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TISVSGAAAATTSAITDEFVTRLAERAREAEELRRLPDATMTDLAASGFTELLTPARFGGQQADFPALLD PVRRMAHGCASSAWTIGFLALHNWMLALFGEQAQAEAYATRPFLAPAPLAPNGRGLPTEGGVRLSGRWSW ATGVMHANWIMVGALCGPDDAIYPALALLPASDIEVVDVWHTDGMRATGSNDVVVTDAFVPEHRLVSVID VYTGTAPGAKVHDAATYRWPMVPALALLAAMPALGSAERAVEIYAQRLSERVIAYEGVKQKDKPAAVAHL GEARVRLRALRGLLADTVGEIEDTVTAGDPVSREVRAQARLAAAHIVRESRAVIALLLASSGASAHFLDN PLQRISRDVGVLSGHVIFDHDTSCELAGALSIGMKISPIAMI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2077 | - | - | 100% (393) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6038 | - | 1e-53 | 35.73% (347) | pigment production hydroxylase |
| M. smegmatis MC2 155 | MSMEG_2892 | - | 1e-41 | 32.09% (374) | pigment production hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3601c | - | 1e-52 | 32.99% (385) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4461 | - | 1e-158 | 69.53% (384) | acyl-CoA dehydrogenase type 2 |
| M. tuberculosis H37Rv | Rv3570c | - | 2e-52 | 32.99% (385) | oxidoreductase |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-06 | 19.62% (372) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0315 | - | 1e-73 | 37.63% (380) | hypothetical protein MAB_0315 |
| M. marinum M | MMAR_3433 | - | 1e-164 | 72.18% (381) | oxidoreductase |
| M. avium 104 | MAV_2166 | - | 1e-143 | 66.40% (378) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_2929 | - | 1e-172 | 76.17% (386) | PUTATIVE acyl-CoA dehydrogenase, C- domain protein |
| M. ulcerans Agy99 | MUL_2707 | - | 1e-163 | 71.65% (381) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1900 | - | 1e-163 | 73.89% (383) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3601c|M.bovis_AF2122/97 -----------MTSIQQRDAQSVLAAIDDLLPEIRDRAQATEDLRRLPDE
Rv3570c|M.tuberculosis_H37Rv -----------MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDE
MSMEG_2077|M.smegmatis_MC2_155 ----------MTISVSGAAAATTSAITDEFVTRLAERAREAEELRRLPDA
TH_2929|M.thermoresistible__bu ---------------MSATAAQTAEITAEFVQRLAERAAEADELRRLPAA
MMAR_3433|M.marinum_M ---------------------MTAGITDTFVHSLAQRAHEAEKLRRLPAA
MUL_2707|M.ulcerans_Agy99 -----MPSPTLDCHTERYGGLMTAGITDTFVHSLAQRAHEAEKLRRLPAA
Mflv_4461|M.gilvum_PYR-GCK ---------------MSSKVTAPAAVTDQFIADLSDRADDAERLRRLPAE
Mvan_1900|M.vanbaalenii_PYR-1 -------------------MPAAHSVTPEFIDRLAERAAEAERLRRLPAD
MAV_2166|M.avium_104 ----------------MVEHHPLHGITDEFVARLGERAEEAERLRRLPAA
MAB_0315|M.abscessus_ATCC_1997 ------------MTSSTAVQPDAVQRARELAPAIAARALEAERLRRMPDE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
: :* .: *:*
Mb3601c|M.bovis_AF2122/97 TVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIV
Rv3570c|M.tuberculosis_H37Rv TVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIV
MSMEG_2077|M.smegmatis_MC2_155 TMTDLAASGFTELLTPARFGGQQADFPALLDPVRRMAHGCASSAWTIGFL
TH_2929|M.thermoresistible__bu TIDDLTASGFTELLVPARYGGRQAEFPALLDPVRRMAHGCTSSAWTIGFF
MMAR_3433|M.marinum_M TVTELTASGFPDLLKPARYGGQQAEFSAIFDPVRRMAHGCASTAWTAAFY
MUL_2707|M.ulcerans_Agy99 TVTELTASGFPDLLKPARYGGQQAEFSAIFDPVRRMAHGCASTAWPAAFY
Mflv_4461|M.gilvum_PYR-GCK TLTDASASGLFDLLVPSRYGGQEAPFPAILEPVRRMAHGCASSAWTLGFY
Mvan_1900|M.vanbaalenii_PYR-1 TVADATASGFFDLLVPARYGGVQAPFPAILDPVREMAHGCASSAWTLGFY
MAV_2166|M.avium_104 TVDEFRQTELFRLLLPARFGGLEASFPELLQPIRRMAQGCASSAWTLGFY
MAB_0315|M.abscessus_ATCC_1997 TIAELSRSGLFSLMAPRRYGGDEASLETLVGAVIEVGKVCGSTAWTFCIY
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
:: : : * .:** . .:. *:. .
Mb3601c|M.bovis_AF2122/97 GVHNWHLALFDQRAQEEVWG---EDPSTRISSSYAPMGAG---------V
Rv3570c|M.tuberculosis_H37Rv GVHNWHLALFDQRAQEEVWG---EDPSTRISSSYAPMGAG---------V
MSMEG_2077|M.smegmatis_MC2_155 ALHNWMLALFGEQAQAEAY----ATRPFLAPAPLAPNGRG---------L
TH_2929|M.thermoresistible__bu ALHNWMLALFDEQAQQEVF----ADRPVLAPAPLAPTGRG---------L
MMAR_3433|M.marinum_M ALHNWMLALFDERAQSEGF----TTTPFLAPAPLAPTGRG---------L
MUL_2707|M.ulcerans_Agy99 ALHNWMLALFDERAQSEGF----TTTPFLAPAPLAPTGRG---------L
Mflv_4461|M.gilvum_PYR-GCK TLHNWMLALFSEEAQQEGF----AARPFLAPAPLAPTGHG---------V
Mvan_1900|M.vanbaalenii_PYR-1 ALHNWMLALFTEQAQSEGF----ATRPFLAPAPLAPTGRG---------T
MAV_2166|M.avium_104 ALHNWMLSLFDPQAQREVF----ASGPVLAPAPLAPTGRA---------T
MAB_0315|M.abscessus_ATCC_1997 GIHNWLAGLFPEQLQDEMFGSVPAGSPLLFPGSWSPSGIA---------T
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
: . * . : . . : .
Mb3601c|M.bovis_AF2122/97 VVDGG-YLVNGSWNWSSGCDHASWTFVGGPVIKDG-----RPVDFGSFLI
Rv3570c|M.tuberculosis_H37Rv VVDGG-YLVNGSWNWSSGCDHASWTFVGGPVIKDG-----RPVDFGSFLI
MSMEG_2077|M.smegmatis_MC2_155 PTEGG-VRLSGRWSWATGVMHANWIMVGALCGPDD----AIYPALA--LL
TH_2929|M.thermoresistible__bu PVDGG-VRLTGRWSWATGVMHANWVLVGALCGPED----AIYPALA--LL
MMAR_3433|M.marinum_M PADGG-VRLSGRWSWATGVMDGNWIIVGTLCGSDD----AIYPALA--LL
MUL_2707|M.ulcerans_Agy99 PADGG-VRLSGRWSWATGVMDGNWIIVGTLCGSDD----AIYPALA--LL
Mflv_4461|M.gilvum_PYR-GCK ACEGG-IRVTGRWSWATGVMDGNWIMVGALCERTAGDPSTLYPVLA--LL
Mvan_1900|M.vanbaalenii_PYR-1 ACDGG-IRLSGRWSWATGVMDGNWMMVGALCEREAGDPSTIYPVLA--LL
MAV_2166|M.avium_104 PADGG-VRLTGRWSWATGAMDADWLIVGALIERTD----RIDPALV--VV
MAB_0315|M.abscessus_ATCC_1997 PVEGG-YKITGRWQFGSGVWHSSWASVAAVVQHEE---PPKYPDLRTFMI
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDK-----GANGISAFIV
:*. :.* : :. .. * * : ::
Mb3601c|M.bovis_AF2122/97 PRSE--YEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAG
Rv3570c|M.tuberculosis_H37Rv PRSE--YEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAG
MSMEG_2077|M.smegmatis_MC2_155 PASD--IEVVDVWHTDGMRATGSNDVVVTDAFVPEHRLVSVIDVYTGTAP
TH_2929|M.thermoresistible__bu PAAD--VTVEDTWHTVGMRATGSADVVVTEAFVPEHRLLRVTDIYAGTTP
MMAR_3433|M.marinum_M PAND--IRIIDVWHTDGMRATGSNDVVIEDVFVPTYRLIKVTDIYAGTTP
MUL_2707|M.ulcerans_Agy99 PAND--IRIIDVWHTDGMRATGSNDVVIEDVFVPTYRLIKVTDIYAGTTP
Mflv_4461|M.gilvum_PYR-GCK PIDE--ARIEDVWHTDGMRATGSNDVIIDGAFVPSHRIVKVTDIYTGAAP
Mvan_1900|M.vanbaalenii_PYR-1 PIDG--VRVEDVWHTDGMRATGSNDVVIDDAFVPAHRLVEVSDIYSGSAP
MAV_2166|M.avium_104 PAGQ--VEVVDTWHTAGMRGTGSHDVVIADVFVPEHRLVAVADIYGGTAP
MAB_0315|M.abscessus_ATCC_1997 PRSD--LEVIDTWFTSGLRGTGSMDIAVNDVFVPEHRVQEFGPLARGQSP
MLBr_00737|M.leprae_Br4923 HKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTAL
: *::.: : : . :* *. :
Mb3601c|M.bovis_AF2122/97 GLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFA
Rv3570c|M.tuberculosis_H37Rv GLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFA
MSMEG_2077|M.smegmatis_MC2_155 GAKVHDAATYRWPMVPALALLAAMPALGSAERAVEIYAQRLSERV-IAYE
TH_2929|M.thermoresistible__bu GAALHDAAAYRWPMVPALALLAAMPALGSAERVTDLFAERLGHRV-IAYE
MMAR_3433|M.marinum_M GSKVHEAPAYRWPLVPALALVAAMPALGAAEHVADVFTARLGERI-LAYE
MUL_2707|M.ulcerans_Agy99 GSKVHEAPAYRWPLVPALALVAAMPALGAAEHVADVFPARLGERI-LAYE
Mflv_4461|M.gilvum_PYR-GCK GAALHDADTYRWPMVPALALLAAMPALGSAERAVEIYTERLSQRF-LAYE
Mvan_1900|M.vanbaalenii_PYR-1 GAALHDADTYRWPMVPALALLAAMPALGSAERAAEIYAERLSQRF-LAYE
MAV_2166|M.avium_104 GAREHAAATYRWPMVPALALTAAMPVLGAAERVVQLFADRLGERV-LAYS
MAB_0315|M.abscessus_ATCC_1997 SAELHGSAIYRIPLFCALSNVAAAPAVGMALGTVELFTEKIKTRV-MRYS
MLBr_00737|M.leprae_Br4923 ATLDHTRP------------TIGAQAVGIAQGALDAAIVYTKDRK---QF
. : . :* * . *
Mb3601c|M.bovis_AF2122/97 GEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELR
Rv3570c|M.tuberculosis_H37Rv GEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELR
MSMEG_2077|M.smegmatis_MC2_155 GVKQKDKPAAVAHLGEARVRLRALRGLLADTVGEIEDTVTAGDPVSREVR
TH_2929|M.thermoresistible__bu GVAQRDKPIAQAHLGRARVRLRALHGLLADTVGQIQQLVAAGDPVPRPVR
MMAR_3433|M.marinum_M GAKQQDKPAAQVRVGEARVRLRALHGLLADTVGRIEDILATGDRVPRPVR
MUL_2707|M.ulcerans_Agy99 GAKQQDKPAAQVRVGEARVRLRALHGLLADTVGRIEDILATGDRVARPIR
Mflv_4461|M.gilvum_PYR-GCK GVMQKDKPVASIHLGSASVRLRALDALLADTVGEIENIIAAGDPVERPVR
Mvan_1900|M.vanbaalenii_PYR-1 GVMQKDKPVAAMHLGEASVRLRALKSLLADTVGEIESIVAAGDPVERPVR
MAV_2166|M.avium_104 AVAQKDQPAAQIRLGEARVRLDALRALVAQTADRIEAIVAGGDRVSRSVR
MAB_0315|M.abscessus_ATCC_1997 MQEQSKLATAHRRMGHVAAQAESARTLLLQTVRDVEDKLRSGEGLTTGDR
MLBr_00737|M.leprae_Br4923 GESISTFQSIQFMLADMAMKVEAARLIVYAAAARAE----RGEPDLGFIS
:. : : . *.
Mb3601c|M.bovis_AF2122/97 ARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHA
Rv3570c|M.tuberculosis_H37Rv ARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHA
MSMEG_2077|M.smegmatis_MC2_155 AQARLAAAHIVRESRAVIALLLASSGASAHFLDNPLQRISRDVGVLSGHV
TH_2929|M.thermoresistible__bu ADARLAAAHIVHESRAIIGDLLAASGASVQFLSHPMQRFQRDVDVLAGHV
MMAR_3433|M.marinum_M ADARLAAAHIVHESRAVIGELLEASGASAHFLNNPLQRAKRDVDVISGHV
MUL_2707|M.ulcerans_Agy99 ADARLAAAHIVHESRAVIGELLEASGASAHFLYNPLQRAKRDVDVISGHV
Mflv_4461|M.gilvum_PYR-GCK AHARLAAAHIVHESRAVIGELLGASGASAHFLDNPLQRVKRDVDVIAGHV
Mvan_1900|M.vanbaalenii_PYR-1 GQARLAAAHIVHESRAVVSGLLAASGASAHFLDNPLQRIKRDVDVIVGHV
MAV_2166|M.avium_104 AEARLAAARTVHESRAIIADVTEASGASAHFLSSPMQRAKRDVDIAAGHV
MAB_0315|M.abscessus_ATCC_1997 VAVRRNCAYIVEVCKQAIGEAVEACGASAQYEDSPLQRHLRDVNTLSTHV
MLBr_00737|M.leprae_Br4923 AASKCFASDIAMEVTTDAVQLFGGAGYTSDF---PVERFMRDAKITQIYE
: . ..* : *::* **. :
Mb3601c|M.bovis_AF2122/97 ANDPERAYVIFGNHEFGLPPGDTMV-
Rv3570c|M.tuberculosis_H37Rv ANDPERAYVIFGNHEFGLPPGDTMV-
MSMEG_2077|M.smegmatis_MC2_155 IFDHDTSCELAGALSIGMKISPIAMI
TH_2929|M.thermoresistible__bu VFDYDTSRELAGALELGLKVSPLAMI
MMAR_3433|M.marinum_M VFDYDVSRELAGALAIGRKISPVAMV
MUL_2707|M.ulcerans_Agy99 VFDYDVSRELAGALAIGRKISPVAMV
Mflv_4461|M.gilvum_PYR-GCK VFDYDTSRELAGAVTMGAPIPRTAMV
Mvan_1900|M.vanbaalenii_PYR-1 VFDYDTSRELAGALTMGRRIPRTAMV
MAV_2166|M.avium_104 VFDYDTSRELAGALAIGAKISPISMI
MAB_0315|M.abscessus_ATCC_1997 VYDTDSAYELYGRVELGLPPGSVAF-
MLBr_00737|M.leprae_Br4923 GTNQIQRVVMSRALLR----------
: :