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AQQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGSTARSGGGVWIPNNEVLKRDGVKDTTEAA RTYLHSIVGDAVPAEKIDTYLDRGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPKPFNAK KLGPDEKGLEPPYGKVPLNMVVMQQDYVRLNQLKRHPRGVLRSLKVGVRSVWANATGKNLVGMGRALIAP LRIGLQKAGVPVLLNTALTDLHVEDGVVTGIYVVATGDSVNAEPQLIRARRAVILGSGGFEHNEQMRVKY QRAPITTEWTVGAVANTGDGILAAEKLGAALEIMEDAWWGPTVPLEGAPWFALSERNSPGSIIVNMAGKR FMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLIFDQQYRDRYIFAGLQPGQRIPSKWLESGVIVKADT LDELAARTGLPTDAFKATVDRFNGFARSGRDEDFKRGESAYDRYYGDPTNKPNPNLGEITQGPFYAAKMV PGDLGTKGGIRTDVHGRALRDDGSVIEGLYAAGNVSSPVMGHTYPGPGGTIGPAMTFGYLAALHIAGAAP AATSSSGKG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1519 | - | - | 100% (570) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4567 | - | e-121 | 43.71% (556) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2403 | - | e-119 | 41.15% (576) | 3-ketosteroid-delta-1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 0.0 | 83.39% (560) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv3537 | - | 0.0 | 83.39% (560) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | MLBr_02387 | lpd | 9e-06 | 43.59% (78) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0622c | - | 0.0 | 80.82% (558) | 3-ketosteroid-delta-1-dehydrogenase |
| M. marinum M | MMAR_5024 | - | 0.0 | 81.85% (562) | dehydrogenase |
| M. avium 104 | MAV_0624 | - | 0.0 | 86.20% (558) | 3-ketosteroid-delta-1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5941 | - | 0.0 | 89.17% (563) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_0368 | - | 0.0 | 89.18% (536) | PROBABLE DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_4098 | - | 0.0 | 81.85% (562) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5237 | - | 0.0 | 90.66% (557) | 3-ketosteroid-delta-1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3567|M.bovis_AF2122/97 ---MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARS
Rv3537|M.tuberculosis_H37Rv ---MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGSTARS
MMAR_5024|M.marinum_M MFYMTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGSTARS
MUL_4098|M.ulcerans_Agy99 ---MTSQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAAHYGGSTARS
MAV_0624|M.avium_104 ---MSAQEYDVVVVGSGGAGMVAALTAAHRGLSTIVIEKAPHFGGSTARS
Mflv_1519|M.gilvum_PYR-GCK ---MAQQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGSTARS
TH_0368|M.thermoresistible__bu ------------------------------------VEKAPHYGGSTARS
MSMEG_5941|M.smegmatis_MC2_155 ---MTGQEYDVVVVGSGAAGMVAALTAAHQGLSTVVVEKAPHYGGSTARS
Mvan_5237|M.vanbaalenii_PYR-1 ---MTEQEYDVVVVGSGAAGMVAALTAAHQGLSTIVVEKAPHYGGSTARS
MAB_0622c|M.abscessus_ATCC_199 ---MTEQEYDVVVVGSGGAGMVAALTAAHNGLSTVLIEKAPHFGGSTARS
MLBr_02387|M.leprae_Br4923 -----MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPK-YWGGICLNV
:* ::** .
Mb3567|M.bovis_AF2122/97 GGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPERIDAYLD
Rv3537|M.tuberculosis_H37Rv GGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVG----EIVEPERIDAYLD
MMAR_5024|M.marinum_M GGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPERIDTYLE
MUL_4098|M.ulcerans_Agy99 GGGVWIPNNQILKRARVSDTTEAARTYLHGIIGDSSVSGVEPERIDTYLE
MAV_0624|M.avium_104 GGGVWIPNNEVLKRDGVKDTPEAARTYLHGIIG----DVVEPERIDTYLE
Mflv_1519|M.gilvum_PYR-GCK GGGVWIPNNEVLKRDGVKDTTEAARTYLHSIVG----DAVPAEKIDTYLD
TH_0368|M.thermoresistible__bu GGGVWIPNNEVLKRDGVTDTPEEARRYLHAIVG----DVVPAEKIDTYLD
MSMEG_5941|M.smegmatis_MC2_155 GGGVWIPNNEILKRDGVKDTPDEARKYLHAIIG----DVVPAEKIDTYLD
Mvan_5237|M.vanbaalenii_PYR-1 GGGVWIPNNEVLKRDGVKDTADAARTYLHAIIG----DVVPAEKIDTYLQ
MAB_0622c|M.abscessus_ATCC_199 GGGVWIPNNEVLKKARQTDTPEAAREYLYSIIG----DVVPREKIDTYLD
MLBr_02387|M.leprae_Br4923 G---CIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSRKVSE
* **.: :*:. . : . : :: :
Mb3567|M.bovis_AF2122/97 RGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKL
Rv3537|M.tuberculosis_H37Rv RGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKL
MMAR_5024|M.marinum_M RGPEMLSFVLEHTPLKMCWVPGYSDYYPEAPGGRSGGRSIEPKPFDARKL
MUL_4098|M.ulcerans_Agy99 RGPEMLSFVLEHTPLKMCWVPGYSDYYSEAPGGRSGGRSIEPKPFDARKL
MAV_0624|M.avium_104 RGPEMLSFVLKHTPLKMCWVPRYSDYYPESPGGRAEGRSIEPKPFNARKL
Mflv_1519|M.gilvum_PYR-GCK RGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPKPFNAKKL
TH_0368|M.thermoresistible__bu RGPEMLSFVLKHTPLKLCWVPGYSDYYPETPGGKPTGRSVEPRPFDAKKL
MSMEG_5941|M.smegmatis_MC2_155 RGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKPTGRSVEPKPFDANKL
Mvan_5237|M.vanbaalenii_PYR-1 RGPEMLSFVLKHSPLKLCWVPGYSDYYPETPGGKATGRSVEPKPFDAKKL
MAB_0622c|M.abscessus_ATCC_199 RGPEMLSFVLANSPLKLDWVPNYSDYYPEAPGGRAAGRSVEPKPFDAKKL
MLBr_02387|M.leprae_Br4923 GRVAGVHFLMKKN--KITEIHGYGRFTDANTLSVELSEGVPETPL-----
: *:: :. *: : *. : . . ...: *:
Mb3567|M.bovis_AF2122/97 GADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
Rv3537|M.tuberculosis_H37Rv GADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
MMAR_5024|M.marinum_M GADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
MUL_4098|M.ulcerans_Agy99 GADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMW
MAV_0624|M.avium_104 GPDEAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSLKVGARTMW
Mflv_1519|M.gilvum_PYR-GCK GPDEKGLEPPYGKVPLNMVVMQQDYVRLNQLKRHPRGVLRSLKVGVRSVW
TH_0368|M.thermoresistible__bu GPDMDTLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLKVGIRSMW
MSMEG_5941|M.smegmatis_MC2_155 GPDLKGLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLKVGIRATW
Mvan_5237|M.vanbaalenii_PYR-1 GEDLPGLEPPYGKVPMNMVVMQQDYVRLNQLKRHPRGVLRSLRVGIRSVW
MAB_0622c|M.abscessus_ATCC_199 GDELPNLEPPYGKVPLNVVVRQQDYVRLNQLKRHPRGVLRSLRVGVRTFW
MLBr_02387|M.leprae_Br4923 ------------KVTFNNVIIATG--------SKTRLVPGTLLSTNVITY
*:.:* *: . :.* * :: :
Mb3567|M.bovis_AF2122/97 AKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSGVY
Rv3537|M.tuberculosis_H37Rv AKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVSGVY
MMAR_5024|M.marinum_M AKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALTDLYLEDGMVRGIY
MUL_4098|M.ulcerans_Agy99 AKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALTDLYLEDGVVRGIY
MAV_0624|M.avium_104 AKATGKNLVGMGRALIGPLRIGLQRAGVPVVLNTALTDLYLEDGVVRGVY
Mflv_1519|M.gilvum_PYR-GCK ANATGKNLVGMGRALIAPLRIGLQKAGVPVLLNTALTDLHVEDGVVTGIY
TH_0368|M.thermoresistible__bu ANATGKNLVGMGRALIAPLRIGLREAGVPLLLNTAMTDLYVEDGVVRGIY
MSMEG_5941|M.smegmatis_MC2_155 GKVSGKNLVGMGRALIAPLRIGLREAGVPVLLNTALTDLYVEDGRVLGIY
Mvan_5237|M.vanbaalenii_PYR-1 ANTTGKNLVGMGRALIAPLRIGLREAGVPVRLNTAMTDLYVEDGVVRGIY
MAB_0622c|M.abscessus_ATCC_199 AQGTGKKLVGMGRALSAALRIGLRDAGVPVKLNTALTDLYIEDGTVRGVY
MLBr_02387|M.leprae_Br4923 EEQILTRELPDSIVIVGAGAIGIEFG---YVLKNYGVDVTIVEFLPRAMP
: .. : . .: .. **:. *:. .*: : : .:
Mb3567|M.bovis_AF2122/97 VRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVG
Rv3537|M.tuberculosis_H37Rv VRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEWTVG
MMAR_5024|M.marinum_M VRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRVKYQRAPITTDWTVG
MUL_4098|M.ulcerans_Agy99 VRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRVKYQRAPITTDWTVG
MAV_0624|M.avium_104 VRDSQAAESAEPRLIRARRGVILASGGFEHNEQMRVKYQRAPITTEWTVG
Mflv_1519|M.gilvum_PYR-GCK VVATGDSVNAEPQLIRARRAVILGSGGFEHNEQMRVKYQRAPITTEWTVG
TH_0368|M.thermoresistible__bu VVDARDPESAEPRLIRARRGVILGSGGFEHNEQMRVKYQRPPITTEWTVG
MSMEG_5941|M.smegmatis_MC2_155 VRDTTAGDDAEPRLIRARHGVILGSGGFEHNEQMRVKYQRAPITTEWTVG
Mvan_5237|M.vanbaalenii_PYR-1 VRDTTAPESAEPQLIRARRGVILGSGGFEHNEQMRVKYQRAPITTEWTVG
MAB_0622c|M.abscessus_ATCC_199 VRETGAPEASEPTLIRGRRGVILASGGFEHNEQMRVKYQRAPITTEWTVG
MLBr_02387|M.leprae_Br4923 NEDAEVSKEIEKQFKKMGIKILTG----TKVESISDNGSHVLVAVSKDGQ
: * : : :: . : *.: : .: ::..
Mb3567|M.bovis_AF2122/97 ASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSI
Rv3537|M.tuberculosis_H37Rv ASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFALSERNSPGSI
MMAR_5024|M.marinum_M AKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWFALSERNSPGSI
MUL_4098|M.ulcerans_Agy99 AKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRPWFALSERNSPGSI
MAV_0624|M.avium_104 AKANTGDGILAAEKLGAALELMEDAWWGPTVPLVGAPWFALSERNSPGSI
Mflv_1519|M.gilvum_PYR-GCK AVANTGDGILAAEKLGAALEIMEDAWWGPTVPLEGAPWFALSERNSPGSI
TH_0368|M.thermoresistible__bu AKANTGDGILAAEKLGAALEIMEDAWWGPTIPLPGAPWFALSERNSPGSI
MSMEG_5941|M.smegmatis_MC2_155 AVANTGDGIVAAEKLGAALELMEDAWWGPTVPLVGAPWFALSERNSPGSI
Mvan_5237|M.vanbaalenii_PYR-1 AKANTGDGILAAEKLGAALDVMEDAWWGPTVPLVDAPWFALSERNSPGSI
MAB_0622c|M.abscessus_ATCC_199 AKANTGDGILAAEKLGAALEFMEDSWWGPTVPLVGRPWFALSERNSPGSI
MLBr_02387|M.leprae_Br4923 FQELKADKVLQAIGFAPNVDGYGLDKVG--VALTADKAVDIDDYMQTNVS
..* :: * :.. :: * :.* . :.: ...
Mb3567|M.bovis_AF2122/97 IVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRD
Rv3537|M.tuberculosis_H37Rv IVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYRD
MMAR_5024|M.marinum_M IVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRYRD
MUL_4098|M.ulcerans_Agy99 IVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRYRD
MAV_0624|M.avium_104 IVNMSGKRFMNESMPYVEACHHMYGGEYGQGPGPGENIPAWLVFDQQYRD
Mflv_1519|M.gilvum_PYR-GCK IVNMAGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLIFDQQYRD
TH_0368|M.thermoresistible__bu IVNMAGKRFMNESMPYVEACHHMYGGEYGQGPGPGENIPAWLIFDQRYRD
MSMEG_5941|M.smegmatis_MC2_155 IVNMSGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLIFDQQYRD
Mvan_5237|M.vanbaalenii_PYR-1 IVNMAGKRFMNESMPYVEACHHMYGGQYGQGPGPGENIPAWLVFDQRYRD
MAB_0622c|M.abscessus_ATCC_199 IVNSSGKRFMNESLPYVEATHRMYGGQYGQGPGPGENLPAWLVFDQEYRN
MLBr_02387|M.leprae_Br4923 HIYAIGDVTGKLQLAHVAEAQGVVAAEAIAG------AETLALSDYRMMP
: *. : .:.:* : : ..: * : : * .
Mb3567|M.bovis_AF2122/97 RYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRF
Rv3537|M.tuberculosis_H37Rv RYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRF
MMAR_5024|M.marinum_M RYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAGLPVDELTSTVSRF
MUL_4098|M.ulcerans_Agy99 RYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAGLPVDELTSTVSRF
MAV_0624|M.avium_104 RYIFAGLQPGQRIPRKWLESGVIIQAETLEELASKAGLPVDEFLATVQRF
Mflv_1519|M.gilvum_PYR-GCK RYIFAGLQPGQRIPSKWLESGVIVKADTLDELAARTGLPTDAFKATVDRF
TH_0368|M.thermoresistible__bu RYLFAGLQPGQRIPKKWLDSGVIVKADTLAELAARIGVPEQDFLATVERF
MSMEG_5941|M.smegmatis_MC2_155 RYIFAGLQPGQRIPSKWLESGVIVKADTLVELAEKTGLPADQFTSTIERF
Mvan_5237|M.vanbaalenii_PYR-1 RYIFAGLQPGQRIPKKWLESGVIVKADTLEELAAKTGLPVDAFKTTVQRF
MAB_0622c|M.abscessus_ATCC_199 RYIFAGLQPGQKIPSKWIESGVIVKADTIEELAKKANLPVEELRATIERF
MLBr_02387|M.leprae_Br4923 RATFCQPN-----VASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMGDP
* *. : : : :. : .. : :
Mb3567|M.bovis_AF2122/97 NAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPG
Rv3537|M.tuberculosis_H37Rv NAFARSGVDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPG
MMAR_5024|M.marinum_M NGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEINHAPYYAAKMVPG
MUL_4098|M.ulcerans_Agy99 NGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEINHAPYYAAKMVPG
MAV_0624|M.avium_104 NGFARTGIDEDYHRGESAYDRYYGDPTNKPNPNLGEISHPPYYAAKMVPG
Mflv_1519|M.gilvum_PYR-GCK NGFARSGRDEDFKRGESAYDRYYGDPTNKPNPNLGEITQGPFYAAKMVPG
TH_0368|M.thermoresistible__bu NGFARAGVDQDFRRGESAYDRYYGDPTNKPNPNLGEIDQAPFYAAKMVPG
MSMEG_5941|M.smegmatis_MC2_155 NGFARSGVDEDFHRGESAYDRYYGDPTNKPNPNLGEIKHGPFYAAKMVPG
Mvan_5237|M.vanbaalenii_PYR-1 NGFARSGVDEDFKRGESAYDRYYGDPTNKPNPNLGEISQGPFYAAKMVPG
MAB_0622c|M.abscessus_ATCC_199 NGFARSGVDEDFGRGKSAYDRYYGDPTNKPNPNLGALTKAPFYAAKMVPG
MLBr_02387|M.leprae_Br4923 SGFVKLVADAKY--GELLGGHMIGHNVSELLPELTLAQKWDLTATELVR-
..*.: * .: *: .: *. .: *:* : .:::*
Mb3567|M.bovis_AF2122/97 DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
Rv3537|M.tuberculosis_H37Rv DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
MMAR_5024|M.marinum_M DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
MUL_4098|M.ulcerans_Agy99 DLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIG
MAV_0624|M.avium_104 DLGTKGGIRTDIHGRALRDDGSIIEGLYAAGNVSAPVMGHTYPGPGGTIG
Mflv_1519|M.gilvum_PYR-GCK DLGTKGGIRTDVHGRALRDDGSVIEGLYAAGNVSSPVMGHTYPGPGGTIG
TH_0368|M.thermoresistible__bu DLGTKGGIRTDVHGRALRDDGSVIDGLYAAGNVSSPVMGHTYPGPGGTIG
MSMEG_5941|M.smegmatis_MC2_155 DLGTKGGIRTDVRGRALRDDDSVIEGLYAAGNVSSPVMGHTYPGPGGTIG
Mvan_5237|M.vanbaalenii_PYR-1 DLGTKGGIVTDVQGRALRDDGSIIEGLYAAGNASAPVMGHTYPGPGGTIG
MAB_0622c|M.abscessus_ATCC_199 DLGTKGGVRTDVKGRVLRDDNSVIEGLYAAGNVSTPVMGHTYAGPGATIG
MLBr_02387|M.leprae_Br4923 -------------------------NVHTHPTLSEALQECFH----GLIG
.::: . * .: : . **
Mb3567|M.bovis_AF2122/97 PAMTFGYLAALHIADQAGKR-------
Rv3537|M.tuberculosis_H37Rv PAMTFGYLAALHIADQAGKR-------
MMAR_5024|M.marinum_M PAMTFGYLAALHIAGDR----------
MUL_4098|M.ulcerans_Agy99 PAMTFGYLAALHIAGDR----------
MAV_0624|M.avium_104 PAMTFGYLAALHIAGEN----------
Mflv_1519|M.gilvum_PYR-GCK PAMTFGYLAALHIAGAAPAATSSSGKG
TH_0368|M.thermoresistible__bu PAMTFGYLAALHVAGAA-TATSDPGKS
MSMEG_5941|M.smegmatis_MC2_155 PAMTFGYLAALDIAATAAASRKG----
Mvan_5237|M.vanbaalenii_PYR-1 PAMTFGYLAALDIARKD----------
MAB_0622c|M.abscessus_ATCC_199 PAMTWGYLAALDIAGK-----------
MLBr_02387|M.leprae_Br4923 HMINF----------------------
:.: