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MTGISGAVAARAQQVADAFARMTGVAVDARVLLTGRAALLGMCPQGCISAGGATHLFPSRKGTWCALTLS RPDDVAAVPALVQADTVDADPWPVVETWAAATEAHAITERARLLGLPAAVLGETVPAAPRITRMWPRGTG RPLTGLLVADLSSMWAGPLCGQLLRQAGATVVKVESHARPDGTRNGPQVFFDWMNHGKLSYVADFGEPSA LGALLDVADVVIESSRPTALVRRGLGPDVVASREGRVWVRITGHGTTGEHADWVAFGDDAAVSGGLVKNH HGTPSFAGDAIADPLTGLHAAHAVAESLTRGGGDLIEFAMSAVAATYADLATTGADIATVEPASAPAGPA LGADNGAVTRLIAGSRPC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0262 | - | - | 100% (368) | hypothetical protein MSMEG_0262 |
| M. smegmatis MC2 155 | MSMEG_4111 | - | 2e-18 | 34.68% (173) | alpha-methylacyl-CoA racemase |
| M. smegmatis MC2 155 | MSMEG_4851 | - | 2e-18 | 34.22% (225) | caib/baif family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 7e-15 | 31.55% (206) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_0444 | - | 1e-109 | 59.89% (364) | hypothetical protein Mflv_0444 |
| M. tuberculosis H37Rv | Rv3272 | - | 7e-15 | 31.55% (206) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 8e-18 | 29.96% (227) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_0311 | - | 8e-20 | 33.04% (227) | hypothetical protein MMAR_0311 |
| M. avium 104 | MAV_4956 | - | 1e-101 | 58.08% (365) | hypothetical protein MAV_4956 |
| M. thermoresistible (build 8) | TH_3905 | - | 4e-18 | 30.26% (228) | PUTATIVE Formyl-CoA transferase |
| M. ulcerans Agy99 | MUL_4811 | - | 6e-20 | 33.04% (227) | hypothetical protein MUL_4811 |
| M. vanbaalenii PYR-1 | Mvan_0223 | - | 1e-113 | 60.61% (363) | hypothetical protein Mvan_0223 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0262|M.smegmatis_MC2_155 ------------------MTGISG--------AVAARAQQVADAFARMTG
MAV_4956|M.avium_104 MGDVSAAATDWGGSGLAYLTGLPDGPADFSRAPVLSRAHQVAAAIGARLG
Mflv_0444|M.gilvum_PYR-GCK ----------------------------MSPVRVPVAVLARAQ--AALGD
Mvan_0223|M.vanbaalenii_PYR-1 ----------------MHRRGAVTHNGPVTSVRIPAAVLEHARSTAARAG
Mb3300|M.bovis_AF2122/97 -------------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVL
Rv3272|M.tuberculosis_H37Rv -------------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVL
MAB_4651c|M.abscessus_ATCC_199 ------------------------MTGALDGIRVLELGTLIAGPFAGRLL
TH_3905|M.thermoresistible__bu ----------------------VTVTGPLDGIRVLELGTLIAGPFAGRLL
MMAR_0311|M.marinum_M ------MSNCGSDCDSSLGAGAGKRTGPLSGVRVVDLTAMVMGPYCTQIM
MUL_4811|M.ulcerans_Agy99 -----------------MGAGAGNRTGPLSGVRVVDLTAMVMGPYCTQIM
:
MSMEG_0262|M.smegmatis_MC2_155 VAVDARVLLT----GRAALLGMCPQGCISAGGATHLFPSRKGTWCALTLS
MAV_4956|M.avium_104 VDAAAAVLLS----GRAALLGLRRAGQVSPGGATRLLAAR-DDHCALTLS
Mflv_0444|M.gilvum_PYR-GCK LRADAEVLIG----GRAALLGLAPDGRISAGGATRLLAGP-DGWCALTLS
Mvan_0223|M.vanbaalenii_PYR-1 IAADTDELLG----GRAALLGLRSGGRVSAGGASRLMAAH-DGWCALTLS
Mb3300|M.bovis_AF2122/97 VDLGAEVIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLT
Rv3272|M.tuberculosis_H37Rv VDLGAEVIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLT
MAB_4651c|M.abscessus_ATCC_199 GDMGAEVLKIEPPGAPDPLRTWGQAEVDG-HHVFWTVHARNKKAITLDLR
TH_3905|M.thermoresistible__bu GDMGAEVIKIELPGAPDPLRTWGQAELDG-HHFFWTVHARNKKAITLNLR
MMAR_0311|M.marinum_M ADMGADVIKIEPPQGDDTRYVS-VGPAAGMSGVFVNVN-RGKRSAVIDLK
MUL_4811|M.ulcerans_Agy99 ADMGADVIKIEPPQGDDTRYVS-VGPAAGMSGVFVNVN-RGKRSAVIDLK
: : . . .: *
MSMEG_0262|M.smegmatis_MC2_155 RPDDVAAVPALVQADTVDADPWPVVETWAAATEAHAITER-ARLLGLPAA
MAV_4956|M.avium_104 RADDLAAVPALLQVDDMAGDPWPALRCWAAGRATAEIVER-ATLLDIPAA
Mflv_0444|M.gilvum_PYR-GCK RPDDVDAVPALLGADDLPDDMWSAIGRVIAETGVWVFAER-ARLLGLPVG
Mvan_0223|M.vanbaalenii_PYR-1 RPDDIAAVPALVEADAVVGDPWPAVERNVHDRGVVAFAER-ARLLGLPVG
Mb3300|M.bovis_AF2122/97 TEQAKQQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLT
Rv3272|M.tuberculosis_H37Rv TEQAKQQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLT
MAB_4651c|M.abscessus_ATCC_199 TEAGRALFLDLVDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVS
TH_3905|M.thermoresistible__bu EPAGRDVFLELVERSDIVVENFRPGTLERWDLGYDVLRSHNNRVILVRVS
MMAR_0311|M.marinum_M SDSGQAAVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCY
MUL_4811|M.ulcerans_Agy99 SDSGQAAVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCY
. * : . . ::
MSMEG_0262|M.smegmatis_MC2_155 VLGETVPAAPRITRMWPRGTGRPLTGLLVADLSSMWAGPLCGQLLRQ--A
MAV_4956|M.avium_104 ALGEARPAAERIQPIAPGGAPRSPRGLLVADLSSMWAGPLCGQLLAR--A
Mflv_0444|M.gilvum_PYR-GCK VLGEATEAPTALCRNGERKAFGDLNGLLVADLSSMWAGPLCGRLLSD--A
Mvan_0223|M.vanbaalenii_PYR-1 VLGETGSAAPVFRRSGDPVQPCGLTGLLVADLSSMWAGPLCGQLLAR--A
Mb3300|M.bovis_AF2122/97 AYGGNGPHGSRP---GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNAS
Rv3272|M.tuberculosis_H37Rv AYGGNGPHGSRP---GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNAS
MAB_4651c|M.abscessus_ATCC_199 GYGQTGPDAHKA---GYASVAEAASGLRHLNGFPGGPPPRMALSIGDTLA
TH_3905|M.thermoresistible__bu GYGQTGPDAHKA---GYASVAEAASGLRHLNGFPGGPPPRLALSLGDTLA
MMAR_0311|M.marinum_M GYGRRGPNRDLP---AYDDTIQAACGLPSVQEQLTGEPSYVGTIMADKVA
MUL_4811|M.ulcerans_Agy99 GYGRRGPNRDLP---AYDDTIQAACGLPSVQEQLTGEPSYVGTIMADKVA
* *: : :
MSMEG_0262|M.smegmatis_MC2_155 GATVVKVESHARPDGTRNGPQVFFDWMNHGKLSYVADFG-EPSALGALLD
MAV_4956|M.avium_104 GATVVKVESPRRPDGTRAGNRAFFDWMNHGKLCYGIDFDRDADQLRELLT
Mflv_0444|M.gilvum_PYR-GCK GATVVKVETRTRPDGTRQGSAAFFDWMNSGKLAYAADLE-DP-GLRRLLG
Mvan_0223|M.vanbaalenii_PYR-1 GATVVKVESATRPDGTRQGPPTFFDWMNGGKLSYRADFT-RPDGVRRLLA
Mb3300|M.bovis_AF2122/97 GHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASD
Rv3272|M.tuberculosis_H37Rv GHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASD
MAB_4651c|M.abscessus_ATCC_199 GMFAAQGALAALYRRTVTGRGQVVDAALTESCLAVQESTIPDYDVGRVVR
TH_3905|M.thermoresistible__bu GMFAAQGAMAALYRRTVTGEGQVVDAALTEACLAVQESTIPDYDIGGVVR
MMAR_0311|M.marinum_M GLTALYATMMALFHRERTGQGQEVEIGMFEAVASF---MLVEHANGAMFD
MUL_4811|M.ulcerans_Agy99 GLTALYATMMALFHRERTGQGQEVEIGMFEAVASF---MLVEHANGAMFD
* * .:
MSMEG_0262|M.smegmatis_MC2_155 -------VADVVIESSR----PTALVRRGLG-PDVVASREGRVWVRITGH
MAV_4956|M.avium_104 -------VSDIVIEGSR----PAALRRRGLG-PADIAPRPGRIWLQITAF
Mflv_0444|M.gilvum_PYR-GCK -------AADVVIESSR----PAALQRRGLG-PTDVAGPAGRVWVRITGH
Mvan_0223|M.vanbaalenii_PYR-1 -------VADVVIESSR----PAALERRGLG-PADVPARRGRIWLRVTGH
Mb3300|M.bovis_AF2122/97 QPKPEPAPKAKRRKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYL
Rv3272|M.tuberculosis_H37Rv QPKPEPAPKAKRRKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYL
MAB_4651c|M.abscessus_ATCC_199 ------GPSGTRLEGI----APSNIYQSADGSWVVIAANQDTVFRRLCEA
TH_3905|M.thermoresistible__bu ------GPSGTRLEGI----APSNIYRSADGSWVVIAANQDTVFRRLCAA
MMAR_0311|M.marinum_M PP---LGPAVYPRTVAP----NRRPYRTSDG-YLAALIYNDKHWAAFVDA
MUL_4811|M.ulcerans_Agy99 PP---LGPAVYPRTVAP----NRRPYRTSDG-YLAALIYNDKHWAAFVDA
: . * : .
MSMEG_0262|M.smegmatis_MC2_155 GTTGEHADWVAFGDDAAVSGGLVKNHHGTPSFAGDAIADPLTGLHAAHAV
MAV_4956|M.avium_104 DD-----DRPGFGDDAAVGGGLVGTSAAGPVFCGDAIADPLTGLHAALAV
Mflv_0444|M.gilvum_PYR-GCK GTDGARADWVAFGDDAAVSGGLVSGSPADPRFCGDAIADPLTGIRAAAEV
Mvan_0223|M.vanbaalenii_PYR-1 GTAGDRADWVAFGDDAAVSGGLVGGSADAPEFCGDAIADPLTGLHAALAV
Mb3300|M.bovis_AF2122/97 IGRPDLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGL
Rv3272|M.tuberculosis_H37Rv IGRPDLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGL
MAB_4651c|M.abscessus_ATCC_199 MGRPELSSDARFANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGV
TH_3905|M.thermoresistible__bu MGRPELATDDRFATHTARGRNQDELDKIIADWAAERAPGEIIDTLNAAGV
MMAR_0311|M.marinum_M VRPP--WASEQYATLEGRARQIDTVYALLAETFAARTTQEWLDLLEELEI
MUL_4811|M.ulcerans_Agy99 VRPP--WASEQYATLEGRARQIDTVYALLAETFAARTTQEWLDLLEELEI
:. . . . . :
MSMEG_0262|M.smegmatis_MC2_155 AESLTRGGGDLIEFAMSAVAATYADLATTG---------ADIATVEPASA
MAV_4956|M.avium_104 AESLGRGGGELIRLSMAGVAAGYAALGTEPP-------TSDAPVSPPAPP
Mflv_0444|M.gilvum_PYR-GCK LASRRRGGGELIELSMAGVAAEYAQLPRGD----------EKPCVATPVA
Mvan_0223|M.vanbaalenii_PYR-1 LESHARGGGELVEISMAAVAAGYAGLPGDD----------ERYCAATPSV
Mb3300|M.bovis_AF2122/97 MACLAHTWKQVVDTPLFAESDLTLEVGRGADTITVIR---TPARYASFRA
Rv3272|M.tuberculosis_H37Rv MACLAHTWKQVVDTPLFAENDLTLEVGRGADTITVIR---TPARYASFRA
MAB_4651c|M.abscessus_ATCC_199 IAGPINTVADVVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGG
TH_3905|M.thermoresistible__bu IAGPINTVAEVVEDPQLRARGMIADHFDERIGRNVKGPGVVPVLSESPGT
MMAR_0311|M.marinum_M PASALSSPAELFDNQHLNAVGFFETIDTAHGPVRFPG---VPTWFSRTPG
MUL_4811|M.ulcerans_Agy99 PASALSSPAELFDNQHLNAVGFFETIDTAHGPVRFPG---VPTWFSRTPG
::.
MSMEG_0262|M.smegmatis_MC2_155 P-AGP--ALGADNGAVTRLIAG--SRPC---------
MAV_4956|M.avium_104 PPSGPASALGADNAAVRHLVSQRRCRSC---------
Mflv_0444|M.gilvum_PYR-GCK APRGP--ALGADNAAVDRLVADRATLPC---------
Mvan_0223|M.vanbaalenii_PYR-1 PDSGP--ELGSGNDVVDRLVADRLAAPC---------
Mb3300|M.bovis_AF2122/97 VVTDPPPTAGEHNAVFLARP-----------------
Rv3272|M.tuberculosis_H37Rv VVTDPPPTAGEHNAVFLARP-----------------
MAB_4651c|M.abscessus_ATCC_199 VRNAGPARPGQDNDDVYVGLLGKSAQDIERLRAEGVL
TH_3905|M.thermoresistible__bu IRNAGPARPGQHNEEIYTGLLGKTAAELRQLRAQGVI
MMAR_0311|M.marinum_M RVSGPAPQLGADTSAVLEELGINAADAQPAGPA----
MUL_4811|M.ulcerans_Agy99 RVLGPAPQLGADTSAVLEELGINAADAQPAGPA----
* . .