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ALFRTSSASSVGDVFALIRHKRDLTRTEIGRLTGLSRTAVTARVSELTSRDLVVEREQAPSTGGRPAALL SFNADAGVVLTAAVGGSRTRLAVCNLAGDVLTAADIDQEPGLGPQDLMPQVVKGLEVLLAESGHSDAVYG VGLSLPGTVDQERGSSIDTPVLSGWDGAPLIPYFRQLTEAPVVLGNDANVIALAEWRAGAGRGFDDLLVV KASTGLGAGIIAGGAPQRGAIRAAGEFGHNKTPAAEGRPCRCGDTGCLETVAGGWALVRTLAQEGRPVRN LRDLVELAHSGDALARRQIRDSGRYIGEVLAGAVNLLNPAALVVAGDAAGAYDIFVAGLRETLYGNATAL ATRVLEIRPAQLGDRGGSIGSAMMVLDQVLGPRAVDALVAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4888 | - | - | 100% (392) | ROK family protein |
| M. vanbaalenii PYR-1 | Mvan_1251 | - | 5e-31 | 32.25% (307) | ROK family protein |
| M. vanbaalenii PYR-1 | Mvan_5295 | - | 2e-26 | 28.72% (376) | ROK family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 8e-27 | 29.80% (302) | sugar kinase |
| M. gilvum PYR-GCK | Mflv_1841 | - | 1e-169 | 77.78% (387) | ROK family protein |
| M. tuberculosis H37Rv | Rv0650 | - | 9e-27 | 29.80% (302) | sugar kinase |
| M. leprae Br4923 | MLBr_01023 | ppgK | 5e-05 | 26.58% (237) | polyphosphate glucokinase |
| M. abscessus ATCC 19977 | MAB_4059c | - | 9e-15 | 25.32% (387) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0987 | - | 1e-26 | 28.81% (302) | carbohydrate kinase |
| M. avium 104 | MAV_4510 | - | 3e-28 | 32.43% (296) | sugar kinase |
| M. smegmatis MC2 155 | MSMEG_0316 | - | 1e-141 | 67.90% (377) | putative NagC regulator |
| M. thermoresistible (build 8) | TH_4374 | - | 6e-22 | 29.41% (306) | PUTATIVE glucokinase |
| M. ulcerans Agy99 | MUL_0739 | - | 7e-27 | 28.81% (302) | carbohydrate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4888|M.vanbaalenii_PYR-1 --------------MALFRTSSASSVGDVFALIRHKRDLTRTEIGRLTGL
Mflv_1841|M.gilvum_PYR-GCK --------------MSSPRTAVPTSVGDIYALIRAKRGLTRSEVGALSGL
MSMEG_0316|M.smegmatis_MC2_155 -----------MEAMPPPATLVSPTPGEVFALIRDRRATTRGELGRLTGL
Mb0669|M.bovis_AF2122/97 --------------------------------------------------
Rv0650|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0987|M.marinum_M --------------------------------------------------
MUL_0739|M.ulcerans_Agy99 --------------------------------------------------
MAV_4510|M.avium_104 --------------------------------------------------
TH_4374|M.thermoresistible__bu --------------------------------------------------
MAB_4059c|M.abscessus_ATCC_199 MTAPVRRPVSRHQIHPPALYIGDSAASSVFRAARVRGPVARDAIAQVTGL
MLBr_01023|M.leprae_Br4923 -----------------MIRLRSAAARDRCQVLSLAYRITVAGRCQTVSP
Mvan_4888|M.vanbaalenii_PYR-1 SRTAVTARVSELTSRDLVVEREQAPST--GGRPAALLSFNADAGVVLTAA
Mflv_1841|M.gilvum_PYR-GCK SRTAVNARVSELTSRGLVVEDQHAPST--GGRPAAVLRFNAAAGIVLTAA
MSMEG_0316|M.smegmatis_MC2_155 SRTAVTARVAALEAGGLVIERDQA-ST--GGRPAAQLMFNVDAGVVFSAA
Mb0669|M.bovis_AF2122/97 -------------------------------------------MLTLCLD
Rv0650|M.tuberculosis_H37Rv -------------------------------------------MLTLCLD
MMAR_0987|M.marinum_M -------------------------------------------MLTLCLD
MUL_0739|M.ulcerans_Agy99 -------------------------------------------MLTLCLD
MAV_4510|M.avium_104 -------------------------------------------MLTLGLD
TH_4374|M.thermoresistible__bu -------------------------------------------VLTLTLD
MAB_4059c|M.abscessus_ATCC_199 SIATVNRQVTALLDAGLLRERADLAVSGAIGRPRVPVELNHEPFLTLGIH
MLBr_01023|M.leprae_Br4923 HHRQAKVSEQPSLAKEIAITSTDATADTPRTSPPSDTAGTTSRHRGFGID
:
Mvan_4888|M.vanbaalenii_PYR-1 VGGSRTRLAVCNLAGDVLTAADIDQEPGLGPQDLMPQVVKGLEVLLAESG
Mflv_1841|M.gilvum_PYR-GCK VGGSRTRLGVCDLAGDALATADIDQEPGQGPASLMPDIVGRLDLLLSEAD
MSMEG_0316|M.smegmatis_MC2_155 IGRSRTQLAVCNLDGTILASTDIDQEPGIAPDDLLPDLVKRLDMLLDESA
Mb0669|M.bovis_AF2122/97 IGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAG
Rv0650|M.tuberculosis_H37Rv IGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAG
MMAR_0987|M.marinum_M IGGTKVAVGLADADGALVHTAQVPTPARCAAEQVWAAVAEAIAEALRVAD
MUL_0739|M.ulcerans_Agy99 IGGTKVAVGLADADGALVHTAQVPTPARCAAEQVWAAVAEAIAEALRVAD
MAV_4510|M.avium_104 IGGTKIAAALVDSSGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAD
TH_4374|M.thermoresistible__bu IGGTKLAAGLVDGDGGLVHHTHAATPG-GDAEAVWTVLAGLIDDALTRAG
MAB_4059c|M.abscessus_ATCC_199 IGARATSIVATDLFGRTLDVVETPTPNGPQGAALASLAGSAQRYLARWHR
MLBr_01023|M.leprae_Br4923 IGGSSIKGGIVDLDIGQLIGDRIKLLTPQPATPLA--VAKTIAEVVNAFG
:* : : :
Mvan_4888|M.vanbaalenii_PYR-1 HSDA-VYGVGLSLPGTVDQERGSSIDTPVLSGWDGAPLIP-YFRQLTEAP
Mflv_1841|M.gilvum_PYR-GCK RRDARIFGVGLSLPGTVDPVRGTSIDTPVLSGWDGAPLFP-YFRDLTPAP
MSMEG_0316|M.smegmatis_MC2_155 RRDAHIFGVGLSLPGTVDQRTGASLDSPNMSGWDGVPLAP-YFTSLTDAP
Mb0669|M.bovis_AF2122/97 ---GAVGGVGIASAGPIDLHSG-RVSPINIGSWGGFPLRDRVAAAVPGVP
Rv0650|M.tuberculosis_H37Rv ---GAVGGVGIASAGPIDLHSG-RVSPINIGSWGGFPLRDRVAAAVPGVP
MMAR_0987|M.marinum_M ---ATVAAVGIASAGPVDLDSG-TVSPINIGSWRGFPLRDRVAAMVPDVP
MUL_0739|M.ulcerans_Agy99 ---ATVAAVGIASAGPVDLDSG-TVSPINIGSWRGFPLRDRVAAMVPDVP
MAV_4510|M.avium_104 ---APIAAVGIASAGPVDLPSG-SVSPINIAGWHRFPLRDKVAAAVPATP
TH_4374|M.thermoresistible__bu ---GRVRAVGVGSAGPIDLTAG-TVSPINLTAWSRFPLTERVSAALPGVP
MAB_4059c|M.abscessus_ATCC_199 ---RRPLWVGVATGGVVDGPAG-TVDHPRLG-WTEAPVGR-VFADTLGLP
MLBr_01023|M.leprae_Br4923 ----WTAPLGVTYPGVVTQGVVRTAAN-VDDSWIGTNARDIISAELNSQE
:*: * : *
Mvan_4888|M.vanbaalenii_PYR-1 VVLGNDANVIALAEWRAGAGRGFDDLLV---VKASTGLGAGIIAGGAPQR
Mflv_1841|M.gilvum_PYR-GCK VVLGNDANVIALAEWREGAGRAFDDLLV---IKASTGLGAGIILGGVLQV
MSMEG_0316|M.smegmatis_MC2_155 VVIDNDANAIAVAERRGGYG-EYDDMLV---VKASTGLAAGIIMGGQLQR
Mb0669|M.bovis_AF2122/97 VRLGGDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGAPCL
Rv0650|M.tuberculosis_H37Rv VRLGGDGVCMALGEHWLGAGRGARFLLG---LVVSTGVGGGLVLDGAPCL
MMAR_0987|M.marinum_M VRLGGDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGVPYP
MUL_0739|M.ulcerans_Agy99 VRLGGDGVCMALGEHWLGAGRGARFLLG---MVVSTGVGGGLVLGGVPYP
MAV_4510|M.avium_104 VVLGGDGLCMALGEQWLGAGRGARFLLG---MVVSTGVGGGLVLDGAPYP
TH_4374|M.thermoresistible__bu VRLGGDGLCMAMGEQWRGAGRGARFVLG---IVVSTGVGGGLVLDGMPYQ
MAB_4059c|M.abscessus_ATCC_199 VSVASHVDAMAGAELLLGLRRFAARSLTSLYVYARETVGFALAIDGRVHS
MLBr_01023|M.leprae_Br4923 VTILNDADAAGLAEGRYGAGKNNSGLIVL--LTFGTGIGSAVIHNGKLIP
* : .. . .* * : : :. .: .*
Mvan_4888|M.vanbaalenii_PYR-1 GAIRAAGEFGHNKTPAAEGRPCRCGDTGCLETVAGGWALVRTLAQEGR--
Mflv_1841|M.gilvum_PYR-GCK GSIRAAGEFGHNKTAAAAGRACRCGDVGCLETVAGGWALVRALREDGR--
MSMEG_0316|M.smegmatis_MC2_155 GAVQAAGEFGHSKTAAAAGVHCRCGDTGCLEAIAGGWALVRALQRDGR--
Mb0669|M.bovis_AF2122/97 GRTGNAGHVGHVVVDPD-GSPCPCGGRGCVETIASGPSLARWARANGWSA
Rv0650|M.tuberculosis_H37Rv GRTGNAGHVGHVVVDPD-GSPCPCGGRGCVETIASGPSLARWARANGWSA
MMAR_0987|M.marinum_M GRTGNAGHVGHVVVDQD-GLRCSCGGRGCVETIAAGPSMVRWARANGWSA
MUL_0739|M.ulcerans_Agy99 GRTGNAGHVGHVVVDQD-GLRCSCGGRGCVETIAAGPSMVRWARANGWSA
MAV_4510|M.avium_104 GRTGNAGHVGHVVVELD-GRPCTCGGHGCVETVASGPSMVRWARENGWSA
TH_4374|M.thermoresistible__bu GRTGNAGHVGHVVVDPR-GVACSCGGRGCVETMAAGPAMVRWARANGWNA
MAB_4059c|M.abscessus_ATCC_199 PSSGPGTIAALPVDSELLGGSGKLETTVSDEAVLAAARKLRIVPAGDG--
MLBr_01023|M.leprae_Br4923 N-----TEFGHLEVDGK---------------------------------
.
Mvan_4888|M.vanbaalenii_PYR-1 -PVRNLRDLVELAHSGDALARRQIRDSGRYIGEVLAGAVNLLNPAALVVA
Mflv_1841|M.gilvum_PYR-GCK -TVENLRDVVVLAHTGDALARRLIRDSGRHVGKVLAAAVNLLNPAALVVA
MSMEG_0316|M.smegmatis_MC2_155 -AVNHLRDVVALAHTGDPEARRMIRESGRHIGEVLAAAVNLLNPAVLVIA
Mb0669|M.bovis_AF2122/97 PPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAVCDLDLAVIG
Rv0650|M.tuberculosis_H37Rv PPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAVCDLDLAVIG
MMAR_0987|M.marinum_M RPEAGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAVCDLDRVVIG
MUL_0739|M.ulcerans_Agy99 RPEAGARELAAAAAAGDAVALAAFRRGTRGLAAMIASVGAVCDLDRVVIG
MAV_4510|M.avium_104 APGAGARDLAAAAAS-DPLAQKAFHRSADALAAMIASVGAVCDLDVVVIG
TH_4374|M.thermoresistible__bu PPDADAEDLAAAAAAGVPVAVRAYRRGADALAAAISSVAAVCDLDLVVIG
MAB_4059c|M.abscessus_ATCC_199 ---VSVSAVYKAARGGNESARELLSERGRVLGQSVALLRDILNPDEVIVG
MLBr_01023|M.leprae_Br4923 ------EAEQRAASSVKDKYKWSYRTWAKQVTRVLVAIENAMCPDLFIAG
* : : : .
Mvan_4888|M.vanbaalenii_PYR-1 GDAAGAYDIFVAGLRETLYGNATAL--------ATRVLEIRPAQLGDRGG
Mflv_1841|M.gilvum_PYR-GCK GDVAGAYDIFVAGLRETLYGNATAL--------ATKNLDVLPAALGDRSG
MSMEG_0316|M.smegmatis_MC2_155 GDMVGAYDLFVAGLRETLYGNATAL--------ATRTLQIVPSIHRERSS
Mb0669|M.bovis_AF2122/97 GGVAKSGRLLFEPLRAALADHARLD--------FLAGLRVVPAELGGAAG
Rv0650|M.tuberculosis_H37Rv GGVAKSGRLLFEPLRAALADHARLD--------FLAGLRVVPAELGGAAG
MMAR_0987|M.marinum_M GGVAKAGRLLFDPLRAALADYLGLD--------FLAGLRVVPAELGGQAG
MUL_0739|M.ulcerans_Agy99 GGVAKAGRLLFDPLRAALADYLGLD--------FLAGLRVVPAELGGQAG
MAV_4510|M.avium_104 GGVAQSGPLLFDPLRERLAHYAGLD--------FLSGLTVVPGELGGNAG
TH_4374|M.thermoresistible__bu GGVARSGPVLFDPLAEALTTYTGLS--------FLRGLRVVPARLGATAG
MAB_4059c|M.abscessus_ATCC_199 GQAFTEYPEVMNDVETAFLDRSTLSKRDIRVTAFGNRVQEAGAGVVSLGG
MLBr_01023|M.leprae_Br4923 GGISRKADRWIPLLEN--------------------RTPMVAAALQNTAG
* . : . ..
Mvan_4888|M.vanbaalenii_PYR-1 SIGSAMMVLDQVLGPRAVDALVAA-
Mflv_1841|M.gilvum_PYR-GCK GIGSATMVLDEVLGPRAVDALVTTS
MSMEG_0316|M.smegmatis_MC2_155 MVGCATNVLDRVLSPDAVDAAMYGD
Mb0669|M.bovis_AF2122/97 LVGAARLAAIA--------------
Rv0650|M.tuberculosis_H37Rv LVGAARLAAIA--------------
MMAR_0987|M.marinum_M LVGAARLAGLG--------------
MUL_0739|M.ulcerans_Agy99 LVGAARLAGLG--------------
MAV_4510|M.avium_104 LIGAARLATLARPAGS---------
TH_4374|M.thermoresistible__bu LIGAARLAISAC-------------
MAB_4059c|M.abscessus_ATCC_199 LFADPLGAMRRASARRGEASALA--
MLBr_01023|M.leprae_Br4923 IVGAAMASTADVTH-----------
.. .