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VHRRGAVTHNGPVTSVRIPAAVLEHARSTAARAGIAADTDELLGGRAALLGLRSGGRVSAGGASRLMAAH DGWCALTLSRPDDIAAVPALVEADAVVGDPWPAVERNVHDRGVVAFAERARLLGLPVGVLGETGSAAPVF RRSGDPVQPCGLTGLLVADLSSMWAGPLCGQLLARAGATVVKVESATRPDGTRQGPPTFFDWMNGGKLSY RADFTRPDGVRRLLAVADVVIESSRPAALERRGLGPADVPARRGRIWLRVTGHGTAGDRADWVAFGDDAA VSGGLVGGSADAPEFCGDAIADPLTGLHAALAVLESHARGGGELVEISMAAVAAGYAGLPGDDERYCAAT PSVPDSGPELGSGNDVVDRLVADRLAAPC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0223 | - | - | 100% (379) | hypothetical protein Mvan_0223 |
| M. vanbaalenii PYR-1 | Mvan_1855 | - | 8e-20 | 38.12% (202) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_4229 | - | 3e-18 | 36.36% (209) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 2e-15 | 32.39% (213) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_0444 | - | 1e-131 | 65.94% (367) | hypothetical protein Mflv_0444 |
| M. tuberculosis H37Rv | Rv3272 | - | 2e-15 | 32.39% (213) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0824 | - | 3e-20 | 32.96% (267) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_3974 | - | 7e-19 | 37.31% (201) | acyl-CoA transferase |
| M. avium 104 | MAV_4956 | - | 1e-104 | 57.26% (379) | hypothetical protein MAV_4956 |
| M. smegmatis MC2 155 | MSMEG_0262 | - | 1e-113 | 60.61% (363) | hypothetical protein MSMEG_0262 |
| M. thermoresistible (build 8) | TH_4570 | - | 1e-19 | 33.48% (230) | PUTATIVE caib/baif family protein |
| M. ulcerans Agy99 | MUL_0328 | - | 1e-18 | 35.89% (209) | acyl-CoA transferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3974|M.marinum_M MLGSVSHGSEGRPTPLDKLHVLEISDRMAGSYCGKLLVDAGAHVRKIEPP
MUL_0328|M.ulcerans_Agy99 ----MEATPPPVQPPLAGYRVVDLSTGIAGAYCTKLLADGGADVVKVEPP
TH_4570|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0444|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0262|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4956|M.avium_104 --------------------------------------------------
MMAR_3974|M.marinum_M QGDPLRTYSASCAPVPEGAPAAPLYCYLNAGKQSLTLAPDSQR----YRA
MUL_0328|M.ulcerans_Agy99 EGDPLRWCSASGTAIPEGN-DGALFNFLAGSQHSVVAAPESDRDLALVEA
TH_4570|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0444|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0262|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4956|M.avium_104 --------------------------------------------------
MMAR_3974|M.marinum_M ELAAADVLIVTAGRSQAGGLGIDPVQLLADSPQAIIVTISDFGWAGPFAE
MUL_0328|M.ulcerans_Agy99 LLAAADAVVWSPGSRVAEHPRLGPQELHRRHPQLTVTSITPFGLDGPWHD
TH_4570|M.thermoresistible__bu -----------------------------------VVRISDFGQHGPLHG
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0444|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0262|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4956|M.avium_104 --------------------------------------------------
MMAR_3974|M.marinum_M RAASEFTLQAWAGSPG--FRGDPAGPPISIGGDLGEYMGGAFAAFGALA-
MUL_0328|M.ulcerans_Agy99 RPATEFTLQAWSGAIIGLGRGLADRAPVFVGGRVGEYLAGAYASVATLA-
TH_4570|M.thermoresistible__bu RPTSPLTMQAASGWVN---AREFGRTPVQAGARIPEYIAGGYAALGALTG
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 -------------------------------------------------M
Mflv_0444|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0262|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4956|M.avium_104 -----------------------------------MGDVSAAATDWGGSG
MMAR_3974|M.marinum_M ISRRVERGGPGEHLDLSMLEAMALMQSSEWLHSQLLQVPPVR---RTLEV
MUL_0328|M.ulcerans_Agy99 SRHRRISDGWGELIDLSMLETQILSQTYYPVTYFEMLGRPWRD-ARRLTV
TH_4570|M.thermoresistible__bu LRVAATVEDRPVEVDVSTFEALLSTLPYPMLLAERLRSMGLPTNSRAAPM
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 HRRGAVTHNGPVTSVR--IPAAVLEHARSTAARAGIAADTDELLGGRAAL
Mflv_0444|M.gilvum_PYR-GCK -----------MSPVR--VPVAVLARAQ--AALGDLRADAEVLIGGRAAL
MSMEG_0262|M.smegmatis_MC2_155 -----------MTGISGAVAARAQQVADAFARMTGVAVDARVLLTGRAAL
MAV_4956|M.avium_104 LAYLTGLPDGPADFSRAPVLSRAHQVAAAIGARLGVDAAAAVLLSGRAAL
MMAR_3974|M.marinum_M PSIVPVKDGYVGITMVTGQQWLDFCVMVECPELEDIPQLRFQIGRWEYRD
MUL_0328|M.ulcerans_Agy99 PGVACAQDGLVDLGCGTAQQWFDLCAMVGHPEWIDE-QSPLSIT--EQAN
TH_4570|M.thermoresistible__bu LGIVRAADGWIGINCLTGQHWLDVCAMVGLPEFGEH-QLAIMLGG-PERD
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 LGLRSGGRVSAGGASRLMAAHDG-WCALTLSRPDDIAAVPALVEADAVVG
Mflv_0444|M.gilvum_PYR-GCK LGLAPDGRISAGGATRLLAGPDG-WCALTLSRPDDVDAVPALLGADDLPD
MSMEG_0262|M.smegmatis_MC2_155 LGMCPQGCISAGGATHLFPSRKGTWCALTLSRPDDVAAVPALVQADTVDA
MAV_4956|M.avium_104 LGLRRAGQVSPGGATRLLAARDD-HCALTLSRADDLAAVPALLQVDDMAG
MMAR_3974|M.marinum_M LIRESIGPWMAERTVEEIVELGQLFRLPIAALGNGATIRNMDHMTARGVF
MUL_0328|M.ulcerans_Agy99 LHAEEIYDWLRSHPSDEIREIATAFRIPNAPVANGANIASLDHFQARGSF
TH_4570|M.thermoresistible__bu EFLAKVQPWLDGQSVADIVELSQALRIPAAPVNDGSSILTCPQYAERGFF
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0824|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 DPWPAVERNVHDRGVVAFAERARLLGLPVGVLGETGSAAPVFRRSG----
Mflv_0444|M.gilvum_PYR-GCK DMWSAIGRVIAETGVWVFAERARLLGLPVGVLGEATEAPTALCRNG----
MSMEG_0262|M.smegmatis_MC2_155 DPWPVVETWAAATEAHAITERARLLGLPAAVLGETVPAAPRITRMW----
MAV_4956|M.avium_104 DPWPALRCWAAGRATAEIVERATLLDIPAAALGEARPAAERIQPIA----
MMAR_3974|M.marinum_M VENP-TGFHQ--PRPPWLMSRCAPAPVGRTAAPGADVDDEPRWSAAESKP
MUL_0328|M.ulcerans_Agy99 VRNPRDGFLQ--PAHPYRISSVHLRRPGPAPRLG---EHGYHYRTAELKP
TH_4570|M.thermoresistible__bu VPGGGPGWEYRRPGAPFRLSGARPGSGGAAEPAD-----------AEGDP
Mb3300|M.bovis_AF2122/97 ------------------MPTSNPAK------------------------
Rv3272|M.tuberculosis_H37Rv ------------------MPTSNPAK------------------------
MAB_0824|M.abscessus_ATCC_1997 ----------------------MTAA------------------------
Mvan_0223|M.vanbaalenii_PYR-1 -------------------DPVQPCG------------------------
Mflv_0444|M.gilvum_PYR-GCK -------------------ERKAFGD------------------------
MSMEG_0262|M.smegmatis_MC2_155 -------------------PRGTGRP------------------------
MAV_4956|M.avium_104 -------------------PGGAPRS------------------------
MMAR_3974|M.marinum_M KPVDQG-----LPLEGLRVIDLTAFWAGPAATHLLAAFGADVVKIESIQR
MUL_0328|M.ulcerans_Agy99 RPVPTPKVLTRLPLSGIRVLDLTTFWAGPSCTHLLAMLGAEVIHVESTRR
TH_4570|M.thermoresistible__bu ----------AAPFAGLKVFDLSTFWAGAYLTCYLGAFGADVVKVESIQR
Mb3300|M.bovis_AF2122/97 ------------PLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGG
Rv3272|M.tuberculosis_H37Rv ------------PLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGG
MAB_0824|M.abscessus_ATCC_1997 ------------ALDGLLVVDFSRVLAGPYATMMLGDFGAEVIKIERPVL
Mvan_0223|M.vanbaalenii_PYR-1 -------------LTGLLVADLSSMWAGPLCGQLLARAGATVVKVESATR
Mflv_0444|M.gilvum_PYR-GCK -------------LNGLLVADLSSMWAGPLCGRLLSDAGATVVKVETRTR
MSMEG_0262|M.smegmatis_MC2_155 -------------LTGLLVADLSSMWAGPLCGQLLRQAGATVVKVESHAR
MAV_4956|M.avium_104 -------------PRGLLVADLSSMWAGPLCGQLLARAGATVVKVESPRR
*: * *:: **. * ** *:::*
MMAR_3974|M.marinum_M PDGIRYSGGMRTDVDDWWEYGWVFHAMNTNKRSVTLDLGSVEGRGLFLRL
MUL_0328|M.ulcerans_Agy99 PDGTRLIAGVPVTEDQWWEKSPIFVALNTNKKGGTLDLGDSRGREVLHRL
TH_4570|M.thermoresistible__bu PDAHRYSGALLRQGDDWYERGPLWQGTNLNKRDLTLDLNSGRGRELALRL
Mb3300|M.bovis_AF2122/97 EAARQITSVLPGRPP----LATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
Rv3272|M.tuberculosis_H37Rv EAARQITSVLPGRPP----LATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
MAB_0824|M.abscessus_ATCC_1997 GDDTRQWGPPYDSDG----QATYFNSVNRNKQSVVLDLTSPDGQHRAREL
Mvan_0223|M.vanbaalenii_PYR-1 PDGTRQG------------PPTFFDWMNGGKLSYRADFT---RPDGVRRL
Mflv_0444|M.gilvum_PYR-GCK PDGTRQG------------SAAFFDWMNSGKLAYAADLE---DP-GLRRL
MSMEG_0262|M.smegmatis_MC2_155 PDGTRNG------------PQVFFDWMNHGKLSYVADFG---EPSALGAL
MAV_4956|M.avium_104 PDGTRAG------------NRAFFDWMNHGKLCYGIDFDR--DADQLREL
: : * .* *: *
MMAR_3974|M.marinum_M IADADLVIENFSPRVMDHFGLSADVLLQANPKLVVARMPAFGLDGPWRER
MUL_0328|M.ulcerans_Agy99 IATCDVIAENFTPRVMDQLGLDFATVQSIRSDAILLRMPGFGLDGPWRDN
TH_4570|M.thermoresistible__bu AADADVVVENFSPRVVEQFGLDYDSLAAGNPDVIMVRMPGFGLAGPWRDY
Mb3300|M.bovis_AF2122/97 ADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSR
Rv3272|M.tuberculosis_H37Rv ADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSR
MAB_0824|M.abscessus_ATCC_1997 AGRADVVVENFRAGTMEKFGLGYQSLKQLNPGLIYCAITGFG-RGAGADL
Mvan_0223|M.vanbaalenii_PYR-1 LAVADVVIESSRPAALERRGLGPADVPA-RRGRIWLRVTGHGTAGDRADW
Mflv_0444|M.gilvum_PYR-GCK LGAADVVIESSRPAALQRRGLGPTDVAG-PAGRVWVRITGHGTDGARADW
MSMEG_0262|M.smegmatis_MC2_155 LDVADVVIESSRPTALVRRGLGPDVVAS-REGRVWVRITGHGTTGEHADW
MAV_4956|M.avium_104 LTVSDIVIEGSRPAALRRRGLGPADIAP-RPGRIWLQITAFD-----DDR
.*:: * . .: : **. : : :.... .
MMAR_3974|M.marinum_M VGFAPTMEQIGGLTWLTGLSDAPP-VTPRGACDPLAGVHAAVAVLAALSF
MUL_0328|M.ulcerans_Agy99 PAFAYVIESAAGISWMTGYPDLTP-YEPYSVGDPNAGVHAANALLLALEH
TH_4570|M.thermoresistible__bu VGWALNIEQLAGMSAVTGYPDGPP-CNLQGPADPIAGVHAGVALLAALHE
Mb3300|M.bovis_AF2122/97 PGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLH
Rv3272|M.tuberculosis_H37Rv PGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLH
MAB_0824|M.abscessus_ATCC_1997 PGYDLLVQAVGGLMSVTGPDAAHPSKVGVALVDVLTALHALSGILAALSY
Mvan_0223|M.vanbaalenii_PYR-1 VAFGDDAAVSGGLVGGS---ADAPEFCGDAIADPLTGLHAALAVLESHA-
Mflv_0444|M.gilvum_PYR-GCK VAFGDDAAVSGGLVSGS---PADPRFCGDAIADPLTGIRAAAEVLASRR-
MSMEG_0262|M.smegmatis_MC2_155 VAFGDDAAVSGGLVKNH---HGTPSFAGDAIADPLTGLHAAHAVAESLT-
MAV_4956|M.avium_104 PGFGDDAAVGGGLVGTS---AAGPVFCGDAIADPLTGLHAALAVAESLG-
. .*: * * :. : :
MMAR_3974|M.marinum_M AERTGLGQQVELPMVEAVLNTTAVQPIEFEVFGTTLGRRGNRGLGGALQN
MUL_0328|M.ulcerans_Agy99 RRRTGRGVLVEAAMVDAALNIAAEQVIEYSAYGRLLERAGNRGPAAVPQN
TH_4570|M.thermoresistible__bu RRRTGGGQLIEVAQIEVGAAVTAEPVIEYSMNGVIREREGNR-HRSYAQG
Mb3300|M.bovis_AF2122/97 RERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRK
Rv3272|M.tuberculosis_H37Rv RERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRK
MAB_0824|M.abscessus_ATCC_1997 RDRTGQGQRVDTDLMSVLLSSLVNQASGYLGAGVVPEALGNRHP------
Mvan_0223|M.vanbaalenii_PYR-1 ---RGGGELVEISMAAVAAGYAGL--------------------------
Mflv_0444|M.gilvum_PYR-GCK ---RGGGELIELSMAGVAAEYAQL--------------------------
MSMEG_0262|M.smegmatis_MC2_155 ---RGGGDLIEFAMSAVAATYADL--------------------------
MAV_4956|M.avium_104 ---RGGGELIRLSMAGVAAGYAALG-------------------------
* . : .
MMAR_3974|M.marinum_M --IYRCA-----GDDDHWIAVSVCDDRQWRALVDLMDDPPWCDAG-LSTA
MUL_0328|M.ulcerans_Agy99 --LYRSSDIDEFGRLDSWVAIAVSTDQHWQQLGAALGSPSWAAEPRLATA
TH_4570|M.thermoresistible__bu --VYPCR------DEDDWVAISVRDDTDWANLVAAMDLPGLARDERFRTA
Mb3300|M.bovis_AF2122/97 GVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRPDLVEDQRFAEQ
Rv3272|M.tuberculosis_H37Rv GVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRPDLVEDQRFAEQ
MAB_0824|M.abscessus_ATCC_1997 ----SIAPYQTFETADRPIAIAVGNDKQFRLLVQALEMPRLARDDRFATN
Mvan_0223|M.vanbaalenii_PYR-1 ----------------------------------PGDDERYCAATPSVPD
Mflv_0444|M.gilvum_PYR-GCK ----------------------------------PRGDEKPCVATPVAAP
MSMEG_0262|M.smegmatis_MC2_155 ----------------------------------ATTGADIATVEPASAP
MAV_4956|M.avium_104 --------------------------------TEPPTSDAPVSPPAPPPP
MMAR_3974|M.marinum_M AGRRDRADEVDGMLREWFAIQPRDSTVELLAAAGIPAAPVVSPSSVTENP
MUL_0328|M.ulcerans_Agy99 AGRRTHEDVIDDHLTAWCGQRGSDEIVATLWQAGVPVAKVMQPHRQSELA
TH_4570|M.thermoresistible__bu AQRRRHHDEFDDVVSTWTRGRTAEQAVAAAIAHGVPAERILTGDRMYDLP
Mb3300|M.bovis_AF2122/97 RSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTP
Rv3272|M.tuberculosis_H37Rv RSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTP
MAB_0824|M.abscessus_ATCC_1997 PLRVRHRGELVRVLEQRLREKNADDWYDTLTAVGVPAGPINDIAEAFRFA
Mvan_0223|M.vanbaalenii_PYR-1 SGPE--LGSGNDVVDRLVADRLAAPC------------------------
Mflv_0444|M.gilvum_PYR-GCK RGPA--LGADNAAVDRLVADRATLPC------------------------
MSMEG_0262|M.smegmatis_MC2_155 AGPA--LGADNGAVTRLIAG--SRPC------------------------
MAV_4956|M.avium_104 SGPASALGADNAAVRHLVSQRRCRSC------------------------
:
MMAR_3974|M.marinum_M QLRGRGFFEGLLHPRTGPMLYPTPPFARLAGQSEWLLRPPPTLGQHTEEI
MUL_0328|M.ulcerans_Agy99 QLASRGFFEVVDHPVNGPVRLSTVPMRLSGWPGRFHTEPAPLLGQHNREL
TH_4570|M.thermoresistible__bu QLDARGYYEEIEHPITGTHRYPGWPFRISPGPARHHRTPPPTLGQHNTEI
Mb3300|M.bovis_AF2122/97 LFAESDLTLEVGRGADTITVIRTP--ARYASFRAVVTDPPPTAGEHNAVF
Rv3272|M.tuberculosis_H37Rv LFAENDLTLEVGRGADTITVIRTP--ARYASFRAVVTDPPPTAGEHNAVF
MAB_0824|M.abscessus_ATCC_1997 ERLGLDVAVTVPGSPE--PQVANP--ISMSKTPVVYRNGPPRLGQSRA--
Mvan_0223|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0444|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0262|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4956|M.avium_104 --------------------------------------------------
MMAR_3974|M.marinum_M LRDRCGLNEHELERLRAGEVIGTRPKGV---
MUL_0328|M.ulcerans_Agy99 LTE-LGLTAAEISELESDGVIGAAPAMYSAT
TH_4570|M.thermoresistible__bu LRA-LGVTDDELGELADQRVIGRRLLHAD--
Mb3300|M.bovis_AF2122/97 LARP---------------------------
Rv3272|M.tuberculosis_H37Rv LARP---------------------------
MAB_0824|M.abscessus_ATCC_1997 -------------------------------
Mvan_0223|M.vanbaalenii_PYR-1 -------------------------------
Mflv_0444|M.gilvum_PYR-GCK -------------------------------
MSMEG_0262|M.smegmatis_MC2_155 -------------------------------
MAV_4956|M.avium_104 -------------------------------