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ARDDRAFPLTRGQLDIWLSQEAGFAGTQWQLGLLVKIDGKVHRDALEQAITQAVAEAEPGRVSFFEVDGQ VVQKPIDYPHVELAFHDLTDHADPVAEAREMSSAIQRTPMPLNGQMFKFVLFQTGHDEFYLFGCCHHIAI DGLGMALVCRRVATIYSAMVAGKPIPDAYFGTVQDLIDLESGYEASPDYAEDKAYWSEHLPPESGPVDRL PDAEGERDHYSPSASVQLDPSVANRIKELSKKLAIRRFSVTTAACALLVRGWSGSGSEVALDFPVSRRVR PESKTLPAMLAGVVPLVLSTAPESTVADFCKHVDKRIRELLAHQRFPVHTLEGDGLRQAPNRVGINFIPS RLTLDLAGSPATASYTNHGPVGHFGLFFLGAGDQLFLSTAGPGQPFASFGVADLAGRLQQILAAMTEDPD RPLSSIELLTGDEPALIDRWSNRPALTEPAPAPVSIPQAFAEHVQRTPDAVAVTFGATSLTYAQLDEASN RLGHLLADHGVGPGDCVAVMFPRCADAIVSMLAVLKTGAAYVPIDPAHASSRMDFVLADAAPSAVITTSD LRSRLDDHDLLVIDVHDPAVEAQPGTALPWPAPENTAYIIYTSGTTGTPKGVAIPHLNVTWLIESLDAGL PPGNVWTQCHSSAFDFSVWEIFGALLRGRRLLVVPESVASSPEDFHALLVAEQVSVLTQTPSAVAMLSPE GLESTALVVAGEACPTDVVDRWAAPGRVMLDAYGPTETTVCASISTPLTAGDPVVPIGSPIAGAAMFVLD KWLQPVPAGVVGELYLAGRGVGHGYVRRPGLTASRFVPNPFGAPGSRMYRTGDLVCWGPDGQLQYLGRAD EQVKIRGFRIELGEIQSVLAGLDGVEQAAVVAREDRPGDKRLVGYITGTADPAELRAQLADRLPPYMVPT AVMVLDALPLTGNGKLDKRALPSPEYAAGEYRAPGDAIEEILADIYAQVLGVERVGVDDSFFDLGGDSIL SMQVVARARAAGVICRPRDVFVEQTVARLARVSQVAVDGELGAADEGIGPVRPTPIMRWLQDIDGPIDEF NQTMVLAAPAGVGVDDVAVVLQALLDRHPMLRLRVQDDGAGGWSLEAPEVGSVRAADCLRAVDSLSDAAL VEARSRLNVSDGVLLSAVWASETSQLALVVHHLAVDGVSWRTLIEDINIAWAQHQGGQEIALPVPGTSFA RWSSILAEYAKSPAVVAAAAAWQQVVATPAVLPAVGPDDTYASAGQLSASLDVETTRLLLGEVPAAFHAG VQDILLIAFGLACTEFVGGGAPIGIDVEGHGRHEEIASGVDLSRTVGWFTTKYPVALRMGRRLDWARVVA GEAALGAVIKDAKEQLRALPDGLSYGLLRYLNPEIEVQGPDPVIGFNYLGRLGAGADLSEEMWRVSADSL SSAAVATAVPMPLAHTVELNAGTMDTDAGPQLHANWRWARSVLTDEQLNRLSRLWFEALTGICAHVQAGG GGLTPSDIAPARLDQQQIDELCQQHQIADVLPLSPVQQGLLFHTGFAQELEDLYAVQLGITVSGTLDPHR LRDAVQNAVNRHPNLVARFFDEFGEPVQIIPAEPEMAWRYLELDGGDIDGQLEQLSADERAAVCDLAGQP AFRAALIRIADDRHRLLLTIHHIVIDGWSLPVLLQEVFAGYYGQRLPAPPSYRSYLMWLSAQDRAAAQDA WREALAGFETPTLVAPPGKIGRRAVATYTVSADTTKALGELARSSRTTVSTVLQGAWAQLLTWLTGQHDV AFGTAVSGRPTELPGADAMVGLLINTVPVRADIAAATTVVDLLEQLQRAHADTLEHEHLALNEIHRVTGH DQLFDTLFLYENYPIDASALLDVHELAVTEFSSREFNHYPLSVVATPGHELSLRVEYDTEVFDEAGIETL IERLRQVLAAMTTDPGQRLSAIDLLDAAEHERLDAWGNRAVLTRRPAAQASIPALFAAQVARAADAVAIT CGERSFTYREVEESANRLAHLLSGQGAGPGQRVAVVIPRSAEAVVAIFAVLKTGAAYVPIDPGVPAARLQ FVLADSAPVAAVTTAEVRDRLDGFTGQIIDFDDPAVAEQPATGLPVPAADNIAYIIYTSGTTGIPKGVAI PHRNVTLLLETLDAQLGLGQVWTQCHSLAFDFSVWEIFGALLHGGRLVIVPDDIVRSPEDLHALLVREQV SVLSQTPSAFYALQSADALAPELGQQLKLQTVVFGGEALEPHRLATWLHRHPGLPRMINMYGITETTVHA SFREIVDADVDSSVSPIGVPLANLAFFVLDGWLRPVPVGVVGELYVAGGGLATGYVGRPGLSATRFVACP FGGPGARMYRTGDLVRWGADGQLQYMGRADAQVKIRGYRIELGEIQAALAGLDGVEHAAVIAREDRPGDK RLVGYITGTADPAEVRAQLGERLPGYMVPSAVVVLDALPLTVNGKLDTRALPAPEYSDVDRYRAPVTAIE EILADIYAQVLGVERVGVDDSFFDLGGDSILSMQVVARARAAGVICRPRDVFTEQTVARLARVATVATGD DDVVDEGTGRVVATPIMRWLQNMDGPVEQFNQTMVLAAPAGVTPDDVAAVLQALLDRHAMLRLRVEDDGA GGWSLEVPEAGSVQAADCLETVDALSPAALVDARSRLNLADGILVRAVWASETSQLALIIHHLAVDGVSW RTLIEDLNIAWAQHHSGQPVALPTGGMSFARWSALLEDHARRPEVVERAEDWRQVAAVPAVLPGAQPGDT YATAGQLSASLDVETTRLLLGEVPAAFHAGVQDILLIAFGLAWTQFIGTGAPIGIDVEGHGRSEELGPQV DLSRTVGWFTAKYPVALRLGGLSWGQVVGGDEALGAVVKEAKEQLRALPDGLTYGLLRYLNPQAGLDVSD PAIAFNYLGRLGGGAAELSPELWRLSPDSFALAGAAGAVELPLPHTVELNAGTMDTEDGPHLQANWTWAR SALDDKQIGRLSELWFDALAGICTHVRAGGGGLTPSDVAAARLTQRDLDELAQRYRVADVLPLTPLQQGL LFHAGTAQGSQEPEDLYAVQLDISVTGAVDPDRLREAVRTVITRHPNVVAHFSEDFGEPVQILSAEPELA WQYVELDAGADLDEQVERLSSAERVAVGDLAQPPFRGALIRTAEDAYRFVLTNHHIVLDGWSKPLLLQEI FAAYFGVRLPAPVPYRNFITWLSAQDRAAAQAAWREVLAGFDTPTLVGPSGRMALGPRGVAEFHVPADTS RLLGELARSCRTTVSTVLQAAWAQLLMWLTGQHDVVFGTAVSGRPTELAGSESMVGLLINTVPVRATIGA ETTIADLLDQLQRAYTHTLEHQHLALNDIHRVTGHDQIFDTMFVYENYPIDTAALSAVDELTITGFTNRE YNHYPLSVQAVPGHEIGLRVEFDTDVFGEARIEKLIERFRRVLEAMTVDLEEQS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3244 | - | - | 100% (3415) | linear gramicidin synthetase subunit D |
M. avium 104 | MAV_3239 | - | 0.0 | 59.01% (2757) | syringomycin synthetase |
M. avium 104 | MAV_3243 | - | 0.0 | 68.45% (2133) | linear gramicidin synthetase subunit B |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0104 | nrp | 0.0 | 47.20% (1019) | peptide synthetase |
M. gilvum PYR-GCK | Mflv_2697 | - | 0.0 | 34.42% (1534) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv0101 | nrp | 0.0 | 47.20% (1019) | peptide synthetase |
M. leprae Br4923 | MLBr_02353 | - | 2e-35 | 27.80% (518) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_4099c | - | 0.0 | 68.83% (3449) | non-ribosomal peptide synthetase |
M. marinum M | MMAR_2518 | - | 0.0 | 51.97% (2567) | non-ribosomal peptide synthetase |
M. smegmatis MC2 155 | MSMEG_0400 | - | 0.0 | 67.06% (2395) | peptide synthetase |
M. thermoresistible (build 8) | TH_3730 | - | 0.0 | 63.21% (2196) | PUTATIVE linear gramicidin synthetase subunit D |
M. ulcerans Agy99 | MUL_3633 | mbtF | 0.0 | 34.74% (1543) | non-ribosomal peptide synthetase MbtF |
M. vanbaalenii PYR-1 | Mvan_3844 | - | 0.0 | 35.06% (1540) | amino acid adenylation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0104|M.bovis_AF2122/97 -------------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKS Rv0101|M.tuberculosis_H37Rv -------------------MHRVRLSRSQRNLYNGVRQDNNPALYLIGKS MAB_4099c|M.abscessus_ATCC_199 --------------MLESEDRALPLSRGQLDIWLSQETGLVGAEWQLGLL MSMEG_0400|M.smegmatis_MC2_155 ---------------MEPVDGALPLSRGQLDIWLSHESGLAGAEWQLGLL MAV_3244|M.avium_104 ---------------MARDDRAFPLTRGQLDIWLSQEAGFAGTQWQLGLL TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M MTVDHHQILRDSGRALEPAESGFALTRGQLDIWFSQEIGRSPQEWYNSGF Mflv_2697|M.gilvum_PYR-GCK --------MTAAKTGAIADVMALSPLQQGLYSLTAMSDG--DDPYLIGMS Mvan_3844|M.vanbaalenii_PYR-1 ----MTQIQQSVEPPVIEDVLALSPLQQGLFSMATLSEGRDDDPYVIAMT MUL_3633|M.ulcerans_Agy99 ---------MTAAAPQIEDVLALTPLQEGLFALHQLAEDG-VDLYSMQFV MLBr_02353|M.leprae_Br4923 ------------------------------------MITPDNAIAVVGMA Mb0104|M.bovis_AF2122/97 YRFRRLELARFLAALHATVLDN--PVQLCVLENSGADYPDLVPRLRFGDI Rv0101|M.tuberculosis_H37Rv YRFRRLELARFLAALHATVLDN--PVQLCVLENSGADYPDLVPRLRFGDI MAB_4099c|M.abscessus_ATCC_199 VRIEGQVERVLLERAIRQAVTEAEPARAAFFEVDGQIVQRPIDHSDLELA MSMEG_0400|M.smegmatis_MC2_155 GKIDGVVDHGLLQQAIRQALQEAEPARATFFEADGQVFQKPLDYSELEVP MAV_3244|M.avium_104 VKIDGKVHRDALEQAITQAVAEAEPGRVSFFEVDGQVVQKPIDYPHVELA TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M AVIAGSVTPDLLSQAIRQVVGEAEPLRAAIIEADGHVVQKVVDYPNLDVP Mflv_2697|M.gilvum_PYR-GCK ADITGALDVSLLHDCAAAVLARHPNLRAGFFQGDLKRPVQVIP-EKVEVL Mvan_3844|M.vanbaalenii_PYR-1 ADATGDLDARLLRECAAELLDRHANLRASFVKGNLSRAVQVIP-KRVDLP MUL_3633|M.ulcerans_Agy99 VDIDGPVDLELLRRSAQAMLDRHPNLRAAFWDRDVPKPVQIVP-VHAALP MLBr_02353|M.leprae_Br4923 GKFPGANDVSAFWTNLRRGKESIVTLSEQELR-DNGVSDKALADPAYVRR Mb0104|M.bovis_AF2122/97 VR--------VGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVH Rv0101|M.tuberculosis_H37Rv VR--------VGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVH MAB_4099c|M.abscessus_ATCC_199 FEDLRDSDDPAGLARKKATDIQRTLMPLTGQLLKFALYRTADDEFHLFGL MSMEG_0400|M.smegmatis_MC2_155 LYDVRDADDPEAKAREMAAEIQHTPLPLTGRLVKFALFQTRDEQFYLFGL MAV_3244|M.avium_104 FHDLTDHADPVAEAREMSSAIQRTPMPLNGQMFKFVLFQTGHDEFYLFGC TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M FHDLRSCADPVAEANRRGLAMHREPMPWNGPLFKFALFQVASEEFYLFVS Mflv_2697|M.gilvum_PYR-GCK WRHVRCDG-TEVEPLEREERARRFDLGRGPAMRFLLLETGQ-QRWRFVIT Mvan_3844|M.vanbaalenii_PYR-1 WRHVTVAGDAELEAAERLERTTPFTLARGPVIRFLLIEAP--QRWRFVVT MUL_3633|M.ulcerans_Agy99 WS-ERVATPAEFDSIARSERRRPFDLSRGPALRVVVLSVPGETKRRMIFT MLBr_02353|M.leprae_Br4923 APLLDGIDEFDADFFGLPPLAAQVLDPQHRLFLQCAWHALEDAGCDPAQF Mb0104|M.bovis_AF2122/97 THHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAK Rv0101|M.tuberculosis_H37Rv THHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAK MAB_4099c|M.abscessus_ATCC_199 CHHINLDGLGMAVVSRRVASIYTALAT-GEPIPPAYFGTLQDLVDWETDY MSMEG_0400|M.smegmatis_MC2_155 GHHISVDGLGMALVSRRISTIYTSLVT-GKPVPEAYFGSLRDLVECEMSY MAV_3244|M.avium_104 CHHIAIDGLGMALVCRRVATIYSAMVA-GKPIPDAYFGTVQDLIDLESGY TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M IHHVVVDGFGYALLVNRIALVYSELSS-GAPVSPTFFGSLQTLVAAEAEY Mflv_2697|M.gilvum_PYR-GCK AHHIVIDGWSLSLLVSELLALYRAAGN-TSALPDAPRPYRDYIG-----W Mvan_3844|M.vanbaalenii_PYR-1 AHHILIDGWSLPLFMGELLTLYRAGGD-VTALPDPPRPYRDYIG-----W MUL_3633|M.ulcerans_Agy99 AHHILVDGWSLAVFFTELLAVYRAGGA-ADALP-AARPYRDYIV-----W MLBr_02353|M.leprae_Br4923 DGSIGVYGTSSPSGYLLHNLLSHRDPHTVLAEGLNFDQFSLFLQNDKDFL Mb0104|M.bovis_AF2122/97 VEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGN Rv0101|M.tuberculosis_H37Rv VEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGN MAB_4099c|M.abscessus_ATCC_199 VASAEYAEDREYWSNNLPPDSGLDYRMPHASEESDGYKPS--DSVQMDDV MSMEG_0400|M.smegmatis_MC2_155 ESSADYQDDLAYWSENLPPDTGLDQGLAPTPHGKNAYTPS--ASVPMDPA MAV_3244|M.avium_104 EASPDYAEDKAYWSEHLPPESGPVDRLPDAEGERDHYSPS--ASVQLDPS TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M EQSDDYRADLAYWKETLDGVT--DHSLAHADGDRGPSATS--VSVEIDPA Mflv_2697|M.gilvum_PYR-GCK LAARDQDHARSLWRAHLADLDGPTLLAPALGAATIGDGLPGMVELTADPS Mvan_3844|M.vanbaalenii_PYR-1 LAGRDEETGRALWRRHLAGVDGPTLLTPALTSSAPTPGRPRLTEVRLDAE MUL_3633|M.ulcerans_Agy99 LANQDRSAALAGWMDYLRGVSEPLMVA---YEATAGQSKPGKTELLLPAA MLBr_02353|M.leprae_Br4923 ATRISHAFNLRGPSIAVQTACSSSLVALHLACLSLLSGECDMALAGGSSL Mb0104|M.bovis_AF2122/97 AFDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDS Rv0101|M.tuberculosis_H37Rv AFDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDS MAB_4099c|M.abscessus_ATCC_199 TVSEIKELTKVLRIRRYSVITAACALLVRGWSTSGSEVALDFPVSRR-VH MSMEG_0400|M.smegmatis_MC2_155 IVGRIKELSKTLRIRRYSVTTAACALLAQSWSSTGDQVALDFPVSRR-VS MAV_3244|M.avium_104 VANRIKELSKKLAIRRFSVTTAACALLVRGWSGSGSEVALDFPVSRR-VR TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M VVDRAEQLAQLAGVRRSSVITAACALMVRQRQG-GPKVVLDFPVSRR-TS Mflv_2697|M.gilvum_PYR-GCK ITEAVVDAARARGVTVNSLVQLAWALTLSSLTDRDDITFGVTVSGRPDDL Mvan_3844|M.vanbaalenii_PYR-1 TTRQLAEAARSRGVTMNTLIQMAWATVLSVITDRTDVSFGVTVSGRPGEL MUL_3633|M.ulcerans_Agy99 DTARLRQWAGRHGLTLNTTVLFAWAVVLSRLTDRRDVVFGTVVSGRPDQL MLBr_02353|M.leprae_Br4923 CIPHRVGYWHSPGSMVSAVGHCRPFDVRADGTVFGSGVALVALKPLQAAI Mb0104|M.bovis_AF2122/97 DLN--VATCLVNSVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEH Rv0101|M.tuberculosis_H37Rv DLN--VATCLVNSVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEH MAB_4099c|M.abscessus_ATCC_199 PDSRTLPGMMAGVVPLVLNAPPQSTVAEFCRHVDTRIRELLQHQRFPVHT MSMEG_0400|M.smegmatis_MC2_155 PESKTLPAMLAGVAPLVLDAPPQLTVGEFCKHVDIRIRELLQHQRFPVHR MAV_3244|M.avium_104 PESKTLPAMLAGVVPLVLSTAPESTVADFCKHVDKRIRELLAHQRFPVHT TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M PQLMTIPGMLSGTVPLVLTVPPDAEVNAFCQHVESQIKQAVRHQRFPMHI Mflv_2697|M.gilvum_PYR-GCK AGVESMIGLFVNTVPLRVRLDPALTAGAQCRALQQDAATLRDHSYLGHAE Mvan_3844|M.vanbaalenii_PYR-1 AGVERMVGLFINTVPLRVRLDPAAPAGEQCLALQREAAALRDHGYLSHSE MUL_3633|M.ulcerans_Agy99 LGVETMVGLFINAVPVVHYVSGTEAVVAQCTQVQRQSSAMRDVSYLSLSE MLBr_02353|M.leprae_Br4923 DASDRIHAVILGSAINNDGSMKMGYAAPNPAAQADVIAEAHAVAGIDSST Mb0104|M.bovis_AF2122/97 YRRMYLAINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATDIGPVEGMT Rv0101|M.tuberculosis_H37Rv YRRMYLAINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATDIGPVEGMT MAB_4099c|M.abscessus_ATCC_199 LEDEE--FGLRGPRHAGNRVAVNFIPARLTLDLAGAPATASYTNHGPMGH MSMEG_0400|M.smegmatis_MC2_155 LGDG---GALRGPRQASNRLAVNFIPSRLTLDFAGAEATASYTNHGPMGH MAV_3244|M.avium_104 LEGD-------GLRQAPNRVGINFIPSRLTLDLAGSPATASYTNHGPVGH TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M LESGA--YQQFNEKSAG-AVSVNFMPSVTLAPFGGAASTVTILSFAQGEQ Mflv_2697|M.gilvum_PYR-GCK LRALAGVGELFDTLLVYENFPPGAVAGAGTLEAAGATFTPVALQSLAHFP Mvan_3844|M.vanbaalenii_PYR-1 LRALGGIGELFDTLLVYENFPPGGLVGQARFEANGATFVPSALESLSHFP MUL_3633|M.ulcerans_Agy99 IQREHGRGPLFDSLFVFENAPIDDAIRPAT-TPDGAQFLPVEMESLTHYP MLBr_02353|M.leprae_Br4923 VSYVETHGTGTPLGDPIEIQGLKTAFEVSQIPRPGPCVLGSVKSNIGHLE Mb0104|M.bovis_AF2122/97 VASVLDEEQRTLNLAIWNRADLPACKTHPKVAERIAAALESMAAMWDRPI Rv0101|M.tuberculosis_H37Rv VASVLDEEQRTLNLAIWNRADLPACKTHPKVAERIAAALESMAAMWDRPI MAB_4099c|M.abscessus_ATCC_199 FGLFFIGASDQLVLSSSGDGEPFARFGVPNLAVRLQRLLSEMAADPDRRL MSMEG_0400|M.smegmatis_MC2_155 FGLFFIGAGEELFLSTAGAGQPFANFEVPELAERLGAIVAAMAADPAMPL MAV_3244|M.avium_104 FGLFFLGAGDQLFLSTAGPGQPFASFGVADLAGRLQQILAAMTEDPDRPL TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M FGMVFTKDGGRLFLHTVGSGGPFADLDVSDLAARLQAVLTVMAAEPGRRL Mflv_2697|M.gilvum_PYR-GCK VTIAAHLTDGRLTVLVEAKDGALGQITPRALGTRLLATVSRIVEGWDRPL Mvan_3844|M.vanbaalenii_PYR-1 VTIAAHLADDELTVFVEVIDGALGALRPGDLGRRVLHTAQRLISCWDAPL MUL_3633|M.ulcerans_Agy99 LTVVSHLREDELLVLIEAIAEALPYLPAAEIGERMLTVLRQLPDIGDGTP MLBr_02353|M.leprae_Br4923 VAAGIAGLIKTILCLKNKAIPATLHYTSPNRELRLDQTPFVVQSNYGPWK Mb0104|M.bovis_AF2122/97 AMIVN----DWFGIGPDGTRCQGDWPARQPSTPAWFLDSARG-------- Rv0101|M.tuberculosis_H37Rv AMIVN----DWFGIGPDGTRCQGDWPARQPSTPAWFLDSARG-------- MAB_4099c|M.abscessus_ATCC_199 SSLDSLVNDELADLAELGNRAILTAPAARPVSIPELFTAQVSAEPDAVAL MSMEG_0400|M.smegmatis_MC2_155 AAVRLLAESESDRLATIGNHSALSESAPDAVSIPERFAARVAEAPDAAAL MAV_3244|M.avium_104 SSIELLTGDEPALIDRWSNRPALTEPAPAPVSIPQAFAEHVQRTPDAVAV TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M SLIDLLDPNEHERLDDWGNRAALTKAVPTPGSLPALFAAQVARTPEATAI Mflv_2697|M.gilvum_PYR-GCK REISISPDDHPVPVPVSEAAPTPSPSTGVHTRFTETASARLGSVALSWDG Mvan_3844|M.vanbaalenii_PYR-1 RSVGVLLPAEHTPAPMVREPLTAN---SIHDRFAGIAGDRLGSVALTWEA MUL_3633|M.ulcerans_Agy99 DDLDIRTAAELKAHGLLAARSAPTFDTTVWEMFERQVQTTPDAVALAAAG MLBr_02353|M.leprae_Br4923 WDGVRRAGVSSFGVGGTNVHVVLEEASVEASTVAASTGPQVILLS----- Mb0104|M.bovis_AF2122/97 -----VHQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIA Rv0101|M.tuberculosis_H37Rv -----VHQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIA MAB_4099c|M.abscessus_ATCC_199 TFGGSSLTYRELDEAADRLAIQLGHRGVGPGDRVILFSDRSARAVIGILA MSMEG_0400|M.smegmatis_MC2_155 TFEGRTLTYRELDEAANRFAHALLARGIGPGSRVALMSPRTDRSVIAILG MAV_3244|M.avium_104 TFGATSLTYAQLDEASNRLGHLLADHGVGPGDCVAVMFPRCADAIVSMLA TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M TDGDVSLTYAQLDAQSTQLAQALTALGARPGELIALLLPRTHRGIIAILA Mflv_2697|M.gilvum_PYR-GCK G----ALTYRQLDEAADRLAAVLTASGVRTETPVAVRLRRGADYVVAMFA Mvan_3844|M.vanbaalenii_PYR-1 GGDSGTLTYRQLDEAADRMAVALTAAGVGPETSVAVLLSRGPDYVVTMLG MUL_3633|M.ulcerans_Agy99 G---VRHTYAELHARACRLAGELAEHGVGPETVVALVLPRSERSIVAILG MLBr_02353|M.leprae_Br4923 -----AQTAAALGESREALATVLEKPGAPDLSDVAYTLAGRRKHNITMAA Mb0104|M.bovis_AF2122/97 CHLAGCGYSVCDTADEISVRTNAITEHGDGILVTVVDVAAT-----QLAV Rv0101|M.tuberculosis_H37Rv CHLAGCGYSVCDTADEISVRTNAITEHGDGILVTVVDVAAT-----QLAV MAB_4099c|M.abscessus_ATCC_199 VLKTGAAYLPVDPAVPASRLEFIVSDAAPVAAITTTDLRGRLDGFGLAVI MSMEG_0400|M.smegmatis_MC2_155 AFKAGAAYVPVDPAVPAARVRFILDDASPVAVVTTAELRSRFDGHDLAVI MAV_3244|M.avium_104 VLKTGAAYVPIDPAHASSRMDFVLADAAPSAVITTSDLRSRLDDHDLLVI TH_3730|M.thermoresistible__bu --------------------------------VTTAELGARLHRSGVPVI MMAR_2518|M.marinum_M VLKTGAGYLPIDPMHPDTRIAFMLNDSTPIAAITTGALHPRLNDYDLPVI Mflv_2697|M.gilvum_PYR-GCK VLKAGGAIVPLDPAMPADRIEVILRRAG-----------------VTVVV Mvan_3844|M.vanbaalenii_PYR-1 VLKAGGVIVPLDPAMPAERISDILEQSR-----------------ASVVV MUL_3633|M.ulcerans_Agy99 VLAAGGAYLPVDVTLPSARVESIVRQASPALAITEADYSQLVGTAVPTLA MLBr_02353|M.leprae_Br4923 VVRDREHAVTVLRAAEHDNVFVGESGADTG--------RSAAASITTLGS Mb0104|M.bovis_AF2122/97 VGHDELRKVVDERVTQVTHDALLATKTAYIMPTSGTTGQPKLVRISHGSL Rv0101|M.tuberculosis_H37Rv VGHDELRKVVDERVTQVTHDALLATKTAYIMPTSGTTGQPKLVRISHGSL MAB_4099c|M.abscessus_ATCC_199 DLDAHTDSPAEGQS-GLVPAAPAPDDIAYIIYTSGTTGAPKGVAVTHHNV MSMEG_0400|M.smegmatis_MC2_155 DID---DPAIASLP-ATAVSDPRPDDIAYVIYTSGTTGTPKGVAVTHKNL MAV_3244|M.avium_104 DVH---DPAVEAQP-GTALPWPAPENTAYIIYTSGTTGTPKGVAIPHLNV TH_3730|M.thermoresistible__bu HID---DPAAPGQAGATTGPAPAPDDIAYIIYTSGTTGVPKGVAVTHRNV MMAR_2518|M.marinum_M DIE---NPPTDTTP-ATNPPTPTPHDLAYIIYTSGSTGTPKGVGITHHNV Mflv_2697|M.gilvum_PYR-GCK DEDTVARAT-AEPPAQYRPAETLPGQAAYVVFTSGTTGEPKGVIGTHRAL Mvan_3844|M.vanbaalenii_PYR-1 DDAFVAAVPDVEPPAGYRPAEVTADRAAYIVFTSGTTGRPKGVVGTHGAV MUL_3633|M.ulcerans_Agy99 LDDPAAVDSISRRSAAAPTVDRRPEQSAYVIFTSGSTGEPKGVAGTNAAV MLBr_02353|M.leprae_Br4923 DRVVFLFPGQGAQHVGMAKGLYDTESVFAEHFDTCSAGFREAMDDLDLHS . : ::* : : . Mb0104|M.bovis_AF2122/97 AVFCDAISRAYG----WGAHDTVLQCAPLTSDIS-VEEIFGGAACGARLV Rv0101|M.tuberculosis_H37Rv AVFCDAISRAYG----WGAHDTVLQCAPLTSDIS-VEEIFGGAACGARLV MAB_4099c|M.abscessus_ATCC_199 TQLMQSLDAG------LPKPGVWPLCHSLAFDVS-VWEIWGALLRGGRLA MSMEG_0400|M.smegmatis_MC2_155 THLIAVLEER------LPKPGVWPLCHSLAFDAS-VWEISNALLRGGRLV MAV_3244|M.avium_104 TWLIESLDAG------LPPGNVWTQCHSSAFDFS-VWEIFGALLRGRRLL TH_3730|M.thermoresistible__bu AALLSALDAE------LASGQVWTQCHSLAFDFS-VWEIWGPLLYGGRVV MMAR_2518|M.marinum_M TQLLNSFDPQST-AILFSPNRVWTQWHSYSFDVS-VWEIWGALLSGARLV Mflv_2697|M.gilvum_PYR-GCK LAYADDHIGAILRPAADRVGRPLRIAHAWSFTFDAAWQPLAALLDGHSVH Mvan_3844|M.vanbaalenii_PYR-1 LGYAEDHAEQVLRPAAARIGRPLRVGHAWSFTFDAAWQPLAALLDGHSVH MUL_3633|M.ulcerans_Agy99 LSYFADHAERVYRAARARLGRPLRIAHAWSLSFDASWQPMVGLLDGHEIH MLBr_02353|M.leprae_Br4923 AIFNGTAIDLERIDRSQPALFTVEYALAKLVESFGVGAGAYIGYSTGEYI . Mb0104|M.bovis_AF2122/97 RSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADG-DAIDAIGRSR Rv0101|M.tuberculosis_H37Rv RSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADG-DAIDAIGRSR MAB_4099c|M.abscessus_ATCC_199 VVPESITASPADFHDLLVAEQVTVLTQTPSAVAMLSPDG---------LE MSMEG_0400|M.smegmatis_MC2_155 VVPEAVAGSPEDFHDLLVAEQVTFLTQTPSAVAMLSPDG---------LE MAV_3244|M.avium_104 VVPESVASSPEDFHALLVAEQVSVLTQTPSAVAMLSPEG---------LE TH_3730|M.thermoresistible__bu IVPDPVVRSPEDLHALLAAEQVGMLSQTPSAFYALQTADSLQPEQARQLQ MMAR_2518|M.marinum_M VVPEHTAKSPDELLGLLVDERVNVLSQTPSAFYALQAAAEASDELSSRLQ Mflv_2697|M.gilvum_PYR-GCK IVDDATQRDAEALVDTIARFGVDMIDTTPSMFARLRDVG-----LLSTVP Mvan_3844|M.vanbaalenii_PYR-1 LLGEESQRDAEALVYRIGRFGIDMLDTTPSMFAQLHDVG-----LLSTVP MUL_3633|M.ulcerans_Agy99 LFDADEMRDADRLVEGIAIGQIDMIDTTPSMFVQLSAAG-----LLDHN- MLBr_02353|M.leprae_Br4923 AATLAGVFDLETAIKTVSLRARLMHESPPGAMVAVALGP-------EDIT . : . ... : Mb0104|M.bovis_AF2122/97 LRQIVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIVC Rv0101|M.tuberculosis_H37Rv LRQIVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIVC MAB_4099c|M.abscessus_ATCC_199 STALAVVGEACPAAVVDKWAP-----GRTMINAYGPTETTMCVAISAPLK MSMEG_0400|M.smegmatis_MC2_155 SMTLAVVGEACPPALVDRWAT-----NRTMINAYGPTETTICVTSSSPLE MAV_3244|M.avium_104 STALVVAGEACPTDVVDRWAAP----GRVMLDAYGPTETTVCASISTPLT TH_3730|M.thermoresistible__bu LQTVVFGGEALEPQRLSAWMRN-HPERPRLINMYGITETTVHASFREIGA MMAR_2518|M.marinum_M LDAALFAGEALQPHRLTSWMSR-HPRRPGLFNLYGTTETTVHASWREIVG Mflv_2697|M.gilvum_PYR-GCK LAVLALGGEAVDPGLWQQIRQECARTGMSAFNCYGPTETTVEAVVAEIGA Mvan_3844|M.vanbaalenii_PYR-1 LAVLALGGEAVSPATWRLIGDECARTGMTAFNCYGPTETTVEAVVAPIDG MUL_3633|M.ulcerans_Agy99 LSVLALGGEAINTGLWDQLR---GLSQMAVYNCYGPTEMTVEAVVAAVKD MLBr_02353|M.leprae_Br4923 EYLAEYSAKGVELSAVNDPGNCVVAGPKDQIRAFSQRLDEVGIPVRRVRA .:. :. : Mb0104|M.bovis_AF2122/97 DQTT---------MDGALLRLGRPILPNTVFLAFGEVVIVGDLVADGYLG Rv0101|M.tuberculosis_H37Rv DQTT---------MDGALLRLGRPILPNTVFLAFGEVVIVGDLVADGYLG MAB_4099c|M.abscessus_ATCC_199 ADLPDAVVPIGSPVPGAALFVLDTWLQPVPAGVVGELYVAGDGVACGYVG MSMEG_0400|M.smegmatis_MC2_155 PGS--VVVPIGSALPRTALFVLDPWLRPVPTGVAGELYVAGDGVTCGYIG MAV_3244|M.avium_104 AGDP--VVPIGSPIAGAAMFVLDKWLQPVPAGVVGELYLAGRGVGHGYVR TH_3730|M.thermoresistible__bu ADLDDNTSPIGRPLPHLAFFVLDGWLRPVPPGVVGELYVAGAGLATGYVS MMAR_2518|M.marinum_M SDTAADVSPIGTPLPSLGFFVLDGWLRPVPVGVVGELYVAGGGVGLGYWR Mflv_2697|M.gilvum_PYR-GCK HERP----TIGRPTAPTRAYVLDSWLRPVPSGAAGELYLAGGQLTRGYLG Mvan_3844|M.vanbaalenii_PYR-1 YQRP----SIGQPTRTMRTYVLDAWLRPVPDGVAGELYLSGRQLTRGYLG MUL_3633|M.ulcerans_Agy99 YRKP----TIGTANAGTFGYVFDSALRMVPDGVVGELYLSGAQLARGYVG MLBr_02353|M.leprae_Br4923 THAFHTS-SMEPMLREFSEFLSRQQLRVPNTPLLSN--LTGTWMSEQQVT : * .: : * : Mb0104|M.bovis_AF2122/97 IDGDGFGTVTAADGSR---RRAFATGDRVTVDAEGFPVFSGRKDAVVKIS Rv0101|M.tuberculosis_H37Rv IDGDGFGTVTAADGSR---RRAFATGDRVTVDAEGFPVFSGRKDAVVKIS MAB_4099c|M.abscessus_ATCC_199 RSDLTASRFVACPFGK-PGTRMYRTGDLVLWGDDGQLQYLGRADEQVKIR MSMEG_0400|M.smegmatis_MC2_155 RSGLTASRFVPCPFGE-PGARMYRTGDLVRWGRDGQLEYLGRADEQVKIR MAV_3244|M.avium_104 RPGLTASRFVPNPFGA-PGSRMYRTGDLVCWGPDGQLQYLGRADEQVKIR TH_3730|M.thermoresistible__bu RSDLTSTRFVACPFGP-PGTRMYRTGDLVRWDTGGELHYIGRADEQVKIR MMAR_2518|M.marinum_M RADLTGTRFVACPFGQTPGTRMYRTGDLVWWGTDGQLRYLGRADNQVKIR Mflv_2697|M.gilvum_PYR-GCK RPGETAARFVPDPFVP--GARMYRTGDVVRRAVDGTLAFLGRSDTQVKIR Mvan_3844|M.vanbaalenii_PYR-1 RAAETAGRFVADPFTP--GQRMYRTGDVVRRGADGGLQFLGRADNQVKIR MUL_3633|M.ulcerans_Agy99 RPGMTAARFVADPLRP--GQRMYRTGDLVRRLSHGGYAYVGRADTQVKIR MLBr_02353|M.leprae_Br4923 DPENWTRQISSTIRFADELDVVLSQSGRVLVEVGPGGSLTGSAMRHPRWS . . .. * * : Mb0104|M.bovis_AF2122/97 GKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTREGE---QDA Rv0101|M.tuberculosis_H37Rv GKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTREGE---QDA MAB_4099c|M.abscessus_ATCC_199 GYRIELGEVQAALGALDGVDQAAAIVREDRPGDKRLVGYVTGT----ADP MSMEG_0400|M.smegmatis_MC2_155 GYRIELGEVQSALAALDGVESAAAIMREDRPGDRRLVGYITGT----ADP MAV_3244|M.avium_104 GFRIELGEIQSVLAGLDGVEQAAVVAREDRPGDKRLVGYITGT----ADP TH_3730|M.thermoresistible__bu GYRIELGEIQAALARLDGVDQAAVIAREDRPGDKRLVGYITGT----ADP MMAR_2518|M.marinum_M GFRIEPCEVGAALSRMAGVDQAVVIARHDHPGDPRLVGYFTGN----ADP Mflv_2697|M.gilvum_PYR-GCK GFRVEPGEVAAVLRTHPAVGQAYVAVRPHRDG-HRLTAYVTGE----PQL Mvan_3844|M.vanbaalenii_PYR-1 GFRVEPGEIAAVLSGHPAVTDAHVVVDRVGTQ-TRLIAYVAAAT--PPAV MUL_3633|M.ulcerans_Agy99 GYRVEVGEIEAALRGQPGVHDAAVSVLRQQDR-TSLVGFVVWQDNMHEDL MLBr_02353|M.leprae_Br4923 SGHRAVRLMRHPLQNVDDHDTFLRALGELWSAGIEVDWAPQRS--VMPHL . : : : Mb0104|M.bovis_AF2122/97 AAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQ----WS Rv0101|M.tuberculosis_H37Rv AAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQ----WS MAB_4099c|M.abscessus_ATCC_199 AEIRGILSKRLPPYMVPAAVVVLETLPLTSNNKLDTRALPAPEY----GG MSMEG_0400|M.smegmatis_MC2_155 VDIRAELADRLPPYMVPTAIVVLPALPLTSSNKLDTRALPAPEY----AN MAV_3244|M.avium_104 AELRAQLADRLPPYMVPTAVMVLDALPLTGNGKLDKRALPSPEY----AA TH_3730|M.thermoresistible__bu VQARAQLADRLPPYMVPAAIVVLESIPLTSNNKLDVRALPAPEY----RA MMAR_2518|M.marinum_M TELRAALATQLPHYMVPTALIPIAELPLTVNGKLDTRALPAVQY----GH Mflv_2697|M.gilvum_PYR-GCK RELRAWLGRRLPRYLMPNAIVAVDRIPLTAHGKIDEPALVALEP-----A Mvan_3844|M.vanbaalenii_PYR-1 ADLRELMAKRLPRYMVPQRVVVLDELPLTSHGKIDEAALAGIA------V MUL_3633|M.ulcerans_Agy99 IKLRAGLTERLPSYMVPARIVTLPRLPVNANGKLDGHALDRLAEDALTSV MLBr_02353|M.leprae_Br4923 VSLPGYPFARQRHWVEPRYTIWAQIPGASSGSPVDSSVDSATVEG----- : . : . . :* Mb0104|M.bovis_AF2122/97 AAGLNTAETGQRAAGLSQIWSRQLG-RAIGPDSSLLGEGIGSLDLIRILP Rv0101|M.tuberculosis_H37Rv AAGLNTAETGQRAAGLSQIWSRQLG-RAIGPDSSLLGEGIGSLDLIRILP MAB_4099c|M.abscessus_ATCC_199 LGADYRAPGNAVEEILAGVYAQVLGVERVGVDDSFFDLGGDSILSMQVVA MSMEG_0400|M.smegmatis_MC2_155 AEKNYRAPSNPVEEVLADIYAQVLGVERIGVDDSFFDLGGDSILSMQVVA MAV_3244|M.avium_104 G--EYRAPGDAIEEILADIYAQVLGVERVGVDDSFFDLGGDSILSMQVVA TH_3730|M.thermoresistible__bu TGAEYRAPGTPLEGLLAGIFAEVLGVERVGVDDSFFDLGGDSILSMQVVA MMAR_2518|M.marinum_M T-QRYRAPDTPAEQTLAAIYAQVLGLDRVSVDDSFFDLGGDSLSAMRVVS Mflv_2697|M.gilvum_PYR-GCK ADGAATRPQTPTEVELAAVLAEVLGVGEIDVTADFLELGLDSIVALSVVQ Mvan_3844|M.vanbaalenii_PYR-1 EDAPSAAPETPTETALVELMAEVLGDDGIDVEADFLEMGLDSIVALTLVQ MUL_3633|M.ulcerans_Agy99 SGGTAVSASTDTERVLCELFEEQLN-AVPHIDDDLFLFGMDSIVAISLVH MLBr_02353|M.leprae_Br4923 ----VRGGESQTEATLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISISM * : . *. .:: * .*: : : Mb0104|M.bovis_AF2122/97 ETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQRPA Rv0101|M.tuberculosis_H37Rv ETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQRPA MAB_4099c|M.abscessus_ATCC_199 RAR-AAGVLCRPRDVFIEQTVSRLAAVAEVSGG-EAYV---------ADE MSMEG_0400|M.smegmatis_MC2_155 RAR-AAGIQCRPRDVFVEQTVARLASVATVAT--EIGV---------VDD MAV_3244|M.avium_104 RAR-AAGVICRPRDVFVEQTVARLARVSQVAVDGELGA---------ADE TH_3730|M.thermoresistible__bu RAR-AAGVQCRPRDIFVEQTVARLASVVKVSGG-EPET---------VDD MMAR_2518|M.marinum_M AAR-AAGLACRTRDIFRHQNVAALARVVEHIGADVCLG---------DDD Mflv_2697|M.gilvum_PYR-GCK TAR-RRGVVMRAKLMLDCATVRELAAAIDDAGSGPP---S-------ADE Mvan_3844|M.vanbaalenii_PYR-1 AAR-RRGLEMRARLMLECNTIRELATAIDSGAHDHAPAAV-------TDD MUL_3633|M.ulcerans_Agy99 KAR-RQGLRVDPRMVLTATTIRQLGAAIDAAVDSQD--AP-------ADA MLBr_02353|M.leprae_Br4923 AAA-NEGMTITPQDMYEHPTLASLTAAVDASFASSGLAKP-------PEA : * : . * Mb0104|M.bovis_AF2122/97 AIPLSFAQRRLWFLDQLQRPAPVYNMAVALRLR----GYLDTEALGAAVA Rv0101|M.tuberculosis_H37Rv AIPLSFAQRRLWFLDQLQRPAPVYNMAVALRLR----GYLDTEALGAAVA MAB_4099c|M.abscessus_ATCC_199 GLGTVAVTPIMHWLRDVDGPIVEFNQTLVIQVP----SSVTQDDVVIVLQ MSMEG_0400|M.smegmatis_MC2_155 GTGSAAPTPIIHWLREAGGATDEFNQTLVVQAP----TGVTEPDVVAVLQ MAV_3244|M.avium_104 GIGPVRPTPIMRWLQDIDGPIDEFNQTMVLAAP----AGVGVDDVAVVLQ TH_3730|M.thermoresistible__bu GTGAVVATPIMRWLRGVDGPTDQFNQTVVLQAPPGTDTAAAEADVVAVLQ MMAR_2518|M.marinum_M GVGSVALTPIMRWFNSVASLVAGLHQTVLVQGP----AGVDQADVVVLIQ Mflv_2697|M.gilvum_PYR-GCK GSGPIALLPNAHWLYEFG-DPRRLASTEALRLP----RGITGPQIRALLQ Mvan_3844|M.vanbaalenii_PYR-1 RFGEVMPAPIMSWMYECG-NYRRFTQNVLVSLP----ADITDSRLEQILQ MUL_3633|M.ulcerans_Agy99 DYGAVLPLPMVSWLYEYG-NYRRFTHTVLLRLP----SGIDRSSIELMLQ MLBr_02353|M.leprae_Br4923 AAHPAVPPNIAYFLERGLCDTGRWRVPLILRLD----PKIGSDDIRAVLT :: : : : Mb0104|M.bovis_AF2122/97 DVVGRHESLRTVFPAVDG-----VPRQLVIEARRADLGCDIVDATAWPAD Rv0101|M.tuberculosis_H37Rv DVVGRHESLRTVFPAVDG-----VPRQLVIEARRADLGCDIVDATAWPAD MAB_4099c|M.abscessus_ATCC_199 ALLDRHPSLRLRLQ---------DN-DGDWSLLVPEAGAVDARDRLHVVG MSMEG_0400|M.smegmatis_MC2_155 ALLDRHATLRLRVQ---------DS-DGEWSLLVPDAATVDARDCLSVVD MAV_3244|M.avium_104 ALLDRHPMLRLRVQ---------DDGAGGWSLEAPEVGSVRAADCLRAVD TH_3730|M.thermoresistible__bu ALIDRHPTLRMRAEGMT-----AGDGTDDWSLFIPEPGATSAREVMHTVD MMAR_2518|M.marinum_M ALLDRHAMLRLQVAR---------DSDGGWSLQARPPGCVDARELMRQAE Mflv_2697|M.gilvum_PYR-GCK SVVDAHPVLRTRLDR-----AAMTLVDGGFDLPLTEIEV------GDEGS Mvan_3844|M.vanbaalenii_PYR-1 ALLDRHDMLRAILDERG---RLVTRPPGAVRVADVLRVV------DAAAH MUL_3633|M.ulcerans_Agy99 LLLDGHDTLRSILTETPEGPRLVTREPAAVRAEDVLTRIRLPEGSDDELA MLBr_02353|M.leprae_Br4923 AVVNHHDVLRLSLVDNDGMWEQHIAATGEFTRLLTQTLPDGVAAGSAEER ::. * ** Mb0104|M.bovis_AF2122/97 RLQRAIEEAARHSFDLATEIPLRTWLFRIADD----EHVLVAVAHHIAAD Rv0101|M.tuberculosis_H37Rv RLQRAIEEAARHSFDLATEIPLRTWLFRIADD----EHVLVAVAHHIAAD MAB_4099c|M.abscessus_ATCC_199 ELSDEALVAARTALDPATGSMLSAVWVPGT-------AQLALVIHHLAVD MSMEG_0400|M.smegmatis_MC2_155 TLSDDVVLAARAKLNPAAGAMVSALWVRQT-------SQLVLIIHHLAVD MAV_3244|M.avium_104 SLSDAALVEARSRLNVSDGVLLSAVWASET-------SQLALVVHHLAVD TH_3730|M.thermoresistible__bu TLTDEVLIAARSRLNPAAGVMLSAVWARGS-------GQLVLMIHHLAVD MMAR_2518|M.marinum_M VMSGELLAGALSRLDPAAGVMVSAVWVSST-------AQLLLAIHHLAVD Mflv_2697|M.gilvum_PYR-GCK AAVARHAAAALEHLDPQRGPLWGAVWLRGSDDADSTSSVLLLTAHVLAMD Mvan_3844|M.vanbaalenii_PYR-1 TVLAAEVVAALDRIDPTSGAMVQAVWFRHG------PPVLALCVHHLSTD MUL_3633|M.ulcerans_Agy99 SAVAHAARVVTDQIDPSAGAMVRAIWFRGTEHRADPANMLLLTAHHLAVD MLBr_02353|M.leprae_Br4923 AVVSSILAELIASQSDLNEPLTAVQITTAHGG----PHYLGLAVHQMVID . . * * : * Mb0104|M.bovis_AF2122/97 GWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGDLDDS Rv0101|M.tuberculosis_H37Rv GWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGDLDDS MAB_4099c|M.abscessus_ATCC_199 GVSWRILLEDINIAWAQHHGGADIELPAGGTSFARWSALLAEHA-----L MSMEG_0400|M.smegmatis_MC2_155 GVSWRILLEDLNIAWAQHHSGQQVQLPAGGTSFLRWSKRLADHA-----H MAV_3244|M.avium_104 GVSWRTLIEDINIAWAQHQGGQEIALPVPGTSFARWSSILAEYA-----K TH_3730|M.thermoresistible__bu GVSWRILVEDLNIAWAQHRTGQPIDLPANGTSFARWSALLADHA-----R MMAR_2518|M.marinum_M GVSWRVLLDDLNTGWAQYRRAGAVSLPAAGSSFRQWATMLVDYA-----Y Mflv_2697|M.gilvum_PYR-GCK PVSWQIVIGELDAGWHALAGGRAPAALGEHTGYRQWSNLLRERA-----E Mvan_3844|M.vanbaalenii_PYR-1 VVSWYLILGALAQIDATLAAGHAPDPAAEYTTYREWTRRLYQRS-----R MUL_3633|M.ulcerans_Agy99 VVSWHIMLGDLAAAWRSLQAGTPPKILPEFTSYRRWCELMWHRA-----S MLBr_02353|M.leprae_Br4923 DASRQILGTDIITAFGQRLAGEEITLEPVTTGWREWSLRCAALA-----T * : : . : : Mb0104|M.bovis_AF2122/97 DSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRGASLVVDWPASVQ Rv0101|M.tuberculosis_H37Rv DSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRGASLVVDWPASVQ MAB_4099c|M.abscessus_ATCC_199 STDVVEQADTWRQVLATPARVGTV---QPEIDTYANAGRLSVALDTETTR MSMEG_0400|M.smegmatis_MC2_155 TAEVTAQADAWREILAKPAALPAV---QPDTDTHASAGRFSATLDPETTR MAV_3244|M.avium_104 SPAVVAAAAAWQQVVATPAVLPAV---GPD-DTYASAGQLSASLDVETTR TH_3730|M.thermoresistible__bu APEVVEHVEAWQRVIAAPSALPAI---RPERDTYATAGQLSVSLDADTTR MMAR_2518|M.marinum_M DPAVTAQLAAWRQIAAVPAVIAAP---DREVDNAASAGHLSVVLDAATTQ Mflv_2697|M.gilvum_PYR-GCK SSDG---LQFWLDQLGGPDPALGARRVRPDTDRAGDVRVTVTVTGADVT- Mvan_3844|M.vanbaalenii_PYR-1 TEAVERRRGFWVEQLAGSDPLLGRRLPDPRHDTWSTLQSTDVVTDAGATR MUL_3633|M.ulcerans_Agy99 APQVQDQRDYWAALVREPDPELGLRYPDPTRDTWSTLQLTRAAIPVDVT- MLBr_02353|M.leprae_Br4923 HPAALDTRSFWIENANKVNLWLADVSLNTDVIQPPGADDLIRMPCTLSVE * . Mb0104|M.bovis_AF2122/97 QQVRRIARQHN----ATSFMVVAAGLAVLLSKLS----GSPDVAVGFPIA Rv0101|M.tuberculosis_H37Rv QQVRRIARQHN----ATSFMVVAAGLAVLLSKLS----GSPDVAVGFPIA MAB_4099c|M.abscessus_ATCC_199 QLLGEVPAAFH--AGVQDILLIAFGLAWNEFLGV----SGAPIAFDIEGH MSMEG_0400|M.smegmatis_MC2_155 QLLGEVPAAFH--AGVQDILLVAFGLAWAEFLNR----SGTPITVDVEGH MAV_3244|M.avium_104 LLLGEVPAAFH--AGVQDILLIAFGLACTEFVG-----GGAPIGIDVEGH TH_3730|M.thermoresistible__bu QLLGAVPAAFH--AGVQDILLIAFGLAWAEFLGA----CDSPIGIDVEGH MMAR_2518|M.marinum_M ALITKVPAAFH--AGVHDILLIAFAVAWQEFLAD----PTGVIGVDVEGH Mflv_2697|M.gilvum_PYR-GCK ---ARLLAGP---HPVLDVLVAALGRTITEWRGRRNQPTPP-PLVALETH Mvan_3844|M.vanbaalenii_PYR-1 AILDRLDGAS---LEVRDFLLTALTLTLASWRIERGQPAHHGALVALEGH MUL_3633|M.ulcerans_Agy99 ---ERVLGAVRRDQGVRELLLAATAMAVASWRRVRAQDPAAGVLVALEGH MLBr_02353|M.leprae_Br4923 QTSELDDARRRFRRSIQAIVLAALGRTIAQTVGDG------VVAVELEGE .:: * : . . Mb0104|M.bovis_AF2122/97 GRS------------DPALDNLVGFFVNTLVLRVNLAG------------ Rv0101|M.tuberculosis_H37Rv GRS------------DPALDNLVGFFVNTLVLRVNLAG------------ MAB_4099c|M.abscessus_ATCC_199 GRQ---EEIGEAVHRRIDLSRTTGWFTTKYPASLAVG--ELSWAQVSAGE MSMEG_0400|M.smegmatis_MC2_155 GRH---EELAS----DIDLSRTVGWFTTKYPVALTVA--DVPWAQVVAGE MAV_3244|M.avium_104 GRH---EEIAS----GVDLSRTVGWFTTKYPVALRMGR-RLDWARVVAGE TH_3730|M.thermoresistible__bu GRA---EELAA----GVDLSRTVGWFTTKYPVALTIP--KLSWEQVRTGG MMAR_2518|M.marinum_M GRN---DELSP----GMDLSATVGWFTTKYPVALHAG--PIAWPQFCTGD Mflv_2697|M.gilvum_PYR-GCK GRAALAEADTADTADTADTSDTVGLLSAIYPLRLHE-------DSPG--- Mvan_3844|M.vanbaalenii_PYR-1 GR------EDALVGGGVDTSATVGWFTSVYPVRLGAGEAAIDVDTAARNP MUL_3633|M.ulcerans_Agy99 GR--------ADAVLDTDTTNTVGWFTNAFPVRLGAGAAAVDIEQAERDP MLBr_02353|M.leprae_Br4923 GRS--------VLRPDVDVRRTIGWFTNYYPIPLVCVK-----------G ** * : : Mb0104|M.bovis_AF2122/97 ----------DPSFAELLGQVRARSLAAYENQDVPFEVLVDRLKPTRALT Rv0101|M.tuberculosis_H37Rv ----------DPSFAELLGQVRARSLAAYENQDVPFEVLVDRLKPTRALT MAB_4099c|M.abscessus_ATCC_199 AALGPVIKTAKEQLRALP-DGLTYGLLRYLNPG----VDLTGPEPTIGFN MSMEG_0400|M.smegmatis_MC2_155 ATLGAVVKDVKEQLRAVP-DGLTYGLLRYLNSE----VELGGTEPTIGFN MAV_3244|M.avium_104 AALGAVIKDAKEQLRALP-DGLSYGLLRYLNPE----IEVQGPDPVIGFN TH_3730|M.thermoresistible__bu DALGAAVKAAKEQLRSVP-DGITYGLLRHLNPD----VELGGAEPAIGFN MMAR_2518|M.marinum_M TVVGAVVKDLKEQLRAVP-EGLTYGLLRYQNHE----VDFAEPDPPIAFN Mflv_2697|M.gilvum_PYR-GCK --------ATTELIAGVPAGGIDYGLLRYLRPDT-SEVLKAHPEPQILLN Mvan_3844|M.vanbaalenii_PYR-1 AAARSLLRAVIQQLAEVPDKGLDYGLLRYTRRD---ETLRALPEPQVEFN MUL_3633|M.ulcerans_Agy99 VAAQDLVHSVVSHLEAIPNDGLDYGLLRYVDGV---AELVDAVDPQIQFS MLBr_02353|M.leprae_Br4923 QGALAQLDAVHNTLKSIPHYGIGYGLLRYMYAPTG-RVFSAQRTPDIHFR : : .* : * : Mb0104|M.bovis_AF2122/97 HHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMDLVFSLAERFSE Rv0101|M.tuberculosis_H37Rv HHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTARMDLVFSLAERFSE MAB_4099c|M.abscessus_ATCC_199 YLGRLGAGAGDLSEDFWRISADSLRLTDVAAAIS-MPLAHSVELNAGTMD MSMEG_0400|M.smegmatis_MC2_155 YLGRLGAGAGELSEELWRIEQGSLALTDVVSAVP-MPLAHTVELNAGTMD MAV_3244|M.avium_104 YLGRLGAGA-DLSEEMWRVSADSLSSAAVATAVP-MPLAHTVELNAGTMD TH_3730|M.thermoresistible__bu YLGRLAAGAGDLPDELWRIDPSGLPITEAASKIP-MPLAHTVEVNAGTLD MMAR_2518|M.marinum_M YLGRFEGFDRLGGSGGWHLSGAGLMLAETARVMADMPLTHTVALNAVTID Mflv_2697|M.gilvum_PYR-GCK YLGRTDLVPSG-----AIVADRLLLSGLSTVPEPNAAVRHELTVVAAVVA Mvan_3844|M.vanbaalenii_PYR-1 YIGRYDLSADQTSQAWSLITDETLNAHMPAAAEPDLPLRYTFDVISVISG MUL_3633|M.ulcerans_Agy99 YLGRLDLGGVADQP-WSLLTGPYLDA-LPIDPEPDLPLRFALNLSVFVGV MLBr_02353|M.leprae_Br4923 YVGVVPEPPSVDATVQFDSDMTIPVQEPVPGMGHAIELRTYRFGGSLHLD : : Mb0104|M.bovis_AF2122/97 GSE-PAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPER------ Rv0101|M.tuberculosis_H37Rv GSE-PAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPER------ MAB_4099c|M.abscessus_ATCC_199 TAA-GPELRANWSWAPSALDGAQADRLSRLWFEALAGICAHVRSGGGGLT MSMEG_0400|M.smegmatis_MC2_155 TDK-GPSLQASWTWAPSVFDEDKAARLSQLWFEALAGICAHVQAGGGGLT MAV_3244|M.avium_104 TDA-GPQLHANWRWARSVLTDEQLNRLSRLWFEALTGICAHVQAGGGGLT TH_3730|M.thermoresistible__bu AGPDGPVLQATWTWAPSLVDEAQIARLSRLWFEALGGVCAHVRSGGGGLT MMAR_2518|M.marinum_M TDA-GPQLHAEWTWASSVFDRGALVKLAGLWFDALAAISAHVDAGGGGLS Mflv_2697|M.gilvum_PYR-GCK HGD-EPALVAQWRVLPEILSDTDVEEMQTIWQD---TLREVL-------- Mvan_3844|M.vanbaalenii_PYR-1 GAD-GPQLRTSWRWSTALSTSTEVDRLTALWQQAVTVLGEAL-------- MUL_3633|M.ulcerans_Agy99 TAE-GTQLIGNWRWSDAVFERSDIDHLTGLWQRGIAALAAGLD------- MLBr_02353|M.leprae_Br4923 WWY---DIRRIPQVTAEALAQSFPVTLSKLIQEGIATQKDAHDESEMAGA : : Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 PSDLAPARLNQPQIDALVQQYDISDVLPLTPLQQGLLFQAGFAEATG--- MSMEG_0400|M.smegmatis_MC2_155 PSDIAPARLTQREIDQLTTQFEVADVLPLTPLQQGLLFQAGFAEAAGAEA MAV_3244|M.avium_104 PSDIAPARLDQQQIDELCQQHQIADVLPLSPVQQGLLFHTGFAQELE--- TH_3730|M.thermoresistible__bu PSDIAPARLTQQQIDELADRHDIADILPLTPVQQGLLFHSAVTRTTA--- MMAR_2518|M.marinum_M PADLPGLSLTQSQIDDLERSYPVKDLLPLTPLQQGLLFHSDAFTSGQ--- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 PQAGVLVDLSTLDAG----------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 -DSTEDDVYAVQLALTLTGALDVARLHDAVSAVAKRHPNLVARFSEE-YG MSMEG_0400|M.smegmatis_MC2_155 AGVPSDDVYAVQLGITLSGSLDPQQLRDAVQAVIRRHPNLAARFVEQ-FG MAV_3244|M.avium_104 ------DLYAVQLGITVSGTLDPHRLRDAVQNAVNRHPNLVARFFDE-FG TH_3730|M.thermoresistible__bu -----DDIYAVQLDLTIAGVVDQHRLRDAVHAVVARHPNLAARFCTD-HD MMAR_2518|M.marinum_M -------AYVVQIGIELAGELDPLRLHDAVQTAITRNPNLAARFAYAGLD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 EPVQIILADPVIAWQHVELIG---DIDQQVEQLCAAERAAVCRLFTEPVF MSMEG_0400|M.smegmatis_MC2_155 EPVQVLSVDPEIGWQFVEFDSGDTGVDERVERLCAAERSAVCKLGEQPVF MAV_3244|M.avium_104 EPVQIIPAEPEMAWRYLELDGG--DIDGQLEQLSADERAAVCDLAGQPAF TH_3730|M.thermoresistible__bu HPVQIIPTEPVAAWRYLDLRGDDQNPEHEVQQLCAAERAAVRDLTERPTF MMAR_2518|M.marinum_M EPVQIILDDPVVPWDVIDLSDG---AQRDIEAVSAGQREALRDISNNCPI Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 RAALISGLGGAEDGEVGKHRLVLTAHHIVIDGWSLPILLQEIFSIYYGHQ MSMEG_0400|M.smegmatis_MC2_155 RAALIR---TADN----LHRFVLTIHHIVIDGWSLPVLLQEIFAAYFDQS MAV_3244|M.avium_104 RAALIR---IADD----RHRLLLTIHHIVIDGWSLPVLLQEVFAGYYGQR TH_3730|M.thermoresistible__bu RAALIR---TGAT----EHRFVLTVHHIVIDGWSLPILLQEIFAGYFGQR MMAR_2518|M.marinum_M RAALVK---TAPD----QYRLILTNHHVVCDGWSMSILLGEVFTRYGNGS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 LPAPAPYRNFVTWLAGQDRVAAQSVWGRALDGFEAPTLVGS--LATAGRR MSMEG_0400|M.smegmatis_MC2_155 LPSAAPYRNFVTWLGAQDRDAAQAAWGSVLEGFETPTLVAP--PAQAGPR MAV_3244|M.avium_104 LPAPPSYRSYLMWLSAQDRAAAQDAWREALAGFETPTLVAP--PGKIGRR TH_3730|M.thermoresistible__bu LPAPARFRDFVTWLAAQDRDAARAAWRELLDGFDTPTLIAP--PGQAGPR MMAR_2518|M.marinum_M LATPVPYREHLVWLADQDRDTALLAWREMFSGFDTPTLVSAQGPGESAQH Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 GVESYRISEDITRSLGELARAQHTTVNTVLQAAWAQVLTWLTGQHDVAFG MSMEG_0400|M.smegmatis_MC2_155 GVESFRLSEATTRTLGELARSQHTTVNTVLQAAWAQLLMWMTGQRDVVFG MAV_3244|M.avium_104 AVATYTVSADTTKALGELARSSRTTVSTVLQGAWAQLLTWLTGQHDVAFG TH_3730|M.thermoresistible__bu GSASYRIDTETTAAIGELARTQRTTVNTVLQAAWAHLLMAMTGQRDVVFG MMAR_2518|M.marinum_M AVQSLTLSDAATGALNELARSHHSTLNVVLQAAFAQLLAWLTGHHDVAFG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 TAVSGRPADLAGADSMVGLLINTVPVRANITAATTVADLLDQLQRMHNDT MSMEG_0400|M.smegmatis_MC2_155 TAVSGRPVDLAGADSMVGLLINTVPVRATSGVATTVTDLLGQLQRDHNDT MAV_3244|M.avium_104 TAVSGRPTELPGADAMVGLLINTVPVRADIAAATTVVDLLEQLQRAHADT TH_3730|M.thermoresistible__bu TAVSGRPADLPGADRIVGLLINTIPVRARIGADTTVADLLAQLQHAHNDT MMAR_2518|M.marinum_M TTVSGRSADLAGSESMVGLLINTVAVRARLTATTTTTELIDQLQQFHTDT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 VEHEHLALNEIHHAIGLDRLFDTLFVYENYPIDADALLGARELGITDFSS MSMEG_0400|M.smegmatis_MC2_155 VDHEHMALNEIHRLTGHDRLFDTLFVYENYPIDANALLSVQDLAVTDFAS MAV_3244|M.avium_104 LEHEHLALNEIHRVTGHDQLFDTLFLYENYPIDASALLDVHELAVTEFSS TH_3730|M.thermoresistible__bu LEHEHLALTEIHHLAGHDQLFDTLFLYESYPIDTGAFSGAQELAVTGFTN MMAR_2518|M.marinum_M LEYHHLPLGDIHRAAGHPRLFDTLFVYENYPINDLTALCPDQLTITDITS Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 REYNHYPLSVVAMPGNELSLRVEFDTDVFDSAEIDTVVDKLRQVLAAMTV MSMEG_0400|M.smegmatis_MC2_155 REYNHYPLSMVATPGHEVVLRVEFDTEIFDAASIEALVDRLRRVLDAMAT MAV_3244|M.avium_104 REFNHYPLSVVATPGHELSLRVEYDTEVFDEAGIETLIERLRQVLAAMTT TH_3730|M.thermoresistible__bu REFNHYPLSVMALPGHELGLRIEYDTEVFDTAAIDALADRFRRVLESMVG MMAR_2518|M.marinum_M FETTHYPLTVFVLPGPQLGFRVEYDTAAFDKTAMDSLIARLQAVLTVMAA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 ----TVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARI Rv0101|M.tuberculosis_H37Rv ----TVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARI MAB_4099c|M.abscessus_ATCC_199 DPATRLSSIDLLDAGEHDRLDKWGNRAVLIRPEPALTSIPELFAAQVARA MSMEG_0400|M.smegmatis_MC2_155 DPGRRLSTIDLLDPQEHDRLDEWGNRAVLTRPAPALESIPASFAESVRRV MAV_3244|M.avium_104 DPGQRLSAIDLLDAAEHERLDAWGNRAVLTRRPAAQASIPALFAAQVARA TH_3730|M.thermoresistible__bu DPARRLSAIEVLDAAEREQLDAWSNRAVLADS-PALESIPEVFARQVARD MMAR_2518|M.marinum_M EPGRRLSLIDLLDPNEHERLDDWGNRAALTKAVPTPGSLPALFAAQVART Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 PEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERCAPA Rv0101|M.tuberculosis_H37Rv PEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERCAPA MAB_4099c|M.abscessus_ATCC_199 PEAIAITCGERSWSYGELDATANRLANHLVTHGARPGERVALLLPRTGEA MSMEG_0400|M.smegmatis_MC2_155 PDAVALSCGDRSWTYRELDEASNRMAHLLAGRGAKPGERVAMLLPRTGEA MAV_3244|M.avium_104 ADAVAITCGERSFTYREVEESANRLAHLLSGQGAGPGQRVAVVIPRSAEA TH_3730|M.thermoresistible__bu PGAVAVTFEGRSMTYGELDDAATELANLLAVYGAGPGESVALLMPRSADA MMAR_2518|M.marinum_M PEATAITDGDVSLTYAQLDAQSTQLAQALTALGARPGELIALLLPRTHRG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 VVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAG Rv0101|M.tuberculosis_H37Rv VVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAG MAB_4099c|M.abscessus_ATCC_199 IAAILAVLKTGAAYLPIDPAHPDSRVDFVLGDAAPIVAVTTAELLPRLSA MSMEG_0400|M.smegmatis_MC2_155 VVTILAILKTGAAYLPIDPAHPDARIEFVLKDAAPVAAVSSADLCTRLIA MAV_3244|M.avium_104 VVAIFAVLKTGAAYVPIDPGVPAARLQFVLADSAPVAAVTTAEVRDRLDG TH_3730|M.thermoresistible__bu IVAILAVLKTGAAYLPIDPAVPAARLEFMLSDAEPIVALTTVELGTRFNG MMAR_2518|M.marinum_M IIAILAVLKTGAGYLPIDPMHPDTRIAFMLNDSTPIAAITTGALHPRLND Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 HDLPIIDVVD-ALAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHR Rv0101|M.tuberculosis_H37Rv HDLPIIDVVD-ALAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHR MAB_4099c|M.abscessus_ATCC_199 SGVPVIDIDDPAVSAQNDTTLPVPAVDDIAYIIYTSGTTGAPKGVAVTHR MSMEG_0400|M.smegmatis_MC2_155 SGVPVIEVDDPAIGAEASTSLPVPAVDDIAYIIYTSGTTGTPKGVAVTHR MAV_3244|M.avium_104 FTGQIIDFDDPAVAEQPATGLPVPAADNIAYIIYTSGTTGIPKGVAIPHR TH_3730|M.thermoresistible__bu TGVPIIEVDDPAPPMYPSSTLLPPAPDDIAYLIYTSGTTGVPKGVAITHA MMAR_2518|M.marinum_M YDLPVIDIENPPTDTTPATNPTTPTPHDLAYIIYTSGSTGTPKGVGITHH Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 NVTRLFASLP-----ARLSAAQVWSQCHSYGFDASAWEIWGALLGGGRLV Rv0101|M.tuberculosis_H37Rv NVTRLFASLP-----ARLSAAQVWSQCHSYGFDASAWEIWGALLGGGRLV MAB_4099c|M.abscessus_ATCC_199 NVAQLLESLD---AELALG--QVWTQCHSLAFDYSVWEIWGALLYGGRLL MSMEG_0400|M.smegmatis_MC2_155 NVAQLLDTLG---AQLELG--QTWTQCHSLAFDYSVWEIWGPLLNGGRLL MAV_3244|M.avium_104 NVTLLLETLD---AQLGLG--QVWTQCHSLAFDFSVWEIFGALLHGGRLV TH_3730|M.thermoresistible__bu NVTRVLHTLP---ADLPAGPGKVWSQWHSLVFDVSVWEIWGALLHGGRLV MMAR_2518|M.marinum_M NVTQLLNSFDPQSTAILFSPNRVWTQWHSYSFDVSVWEIWGALLSGARLV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 IVPESVAASPNDFHGLLVAEHVSVLTQTP---------AAVAMLPTQGLE Rv0101|M.tuberculosis_H37Rv IVPESVAASPNDFHGLLVAEHVSVLTQTP---------AAVAMLPTQGLE MAB_4099c|M.abscessus_ATCC_199 VVPDAVVRSPEELHALLVSEEVSVLSQTPSAFYALQTADALQPEMGQQLK MSMEG_0400|M.smegmatis_MC2_155 MVPDAVVRSPEDLHAMLVAEQVSMLSQTPSAFYALQTADALYPERGEQLK MAV_3244|M.avium_104 IVPDDIVRSPEDLHALLVREQVSVLSQTPSAFYALQSADALAPELGQQLK TH_3730|M.thermoresistible__bu IVPESITGSPDDLHDLLVAEHVDVVYQTP-------SAAGMLSQRG--LD MMAR_2518|M.marinum_M VVPEHTAKSPDELHALLVAEHVEVLTQTP-------SAAAALSPQG--LE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 SVALVVAGEACPAALVDRWAPGR----VMLNAYGPTETTICAAISAPLRP Rv0101|M.tuberculosis_H37Rv SVALVVAGEACPAALVDRWAPGR----VMLNAYGPTETTICAAISAPLRP MAB_4099c|M.abscessus_ATCC_199 LQTVVFGGEALEPQRLSSWFDSHPGLPRMINMYGITETTVHASFREIDDG MSMEG_0400|M.smegmatis_MC2_155 LQTVVFGGEALEPHRLSGWMHAHPGMPRMINMYGITETTVHASFREIGEA MAV_3244|M.avium_104 LQTVVFGGEALEPHRLATWLHRHPGLPRMINMYGITETTVHASFREIVDA TH_3730|M.thermoresistible__bu STALVVAGEACPTDLVDRWAPGR----VMINAYGPTETTMCVAISAPLTP MMAR_2518|M.marinum_M SVTLVVGGEACPAGLVDQWAPGR----TMINAYGPTEATIYAAMSSPLVP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 --GSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRR Rv0101|M.tuberculosis_H37Rv --GSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRR MAB_4099c|M.abscessus_ATCC_199 DVDSNSSPIGVPLEHLAFFVLDGWLRKVPVGVVGELYVAGSGQASGYLGR MSMEG_0400|M.smegmatis_MC2_155 DLANSTSPIGVPLEHLSFFVLDGWLRQVPVGVVGELYVAGEGLACGYISR MAV_3244|M.avium_104 DVDSSVSPIGVPLANLAFFVLDGWLRPVPVGVVGELYVAGGGLATGYVGR TH_3730|M.thermoresistible__bu --GSGAVPIGTPVPRAALFVLDSWMRPVPAGVIGELYVAGDGVAVGYVGR MMAR_2518|M.marinum_M --GSGATPIGSPVAGASLFVLDGWLRPVPVGVVGELYVAGGGVGLGYWRR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 AGLTASRFVACPFGG-SGARMYRTGDLVCWRADGQLEFLGRTDDQVKIRG Rv0101|M.tuberculosis_H37Rv AGLTASRFVACPFGG-SGARMYRTGDLVCWRADGQLEFLGRTDDQVKIRG MAB_4099c|M.abscessus_ATCC_199 SDLTTTRFVACPFGA-PGSRMYRTGDLVQWGEDGQLRYVGRADKQVKIRG MSMEG_0400|M.smegmatis_MC2_155 SDLTSTRFVACPFGA-PGARMYRTGDLVRWGADGQLQYVGRADEQVKIRG MAV_3244|M.avium_104 PGLSATRFVACPFGG-PGARMYRTGDLVRWGADGQLQYMGRADAQVKIRG TH_3730|M.thermoresistible__bu SELTASRFVACPFGP-PGSRMYRTGDLVRWGADGQLQYLGRADEQVKIRG MMAR_2518|M.marinum_M ADLTGTRFVACPFGQTPGTRMYRTGDLVWWGTDGQLRYLGRADNQVKIRG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 YRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPA Rv0101|M.tuberculosis_H37Rv YRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPA MAB_4099c|M.abscessus_ATCC_199 YRIELGEVHAALARVAGVDQAAVIAREDRPGDKRLVGYITESTAGTLDPT MSMEG_0400|M.smegmatis_MC2_155 YRIELGEVHAALVGLDGVEQAAVIAREDRP-------------------- MAV_3244|M.avium_104 YRIELGEIQAALAGLDGVEHAAVIAREDRPGDKRLVGYITG----TADPA TH_3730|M.thermoresistible__bu YRIELGEVQTALTAVDGVENAVVIAREDRPGDKRLVGYITG----TADPD MMAR_2518|M.marinum_M FRIEPGEVGAALSRMAGVDQAVVIARHDHPGDPRLVGYFTG----NADPT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 GLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGDTNGYR Rv0101|M.tuberculosis_H37Rv GLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGDTNGYR MAB_4099c|M.abscessus_ATCC_199 AVRATLAERLPSYMVPAAVVVLDALPLTVNGKLDTRALPAPEFQDADHYR MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 EVRAQLGERLPGYMVPSAVVVLDALPLTVNGKLDTRALPAPEYSDVDRYR TH_3730|M.thermoresistible__bu QARARLADRLPAYMVPTAVVVLDALPLTVNGKLDTRALPAPEYQDAEQYR MMAR_2518|M.marinum_M ELRAALATQLPHYMVPTALIPIAELPLTVNGKLDTRALPAVQYGHTQRYR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 APAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTL Rv0101|M.tuberculosis_H37Rv APAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTL MAB_4099c|M.abscessus_ATCC_199 APEDAVEEILAGIYAQVLGVEQIGVDDSFFDLGGDSISSMQVVARARAAG MSMEG_0400|M.smegmatis_MC2_155 -----------------------------------ATSGWSVMSPARST- MAV_3244|M.avium_104 APVTAIEEILADIYAQVLGVERVGVDDSFFDLGGDSILSMQVVARARAAG TH_3730|M.thermoresistible__bu APTHAVEEVLAGIYAEVLGIDKVGVDDSFFDLGGDSISSMQVVARARAAG MMAR_2518|M.marinum_M APDTPVEQTLAAIYAQVLGLDRVSVDDSFFDLGGDSLSAMRVVSAINTTL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 NADLPVRALLHASSTRGLSQLLGRDARPTSDPRLVSVHGDNPTEVHASDL Rv0101|M.tuberculosis_H37Rv NADLPVRALLHASSTRGLSQLLGRDARPTSDPRLVSVHGDNPTEVHASDL MAB_4099c|M.abscessus_ATCC_199 LLLRPRDIFVEQTVSR----LAQVAVFADGEATVVDAGTGPVVATPIIRW MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 VICRPRDVFTEQTVAR----LARVATVATGDDDVVDEGTGRVVATPIMRW TH_3730|M.thermoresistible__bu LTIRPRDIFVERTVAR----LAQVAVPTGADAAVDDAGTGPVVATPIMRW MMAR_2518|M.marinum_M NTDVAVRVLFDAP------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 TLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLDV Rv0101|M.tuberculosis_H37Rv TLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLDV MAB_4099c|M.abscessus_ATCC_199 LHGLGGNVGEFNQTVVLQAPEGVSEDDVVTVLQALLDRHATLRLRAEEN- MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 LQNMDGPVEQFNQTMVLAAPAGVTPDDVAAVLQALLDRHAMLRLRVEDDG TH_3730|M.thermoresistible__bu LYDTRGPIDQFNQTVVLRAPAGVTEADVVEILQAVLDRHAMLRLRAADVE MMAR_2518|M.marinum_M ------------TVCTLAQKLSAPESSVEIVPVEVLQDGCGLPLFCLPP- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 DGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGDK Rv0101|M.tuberculosis_H37Rv DGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGDK MAB_4099c|M.abscessus_ATCC_199 DGEWALLIPEVGTVDARACLLAVEALSDEALRHARSRLNPATGSMLSALW MSMEG_0400|M.smegmatis_MC2_155 ----------------------------------RSRPGPRSPSGSPRTW MAV_3244|M.avium_104 AGGWSLEVPEAGSVQAADCLETVDALSPAALVDARSRLNLADGILVRAVW TH_3730|M.thermoresistible__bu N----LTVPESGAVTARGCLRTVHRLSGDELRSARAELDPAAGTMVRALW MMAR_2518|M.marinum_M -----------GGGISWAYRNLSPYLDCPIVGLQQIHDGPESVRELASAY Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 SEPDLGLDQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGTAELIR Rv0101|M.tuberculosis_H37Rv SEPDLGLDQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGTAELIR MAB_4099c|M.abscessus_ATCC_199 ESGKNRLVLIVHHLAVDAVSWRILLEDFNIAWAQHHGGQAVELPSGGTSF MSMEG_0400|M.smegmatis_MC2_155 CPRR---------------SW----------------------------- MAV_3244|M.avium_104 ASETSQLALIIHHLAVDGVSWRTLIEDLNIAWAQHHSGQPVALPTGGMSF TH_3730|M.thermoresistible__bu APDTRRLALIVHHLAVDAVSWRILVEDINIAWGQRHTGQPIDLPAGGTSF MMAR_2518|M.marinum_M ADAIQTHD--------PEGPYQLLGWSFGGVTAHQVAVELQQRGAVVVRL Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 IALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGY Rv0101|M.tuberculosis_H37Rv IALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGY MAB_4099c|M.abscessus_ATCC_199 ARWATLLDERARTADVEALTDTWRQVEKIPPALPAVHPTMDTYASAGQLS MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 ARWSALLEDHARRPEVVERAEDWRQVAAVPAVLPGAQP-GDTYATAGQLS TH_3730|M.thermoresistible__bu ARWSTLLAEYADTPEVVAQAGVWQQVAAX--XWPSCSTPTTTSSSTSTWR MMAR_2518|M.marinum_M IALDPILIRDASTATVVSESDVLEAILQAVGVAAEQYCRPLTYSQAQTL- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 GTSKWAG-------------------------------EVLLREANDLCA Rv0101|M.tuberculosis_H37Rv GTSKWAG-------------------------------EVLLREANDLCA MAB_4099c|M.abscessus_ATCC_199 VSLDADLTRELLGEVPVAYHAGVQDILLIAFALAWNEFLGSAGAPIGIDV MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 ASLDVETTRLLLGEVPAAFHAGVQDILLIAFGLAWTQFIG-TGAPIGIDV TH_3730|M.thermoresistible__bu STRS-------------------------------------TGRPVRTGC MMAR_2518|M.marinum_M -----------------------------------------IQQEVDAEF Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 LPVAVFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSFYEPDSE Rv0101|M.tuberculosis_H37Rv LPVAVFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSFYEPDSE MAB_4099c|M.abscessus_ATCC_199 EGHGRNEEFVADADLSRTVGWFTSKYPVSLAVGELSWAQVVAGDPALGPV MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 EGHGRSEELGPQVDLSRTVGWFTAKYPVALRLGGLSWGQVVGGDEALGAV TH_3730|M.thermoresistible__bu S---------TRCSSTRTIRSMRRRWPGRKALR--------------SPI MMAR_2518|M.marinum_M ALPSRRLVQIMVANANTNLQLNAQHQPGIFAGR----------MVLFSAQ Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 GNRQRAHFDGLPVTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGL Rv0101|M.tuberculosis_H37Rv GNRQRAHFDGLPVTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGL MAB_4099c|M.abscessus_ATCC_199 IKGAKEQLRTLPDGLTYGLLRYLNPDADVAGPDPSIGFNYLGRLGAGGVD MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 VKEAKEQLRALPDGLTYGLLRYLNPQAGLDVSDPAIAFNYLGRLGGGAAE TH_3730|M.thermoresistible__bu SRAANTTTIRCRWSQCPGTSSDCASNTTPRCSTPRMSRHWSAGCGGC--- MMAR_2518|M.marinum_M PVRSGADLQQCWRQYVAGEVTEYPVNCTHEELLNPAALKTFGDLIRAALD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 DEYVDWLIEAGYPIRRIDDFAEWLQR-----FEASLGALPDRQRRHSVLP Rv0101|M.tuberculosis_H37Rv DEYVDWLIEAGYPIRRIDDFAEWLQR-----FEASLGALPDRQRRHSVLP MAB_4099c|M.abscessus_ATCC_199 LSDDLWRIDQDGVAITAAATAVPTPLGHTVELNAGVMEDADAGARLHATW MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 LSPELWRLSPDSFALAGAAGAVELPLPHTVELNAGTMDTEDG-PHLQANW TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M QP------------------------------------------------ Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 MLLASNSQRLQPLKPTRGCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAP Rv0101|M.tuberculosis_H37Rv MLLASNSQRLQPLKPTRGCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAP MAB_4099c|M.abscessus_ATCC_199 TWALSALSHNQVDRISRLWFDSLAGICAHVRGGGGGLSPSDVMPARLTQQ MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 TWARSALDDKQIGRLSELWFDALAGICTHVRAGGGGLTPSDVAAARLTQR TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 TIINYVTNLQLLGLL----------------------------------- Rv0101|M.tuberculosis_H37Rv TIINYVTNLQLLGLL----------------------------------- MAB_4099c|M.abscessus_ATCC_199 QIDQLDEQYEIADVLPLTPLQQGLLFHSNLAPEGLEGSDDLYAVQLDVAL MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 DLDELAQRYRVADVLPLTPLQQGLLFHAG-TAQGSQEPEDLYAVQLDISV TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 SGPLDPKRLQDAVHSAIRRRPNVVARFYEEFGEPVQLIPADPELAWQYLE MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 TGAVDPDRLREAVRTVITRHPNVVAHFSEDFGEPVQILSAEPELAWQYVE TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 LDADSEAEEQVERLAASERAAVCDLAGQPAFRAALARTGTDQYRFLVTNH MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 LDAGADLDEQVERLSSAERVAVGDLA-QPPFRGALIRTAEDAYRFVLTNH TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 HIVLDGWSKPILLQEIFASYFGERLPAPVAYRRFVTWLSGQDNDAARSAW MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 HIVLDGWSKPLLLQEIFAAYFGVRLPAPVPYRNFITWLSAQDRAAAQAAW TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 GKVFEGFETPTLVGPPGRMVLGRRGVESFEVSAETTQALGELARSCRTTV MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 REVLAGFDTPTLVGPSGRMALGPRGVAEFHVPADTSRLLGELARSCRTTV TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 STVLQAAWAQLLMWLTGQTDVAFGTAVSGRPTDLVGAESMVGLLINTVPV MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 STVLQAAWAQLLMWLTGQHDVVFGTAVSGRPTELAGSESMVGLLINTVPV TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 RATITPDTTIASLLNQLQAAYGETLEHQHLALKEIHHAVGHDQLFDTMFV MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 RATIGAETTIADLLDQLQRAYTHTLEHQHLALNDIHRVTGHDQIFDTMFV TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MAB_4099c|M.abscessus_ATCC_199 YENYPIDTAALSRVHELSITGFSNREYNHYPLAVQATPGHELGLRVEFDT MSMEG_0400|M.smegmatis_MC2_155 -------------------------------------------------- MAV_3244|M.avium_104 YENYPIDTAALSAVDELTITGFTNREYNHYPLSVQAVPGHEIGLRVEFDT TH_3730|M.thermoresistible__bu -------------------------------------------------- MMAR_2518|M.marinum_M -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 -------------------------------------------------- MUL_3633|M.ulcerans_Agy99 -------------------------------------------------- MLBr_02353|M.leprae_Br4923 -------------------------------------------------- Mb0104|M.bovis_AF2122/97 ---------------------------------- Rv0101|M.tuberculosis_H37Rv ---------------------------------- MAB_4099c|M.abscessus_ATCC_199 DVFNAVRIGKLVKRFQRVLEAMTSDVKGKKKEPT MSMEG_0400|M.smegmatis_MC2_155 ---------------------------------- MAV_3244|M.avium_104 DVFGEARIEKLIERFRRVLEAMTVDLEEQS---- TH_3730|M.thermoresistible__bu ---------------------------------- MMAR_2518|M.marinum_M ---------------------------------- Mflv_2697|M.gilvum_PYR-GCK ---------------------------------- Mvan_3844|M.vanbaalenii_PYR-1 ---------------------------------- MUL_3633|M.ulcerans_Agy99 ---------------------------------- MLBr_02353|M.leprae_Br4923 ----------------------------------