For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSSNAHNVAPAWALSAIYPLQNDLPVLAETDVLVVGAGASGVAAATTAAEAGKSVLIVEKYGFAGGAAVA GMSGTICGMYYATARPRQPEQVVYGFTERFRSALAARGGLTEPQLYGKTFTCAHDPHMWAEVADEFLENA GVRILFHTAVTGVVMDGDRYAGVVLESNAGRSVVLAQRTIDASGDAAVVSRANGAYYFGADGRIQNPTMF FRLADVDIDEFDEYYGQDTICPPKLTDMIEQERKAGANLPRSRIWVFRTPRRNELMVNATRVAGRDGRAL NVIDPEDFTEGEVVGRRQAREYADFFRKHVPGCASSYLEDTGTEVGVRQTRSIVGHETLRNDDVLQGRKR DDGICRVPWPIELHDSKGSNLHWLLDDYYEVPYLSLVPVAGENIIVAGRCLSAEHEALASARVTAQCFEY GHAAGVASVLSLDENLPYAKIDGRAVRNAMAANGSAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3987 | - | - | 100% (457) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_0481 | - | e-160 | 64.75% (434) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_1796 | - | 3e-41 | 28.48% (446) | membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1848 | - | 5e-05 | 39.71% (68) | hypothetical protein Mb1848 |
| M. gilvum PYR-GCK | Mflv_3157 | - | 2e-06 | 26.34% (205) | fumarate reductase/succinate dehydrogenase flavoprotein |
| M. tuberculosis H37Rv | Rv1817 | - | 5e-05 | 39.71% (68) | hypothetical protein Rv1817 |
| M. leprae Br4923 | MLBr_02276 | - | 3e-05 | 28.33% (180) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0623 | - | 2e-06 | 39.06% (64) | hypothetical protein MAB_0623 |
| M. marinum M | MMAR_0910 | - | 4e-05 | 26.23% (183) | FAD-linked oxidoreductase |
| M. avium 104 | MAV_3022 | - | 2e-05 | 42.86% (70) | hypothetical protein MAV_3022 |
| M. thermoresistible (build 8) | TH_3850 | - | 3e-05 | 51.06% (47) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0254 | - | 2e-05 | 47.73% (44) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1580 | - | 2e-05 | 51.11% (45) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1848|M.bovis_AF2122/97 ---------MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAA
Rv1817|M.tuberculosis_H37Rv ---------MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAA
MAV_3022|M.avium_104 ---------MNTDVTP-IPASSITSWDHEADVVIAGYGVAGAAAAVEAAR
MLBr_02276|M.leprae_Br4923 -------------------MRVETS----ADVVVVGAGPAGSAAATWAAR
MMAR_0910|M.marinum_M -------------------METRVPRALGADLVVVGAGPAGSAAAAWAAR
MAB_0623|M.abscessus_ATCC_1997 --------------------MPGRSDMPSADVIIVGYGVAGASAALAALE
TH_3850|M.thermoresistible__bu ----------------MRIPELSETVRFDTDVLVIGGGTAGTMAALTAAE
Mflv_3157|M.gilvum_PYR-GCK ------------------MTAAGDAATHVTDVLVIGGGPAATWAAIAAAE
MSMEG_3987|M.smegmatis_MC2_155 MSSNAHNVAPAWALSAIYPLQNDLPVLAETDVLVVGAGASGVAAATTAAE
Mvan_1580|M.vanbaalenii_PYR-1 -------------------------------MVVVGGGIAGLAAATGLAE
MUL_0254|M.ulcerans_Agy99 --------------------------MKEFDVVVVGGGHNGLVAAAYLAR
: : * * . **
Mb1848|M.bovis_AF2122/97 AGARVLVLERAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYL
Rv1817|M.tuberculosis_H37Rv AGARVLVLERAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYL
MAV_3022|M.avium_104 AGADVLVLERTGSWGGAAAMAGGFIYLGGGTPIQKACGFTDSVDNMAAFL
MLBr_02276|M.leprae_Br4923 AGNDVIVIDSVCFPR------------------DKACGDGLTPRAVAELK
MMAR_0910|M.marinum_M AGRDVLVIDSAGFPR------------------DKACGDGLTPRAIAELQ
MAB_0623|M.abscessus_ATCC_1997 RGASVIILERFDGGG-ASAISGGIYYAGGGTNIQRDAGVEDTPELMLEYL
TH_3850|M.thermoresistible__bu HGARVLLLEKA---------------------------------------
Mflv_3157|M.gilvum_PYR-GCK SGSRVTLVDKGYCGTSGATAAGGNNLWLIPPGPRRDESIREREAAAGGLT
MSMEG_3987|M.smegmatis_MC2_155 AGKSVLIVEKYGFAG------------------------GAAVAGMSGTI
Mvan_1580|M.vanbaalenii_PYR-1 RGVAVEVIEKHGYLG--GRVGGWSDTLADGTPVAMNRGFHAFFRQYYNLR
MUL_0254|M.ulcerans_Agy99 AGLRVRVLERLGYVG------------------GAAVSIQAFDGVEVRLS
* * :::
Mb1848|M.bovis_AF2122/97 -VAVSREPDHDKIRAYCDGSVEHFNW-LEGLGFQFERSYFPGKAVIQPNT
Rv1817|M.tuberculosis_H37Rv -VAVSREPDHDKIRAYCDGSVEHFNW-LEGLGFQFERSYFPGKAVIQPNT
MAV_3022|M.avium_104 NVAMGPGADADRIADYCAGSLAHFEW-LVGCGVPFKAEFFGEPGWEPMGD
MLBr_02276|M.leprae_Br4923 RLGLD---------DWLNTRIRHRGLRMSGFGGEVEVD-WPGPSFPSTSS
MMAR_0910|M.marinum_M QLGLG---------EWLAGRIQHRGLRMSGFGGEVEIG-WPGPSFPAYSS
MAB_0623|M.abscessus_ATCC_1997 RLEVGDAVKPETLQKFVDGSVDTLNW-LQGYGVPFEGSLAPFKTSYPTDD
TH_3850|M.thermoresistible__bu -------------------HVRHSGALAMGMDGVNNAGIVNQCTIYQTAT
Mflv_3157|M.gilvum_PYR-GCK DAEWMARVLSASWDRIEQLADWGYPFPTGDDGRQLRVSLQGPEYMRRMRR
MSMEG_3987|M.smegmatis_MC2_155 CGMYYATARPRQPEQVVYGFTERFRSALAARGGLTEPQLYGKTFTCAHDP
Mvan_1580|M.vanbaalenii_PYR-1 ALLRRSDPGLSALTPVEDYPLIDGAGRRDTFRGLPQTPPLNALAFALRSP
MUL_0254|M.ulcerans_Agy99 RYSYLVSLLPPQIIKDLGAPVRLARRQFSSYTPQPDTHGRSGLLIGTAGD
Mb1848|M.bovis_AF2122/97 EGLMFTGNEKVWPFLELAVPAPRGHKVPVP----------GDTGGAAMVI
Rv1817|M.tuberculosis_H37Rv EGLMFTGNEKVWPFLELAVPAPRGHKVPVP----------GDTGGAAMVI
MAV_3022|M.avium_104 QGLMYSGGENSYPFNTIASPAPRGHVPQMQNKK------QGEASAGYMLM
MLBr_02276|M.leprae_Br4923 AVPRLELDDRIR-----KVAENSGARMLLG-------------TKAVSVY
MMAR_0910|M.marinum_M AVARLELDDRIR-----KVAEESGARMLLG-------------TKAVAAH
MAB_0623|M.abscessus_ATCC_1997 YYLYFSGSESSGMARAATPPRQRGHRAFGR------------GVSGKALF
TH_3850|M.thermoresistible__bu R--------------------------------------------GFAMV
Mflv_3157|M.gilvum_PYR-GCK KAHRSGVRILDHHPATALTTDSDGIVNGATGIARQDAGRPWRIGAGAVVL
MSMEG_3987|M.smegmatis_MC2_155 HMWAEVADEFLENAGVRILFHTAVTGVVMD-----------GDRYAGVVL
Mvan_1580|M.vanbaalenii_PYR-1 TFRLRDLVRLDAKAAAPLAAVSVPETYDLLD---------GRDAETFLRD
MUL_0254|M.ulcerans_Agy99 DTFAAVGAAGDEPGFAAFYRRCRLVTERLWPTLLEPLR--TRDQARRTVV
Mb1848|M.bovis_AF2122/97 DLLLKRAASLGIQIRYETGATELIVDGTGKVTGV----------------
Rv1817|M.tuberculosis_H37Rv DLLLKRAASLGIQIRYETGATELIVDGTGKVTGV----------------
MAV_3022|M.avium_104 KPLVESATAAGARALYDVRVQRLITESDGRVVGM----------------
MLBr_02276|M.leprae_Br4923 HDSSRRAASVTLADGTEVGCRQLIIADGARSP------------------
MMAR_0910|M.marinum_M HDSSRRVVSLTLADRTEVACRQLIVADGARSS------------------
MAB_0623|M.abscessus_ATCC_1997 APLADSAERLGADVWRQTRVTGLVVE-EGRVVGVRGMTLKDAPAWARRLY
TH_3850|M.thermoresistible__bu QRLERYGVKFEKDEHGEYAVRRVHRSGSYALP------------------
Mflv_3157|M.gilvum_PYR-GCK ATGGTAFLSGSLGTNVDTGDGYLMAAEAGAALSG----------------
MSMEG_3987|M.smegmatis_MC2_155 ESNAGRSVVLAQRTIDASGDAAVVSRANGAYYFG----------------
Mvan_1580|M.vanbaalenii_PYR-1 INFPEAARHLAFEVFARSFFARPETLSAGELVTMFHIYFLG---------
MUL_0254|M.ulcerans_Agy99 DYGAPEALGAWHAMIEEPIGRAITAAVHDDLVRG----------------
Mb1848|M.bovis_AF2122/97 ---------------------------MWKRFSETGAIKAKS-VIIAAGG
Rv1817|M.tuberculosis_H37Rv ---------------------------MWKRFSETGAIKAKS-VIIAAGG
MAV_3022|M.avium_104 ---------------------------RARRYGTEMNIRARTGVVLATGS
MLBr_02276|M.leprae_Br4923 ---------------------------LGRKLGRS--WHQKTVYGVAARG
MMAR_0910|M.marinum_M ---------------------------LGRKLGRR--WHQETVYGVAARG
MAB_0623|M.abscessus_ATCC_1997 SRLTHYATKPGIYYPPMRKTLEGPAYALERRFAKPFEIRADDGVILSSGG
TH_3850|M.thermoresistible__bu ---------------------------------------MPEGKDVKKAL
Mflv_3157|M.gilvum_PYR-GCK ------------------------MEFSTAYALAPEWGTHTKGRMLAWAS
MSMEG_3987|M.smegmatis_MC2_155 --------------------------ADGRIQNPTMFFRLADVDIDEFDE
Mvan_1580|M.vanbaalenii_PYR-1 --------------------------SSEGLIFDVANANFDVALWNPLRR
MUL_0254|M.ulcerans_Agy99 ------------------------VIATDALIGTFAGLDEPSLTQNICFL
Mb1848|M.bovis_AF2122/97 FVMNPDMVAKYTPKLAEKPFVLGNTYDDGLGIRLGVSAGGATQHMDQ-MF
Rv1817|M.tuberculosis_H37Rv FVMNPDMVAKYTPKLAEKPFVLGNTYDDGLGIRLGVSAGGATQHMDQ-MF
MAV_3022|M.avium_104 FAYNDSMVARYAPRIAGRPAAS-IEQHDGQAIRMAQALGADLAHMDA-TE
MLBr_02276|M.leprae_Br4923 YLTTPRSDDLWLTSHLELRSPDGAVLPG---YGWIFPLGNGEVNIGV-GA
MMAR_0910|M.marinum_M YLTTARSEDPWLTSHLELRSPDGAVLPG---YGWIFPLGNGEVNIGV-GA
MAB_0623|M.abscessus_ATCC_1997 FIANRELVRRHAPAYLDG-LELGTAGDDGTALKLAEPLGAATGHLDE-IS
TH_3850|M.thermoresistible__bu YRVLRQRKMREKIQIENRLTPVRVLTDG------TRAVGAAALHTRT-GD
Mflv_3157|M.gilvum_PYR-GCK FYDEDGHPIATECGLAGRRDAQRALARGQRVFARLDRAPEHIRRVMR-DA
MSMEG_3987|M.smegmatis_MC2_155 YYGQDTICPPKLTDMIEQERKAGANLPRSRIWVFRTPRRNELMVNAT-RV
Mvan_1580|M.vanbaalenii_PYR-1 YLEGRGVVFHTGAEVDSVTVADEVTVTGSR--AQVWSADAAVLATDP-GS
MUL_0254|M.ulcerans_Agy99 YHLLGGGTGDWDVPIGGMGSVTAGLAAAATGYGAEIVTGAEAVAVTPNGD
:
Mb1848|M.bovis_AF2122/97 ITAPPYPPSILLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIV
Rv1817|M.tuberculosis_H37Rv ITAPPYPPSILLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIV
MAV_3022|M.avium_104 VAIFIDP-QQLVRGILVNGRGQRYVAEDTYPGRIGQLTLYQQDNTAYLII
MLBr_02276|M.leprae_Br4923 LSTSKRPADLALRSLIS-------YYTDLRRHEWGFSGQPRAVSSALLPM
MMAR_0910|M.marinum_M LSTTKRPADLALRPLMS-------YYTDLRRDEWGFTGQPRAVASALLPM
MAB_0623|M.abscessus_ATCC_1997 AWRFIVPPAAFLGSLLVDTKGQRMIDESRYGAALGKEIVRTAGGVGYLVA
TH_3850|M.thermoresistible__bu FVAVAAKAVILAT------------------GACGRLGLPASAISTALMR
Mflv_3157|M.gilvum_PYR-GCK QPNYFLPLDKAGIDPFVTAYPLRMVYEGSVRGTGGLRLVGPDCATSVPGL
MSMEG_3987|M.smegmatis_MC2_155 AGRDGRALNVIDPEDFTEG---EVVGRRQAREYADFFRKHVPGCASSYLE
Mvan_1580|M.vanbaalenii_PYR-1 LRRVVAASPGLGDPSWRERVAAIGTAPPFVVLRLWLDRPVRHDRAAFVGT
MUL_0254|M.ulcerans_Agy99 VRYRAGDDEHLVRGRFVLAGVTPAVLAKLLGDTEPSFAPGAQVKVNMVLR
Mb1848|M.bovis_AF2122/97 D-----EAHLEH------------------PKMPLVPLIDGWETVVEMEA
Rv1817|M.tuberculosis_H37Rv D-----EAHLEH------------------PKMPLVPLIDGWETVVEMEA
MAV_3022|M.avium_104 DGDAQDEAMASWS-----------------PKLMLRPATWVADTVADLER
MLBr_02276|M.leprae_Br4923 GG---AVSGVAGP-----------------NWMLIGDAAACVNPLNGEGI
MMAR_0910|M.marinum_M GG---AVSGVAGP-----------------NWMLIGDAAACVNPLNGEGI
MAB_0623|M.abscessus_ATCC_1997 DQPLVKRARQQLGSQTL-------WFQRIQAEAFLNVGRKKAGSIEELAA
TH_3850|M.thermoresistible__bu T-----------------------------PPTPVTATRWRITPVPNCRV
Mflv_3157|M.gilvum_PYR-GCK YAAGDAATRELITGAIS-------GGGSHNGSWAIASGSFAGRGAAEYSR
MSMEG_3987|M.smegmatis_MC2_155 DTG-------------------------TEVGVRQTRSIVGHETLRNDDV
Mvan_1580|M.vanbaalenii_PYR-1 GGRDPLDNISVLER---------------YEREAAQWCSRTGGSVVELHA
MUL_0254|M.ulcerans_Agy99 RLPRLRDAVVTPEQAFAGTFHANETWTQLEAAHQRAAAGHLPDPLPCEAY
Mb1848|M.bovis_AF2122/97 ALGIP-PGNLAATLDRYNAYAARGA-----DPDFHKQPEFLAAQDNGPWG
Rv1817|M.tuberculosis_H37Rv ALGIP-PGNLAATLDRYNAYAARGA-----DPDFHKQPEFLAAQDNGPWG
MAV_3022|M.avium_104 DMALP-PGSLQDTVAAYNAGAARGE-----DPLLHKKPEWIRPIG-SPVG
MLBr_02276|M.leprae_Br4923 DYGLE-TGRLAAELLDL------------------RDLSYVWPSLLQQHY
MMAR_0910|M.marinum_M DYGLE-TGRLAAELLDS------------------PDLSQLWPSLLQAHY
MAB_0623|M.abscessus_ATCC_1997 KAGID-PEGLARTVSEHNRAIAGGT-----PDPLGKPDDIRVPIERAPFY
TH_3850|M.thermoresistible__bu SNAFR-STR-----------------------------------------
Mflv_3157|M.gilvum_PYR-GCK RRTFAGFVEVDGVGLRPGPQHAPTV-----DDVVRVAQDHILPPMRSHLK
MSMEG_3987|M.smegmatis_MC2_155 LQGRKRDDGICRVPWPIELHDSKGS-----NLHWLLDDYYEVPYLSLVPV
Mvan_1580|M.vanbaalenii_PYR-1 YSVRDEDADVRDRLIARMHELYPET-----ATASIVAERLLRRDDCPRFA
MUL_0254|M.ulcerans_Agy99 CHSLSDPSILSPALRDVGAQTMTVFGLHTPHSVFGNADPDVLRDQLTAAV
Mb1848|M.bovis_AF2122/97 AFDMSLGKAMYA---GFTLGG---LATSVDG-QVLRDDGAVVAGLYAVGA
Rv1817|M.tuberculosis_H37Rv AFDMSLGKAMYA---GFTLGG---LATSVDG-QVLRDDGAVVAGLYAVGA
MAV_3022|M.avium_104 AVDL---RESTG---GFTLGG---LATTLDA-EVLHVSGQPIPGLFAAGR
MLBr_02276|M.leprae_Br4923 GRGFSVARRLAL---LLTFKR---CLPAIGP-SAMRSTSLITIAVRVMAN
MMAR_0910|M.marinum_M GRGFSVARRLAL---LLTYQR---FLPTTGP-VAMRSTALMKVAVRVMAN
MAB_0623|M.abscessus_ATCC_1997 LFNVSIKTNMLNPCPMLTLGG---LVVDEETGAVQTTSGAAIPGLYAAGR
TH_3850|M.thermoresistible__bu --------------------------------------------------
Mflv_3157|M.gilvum_PYR-GCK SQVRLTESAGVLEQLWTDIAAGLAPVPARDAYKPRQAVALVAAARWITAA
MSMEG_3987|M.smegmatis_MC2_155 AGENIIVAGRCLSAEHEALAS-----ARVTAQCFEYGHAAGVASVLSLDE
Mvan_1580|M.vanbaalenii_PYR-1 PGDFADRPTVSTPDPRLKLAG----DGIRIDLPVALMERAATTGWTAANE
MUL_0254|M.ulcerans_Agy99 LASLNSVLAEPIQDVLLTDADGRPCIETTTTADLQHTLHMTAGNIFHGAL
Mb1848|M.bovis_AF2122/97 CASNIAQDGKGYASGTQLGEGSFFGRRAGAHAA-ARAQGM----------
Rv1817|M.tuberculosis_H37Rv CASNIAQDGKGYASGTQLGEGSFFGRRAGAHAA-ARAQGM----------
MAV_3022|M.avium_104 CTAGLAAWG--YASGISLGDGSFYGRRAGASAAGCRLPRV----------
MLBr_02276|M.leprae_Br4923 LVTDDDADWVARVWRSGGWASWLVDRRPPFS-------------------
MMAR_0910|M.marinum_M LVTEEDSDWVARLWRGGGRASRLIDRRPPFH-------------------
MAB_0623|M.abscessus_ATCC_1997 AAVGICSNS--YVSGLSLADCVFSGRRAGTETGRRIDA------------
TH_3850|M.thermoresistible__bu --------------------------------------------------
Mflv_3157|M.gilvum_PYR-GCK SLARAETRGIHRREDLPGTDHRLSHRILVGGLDTVWTIPDPVLPELISSE
MSMEG_3987|M.smegmatis_MC2_155 NLPYAKIDGRAVRNAMAANGSAL---------------------------
Mvan_1580|M.vanbaalenii_PYR-1 LLTGFGLAGHTLHTVPNRGRSAVLRRLATSAGGVR---------------
MUL_0254|M.ulcerans_Agy99 SWPFAENDDTLATPAQQWGVATNHDRIMLCGSGARRGGAVSGIGGHNAAM
Mb1848|M.bovis_AF2122/97 ----------
Rv1817|M.tuberculosis_H37Rv ----------
MAV_3022|M.avium_104 ----------
MLBr_02276|M.leprae_Br4923 ----------
MMAR_0910|M.marinum_M ----------
MAB_0623|M.abscessus_ATCC_1997 ----------
TH_3850|M.thermoresistible__bu ----------
Mflv_3157|M.gilvum_PYR-GCK AVA-------
MSMEG_3987|M.smegmatis_MC2_155 ----------
Mvan_1580|M.vanbaalenii_PYR-1 ----------
MUL_0254|M.ulcerans_Agy99 AVLAYLRQDR