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MSFVFASPEVLGAAAAQAAVIGSGVQTAGAWAAGPTTALAGALGADEVSVAVAQLFDGHGQAYQAISAQA AVFHGRFVAALNAAADSYAGAEAAGVSVLQSAGADVMGALNAPTMAWLGRPLIGDGANGVDGTGGNGGAG GLLWGNGGRGGSGAAGQAGGRGGSAGLIGTGGAGGAGGASVSGAGGVGGGGGAGGWLFGAGGQGGTGGNG LTTAGVGGHGGGTGLFGAGGAGGTGGISGTGVGGGGGHGGNGGWVAGDGGAGGAGGTSNTGAGGSGGGAG RGGWVFGDGGAGGAGGDGATGAAGAQGLTGQTGQTGHDGGAGGAGGAGGRGGWLFSAGGNGGAGGAGGAG GAGGAGGAGATATTAGTSGGNGGNGGAGGTGGDGGAGGAGGATGWFGSTGTTGAGGNGGTGGNGAIAGNG GAGANGDVLHLDGGNGGNGGNPGASGAGGSGGTGSRTGAHGLAGTTPTTNAGDGGRGGDGYTSTDPTLNG GAGGNGGNGGDYGNGGAGGNGGNGATGALGTAPPAAGDPGGNGGNGSNGGNGGAGGTGGLIAGDGGAGGH GGGGGNGGNGAAGANGTNATISGTNGGNAGAGGNGGNGGTGGNGGAGGAATHGSAGANGAGGAGGNGGDG AIAGDGGTGANGDATHFDGGNGGNGANPGIGGLGGAGGTSGDGTTPAAHGTNGTTPTTTNGSGGRGGDGY TSTDPTLNGGKGGTGGNGGDYGNGGAGGNGGNGATGTTGTNPTPHPVTSTAASGANGTADTFNGGTGDNG AYAGQAGGNGGIGYYDAQNALGGNGGDGGIGGPGTIGGNGGHGGPGVDVAGTGGDGGAGGDGGGAGGNGG AGGNSFYYGNDGGAGGNGGAGGGTGGNGGNGGYSTQRGHNGTGGTGGTGGIGATGGDGSNGGAGGAGGTG GLYGNGGNGGTGGTGGNGGTGATGGTGGTGGNGQTYYNGDSSSPGTGGDGGTGGTGGTGGNGGDGGAAGA GGTYGQSGSNGTGGDAGTGGSGGDGGAPGDGGATVDEYGFNPGPPYGADGQAGAMGATGQDGVAGMTPGT GTAGNGGNGGPGVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5307 | - | - | 100% (1064) | PE-PGRS family protein |
| M. marinum M | MMAR_5308 | - | 0.0 | 90.83% (1080) | PE-PGRS family protein |
| M. marinum M | MMAR_5341 | - | 0.0 | 67.64% (1026) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1485c | PE_PGRS27 | 0.0 | 52.65% (1132) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-168 | 45.17% (828) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1450c | PE_PGRS27 | 0.0 | 47.91% (1269) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 9e-10 | 36.96% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 3e-48 | 30.28% (578) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 5e-24 | 45.68% (162) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-176 | 40.36% (1110) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 6e-49 | 41.42% (309) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 48.08% (1121) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-167 | 45.12% (820) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1485c|M.bovis_AF2122/97 --------------------------------------------------
Rv1450c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5307|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 ------------------MSLVIVAPETVAAAALDVARIGSSIGVANSAA
Rv1450c|M.tuberculosis_H37Rv ------------------MSLVIVAPETVAAAALDVARIGSSIGAANAAA
MMAR_5307|M.marinum_M ------------------MSFVFASPEVLGAAAAQAAVIGSGVQTAGAWA
MUL_4367|M.ulcerans_Agy99 ------------------MSFVSVGPGLLEAAARDLAGLGAGLREANLAA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ---------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAID
Mb1485c|M.bovis_AF2122/97 AGSTTSVL-AAGADEVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLS
Rv1450c|M.tuberculosis_H37Rv AGSTTSVL-AAGADEVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLS
MMAR_5307|M.marinum_M AGPTTALAGALGADEVSVAVAQLFDGHGQAYQAISAQAAVFHGRFVAALN
MUL_4367|M.ulcerans_Agy99 AGATVGVL-PAAGDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALT
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPD
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 VTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAAL
Mb1485c|M.bovis_AF2122/97 -----------------------AAVGSYVSAEATNAAPLATLEHNVLNA
Rv1450c|M.tuberculosis_H37Rv -----------------------AAVGSYVSAEATNAAPLATLEHNVLNA
MMAR_5307|M.marinum_M -----------------------AAADSYAGAEAAGVSVLQSAGADVMGA
MUL_4367|M.ulcerans_Agy99 -----------------------AGGSAYGQAEALNMWPLQELEQQALGV
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------GPSILSPSLLSP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 R-------------------------DALAARRIDNVMLVSAFLAAAALA
Mb1485c|M.bovis_AF2122/97 LN--------------------APTQALLG--------RPLIGDGAAGAP
Rv1450c|M.tuberculosis_H37Rv LN--------------------APTQALLG--------RPLIGDGAAGAP
MMAR_5307|M.marinum_M LN--------------------APTMAWLG--------RPLIGDGANGVD
MUL_4367|M.ulcerans_Agy99 VN--------------------APSMALFG--------RPSIGNGVDGVA
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 RD------------------------------------NDFLSHNDTDFA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 QN----------------------VGGAMG------------YERTAVLL
Mb1485c|M.bovis_AF2122/97 GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAGGAG
Rv1450c|M.tuberculosis_H37Rv GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAGGAG
MMAR_5307|M.marinum_M GTGGNGGAGGLLWGNGGRGG-SGAAGQAGGRGGSAGLIGTGGAGGAGGAS
MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGGVG
Mflv_5091|M.gilvum_PYR-GCK QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG
Mvan_1264|M.vanbaalenii_PYR-1 QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG
MSMEG_0868|M.smegmatis_MC2_155 DNP-NGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA
TH_3810|M.thermoresistible__bu ------------------------VDGDGGSGGRTGLFSKLSRGGDG---
MAB_4284c|M.abscessus_ATCC_199 SHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 VEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLES
Mb1485c|M.bovis_AF2122/97 AAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGVGGTGGPG
Rv1450c|M.tuberculosis_H37Rv AAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGVGGTGGPG
MMAR_5307|M.marinum_M VSG-----------------------------------------------
MUL_4367|M.ulcerans_Agy99 AAG-----------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGN-----------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 SGD-----------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 GLD-----------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VGG-----------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 LPG-----------------------------------------------
Mb1485c|M.bovis_AF2122/97 GPGGPGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGP-IGGVG
Rv1450c|M.tuberculosis_H37Rv GPGG---------PGGVGGTGGAGGLGGTLYGAGGHGGAGGPGP-IGGVG
MMAR_5307|M.marinum_M ----------------AGGVGGGGGAGGWLFGAGGQGGTGGNGLTTAGVG
MUL_4367|M.ulcerans_Agy99 ---------------MTGGSGGAGGGGGWLWGAGGSGGAAGAGG-SGGSG
Mflv_5091|M.gilvum_PYR-GCK -----------------GGNGGNAGAF-ALFGNGGNGGNGGVGV------
Mvan_1264|M.vanbaalenii_PYR-1 -----------------GGNGGDAGLF-SLFGRGGNGGNGGVGI------
MSMEG_0868|M.smegmatis_MC2_155 -----------------GGNGGSGG---LLMGIGGAGGAGGVGA------
TH_3810|M.thermoresistible__bu -------------------------------GDGGLGGNGGHG-------
MAB_4284c|M.abscessus_ATCC_199 -----------------------SNSGPIASGQGSTAVNGDVRD------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------GLLLVGSGVDVAPLKQVL------
Mb1485c|M.bovis_AF2122/97 ----GHGGVGGAAGLLGVGGHGGAGGHGAAGIAGAAGKGGIFPDGSNGGA
Rv1450c|M.tuberculosis_H37Rv ----GHGGVGGAAGLLGVGGHGGAGGHGAEGVAGAAG-EDLSPHGTSGGV
MMAR_5307|M.marinum_M ----GHG---GGTGLFGAGGAGGTGGISGTGVG-----------------
MUL_4367|M.ulcerans_Agy99 GWLWGNAGQTAGAGVGGAGGAGGAGDAGDQGVS-----------------
Mflv_5091|M.gilvum_PYR-GCK ---------VGATGAVG--APGVAGATGATGVTS----------------
Mvan_1264|M.vanbaalenii_PYR-1 ---------AGATGAVG--APGVAGATGATGVTS----------------
MSMEG_0868|M.smegmatis_MC2_155 ---------DGTSAHVDGGTGGTGGTGGGTGGTG----------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------SNIINADHGSNVGVDQSQTRVG----------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ----------QTTTFLDVSVAEEPETALARGAAL----------------
Mb1485c|M.bovis_AF2122/97 GGDAGDGGTGGRGGWLAGAGGAGGDGGIGGTGGAGGAGFSRALIVAGDNG
Rv1450c|M.tuberculosis_H37Rv GGDAGDGGTGGRGGWLAGAGGAGGAGGVGGTGGAGGAGFSRALIVAGDNG
MMAR_5307|M.marinum_M ----GGGGHGGNGGWVAGDGGAGGAGGTSNTG------------------
MUL_4367|M.ulcerans_Agy99 ------GVAPGEAGAVGFAGGAGGAGGAGGNG------------------
Mflv_5091|M.gilvum_PYR-GCK ------GVVGGNGEDAVGYGATGAAGAAGAAG------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------NVTGGNGADAVGYGATGAAGAAGAAG------------------
MSMEG_0868|M.smegmatis_MC2_155 ------GIGGTGGGLFGLLGHSGSTGAAGAAG------------------
TH_3810|M.thermoresistible__bu -------------------GGTGIISLLSLAG------------------
MAB_4284c|M.abscessus_ATCC_199 -------------GDYTNVSGHGSADIDKSVT------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------AAANAPLFASSTAALAYAQDPGTG------------------
Mb1485c|M.bovis_AF2122/97 GDGGNGGMGGAGGAGGPGGAGGLISLLGGQGAGGDGGDGGAGGVGGDRGA
Rv1450c|M.tuberculosis_H37Rv GD------------------------------------------------
MMAR_5307|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 GANGNQAVNAGAGGAGGHGGDPGAGGAGGTGGAGSTIGAHGAAGASPTSG
Rv1450c|M.tuberculosis_H37Rv ---------------------PGAGGAGGTGGAGSTIGAHGAAGASPTSG
MMAR_5307|M.marinum_M -----------------------AGGSG----------------------
MUL_4367|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 GNGGAGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGAGGAGGNGAPGAPPS
Rv1450c|M.tuberculosis_H37Rv GNGGAGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGAGGAGGNGAPGAPPS
MMAR_5307|M.marinum_M --GGAG-------RGGWVFGDGGAGGAG---GDGATGAAGAQGLTGQTGQ
MUL_4367|M.ulcerans_Agy99 -------------VGGGVNGAGGAGGAG------GVGGGGGAGASGVGAG
Mflv_5091|M.gilvum_PYR-GCK --------------AAGAAG--------------AVGSAGAAGEAGETGT
Mvan_1264|M.vanbaalenii_PYR-1 --------------AAGKAG--------------AVGSAGTAGSAGAPGV
MSMEG_0868|M.smegmatis_MC2_155 --------------NGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------------------VVDDHSQRNTTNINDS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ----------------------------------AVDQYSLPDYLYVPVD
Mb1485c|M.bovis_AF2122/97 GGDPNGGGGGAGGAGGKGGD-------------GGAQAGDGGAGGAG---
Rv1450c|M.tuberculosis_H37Rv GGDPNGGGGGAGGAGGKGGD-------------GGAQAGDGGAGGAG---
MMAR_5307|M.marinum_M TG-HDGGAGGAGGAGGRGGW-------------LFSAGGNGGAGGAG---
MUL_4367|M.ulcerans_Agy99 VAGGDGGTGGAGGAAGVGG--------------AAGTGGTGGAAGVA---
Mflv_5091|M.gilvum_PYR-GCK WG--NAGLPGKAGDAGGAG----------------AVGAAGAAG------
Mvan_1264|M.vanbaalenii_PYR-1 WG--NAGLPGAAGAAGGAG----------------AIGTAGVAG------
MSMEG_0868|M.smegmatis_MC2_155 GGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGHAIGGNGGNGGNGSTT
TH_3810|M.thermoresistible__bu ----NGGNGGNGYRTTDNN-------------------------------
MAB_4284c|M.abscessus_ATCC_199 FNTDRSTNIGSGNTTNTEIG-------------------SHNQANIG---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PEPGDDELAYSAVGEEDAES---------------PTVVIEKLFLPEDSE
Mb1485c|M.bovis_AF2122/97 GKGGNGGNGATGATGLNGLGAGADGT-DGGKGGNGGAGGGGGAGGQGGKA
Rv1450c|M.tuberculosis_H37Rv GKGGNGGNGATGATGLNGLGAGADGT-DGGKGGNGGAGGGGGAGGQGGKA
MMAR_5307|M.marinum_M GAGGAGGAGGAGAT------ATTAGT-SGGNGGNGGAGGTGGDGGAGG-A
MUL_4367|M.ulcerans_Agy99 GTGGDGGDGGAG-------GAGSDAS-LAGQAG--FAGGSGGAGGVGG--
Mflv_5091|M.gilvum_PYR-GCK TVGTAGATGGTG---------------TGANGGAGGVGGVGGTGAAG---
Mvan_1264|M.vanbaalenii_PYR-1 AAGTAGATGGTG---------------VGGNGGAGQAGGIGGTGAAG---
MSMEG_0868|M.smegmatis_MC2_155 AAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGS--
TH_3810|M.thermoresistible__bu --ALDGGHGGNG-----------------GNVGFFSLFNLGG--------
MAB_4284c|M.abscessus_ATCC_199 TSTSAGGSAAVG-----------------GNAGLAGNAGLAGNAGLAG--
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PRRRPVLLVGSG----------------LAVVGISAVLALEIALAIG---
Mb1485c|M.bovis_AF2122/97 LAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGGNG
Rv1450c|M.tuberculosis_H37Rv LAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDNGGDGVGGNGGNG
MMAR_5307|M.marinum_M GGATGWFGSTGTTGAGGNGGTGGNGAIAGNGGAGANGDVLHLDGGNGGNG
MUL_4367|M.ulcerans_Agy99 --------SAGAGGVNGSGGDGGAGAAGGAGGASATVAGSGGVGGDGGAG
Mflv_5091|M.gilvum_PYR-GCK -------------AAGGAGGLGETGTTGGAGGVGGQ--GTAGGTGGVGGI
Mvan_1264|M.vanbaalenii_PYR-1 -------------AAGQAGTAGETGVTGGVGGIGGQ--GTEGGTGGVGGV
MSMEG_0868|M.smegmatis_MC2_155 VYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAG
TH_3810|M.thermoresistible__bu --------------AGGWGGSGVDG-------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------NAGLAGNAGLAGNAGLAGNAG--------LAGNAGLA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------IRTTGTVALQPTPNQHLIVPTEQAPAPPPVQASAPQ
Mb1485c|M.bovis_AF2122/97 GSRG-IGGAGGIGGAGSTAGADGARGATPTS-GGNGGTGGNGANATVAGG
Rv1450c|M.tuberculosis_H37Rv GSRG-IGGAGGIGGAGSTAGADGARGATPTS-GGNGGTGGNGANATVAGG
MMAR_5307|M.marinum_M GNPG-ASGAGGSGGTGSRTGAHGLAGTTPTTNAGDGGRGGDGYTSTDPTL
MUL_4367|M.ulcerans_Agy99 GAAGGGVGAASLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGG----AGG
Mflv_5091|M.gilvum_PYR-GCK GGAGSTGAVGGVGGKG----IQGGQG-------------LQGGK----GG
Mvan_1264|M.vanbaalenii_PYR-1 GGVGATGGAGGVGGKG----IQGGQG-------------LQGGQ----GG
MSMEG_0868|M.smegmatis_MC2_155 GDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGK----AS
TH_3810|M.thermoresistible__bu --------VDVVGGNP----------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAG----------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 PKISVPEPVAAPKPLSPPVAAPLPAAP-----------------------
Mb1485c|M.bovis_AF2122/97 AGGAGGK-GGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGG
Rv1450c|M.tuberculosis_H37Rv AGGAGGK-GGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGG
MMAR_5307|M.marinum_M NGGAGGN-GGNGGDYGNGGAGGNGGNGATGALGTAPPAAGDPGGNGGNGS
MUL_4367|M.ulcerans_Agy99 AGGTGGDSGGVGGVNGDGGAGGGGGRGGDGGSSTSTSGVGGAGGAGGNGG
Mflv_5091|M.gilvum_PYR-GCK DGGAGGK-GGDADSMGS------------------AGATGGKGGNGGNGG
Mvan_1264|M.vanbaalenii_PYR-1 DGGTGGT-GGDATSMGE------------------AGATGGKGGNGGNGG
MSMEG_0868|M.smegmatis_MC2_155 DGGKGGN-GGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTN
TH_3810|M.thermoresistible__bu ---DGGT----------------------------PGAHGESHTPGVYTD
MAB_4284c|M.abscessus_ATCC_199 ---LAGN----------------------------AGLAGNAGLAGNAGL
MLBr_01183|M.leprae_Br4923 -----------------------------------MPLFLNAEPQALTAA
MAV_4827|M.avium_104 -----------------------------------PPAAPPLPEAPPIPA
Mb1485c|M.bovis_AF2122/97 AGGAGG--------AGGRGGDFGGDGGTGGAGGNGADGGAGGNGANGANA
Rv1450c|M.tuberculosis_H37Rv AGGAGG--------AGGRGGDFGGDGGTG---------GAGGNGANGANA
MMAR_5307|M.marinum_M NGGNGG--------AGGTGGLIAGDGGAGGHGGGGGNGGNGAAGANGTNA
MUL_4367|M.ulcerans_Agy99 NAGFGV--------SAGGTGGSAGDGGAG--GGAGGVDGVGGASGNGGAA
Mflv_5091|M.gilvum_PYR-GCK RGGLFG---------------KGGNAGNGAD-------------------
Mvan_1264|M.vanbaalenii_PYR-1 RGSLFG---------------RGGNAGNGGN-------------------
MSMEG_0868|M.smegmatis_MC2_155 IAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKG
TH_3810|M.thermoresistible__bu RQ------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AG------------------------------------------------
MLBr_01183|M.leprae_Br4923 AN------------------------------------------------
MAV_4827|M.avium_104 APPVVP--------------------------------------------
Mb1485c|M.bovis_AF2122/97 TTPGAKGGDGGHGGPGA-QGGNGGQGGPGG-LAGNLFGQNGIQGVGGSGG
Rv1450c|M.tuberculosis_H37Rv TTPGAKGGDGGHGGPGA-QGGNGGQGGPGG-LAGNLFGQNGIQGVGGSGG
MMAR_5307|M.marinum_M TISGTNGGNAGAGGNGG-NGGTGGNGGAGG-AAT--HGSAGANGAGGAGG
MUL_4367|M.ulcerans_Agy99 GAGGAGGSGIGAGIDGG-AGGAGGTGGAAG-FPGG-GGTTGAWGTGGAGG
Mflv_5091|M.gilvum_PYR-GCK ---GGTGGAGGAGGTGG-TGGAGGTGG-----------------TGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 ---GGTGGNGGNGGTGG-TGGNGGTGG-----------------TGGTGG
MSMEG_0868|M.smegmatis_MC2_155 KAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGG
TH_3810|M.thermoresistible__bu -------GEDGEDGTGTGIGGRGGNGG----------------------S
MAB_4284c|M.abscessus_ATCC_199 --------NAGLAGNAGLAGNAGLAGN---------------------AG
MLBr_01183|M.leprae_Br4923 ----------TLEGLSAATVASNAAAA----------------------Q
MAV_4827|M.avium_104 ----VPVVVPPVPVPVPVRIPVPDPVSPPQ--------------LLAPPR
Mb1485c|M.bovis_AF2122/97 KGGAGGLAGDGGNGANGN-FAFGDGNGGHGGNGGNPGAGGQGGSGGAGST
Rv1450c|M.tuberculosis_H37Rv KGGAGGLAGDGGNGANGN-FAFGDGNGGHGGNGGNPGAGGQGGSGGAGST
MMAR_5307|M.marinum_M NGGDGAIAGDGGTGANGDATHFDGGNGGNGANPGIGGLGGAGGTSGDGTT
MUL_4367|M.ulcerans_Agy99 AGGAGGAGDHGGVGVNPG------DSGTAGWAGGAGGAGGAGGSAAFNGV
Mflv_5091|M.gilvum_PYR-GCK IGGAGSTGGTGGTGGTGG------TGGTGGTG-GTGGTGGTGGTGGKGGT
Mvan_1264|M.vanbaalenii_PYR-1 IGGAGSTGGTGGTGGTGG------TGGTGGTG-GTGGTGGTGGTGGKGGT
MSMEG_0868|M.smegmatis_MC2_155 RGGDGGTFVNAGANGNGG------AGGAGGVSEGEGGTGGHGGDGGRGGD
TH_3810|M.thermoresistible__bu SSGTHPMAEDGEHVKALD--------GRPGLDGGNGSHGGNGGHGGRGGF
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAG----------LAGNAAVAGNAAVAGNAAVAGN
MLBr_01183|M.leprae_Br4923 LTTEIAPPAADDVSILLA-----------HFFSGHGRQYQAHASQGATNH
MAV_4827|M.avium_104 LSVPQPVQPPVRVPQPPS------PPQVGGTVPQSPPQHQTPPGEGTPPK
.
Mb1485c|M.bovis_AF2122/97 PGAKGAHGFTPTSG-GDGGDGGNGGHSQVVG--------GNGGDGGNGGN
Rv1450c|M.tuberculosis_H37Rv PGAKGAHGFTPTSG-GDGGDGGNGGNSQVVG--------GNGGDGGNGGN
MMAR_5307|M.marinum_M PAAHGTNGTTPTTTNGSGGRGGDGYTSTDPT--------LNGGKGGTGGN
MUL_4367|M.ulcerans_Agy99 NGAGGAGGNG-----GAGGGGGAGASGIGAG--------VAGGDGGTGGT
Mflv_5091|M.gilvum_PYR-GCK GGTGGAGGTG-----GDGGTGGTGGTGGTG---------GTGGTGGTGGA
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGDGGTG-----GTGGTGGTGGTGGTG---------GTGGTGGTGGA
MSMEG_0868|M.smegmatis_MC2_155 GALGGNGGTGGVGL-GNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGA
TH_3810|M.thermoresistible__bu LGIGGSGGWG-----GHGGNGGD-----------------TDADGGNGGD
MAB_4284c|M.abscessus_ATCC_199 AAVGGVLNTG-----VSGAIGGSSHVGGAIN----------ESLGGSGSV
MLBr_01183|M.leprae_Br4923 QDLIQSLLTS------SSAYAGT-------------------ETANHDSL
MAV_4827|M.avium_104 PDGPGNYGGGHVPTPGAGGSGGSGGGHVPTP-----------GAGGSGGS
.. .* .. ..
Mb1485c|M.bovis_AF2122/97 GG---------SAGTGGNGGRGGDG-AFGGMSANATNPGENGPNGNPGGN
Rv1450c|M.tuberculosis_H37Rv GG---------SAGTGGNGGRGGDG-AFGGMSANATNPGENGPNGNPGGN
MMAR_5307|M.marinum_M GG---------DYGNGGAGGNGGNG-ATGTTGTNPT-PHPVTSTAASGAN
MUL_4367|M.ulcerans_Agy99 GG---------AAGTGGAAGTGGTG-GAAGAAGSAGDGGAGG-AGGAGDD
Mflv_5091|M.gilvum_PYR-GCK G-----------DGTGGTGGTGG----TGGQGGQGGQGG-----------
Mvan_1264|M.vanbaalenii_PYR-1 G-----------DGLGGTGGTGG----TGGFGGQGGQGG-----------
MSMEG_0868|M.smegmatis_MC2_155 GRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGS
TH_3810|M.thermoresistible__bu GG------------NGGSAGRGGTG-------------------------
MAB_4284c|M.abscessus_ATCC_199 GG---------STAVGGGAHTGVGG-------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 GG--------GHVPTPGTGGPGGTG-------------------------
Mb1485c|M.bovis_AF2122/97 GGAG-GAGGAGLNGGNGG-AGGNGGLGGFGGNGAAGANGVAVG-APGQPG
Rv1450c|M.tuberculosis_H37Rv GGAG-GAGGAGLNGGNGG-AGGNGGLGGFGGNGAAGANGVAVG-APGQPG
MMAR_5307|M.marinum_M GTADTFNGGTGDNGAYAGQAGGNGGIGYYDAQNALGGN-----------G
MUL_4367|M.ulcerans_Agy99 GSAGVVSGDPGTAGKAGG-AGGAGGVGGNGVAGGVNGS-----------G
Mflv_5091|M.gilvum_PYR-GCK ------TGGTGGQGG-LGGGGGTG-----------------------GQG
Mvan_1264|M.vanbaalenii_PYR-1 ------TGGTGGQGG-LGGVGGTG-----------------------GTG
MSMEG_0868|M.smegmatis_MC2_155 NASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 GAGGHGGAGGNGGAGGNGGQGVVSDGAG-GAGGAGGDGGAPGDGANGGNG
Rv1450c|M.tuberculosis_H37Rv GAGGHGGAGGNGGAGGNGGQGVVSDGAG-GAGGAGGDGGAPGDGANGGNG
MMAR_5307|M.marinum_M GDGGIGGPGTIGGNGGHGGPGVDVAGTG-GDGGAGGDG------------
MUL_4367|M.ulcerans_Agy99 GAGGAGGAGGTGGAGASGVPASVDGGDG-GAGGAGGAAGTGGSGGSAGNT
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGG-----------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGG-----------
MSMEG_0868|M.smegmatis_MC2_155 GSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGI-----------
TH_3810|M.thermoresistible__bu --GLRGVFGINGGNGR----------------------------------
MAB_4284c|M.abscessus_ATCC_199 --GVSTGVGVGSHVGGGISES-----------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --GSGGGHVPTPGAGTPGGSG-----------------------------
Mb1485c|M.bovis_AF2122/97 QGAGAFAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGN
Rv1450c|M.tuberculosis_H37Rv QGAGAFAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGN
MMAR_5307|M.marinum_M -------GGAGGNGGAGGNSFYYGN---------------------DGGA
MUL_4367|M.ulcerans_Agy99 G-----AGGAGGAGGAGGSAASTGVNGDGGAGG-------------AGGV
Mflv_5091|M.gilvum_PYR-GCK ------LGGLGGFGGSGGTGGQGGLGGPGGSTG--------------GAG
Mvan_1264|M.vanbaalenii_PYR-1 ------LGGLGGFGGVGGTGGQGGQGGPGGSTG--------------GAG
MSMEG_0868|M.smegmatis_MC2_155 ------DGGLGGNGGDGVVNTTANAANPGSATG--------------TAT
TH_3810|M.thermoresistible__bu -------AGLGGRGXXXX--------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------LGGSGSVGGSTAVGGGAHTGVGGG--------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 -------GGHLPFPGAGSTPGGSGG-------------------------
Mb1485c|M.bovis_AF2122/97 GGHGGHGAASGGNGGPGGHG--GNGGNGGTGANGGNGGIGGTGGAGSTGA
Rv1450c|M.tuberculosis_H37Rv GGHGGHGAASGGNGGPGGHG--GNGGNGGTGANGGNGGIGGTGGAGSTGA
MMAR_5307|M.marinum_M GGNGGAGGGTGGNGGNGGYS--TQRGHNGTGGTGGTGGIGATGGDGSNGG
MUL_4367|M.ulcerans_Agy99 GGLGGDSAATAGGGGAGGDG--GKGGAGGAGVNGVGGGDGGKGGTGGAGG
Mflv_5091|M.gilvum_PYR-GCK GAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATGA
Mvan_1264|M.vanbaalenii_PYR-1 GAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATGA
MSMEG_0868|M.smegmatis_MC2_155 GGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGG
TH_3810|M.thermoresistible__bu ------------------------GGGVGAAVRSGNGVFSGGGGTPSAG-
MAB_4284c|M.abscessus_ATCC_199 -----------------------VSTGVGVGSHVGGGISESLGGSGSVGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ------------------------GHLPTPGAGTPGGGLGGFGG------
Mb1485c|M.bovis_AF2122/97 KGVLGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGGTPGNGGNGG
Rv1450c|M.tuberculosis_H37Rv KGVLGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGGTPGNGGNGG
MMAR_5307|M.marinum_M AGGAGGTGGLYGNGGNGGTGGTGGNGGTGAT-----GGTGGTGGNGQTYY
MUL_4367|M.ulcerans_Agy99 AGGAGSDGIIPSNGGLGGNGGNGGNGGQAFG-----DGVGGAGGIGGKGG
Mflv_5091|M.gilvum_PYR-GCK QGATG------AQGATG-ATGAAGKAGATGA-----AGAAGAAGSAG---
Mvan_1264|M.vanbaalenii_PYR-1 QGATG------AQGATG-ATGASGAQGSAGS-----AGSAGVAGSAG---
MSMEG_0868|M.smegmatis_MC2_155 VAGNGGNALVMAAGTTGVATGNTATGGDGGA-----ATTAGATGGAGGFS
TH_3810|M.thermoresistible__bu ---------------FGVPTTIQFPAG---------SCTSRAVSREG---
MAB_4284c|M.abscessus_ATCC_199 STAVG----------GGAHTGVGGGVNTGVG-------VGSHVGGG----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ----------------GHAPAPGGGLGGGGG-------------------
Mb1485c|M.bovis_AF2122/97 NGASGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTG---
Rv1450c|M.tuberculosis_H37Rv NGASGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTG---
MMAR_5307|M.marinum_M NGDS----SSPGTGGDGGTGGTGGTGGNGGDGGAAGAGGTYGQSGSN---
MUL_4367|M.ulcerans_Agy99 NAAIGTIVINGGVGGAGGSGGLGG-ATEDGVGGVGCAGGAGGNGGRGDM-
Mflv_5091|M.gilvum_PYR-GCK --------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-----
Mvan_1264|M.vanbaalenii_PYR-1 --------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-----
MSMEG_0868|M.smegmatis_MC2_155 NIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIAN
TH_3810|M.thermoresistible__bu -------IMPSSRAASARAGAACASSTSRSRRSFCCSRA-----------
MAB_4284c|M.abscessus_ATCC_199 --------ISESLGGSGSVGGSTAVGGGAHTSAINDALGGSGSVG-----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ----------HAPAPGGGLGGFGGGHSGGGLGGLGGGHK-----------
Mb1485c|M.bovis_AF2122/97 --GTGGTGGTGGQGANGGLTGGRGGTGGNGG---------AGGTGGTGHN
Rv1450c|M.tuberculosis_H37Rv --GTGGTGGTGGQGANGGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHN
MMAR_5307|M.marinum_M --GTGGDAGTGGSGGDGGAPGDGGATVDEYG------------------F
MUL_4367|M.ulcerans_Agy99 LFTVGGSGGTGGDGGGGGSASGSG-TGGSGG------------------T
Mflv_5091|M.gilvum_PYR-GCK ---AAGEDGDAGSGGSG-INGGAGGAGG---------------------A
Mvan_1264|M.vanbaalenii_PYR-1 ---AAGDAGDPGSEAVD-INGGAGGAGG---------------------A
MSMEG_0868|M.smegmatis_MC2_155 SSAVAGNGGDGGVNGTGGASGGDGGNGGNTS----------VWKSGGQTA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----GSTAVGGGAHTSAINESMNSSIN----------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 GSQPGMGGNGGAGGFGGN--------GFAGVGGRGGMGGSGGTGGTGDAG
Rv1450c|M.tuberculosis_H37Rv GSQPGMGGNGGAGGFGGN--------GFAGVGGRGGMGGSGGTGGTGDAG
MMAR_5307|M.marinum_M NPGPPYGADGQAGAMGAT--------GQDGVAG----------------M
MUL_4367|M.ulcerans_Agy99 GGVGGIGGDGKLGGFGGD--------GGDGGDG--------------GFG
Mflv_5091|M.gilvum_PYR-GCK GGEGGEGGDGGKGGAGAE--------GGAGGGG----------------G
Mvan_1264|M.vanbaalenii_PYR-1 GGEGGEGGAGGAGGDGSE--------GGAGGSG----------------G
MSMEG_0868|M.smegmatis_MC2_155 DGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNG----------------G
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----ASHSSSMNESFGSS--------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 PFGTGTGGTG--GHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAG
Rv1450c|M.tuberculosis_H37Rv PFGTGTGGTG--GHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAG
MMAR_5307|M.marinum_M TPGTGTAGNG--GNGGPGVP------------------------------
MUL_4367|M.ulcerans_Agy99 VIG-GQGGGG--GFGGLGGTGAGGAPSDKGINGEPGNPG-----------
Mflv_5091|M.gilvum_PYR-GCK AGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD------------
Mvan_1264|M.vanbaalenii_PYR-1 AGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-------------
MSMEG_0868|M.smegmatis_MC2_155 TGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 MGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH---------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 GGGGFGGLGGGEFV
Rv1450c|M.tuberculosis_H37Rv GGGGFGGLGGGEFV
MMAR_5307|M.marinum_M --------------
MUL_4367|M.ulcerans_Agy99 --------------
Mflv_5091|M.gilvum_PYR-GCK --------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------
MSMEG_0868|M.smegmatis_MC2_155 --------------
TH_3810|M.thermoresistible__bu --------------
MAB_4284c|M.abscessus_ATCC_199 --------------
MLBr_01183|M.leprae_Br4923 --------------
MAV_4827|M.avium_104 --------------