum_M IVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRYRD
MUL_4098|M.ulcerans_Agy99 IVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRYRD
MAV_0624|M.avium_104 IVNMSGKRFMNESMPYVEACHHMYGGEYGQGPGPGENIPAWLVFDQQYRD
MSMEG_5941|M.smegmatis_MC2_155 IVNMSGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLIFDQQYRD
Mvan_5237|M.vanbaalenii_PYR-1 IVNMAGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRYRD
Mflv_1519|M.gilvum_PYR-GCK IVNMAGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLIFDQQYRD
TH_0368|M.thermoresistible__bu IVNMAGKRFMNESMPYVEACHHMYGGEYGQGPGPGENIPAWLIFDQRYRD
MAB_0622c|M.abscessus_ATCC_199 IVNSSGKRFMNESLPYVEATHRMYGGQYGQGPGPGENLPAWLVFDQEYRN
MLBr_02387|M.leprae_Br4923 HIYAIGDVTGKLQLAHVAEAQGVVAAEAIAG------AETLALSDYRMMP
: *. : .:.:* : : ..: * : : * .
Rv3537|M.tuberculosis_H37Rv RYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRF
Mb3567|M.bovis_AF2122/97 RYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRF
MMAR_5024|M.marinum_M RYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAGLPVDELTSTVSRF
MUL_4098|M.ulcerans_Agy99 RYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAGLPVDELTSTVSRF
MAV_0624|M.avium_104 RYIFAGLQPGQRIPRKWLESGVIIQAETLEELASKAGLPVDEFLATVQRF
MSMEG_5941|M.smegmatis_MC2_155 RYIFAGLQPGQRIPSKWLESGVIVKADTLVELAEKTGLPADQFTSTIERF
Mvan_5237|M.vanbaalenii_PYR-1 RYIFAGLQPGQRIPKKWLESGVIVKADTLEELAAKTGLPVDAFKTTVQRF
Mflv_1519|M.gilvum_PYR-GCK RYIFAGLQPGQRIPSKWLESGVIVKADTLDELAARTGLPTDAFKATVDRF
TH_0368|M.thermoresistible__bu RYLFAGLQPGQRIPKKWLDSGVIVKADTLAELAARIGVPEQDFLATVERF
MAB_0622c|M.abscessus_ATCC_199 RYIFAGLQPGQKIPSKWIESGVIVKADTIEELAKKANLPVEELRATIERF
MLBr_02387|M.leprae_Br4923 RATFCQPN-----VASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMGDP
* *. : : : :. : .. : :
Rv3537|M.tuberculosis_H37Rv NAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPG
Mb3567|M.bovis_AF2122/97 NAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPG
MMAR_5024|M.marinum_M NGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEINHAPYYAAKMVPG
MUL_4098|M.ulcerans_Agy99 NGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEINHAPYYAAKMVPG
MAV_0624|M.avium_104 NGFARTGIDEDYHRGESAYDRYYGDPTNKPNPNLGEISHPPYYAAKMVPG
MSMEG_5941|M.smegmatis_MC2_155 NGFARSGVDEDFHRGESAYDRYYGDPTNKPNPNLGEIKHGPFYAAKMVPG
Mvan_5237|M.vanbaalenii_PYR-1 NGFARSGVDEDFKRGESAYDRYYGDPTNKPNPNLGEISQGPFYAAKMVPG
Mflv_1519|M.gilvum_PYR-GCK NGFARSGRDEDFKRGESAYDRYYGDPTNKPNPNLGEITQGPFYAAKMVPG
TH_0368|M.thermoresistible__bu NGFARAGVDQDFRRGESAYDRYYGDPTNKPNPNLGEIDQAPFYAAKMVPG
MAB_0622c|M.abscessus_ATCC_199 NGFARSGVDEDFGRGKSAYDRYYGDPTNKPNPNLGALTKAPFYAAKMVPG
MLBr_02387|M.leprae_Br4923 SGFVKLVADAKY--GELLGGHMIGHNVSELLPELTLAQKWDLTATELVR-
..*.: * .: *: .: *. .: *:* : .:::*
Rv3537|M.tuberculosis_H37Rv DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
Mb3567|M.bovis_AF2122/97 DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
MMAR_5024|M.marinum_M DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
MUL_4098|M.ulcerans_Agy99 DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
MAV_0624|M.avium_104 DLGTKGGIRTDIHGRALRDDGSIIEGLYAAGNVSAPVMGHTYPGPGGTIG
MSMEG_5941|M.smegmatis_MC2_155 DLGTKGGIRTDVRGRALRDDDSVIEGLYAAGNVSSPVMGHTYPGPGGTIG
Mvan_5237|M.vanbaalenii_PYR-1 DLGTKGGIVTDVQGRALRDDGSIIEGLYAAGNASAPVMGHTYPGPGGTIG
Mflv_1519|M.gilvum_PYR-GCK DLGTKGGIRTDVHGRALRDDGSVIEGLYAAGNVSSPVMGHTYPGPGGTIG
TH_0368|M.thermoresistible__bu DLGTKGGIRTDVHGRALRDDGSVIDGLYAAGNVSSPVMGHTYPGPGGTIG
MAB_0622c|M.abscessus_ATCC_199 DLGTKGGVRTDVKGRVLRDDNSVIEGLYAAGNVSTPVMGHTYAGPGATIG
MLBr_02387|M.leprae_Br4923 -------------------------NVHTHPTLSEALQECFH----GLIG
.::: . * .: : . **
Rv3537|M.tuberculosis_H37Rv PAMTFGYLAALHIADQAGKR-------
Mb3567|M.bovis_AF2122/97 PAMTFGYLAALHIADQAGKR-------
MMAR_5024|M.marinum_M PAMTFGYLAALHIAGDR----------
MUL_4098|M.ulcerans_Agy99 PAMTFGYLAALHIAGDR----------
MAV_0624|M.avium_104 PAMTFGYLAALHIAGEN----------
MSMEG_5941|M.smegmatis_MC2_155 PAMTFGYLAALDIAATAAASRKG----
Mvan_5237|M.vanbaalenii_PYR-1 PAMTFGYLAALDIARKD----------
Mflv_1519|M.gilvum_PYR-GCK PAMTFGYLAALHIAGAAPAATSSSGKG
TH_0368|M.thermoresistible__bu PAMTFGYLAALHVAGAA-TATSDPGKS
MAB_0622c|M.abscessus_ATCC_199 PAMTWGYLAALDIAGK-----------
MLBr_02387|M.leprae_Br4923 HMINF----------------------
:.: