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VEHHPLHGITDEFVARLGERAEEAERLRRLPAATVDEFRQTELFRLLLPARFGGLEASFPELLQPIRRMA QGCASSAWTLGFYALHNWMLSLFDPQAQREVFASGPVLAPAPLAPTGRATPADGGVRLTGRWSWATGAMD ADWLIVGALIERTDRIDPALVVVPAGQVEVVDTWHTAGMRGTGSHDVVIADVFVPEHRLVAVADIYGGTA PGAREHAAATYRWPMVPALALTAAMPVLGAAERVVQLFADRLGERVLAYSAVAQKDQPAAQIRLGEARVR LDALRALVAQTADRIEAIVAGGDRVSRSVRAEARLAAARTVHESRAIIADVTEASGASAHFLSSPMQRAK RDVDIAAGHVVFDYDTSRELAGALAIGAKISPISMI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2166 | - | - | 100% (387) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_0591 | - | 5e-57 | 34.15% (366) | pigment production hydroxylase |
| M. avium 104 | MAV_3020 | - | 3e-43 | 30.62% (369) | pigment production hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3601c | - | 8e-54 | 33.06% (366) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4461 | - | 1e-136 | 61.52% (382) | acyl-CoA dehydrogenase type 2 |
| M. tuberculosis H37Rv | Rv3570c | - | 1e-53 | 33.06% (366) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0315 | - | 6e-72 | 37.53% (373) | hypothetical protein MAB_0315 |
| M. marinum M | MMAR_3433 | - | 1e-145 | 65.70% (379) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2077 | - | 1e-143 | 66.40% (378) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_2929 | - | 1e-148 | 67.99% (378) | PUTATIVE acyl-CoA dehydrogenase, C- domain protein |
| M. ulcerans Agy99 | MUL_2707 | - | 1e-144 | 65.17% (379) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1900 | - | 1e-139 | 63.54% (384) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2077|M.smegmatis_MC2_155 -----MTISVSGAAAATTSAITDEFVTRLAERAREAEELRRLPDATMTDL
TH_2929|M.thermoresistible__bu ----------MSATAAQTAEITAEFVQRLAERAAEADELRRLPAATIDDL
Mflv_4461|M.gilvum_PYR-GCK ----------MSSKVTAPAAVTDQFIADLSDRADDAERLRRLPAETLTDA
Mvan_1900|M.vanbaalenii_PYR-1 --------------MPAAHSVTPEFIDRLAERAAEAERLRRLPADTVADA
MMAR_3433|M.marinum_M ----------------MTAGITDTFVHSLAQRAHEAEKLRRLPAATVTEL
MUL_2707|M.ulcerans_Agy99 MPSPTLDCHTERYGGLMTAGITDTFVHSLAQRAHEAEKLRRLPAATVTEL
MAV_2166|M.avium_104 -----------MVEHHPLHGITDEFVARLGERAEEAERLRRLPAATVDEF
MAB_0315|M.abscessus_ATCC_1997 -------MTSSTAVQPDAVQRARELAPAIAARALEAERLRRMPDETIAEL
Mb3601c|M.bovis_AF2122/97 ------MTSIQQRDAQSVLAAIDDLLPEIRDRAQATEDLRRLPDETVKAL
Rv3570c|M.tuberculosis_H37Rv ------MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKAL
: : ** :: ***:* *:
MSMEG_2077|M.smegmatis_MC2_155 AASGFTELLTPARFGGQQADFPALLDPVRRMAHGCASSAWTIGFLALHNW
TH_2929|M.thermoresistible__bu TASGFTELLVPARYGGRQAEFPALLDPVRRMAHGCTSSAWTIGFFALHNW
Mflv_4461|M.gilvum_PYR-GCK SASGLFDLLVPSRYGGQEAPFPAILEPVRRMAHGCASSAWTLGFYTLHNW
Mvan_1900|M.vanbaalenii_PYR-1 TASGFFDLLVPARYGGVQAPFPAILDPVREMAHGCASSAWTLGFYALHNW
MMAR_3433|M.marinum_M TASGFPDLLKPARYGGQQAEFSAIFDPVRRMAHGCASTAWTAAFYALHNW
MUL_2707|M.ulcerans_Agy99 TASGFPDLLKPARYGGQQAEFSAIFDPVRRMAHGCASTAWPAAFYALHNW
MAV_2166|M.avium_104 RQTELFRLLLPARFGGLEASFPELLQPIRRMAQGCASSAWTLGFYALHNW
MAB_0315|M.abscessus_ATCC_1997 SRSGLFSLMAPRRYGGDEASLETLVGAVIEVGKVCGSTAWTFCIYGIHNW
Mb3601c|M.bovis_AF2122/97 DDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNW
Rv3570c|M.tuberculosis_H37Rv DDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNW
: *: * ::** :. :. . .:. * *:.* : :***
MSMEG_2077|M.smegmatis_MC2_155 MLALFGEQAQAEAY----ATRPFLAPAPLAPNGRGLPTEGGVRLSGRWSW
TH_2929|M.thermoresistible__bu MLALFDEQAQQEVF----ADRPVLAPAPLAPTGRGLPVDGGVRLTGRWSW
Mflv_4461|M.gilvum_PYR-GCK MLALFSEEAQQEGF----AARPFLAPAPLAPTGHGVACEGGIRVTGRWSW
Mvan_1900|M.vanbaalenii_PYR-1 MLALFTEQAQSEGF----ATRPFLAPAPLAPTGRGTACDGGIRLSGRWSW
MMAR_3433|M.marinum_M MLALFDERAQSEGF----TTTPFLAPAPLAPTGRGLPADGGVRLSGRWSW
MUL_2707|M.ulcerans_Agy99 MLALFDERAQSEGF----TTTPFLAPAPLAPTGRGLPADGGVRLSGRWSW
MAV_2166|M.avium_104 MLSLFDPQAQREVF----ASGPVLAPAPLAPTGRATPADGGVRLTGRWSW
MAB_0315|M.abscessus_ATCC_1997 LAGLFPEQLQDEMFGSVPAGSPLLFPGSWSPSGIATPVEGGYKITGRWQF
Mb3601c|M.bovis_AF2122/97 HLALFDQRAQEEVWG---EDPSTRISSSYAPMGAGVVVDGGYLVNGSWNW
Rv3570c|M.tuberculosis_H37Rv HLALFDQRAQEEVWG---EDPSTRISSSYAPMGAGVVVDGGYLVNGSWNW
.** . * * : . ... :* * . :** :.* *.:
MSMEG_2077|M.smegmatis_MC2_155 ATGVMHANWIMVGALCGPDD----AIYPALA--LLPASDIEVVDVWHTDG
TH_2929|M.thermoresistible__bu ATGVMHANWVLVGALCGPED----AIYPALA--LLPAADVTVEDTWHTVG
Mflv_4461|M.gilvum_PYR-GCK ATGVMDGNWIMVGALCERTAGDPSTLYPVLA--LLPIDEARIEDVWHTDG
Mvan_1900|M.vanbaalenii_PYR-1 ATGVMDGNWMMVGALCEREAGDPSTIYPVLA--LLPIDGVRVEDVWHTDG
MMAR_3433|M.marinum_M ATGVMDGNWIIVGTLCGSDD----AIYPALA--LLPANDIRIIDVWHTDG
MUL_2707|M.ulcerans_Agy99 ATGVMDGNWIIVGTLCGSDD----AIYPALA--LLPANDIRIIDVWHTDG
MAV_2166|M.avium_104 ATGAMDADWLIVGALIERTD----RIDPALV--VVPAGQVEVVDTWHTAG
MAB_0315|M.abscessus_ATCC_1997 GSGVWHSSWASVAAVVQHEE---PPKYPDLRTFMIPRSDLEVIDTWFTSG
Mb3601c|M.bovis_AF2122/97 SSGCDHASWTFVGGPVIKDG-----RPVDFGSFLIPRSEYEIKDVWYVVG
Rv3570c|M.tuberculosis_H37Rv SSGCDHASWTFVGGPVIKDG-----RPVDFGSFLIPRSEYEIKDVWYVVG
.:* ...* *. : ::* : *.*.. *
MSMEG_2077|M.smegmatis_MC2_155 MRATGSNDVVVTDAFVPEHRLVSVIDVYTGTAPGAKVHDAATYRWPMVPA
TH_2929|M.thermoresistible__bu MRATGSADVVVTEAFVPEHRLLRVTDIYAGTTPGAALHDAAAYRWPMVPA
Mflv_4461|M.gilvum_PYR-GCK MRATGSNDVIIDGAFVPSHRIVKVTDIYTGAAPGAALHDADTYRWPMVPA
Mvan_1900|M.vanbaalenii_PYR-1 MRATGSNDVVIDDAFVPAHRLVEVSDIYSGSAPGAALHDADTYRWPMVPA
MMAR_3433|M.marinum_M MRATGSNDVVIEDVFVPTYRLIKVTDIYAGTTPGSKVHEAPAYRWPLVPA
MUL_2707|M.ulcerans_Agy99 MRATGSNDVVIEDVFVPTYRLIKVTDIYAGTTPGSKVHEAPAYRWPLVPA
MAV_2166|M.avium_104 MRGTGSHDVVIADVFVPEHRLVAVADIYGGTAPGAREHAAATYRWPMVPA
MAB_0315|M.abscessus_ATCC_1997 LRGTGSMDIAVNDVFVPEHRVQEFGPLARGQSPSAELHGSAIYRIPLFCA
Mb3601c|M.bovis_AF2122/97 LRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTM
Rv3570c|M.tuberculosis_H37Rv LRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTM
:*.*** : : .*** :*. : : . : : *: *
MSMEG_2077|M.smegmatis_MC2_155 LALLAAMPALGSAERAVEIYAQRLSERV-IAYEGVKQKDKPAAVAHLGEA
TH_2929|M.thermoresistible__bu LALLAAMPALGSAERVTDLFAERLGHRV-IAYEGVAQRDKPIAQAHLGRA
Mflv_4461|M.gilvum_PYR-GCK LALLAAMPALGSAERAVEIYTERLSQRF-LAYEGVMQKDKPVASIHLGSA
Mvan_1900|M.vanbaalenii_PYR-1 LALLAAMPALGSAERAAEIYAERLSQRF-LAYEGVMQKDKPVAAMHLGEA
MMAR_3433|M.marinum_M LALVAAMPALGAAEHVADVFTARLGERI-LAYEGAKQQDKPAAQVRVGEA
MUL_2707|M.ulcerans_Agy99 LALVAAMPALGAAEHVADVFPARLGERI-LAYEGAKQQDKPAAQVRVGEA
MAV_2166|M.avium_104 LALTAAMPVLGAAERVVQLFADRLGERV-LAYSAVAQKDQPAAQIRLGEA
MAB_0315|M.abscessus_ATCC_1997 LSNVAAAPAVGMALGTVELFTEKIKTRV-MRYSMQEQSKLATAHRRMGHV
Mb3601c|M.bovis_AF2122/97 HPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEA
Rv3570c|M.tuberculosis_H37Rv HPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEA
. : * :* * . . : *. : . . * ::. .
MSMEG_2077|M.smegmatis_MC2_155 RVRLRALRGLLADTVGEIEDTVTAGDPVSREVRAQARLAAAHIVRESRAV
TH_2929|M.thermoresistible__bu RVRLRALHGLLADTVGQIQQLVAAGDPVPRPVRADARLAAAHIVHESRAI
Mflv_4461|M.gilvum_PYR-GCK SVRLRALDALLADTVGEIENIIAAGDPVERPVRAHARLAAAHIVHESRAV
Mvan_1900|M.vanbaalenii_PYR-1 SVRLRALKSLLADTVGEIESIVAAGDPVERPVRGQARLAAAHIVHESRAV
MMAR_3433|M.marinum_M RVRLRALHGLLADTVGRIEDILATGDRVPRPVRADARLAAAHIVHESRAV
MUL_2707|M.ulcerans_Agy99 RVRLRALHGLLADTVGRIEDILATGDRVARPIRADARLAAAHIVHESRAV
MAV_2166|M.avium_104 RVRLDALRALVAQTADRIEAIVAGGDRVSRSVRAEARLAAARTVHESRAI
MAB_0315|M.abscessus_ATCC_1997 AAQAESARTLLLQTVRDVEDKLRSGEGLTTGDRVAVRRNCAYIVEVCKQA
Mb3601c|M.bovis_AF2122/97 ASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIAS
Rv3570c|M.tuberculosis_H37Rv ASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIAS
: : .. : *. : * .* . . .
MSMEG_2077|M.smegmatis_MC2_155 IALLLASSGASAHFLDNPLQRISRDVGVLSGHVIFDHDTSCELAGALSIG
TH_2929|M.thermoresistible__bu IGDLLAASGASVQFLSHPMQRFQRDVDVLAGHVVFDYDTSRELAGALELG
Mflv_4461|M.gilvum_PYR-GCK IGELLGASGASAHFLDNPLQRVKRDVDVIAGHVVFDYDTSRELAGAVTMG
Mvan_1900|M.vanbaalenii_PYR-1 VSGLLAASGASAHFLDNPLQRIKRDVDVIVGHVVFDYDTSRELAGALTMG
MMAR_3433|M.marinum_M IGELLEASGASAHFLNNPLQRAKRDVDVISGHVVFDYDVSRELAGALAIG
MUL_2707|M.ulcerans_Agy99 IGELLEASGASAHFLYNPLQRAKRDVDVISGHVVFDYDVSRELAGALAIG
MAV_2166|M.avium_104 IADVTEASGASAHFLSSPMQRAKRDVDIAAGHVVFDYDTSRELAGALAIG
MAB_0315|M.abscessus_ATCC_1997 IGEAVEACGASAQYEDSPLQRHLRDVNTLSTHVVYDTDSAYELYGRVELG
Mb3601c|M.bovis_AF2122/97 IDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFG
Rv3570c|M.tuberculosis_H37Rv IDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFG
: :.**:. *:** **. *. * : : : * :*
MSMEG_2077|M.smegmatis_MC2_155 MKISPIAMI
TH_2929|M.thermoresistible__bu LKVSPLAMI
Mflv_4461|M.gilvum_PYR-GCK APIPRTAMV
Mvan_1900|M.vanbaalenii_PYR-1 RRIPRTAMV
MMAR_3433|M.marinum_M RKISPVAMV
MUL_2707|M.ulcerans_Agy99 RKISPVAMV
MAV_2166|M.avium_104 AKISPISMI
MAB_0315|M.abscessus_ATCC_1997 LPPGSVAF-
Mb3601c|M.bovis_AF2122/97 LPPGDTMV-
Rv3570c|M.tuberculosis_H37Rv LPPGDTMV-
.