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TTQVQTHDVLDLPGALRASIEASVEEADGLGDIPSRLHDELRDAGAFRLLTPRELGGWAAPLPTALSVYE KFGRIDGSVGLLVWNTNFGFIGAMLPETGNKRIWGTGVEPVFANSGMPGTATPTNGGFQLSGHWKIVTGI RSATWIVVVGIVTGDTNGAPDVRLFAVPTDQIDIQDTWNVTGLRATGSRDVVIDDVFVPEDLATRLDAPV NTDSPVYRGFIGNLVFGGCAAVTLGIAAHMIEETVTLVRSKASVVGGVVADATRTQYLVAKAQASVDAAR LLLLSTASELADAGDQLTLDQRAAHRAAITHAAEVSRIALVDMYNLAGSSALYRTNTIERIFRDGMAATQ HANQSALFMEGAGRVRLGMDHGLPLF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0198 | - | - | 100% (377) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2892 | - | 2e-28 | 25.88% (371) | pigment production hydroxylase |
| M. smegmatis MC2 155 | MSMEG_2077 | - | 3e-27 | 28.81% (361) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3121c | - | 5e-34 | 32.46% (345) | hypothetical protein Mb3121c |
| M. gilvum PYR-GCK | Mflv_4548 | - | 1e-31 | 25.95% (370) | acyl-CoA dehydrogenase type 2 |
| M. tuberculosis H37Rv | Rv3094c | - | 5e-34 | 32.46% (345) | hypothetical protein Rv3094c |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-07 | 21.37% (365) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0315 | - | 3e-34 | 28.57% (399) | hypothetical protein MAB_0315 |
| M. marinum M | MMAR_1556 | - | 5e-34 | 31.69% (344) | dehydrogenase |
| M. avium 104 | MAV_2166 | - | 1e-30 | 27.05% (366) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3059 | - | 7e-28 | 25.67% (374) | PUTATIVE pigment production hydroxylase |
| M. ulcerans Agy99 | MUL_3474 | - | 2e-31 | 29.52% (376) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3194 | - | 5e-28 | 27.59% (377) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4548|M.gilvum_PYR-GCK ------------------------MSERVLDRLNELAGQFKE-QAVEAEK
TH_3059|M.thermoresistible__bu ------------------------MTKRVIDGIAELADQLRE-QSIEAER
MAB_0315|M.abscessus_ATCC_1997 ------------------MTSSTAVQPDAVQRARELAPAIAA-RALEAER
MAV_2166|M.avium_104 ------------------MVEHHPLHG----ITDEFVARLGE-RAEEAER
Mb3121c|M.bovis_AF2122/97 -----------MNQ----------SETEIEILAEKIARWARA-RSAEIER
Rv3094c|M.tuberculosis_H37Rv -----------MNQ----------SETEIEILAEKIARWARA-RSAEIER
MMAR_1556|M.marinum_M -----------MNQPDLSAAPLRRADSEMENLAEKIALTARE-MSAEIDR
MUL_3474|M.ulcerans_Agy99 MTEPPSLPGVLMNQPDLSAAPLRRADSEMEDLAEKIALTARE-MSAEIDR
Mvan_3194|M.vanbaalenii_PYR-1 ----------------------------MVERARGMRDLVRA-QAAESEQ
MSMEG_0198|M.smegmatis_MC2_155 -------------------MTTQVQTHDVLDLPGALRASIEA-SVEEADG
MLBr_00737|M.leprae_Br4923 -------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQ
: : :
Mflv_4548|M.gilvum_PYR-GCK LGKLPDATVKSMKSIGSIRLLQPKKHGGLEVHPREFAETVMATAALDPAA
TH_3059|M.thermoresistible__bu IGKLTDQTVKIMKKLGSIRLLQPKKHGGLEVHPREFAETVMATAALDPSA
MAB_0315|M.abscessus_ATCC_1997 LRRMPDETIAELSRSGLFSLMAPRRYGGDEASLETLVGAVIEVGKVCGST
MAV_2166|M.avium_104 LRRLPAATVDEFRQTELFRLLLPARFGGLEASFPELLQPIRRMAQGCASS
Mb3121c|M.bovis_AF2122/97 DRRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASA
Rv3094c|M.tuberculosis_H37Rv DRRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASA
MMAR_1556|M.marinum_M DRRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASA
MUL_3474|M.ulcerans_Agy99 DRRLPDELVARLGEAGLLRATMPREVQAAELAPGPALRCAEAVARGDASA
Mvan_3194|M.vanbaalenii_PYR-1 IRTMTPAIVEAMWSTGLMSAFNPAPAGGVEPSFAEMIETWIEMAWQDGSF
MSMEG_0198|M.smegmatis_MC2_155 LGDIPSRLHDELRDAGAFRLLTPRELGGWAAPLPTALSVYEKFGRIDGSV
MLBr_00737|M.leprae_Br4923 RARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
:. : * . . :
Mflv_4548|M.gilvum_PYR-GCK GWVNGVVGVHPYQLA----------YADPKVGEEIWADD---IDTWVASP
TH_3059|M.thermoresistible__bu GWINGVVGVHPYQLA----------YADPRVAEEIWAED---VDTWIASP
MAB_0315|M.abscessus_ATCC_1997 AWTFCIYGIHNWLAG----------LFPEQLQDEMFGSVPAGSPLLFPGS
MAV_2166|M.avium_104 AWTLGFYALHNWMLS----------LFDPQAQREVFASG----PVLAPAP
Mb3121c|M.bovis_AF2122/97 GWCVSIAITSALLVA----------YLPARSREEMFGGG----RGVAAGV
Rv3094c|M.tuberculosis_H37Rv GWCVSIAITSALLVA----------YLPARSREEMFGGG----RGVAAGV
MMAR_1556|M.marinum_M GWCVSIAITSALLVA----------YLPASSRDEMFGAG----RSVAAGV
MUL_3474|M.ulcerans_Agy99 GWCVSIAITSALLVA----------YLPASSRDEMFGAG----RSVAAGV
Mvan_3194|M.vanbaalenii_PYR-1 GWVGIANLPSSFAAAT---------YLPDGGFAEVFTAN--HNRVTMGGQ
MSMEG_0198|M.smegmatis_MC2_155 GLLVWNTNFG--FIGA---------MLPETGNKRIWGTG---VEPVFANS
MLBr_00737|M.leprae_Br4923 SLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDA
.
Mflv_4548|M.gilvum_PYR-GCK YAPQGVAVPTDGGYIFTGRWQFSSGTDACDWIILGAMVGDAKGVPLM---
TH_3059|M.thermoresistible__bu YAPQGVARPVDGGYLFNGRWQFSSGTDHCDWIILGAMVGDADGTPVT---
MAB_0315|M.abscessus_ATCC_1997 WSPSGIATPVEGGYKITGRWQFGSGVWHSSWASVAAVVQHEEPP--K---
MAV_2166|M.avium_104 LAPTGRATPADGGVRLTGRWSWATGAMDADWLIVGALIERTDR-------
Mb3121c|M.bovis_AF2122/97 WAPRGTARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVP------
Rv3094c|M.tuberculosis_H37Rv WAPRGTARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVP------
MMAR_1556|M.marinum_M WAPRGKAKSVDGGVVVSGRWPFCSGINHADMMFAGCFVEGQPVP------
MUL_3474|M.ulcerans_Agy99 WAPRGKAKSVDGGVVVSGRWPFCSGINHADMMFAGCFVEGQPVP------
Mvan_3194|M.vanbaalenii_PYR-1 FFPNGQGHAVDGGYRLTGSWSFGSGTGHAEYVAAGFLPMVDGEIRWAGDG
MSMEG_0198|M.smegmatis_MC2_155 GMP-GTATPTNGGFQLSGHWKIVTGIRSATWIVVVGIVTGDTNG------
MLBr_00737|M.leprae_Br4923 ASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGAN-----
. . .. ..* :. . .
Mflv_4548|M.gilvum_PYR-GCK PPQMLHMILPRKDYQIVDDS-WDVVGLRGTGSKDVIVDGAFVPTYRTMDG
TH_3059|M.thermoresistible__bu PPRMLHMILPRKDYEIVEDS-WDVVGLRGTGSKDVIVKDAFVPAYRTMDG
MAB_0315|M.abscessus_ATCC_1997 YPDLRTFMIPRSDLEVIDT--WFTSGLRGTGSMDIAVNDVFVPEHRVQEF
MAV_2166|M.avium_104 -IDPALVVVPAGQVEVVDT--WHTAGMRGTGSHDVVIADVFVPEHRLVAV
Mb3121c|M.bovis_AF2122/97 ----SVVALNKDELQVLDT--WHTLGLRGTGSHDCVADDVFVPADRVFS-
Rv3094c|M.tuberculosis_H37Rv ----SVVALNKDELQVLDT--WHTLGLRGTGSHDCVADDVFVPADRVFS-
MMAR_1556|M.marinum_M ----SVVALPKDDLRALDT--WHTLGLRGTGSHDCVAEEVFVPADRVFS-
MUL_3474|M.ulcerans_Agy99 ----SVVALPKDDLRALDT--WHTLGLCGTGSHDCVAEEVFVPADRVFS-
Mvan_3194|M.vanbaalenii_PYR-1 VPDMQVAVVPRAEVSFKDG--WHVQGLKGTGSYDYSIDDVFVPHDRTFAL
MSMEG_0198|M.smegmatis_MC2_155 APDVRLFAVPTDQIDIQDT--WNVTGLRATGSRDVVIDDVFVPEDLATRL
MLBr_00737|M.leprae_Br4923 --GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIG-
: : *: .: : : :*
Mflv_4548|M.gilvum_PYR-GCK MKVMDGSAQIEAGMTEPLYKMPWSTMFPLGISSATIGICEGALAAHLDYQ
TH_3059|M.thermoresistible__bu MKVMDGTAQREAGMTEPLYLMPWSTMFPLGISSATIGIAEGALAAALDYQ
MAB_0315|M.abscessus_ATCC_1997 GPLARGQSPSAELHGSAIYRIPLFCALSNVAAAPAVGMALGTVELFTEKI
MAV_2166|M.avium_104 ADIYGGTAPGAREHAAATYRWPMVPALALTAAMPVLGAAERVVQLFADRL
Mb3121c|M.bovis_AF2122/97 --VFDGPI-----VDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELA
Rv3094c|M.tuberculosis_H37Rv --VFDGPI-----VDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELA
MMAR_1556|M.marinum_M --VFDGPS-----IDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELA
MUL_3474|M.ulcerans_Agy99 --VFDGPT-----IDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELA
Mvan_3194|M.vanbaalenii_PYR-1 FTREPRRG------SSPATRMGMMPVTAAGHAAWALGVAKSMLDDVSELA
MSMEG_0198|M.smegmatis_MC2_155 DAPVNTDS--------PVYRGFIGNLVFGGCAAVTLGIAAHMIEETVTLV
MLBr_00737|M.leprae_Br4923 ---EPGTG--------FKTALATLDHTRPTIGAQAVGIAQGALDAAIVYT
. .:* . :
Mflv_4548|M.gilvum_PYR-GCK RERVGANGTAIKDD-PYVMYAIGDAAAEIEASRNTLLSNVDRVYDIVDSG
TH_3059|M.thermoresistible__bu RRRVNSSGVAVKDD-PYVMYAIGEAAADINAARQELLANADRIYDIVASG
MAB_0315|M.abscessus_ATCC_1997 KTRVMRYSMQEQSKLATAHRRMGHVAAQAESARTLLLQTVRDVEDKLRSG
MAV_2166|M.avium_104 GERVLAYSAVAQKDQPAAQIRLGEARVRLDALRALVAQTADRIEAIVAGG
Mb3121c|M.bovis_AF2122/97 GGKKGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDA
Rv3094c|M.tuberculosis_H37Rv GGKKGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDA
MMAR_1556|M.marinum_M GDKKGLGAKRTLAERSATQTAVATAEAALGAARALFYEAIDSAWQASHNP
MUL_3474|M.ulcerans_Agy99 GDKKGLGAKRTLAERSATQTAVATAEAALGAARALFYEAIDSAWQASHNP
Mvan_3194|M.vanbaalenii_PYR-1 ATKFRMSDMAALASRPTFQKGLAHHVAAWRAARLLVLDAFGTAEAAVAGG
MSMEG_0198|M.smegmatis_MC2_155 RSKASVVGG-VVADATRTQYLVAKAQASVDAARLLLLSTAS---ELADAG
MLBr_00737|M.leprae_Br4923 KDRKQ--FGESISTFQSIQFMLADMAMKVEAARLIVYAAAAR----AERG
: . : * .
Mflv_4548|M.gilvum_PYR-GCK R----------EVTFETRAAVRRSQIKAVWRAVAAVDQIFARSGGNALRM
TH_3059|M.thermoresistible__bu A----------EVSFEDRAAGRRTQVRAVWRAVSAVDEIFARCGGNAARM
MAB_0315|M.abscessus_ATCC_1997 E----------GLTTGDRVAVRRNCAYIVEVCKQAIGEAVEACGASAQYE
MAV_2166|M.avium_104 D----------RVSRSVRAEARLAAARTVHESRAIIADVTEASGASAHFL
Mb3121c|M.bovis_AF2122/97 E----------AVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYD
Rv3094c|M.tuberculosis_H37Rv E----------AVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYD
MMAR_1556|M.marinum_M D----------PVPVALRNRLRLAATHAARTSADVVRIMYDLAGSSAIYD
MUL_3474|M.ulcerans_Agy99 DPVPVPVPVPVPVPVALRNRLRLAATHAARTSADVVRTMYDLAGSSAIYD
Mvan_3194|M.vanbaalenii_PYR-1 D----------DLTPTLRADMRVAAVFATDTARACAEWAHLVAGTSSIRE
MSMEG_0198|M.smegmatis_MC2_155 D----------QLTLDQRAAHRAAITHAAEVSRIALVDMYNLAGSSALYR
MLBr_00737|M.leprae_Br4923 E-------------PDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTS
. * .
Mflv_4548|M.gilvum_PYR-GCK DKPLQRYWRDAHAGVAHAIHVPGTVYHASALSSLGVDPQGPLRAMI
TH_3059|M.thermoresistible__bu DQPLQRFWRDVHVAQAHAIHSPGTVYHASALSSLGVEPQGPLRAMI
MAB_0315|M.abscessus_ATCC_1997 DSPLQRHLRDVNTLSTHVVYDTDSAYELYGRVELGLPP-GSVAF--
MAV_2166|M.avium_104 SSPMQRAKRDVDIAAGHVVFDYDTSRELAGALAIGAKI-SPISMI-
Mb3121c|M.bovis_AF2122/97 NAPLQRRFRDAFTATAHFQVN-EASRELPGRVLLDQPADVSML---
Rv3094c|M.tuberculosis_H37Rv NAPLQRRFRDAFTATAHFQVN-EASRELPGRVLLDQPADVSML---
MMAR_1556|M.marinum_M GSPLQRRFRDAFTATAHFQVN-EASRELPGRVLLGQHCDTSML---
MUL_3474|M.ulcerans_Agy99 GSPLQRRFRDAFTATAHFQVN-EASRELPGRVLLGQHCDTSML---
Mvan_3194|M.vanbaalenii_PYR-1 GSRLERAFRDVYTGTQHAFISEKVAIDAAQVWLGVVEDQFGL----
MSMEG_0198|M.smegmatis_MC2_155 TNTIERIFRDGMAATQHANQS-ALFMEGAGRVRLGMDHGLPLF---
MLBr_00737|M.leprae_Br4923 DFPVERFMRDAKITQIYEGTN-QIQRVVMSRALLR-----------
::* ** :