For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. marinum M MMAR_4810 (mmpL13_1)

annotation: transmembrane transport protein MmpL13_1
coordinates: 5861949 - 5864258
length: 769

MLTRMARLSLSAPRRVIAVVVLVMIGTAIFGIPAANSLAAGGFLDPSSESARAAAVLADKFHRGDMEMVL
LVSSDDGVRDGPARIVGTDIARQLAQSPFVAQVASPWDTPQPPPDMLSADGKSALILVALKGDENSAPRH
AQALAQRLAHDRGGVTVQAGGSAMVYAQVNQQTEKDLLRMEFIAVPVSFAALVWVFGGLLAAALPVAVGG
FAILGSLAVLRGVAMVTDVSIFALNVTVALGMALAIDYTLLIIRRYRDELGEGRSHEDALVRTMTTAGRT
VLFSAVTVGLSLVAMALFPMYFLKSFAYAGVAVVAFSALAAMVVAPTVIVLLGDRLDALNVWKLGRRLLG
RPEPPPRPVAQSFWYRTAKLVTRHAIPVGLAIIVLLIALGIPFLNIKWGYPDDRVLPPSASARMVSDRIR
SDFGSNSASRVTVVITDTAGLTKPDLNHYAAQLSEVSDVSAVSAPTGTFVAGELRGPPSAPTAMAAGSAY
LTVESTAPLYTKASANQLDRLHAVALPGDTAVQMTGVAQMNRDSVNGITSRLPMVFGFIAIVTLVLLFLL
TGSVLLPIKAVVLNMLSLTAAFGALVWIFQDGHLGALGTTPTGTLVANIPVLMFCIAFGLSMDYEVFLLS
RIREFWLGSPQQSADNDESIALGLAHTGRVITAAALLMSISFAGLISAEVSFMRMFGVGLTIAVLVDATL
VRVLLVPAFMHVFGGLNWWAPKPLERWHSRSGADRSAGQTGPSDGAVGGNSSKFDSNRRVDDHVHRSPR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_4810mmpL13_1-100% (769)transmembrane transport protein MmpL13_1
M. marinum MMMAR_4305mmpL130.062.63% (760) transmembrane transport protein MmpL13
M. marinum MMMAR_0446mmpL32e-8830.53% (750) transmembrane transport protein MmpL3

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1177mmpL130.061.84% (760) transmembrane transport protein MmpL13
M. gilvum PYR-GCKMflv_2131-0.063.11% (740) MMPL domain-containing protein
M. tuberculosis H37RvRv1146mmpL13b1e-15662.58% (449) transmembrane transport protein MmpL13B
M. leprae Br4923MLBr_02620-2e-9029.79% (752) hypothetical protein MLBr_02620
M. abscessus ATCC 19977MAB_1287-0.055.80% (733) MmpL family membrane protein
M. avium 104MAV_1287-0.062.27% (750) mmpL protein
M. smegmatis MC2 155MSMEG_5178-0.065.68% (740) integral membrane protein
M. thermoresistible (build 8)TH_1538-0.059.97% (742) PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL13B
M. ulcerans Agy99MUL_0989mmpL130.062.24% (760) transmembrane transport protein MmpL13
M. vanbaalenii PYR-1Mvan_4573-0.063.30% (763) MMPL domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb1177|M.bovis_AF2122/97            -MLQRIARLAIAAPRRIIGFAVFVFIAAAVFGVPVADSLSPGGFQDPRSE
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                -MLQKIARVAIAAPRRIIALGVLVFLAAAVFGIPVAKSLSPGGFQDPDSE
MUL_0989|M.ulcerans_Agy99           -MLQGIARLAIAAPRRIIGVALLVFIAAAVFGIPVANSLSRGGFQDPNAE
Mflv_2131|M.gilvum_PYR-GCK          -MLHRIARLAIAAPRRVLMAALLVAIACGVFGIPVVTHLSAGGFQDPTSE
Mvan_4573|M.vanbaalenii_PYR-1       -MLHRIALLAIAAPRRVLVVALLIMVGCGIFGAPVAKHLSAGGFQDPTSE
MSMEG_5178|M.smegmatis_MC2_155      -MLQRIATTAIAAPRRILVVAALVMIAAGIFGIPVANKLSAGGFQDPTAE
MMAR_4810|M.marinum_M               -MLTRMARLSLSAPRRVIAVVVLVMIGTAIFGIPAANSLAAGGFLDPSSE
TH_1538|M.thermoresistible__bu      -MLETLARRIVAAPRRVLALVVLVIVGAAMFGLPVAGSLSAGGFRDPHSE
MAB_1287|M.abscessus_ATCC_1997      MMLERLARSVIAAPRLVLGMALLIAIAAALFGVPVTKHLAAGGQQDPNSE
MLBr_02620|M.leprae_Br4923          -MFAWWGRTVYRYRFIVIGITVALCLCGGVFGLSLGKHVTQSGFYDDSSQ
                                                                                      

Mb1177|M.bovis_AF2122/97            SARAIEVLTDKFGQSGQKMLIVVTAA---AGADSPPAREVGTDIVEVLR-
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                SARAIGVLTDKFGQSGQQMLILVTAP---GGSNSDPARRVGTELVEQLQ-
MUL_0989|M.ulcerans_Agy99           SARAIKVLADKFGQSGQQMLILVTAP---GGVGTERARAVGTDIVAELN-
Mflv_2131|M.gilvum_PYR-GCK          SARATQMLVDTFGQGDMELILAVTSD---DGAQSPAARDVGVELVERLS-
Mvan_4573|M.vanbaalenii_PYR-1       SARATQLLVDKFDQGDMELLISITDDNSADGANSPAARAVGTDLADRLA-
MSMEG_5178|M.smegmatis_MC2_155      SARATQLLADKFHRGDMQLVIAVTAEAPGGRADGGRAREVGTEIVSELK-
MMAR_4810|M.marinum_M               SARAAAVLADKFHRGDMEMVLLVSSD---DGVRDGPARIVGTDIARQLA-
TH_1538|M.thermoresistible__bu      SAQASALLAERFDQTDMQLLVTVSSS---AGVYGEAARRVGTEIVAALE-
MAB_1287|M.abscessus_ATCC_1997      SAYVTKALRDKFDISDQSLVFMLTSE---QGVKSPQMRAVAADLERQLK-
MLBr_02620|M.leprae_Br4923          SVKASILGDQVYGRDRSGHIVAIFHAPDGKTVNDPAWAKKITDELNQFQR
                                                                                      

Mb1177|M.bovis_AF2122/97            -RSPLVYNVTSPWTVP---PTAAADLLSTDGKSGLIVVNVKGGENDAQNH
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                -RSPLVYNVSSPWTAP---PQASADLVSRDGKSGLIVVNLKGGENFVQNN
MUL_0989|M.ulcerans_Agy99           -HSPLVFNVSSPWTGPSADPKSAPDLVSKDGKSGLIVVNIKGGESNAQKN
Mflv_2131|M.gilvum_PYR-GCK          -DSPHVAAITSAWTSP---PSAAPALISEDGRTGLIVAGITGGESGAQKL
Mvan_4573|M.vanbaalenii_PYR-1       -ASPHVGAVTSAWTAP---PSAAPALVSEDGRTGLIIAGITGGESEAQKH
MSMEG_5178|M.smegmatis_MC2_155      -ASPYVTEVTSAWTAP---PSAAAALVSKDARTGLIVAGLNGGENGAQQH
MMAR_4810|M.marinum_M               -QSPFVAQVASPWDTP----QPPPDMLSADGKSALILVALKGDENSAPRH
TH_1538|M.thermoresistible__bu      -ASPQVAGVQSPWTVP---PGAGDRLVSEDATAGLIVAPIRGNETESSDI
MAB_1287|M.abscessus_ATCC_1997      -DSGVVINLTSAWTAP---PQVAEELLGADGKAGLIVAGLTGGENDAQKH
MLBr_02620|M.leprae_Br4923          NNSNKVTGWAGYLRASDTTNTVVQGMATPDKKYTFVSIPLKGDDDDTILN
                                                                                      

Mb1177|M.bovis_AF2122/97            AQTLSDEVAHDRDGVTVRAGGSAMEYAQINRQNKDDLLVMELIAIPLSFL
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                AQTLADQFVHDRDGVTVRAGGAAMQYAQINTQNQADLLVMEMIALPLSFL
MUL_0989|M.ulcerans_Agy99           AQTLADEIVHDRDGVTVRAGGSAMEYAQINKQNQDDLLVMELIAIPLSFL
Mflv_2131|M.gilvum_PYR-GCK          AKALTDELVYDRDGVTVRAGGAAMTYVQINTQTEKDLLLMESIAIPLSFV
Mvan_4573|M.vanbaalenii_PYR-1       AKTLTDELVRDRDGVTVRAGGVAMTYVQINTQSEKDLLMMESIAIPLSFV
MSMEG_5178|M.smegmatis_MC2_155      AKELTDQFVRDHDGVRVRAGGEAMIYVQINGQSEKDLLMMESIAIPLSFV
MMAR_4810|M.marinum_M               AQALAQRLAHDRGGVTVQAGGSAMVYAQVNQQTEKDLLRMEFIAVPVSFA
TH_1538|M.thermoresistible__bu      ARQLAAAVGSDRDRVNVRAGGPALVNAQIDTQTEHDLLVMEAIAIPLSFV
MAB_1287|M.abscessus_ATCC_1997      AAKLIKSLAVDRDGVAVKAGGVATLYNQIVTQSEKDLLVMESIAIPISFV
MLBr_02620|M.leprae_Br4923          NYKAIAPDLQKLDGGTVQLAGLDPIANALTSTIATDQRRMEVLALPLVAV
                                                                                      

Mb1177|M.bovis_AF2122/97            VLIWVFGGLLAAGLPMAQAVLAVVGSMAVLRLVTFATEVSTFALNLSTAL
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                VLIWVFGGLLAAALPMALGALAVVGSMSVLRLITFTTEVSIFALNLSTAL
MUL_0989|M.ulcerans_Agy99           VLVWVFGGLLAAALPMALGALAVVGSMSVLRLVTFTTDVSIFALNLSTAL
Mflv_2131|M.gilvum_PYR-GCK          VLVWVFGGLLAAALPLAVGVFAILGSMAVLRGFTLVTDVSIFALNLSIAM
Mvan_4573|M.vanbaalenii_PYR-1       VLVWVFGGLLAAALPLAVGAFAILGSMAVLRAVTLVTDVSIFALNLSIAM
MSMEG_5178|M.smegmatis_MC2_155      VLVWVFGGLLAAALPLAVGGFAILGSLAVLRLFTMVTDVSIFALNLTVAM
MMAR_4810|M.marinum_M               ALVWVFGGLLAAALPVAVGGFAILGSLAVLRGVAMVTDVSIFALNVTVAL
TH_1538|M.thermoresistible__bu      VLVWVFGGLLAAALPLAVGVLAIVGSMAVLRTFTMFTEVSVFALNLSIAM
MAB_1287|M.abscessus_ATCC_1997      VLVWIFGGLYAALLPLVVGVFSIVGAMSILRGLTYVTDVSVFALNLAVAM
MLBr_02620|M.leprae_Br4923          VLFLVFGGVIAACLPVMVGGLSIAGALGILRFIALFGPVHFFAQPVVSLI
                                                                                      

Mb1177|M.bovis_AF2122/97            GLALAIDYTLLIVSRYRDELAEGSDRDEALIRTMATSGRTVLFSAVTVAL
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                GLALAIDYTLLIVSRYRDELAEGHDRDQALIRTMATSGRTVLFSAVTVAL
MUL_0989|M.ulcerans_Agy99           GLALAIDYTLLIISRYRDELAEGSSREEALVRTMATSGRTVLFSAVTVAL
Mflv_2131|M.gilvum_PYR-GCK          GLALAIDYTLLIISRYRDELADGHDRDTALLRTMTTAGRTVVFSATTVAL
Mvan_4573|M.vanbaalenii_PYR-1       GLALAIDYTLLIISRYRDELAEGHDRDSALVRTMMTAGRTVLFSALTVAL
MSMEG_5178|M.smegmatis_MC2_155      GLALAIDYTLLIISRFRDELAEGADRETALVRTMMTAGRTVLFSAMTVAL
MMAR_4810|M.marinum_M               GMALAIDYTLLIIRRYRDELGEGRSHEDALVRTMTTAGRTVLFSAVTVGL
TH_1538|M.thermoresistible__bu      GLALAIDYTLLLLNRYRDELAEGCSREQAVIRTMTSAGRTVIFSAVIVAT
MAB_1287|M.abscessus_ATCC_1997      GLALAIDYSLLIISRYREEVNAGKPRDEALVLTMTTAGRTVLFSALTVAL
MLBr_02620|M.leprae_Br4923          GLGIAVDYGLFVVSRFREEIAEGYDTEAAVRRTVMTAGRTVTFSAVLIAA
                                                                                      

Mb1177|M.bovis_AF2122/97            SMSATALFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGPRLDALD
Rv1146|M.tuberculosis_H37Rv         --------------------MATVAFVATASIVITPAAIVLLGPRLDALD
MAV_1287|M.avium_104                SMSATVAFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGDRLDALD
MUL_0989|M.ulcerans_Agy99           SMSATVAFPMYFLKSFAYAGVATVAFVATASIVVTPAAIVLLGPRLDALN
Mflv_2131|M.gilvum_PYR-GCK          SMVAMVLFPMYFLKSFAYAGIAVVSFAALAAIVVTPAAIALAGDRLDALD
Mvan_4573|M.vanbaalenii_PYR-1       SMVAMVLFPMYFLKSFAYAGIAVVGFAAVAAIVVAPAAIVLAGARLDSMD
MSMEG_5178|M.smegmatis_MC2_155      SMVAMVLFPMYFLKSFAYAGIAVVALAATAAIVLTPAAIVLLGDRLDAYD
MMAR_4810|M.marinum_M               SLVAMALFPMYFLKSFAYAGVAVVAFSALAAMVVAPTVIVLLGDRLDALN
TH_1538|M.thermoresistible__bu      SMVPLALFPMYFLRSFAYAGVGVVAFALCAALVITPAAITVLGARLDSWD
MAB_1287|M.abscessus_ATCC_1997      ALVALILFPMYFLKSFGYAGVAVVFVGAIAALVIVPAVVTLLGDRIDALD
MLBr_02620|M.leprae_Br4923          SGASLLLLPQGFVKSLTYALIAAVTLAALLSITLLPACLAILAKHVDALG
                                                        :..* .    ::.: *: :.: . ::*: .

Mb1177|M.bovis_AF2122/97            VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR
Rv1146|M.tuberculosis_H37Rv         VRRLVRRLLGRP-----------------DPVHKPVKQLFWYRSSKFVMR
MAV_1287|M.avium_104                VRRLLRRALRRA-----------------QPVRKPVEQLFWYRSSKFVMR
MUL_0989|M.ulcerans_Agy99           VRRLARRMLGRP-----------------KPQHKPVDQLFWYRSTKFVMR
Mflv_2131|M.gilvum_PYR-GCK          VRRLVRRILGRP-----------------DPVAKPVEQNFWYRSTTFVMR
Mvan_4573|M.vanbaalenii_PYR-1       VRRLVRRVLGRP-----------------EPVAKPVEQMFWYRSTKFVMR
MSMEG_5178|M.smegmatis_MC2_155      VRRFFRRVFGRP-----------------EPEPKPVEQGFWYRTAKAAMR
MMAR_4810|M.marinum_M               VWKLGRRLLGRP-----------------EPPPRPVAQSFWYRTAKLVTR
TH_1538|M.thermoresistible__bu      IRRLIRRLMRRTP-------------AAAEPAPRAVCGSKWYRWAKAVMR
MAB_1287|M.abscessus_ATCC_1997      VRRLIRRVLGRP-----------------EPVAKDVTQSFWYRTTKRVMA
MLBr_02620|M.leprae_Br4923          VRTLFRVPLLRNWRMSHACLNWLADRLQKTKTREEVEAGFWGKLVNFVMK
                                    :  : *  : *                      . *    * :  . .  

Mb1177|M.bovis_AF2122/97            RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF
Rv1146|M.tuberculosis_H37Rv         RWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDF
MAV_1287|M.avium_104                RWAPVGLIVVGLLLLLGLPFFSVKWGFPDDRVLPRSASAHQVGDRLRSGF
MUL_0989|M.ulcerans_Agy99           RALPVGLAVVAVLVILGLPFFSVKWGFPDDRVLPATASSHQVGDELRTNF
Mflv_2131|M.gilvum_PYR-GCK          RSIPIGGVVVVLLVLLGAPFLGATWGFPDDRVLPETASARQIGDELRQDF
Mvan_4573|M.vanbaalenii_PYR-1       RSIPIGVVVVTLLLLLGAPFLGANWGFPDDRVLPQSASARQVGDELRTDF
MSMEG_5178|M.smegmatis_MC2_155      RAVPIGVGIIALLVLLGVPFTGIKWGFPDDRVLPQSASARQIGDEMRTNF
MMAR_4810|M.marinum_M               HAIPVGLAIIVLLIALGIPFLNIKWGYPDDRVLPPSASARMVSDRIRSDF
TH_1538|M.thermoresistible__bu      HWLVAGLAVTVVLLLLGAPFLGVRWGFPDERVLPRSASAHQVGHELRTNF
MAB_1287|M.abscessus_ATCC_1997      RAVPIAIIIVSALVVLGLPFLDGKFGFPDDRVLPASASAHQVGNEMRRNF
MLBr_02620|M.leprae_Br4923          RPLVFAIPIVIGMILLVIPLGNLSFGGMSEKYLPPNNAVRQSQEHFDQLF
                                    :    .  :   :: *  *: .  :*  .:: ** . : :   . :   *

Mb1177|M.bovis_AF2122/97            GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS
Rv1146|M.tuberculosis_H37Rv         GHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGS
MAV_1287|M.avium_104                AHDSATSVPVVIPDAAGLSPADLDDYAAALSRVPDVSAVSAPGGTFTGGT
MUL_0989|M.ulcerans_Agy99           AHDLAMAVPVVVPDVHGLVPADLDGYAADLSRVPDVASVTAPSGTFVNGS
Mflv_2131|M.gilvum_PYR-GCK          AVDSSTNVVVVLPDADGISREDFDAYAIALSGVADVSSVSAPSGTFIGGA
Mvan_4573|M.vanbaalenii_PYR-1       AVDSSANVVVVLPDAEGLGPDALDGYAAELSRVQDVSSVSAPGGTFVDGA
MSMEG_5178|M.smegmatis_MC2_155      AVDSATSVTVVLPDATTVAPAEIDRYAARLSQVADVSSVSAPGGTDVQGR
MMAR_4810|M.marinum_M               GSNSASRVTVVITDTAGLTKPDLNHYAAQLSEVSDVSAVSAPTGTFVAGE
TH_1538|M.thermoresistible__bu      ATDSASDVTVVLPDAPGLTADELAGYAARLSEVTDVAWVSAPAGTFVRGR
MAB_1287|M.abscessus_ATCC_1997      NNNSSTNLSVIAEGVGSVPPREIDEYAADLSNIEDVKEVAAPTGAFIRGM
MLBr_02620|M.leprae_Br4923          PGYRTNPLTLVIQTSN-HQPVTDQEIADIRSKAMAISGFIEPDNNYVN--
                                        :  : ::               *   *    :  .  * .      

Mb1177|M.bovis_AF2122/97            WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV
Rv1146|M.tuberculosis_H37Rv         WVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVV
MAV_1287|M.avium_104                RVGPPAGATGLGDGSAFLTVSSTAPLFSTANDVQLKRLHEVPGPAGRSVE
MUL_0989|M.ulcerans_Agy99           RVGPPAGATGFSDGSAFLTVDSTAPLFSHASDIQLKRLHQVTGPAGRTVE
Mflv_2131|M.gilvum_PYR-GCK          RAGPPSAATGSADGSAFLTIGSRAPLFTDASEVQLDRLHAIAPPGDRQVL
Mvan_4573|M.vanbaalenii_PYR-1       KAGPPSAATGIAEGSAFLTIGSTAPLFTDASETQLDRLHDVAPPEGRDVL
MSMEG_5178|M.smegmatis_MC2_155      HVGPPSAATGIGDGSAFLTVGSDAPLFSDASEAQLDALHAVAAH--AEVQ
MMAR_4810|M.marinum_M               LRGPPSAPTAMAAGSAYLTVESTAPLYTKASANQLDRLHAVALPGDTAVQ
TH_1538|M.thermoresistible__bu      SVGPPSAPTGIADGSAFVTVGSVAPLFSDDSLEQLNDIRAVPAPGGTAVQ
MAB_1287|M.abscessus_ATCC_1997      KVGPSASATGIKNDTALFTVQTAAKPYTEAAERQLDAIHALPGPADVLVR
MLBr_02620|M.leprae_Br4923          -MWQERTVAPGASKDPSVRVLQNGLINPNDASKKINELRSITPPKGLTVS
                                            :      . . :   .   .     ::. :: :.      * 

Mb1177|M.bovis_AF2122/97            MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC
Rv1146|M.tuberculosis_H37Rv         MAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVC
MAV_1287|M.avium_104                MGGVAQVNRDSVDAVTDRLPLVLGLMAAITFVLLFLLTGSVLLPAKALAC
MUL_0989|M.ulcerans_Agy99           MAGVAQVNRDSVDAVTERLPLVLGLMAAITFVLLFLLTGSVVLPAKALIC
Mflv_2131|M.gilvum_PYR-GCK          LTGLAQINRDSADAITSRLPLVLAVIAAITFVLLFVLTGSVVLPLKALVL
Mvan_4573|M.vanbaalenii_PYR-1       LTGLAQINRDSADAITSRLPTVLAVIAAITFVLLFLLTGSVVLPLKALVL
MSMEG_5178|M.smegmatis_MC2_155      FTGVAQVNRDSSQAITSRLPLVLGIIAGITFVLLFLLTGSVVLPLKALVL
MMAR_4810|M.marinum_M               MTGVAQMNRDSVNGITSRLPMVFGFIAIVTLVLLFLLTGSVLLPIKAVVL
TH_1538|M.thermoresistible__bu      LTGTAQINHDIVVAVTSRLTVVLTVIALTTLVWLFLLTGSIVLPIKALVL
MAB_1287|M.abscessus_ATCC_1997      IGGGAQLDRDAVDGIVHKLPLVLAIIAVVTFVLLFLLTGSVVLPIKALVL
MLBr_02620|M.leprae_Br4923          VGGTPALEQDSIHSLVAQAPLMVIMLITTTMLLMFLAFGSFVLPIKAAVM
                                    . * . :::*   .:. : . :. .:   * : :*:  **.:** **   

Mb1177|M.bovis_AF2122/97            NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD
Rv1146|M.tuberculosis_H37Rv         NVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMD
MAV_1287|M.avium_104                NFLSLTAAFGALVWIFQDGHLGALGTTPSGTLVANMPVLLFCIAFGLSMD
MUL_0989|M.ulcerans_Agy99           NVLSLTAAFGALVWIFQDGHLGALGTIPSGTLVANMPVLLFCIAFGLSMD
Mflv_2131|M.gilvum_PYR-GCK          NVLSLTAAFGALVWIFQEGHLGALGTTPTGTLVATMPVLLFCIAFGLSMD
Mvan_4573|M.vanbaalenii_PYR-1       NVLSLTAAFGALVWIFQDGHLGALGTTPTGTLVANMPVLLFCIAFGLSMD
MSMEG_5178|M.smegmatis_MC2_155      NVLSLSAAFGALVWIFQDGHLGALGTTPTGTLVANLPVLLFCIAFGLSMD
MMAR_4810|M.marinum_M               NMLSLTAAFGALVWIFQDGHLGALGTTPTGTLVANIPVLMFCIAFGLSMD
TH_1538|M.thermoresistible__bu      NALSLTAAFGALVWIFQDGHLGALGTTPSGTMAVTMPALLLCVAFGISMD
MAB_1287|M.abscessus_ATCC_1997      NVLSLTATFGALIWIFQEGHLGGFGTEVTGTIVATMPMLLFCIAFGLSMD
MLBr_02620|M.leprae_Br4923          SALTLGSTMGILTWIFVDGHLSKWLNFTPTPLMVVIIALVVAVGYGLATD
                                    . *:* :::* * *** :**:.   .  . .: . :  *:..:.:*:: *

Mb1177|M.bovis_AF2122/97            YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART
Rv1146|M.tuberculosis_H37Rv         YEVFLVSRIREYWLESGAAR------PARRSVAEVHAANDESVALGVART
MAV_1287|M.avium_104                YEVFLLSRIREYWLASGAAR------PARPTPKRAHAANDESVALGVART
MUL_0989|M.ulcerans_Agy99           YEVFLVARIREYWLASGAAG------PATPSPAQAHAANDESVALGLART
Mflv_2131|M.gilvum_PYR-GCK          YEVFLVSRIREYWLETG--------------------ENGRSVALGLART
Mvan_4573|M.vanbaalenii_PYR-1       YEVFLVSRIREYWLASGGAGADSSTAHQRSDDLAPHVRSDESVALGLART
MSMEG_5178|M.smegmatis_MC2_155      YEVFLVSRIREFWLQSDQS----------------RAANEESVALGLAHT
MMAR_4810|M.marinum_M               YEVFLLSRIREFWLGSPQQS----------------ADNDESIALGLAHT
TH_1538|M.thermoresistible__bu      YEVFLIARIREHWLASSRTA----------------AANDEAVALGVART
MAB_1287|M.abscessus_ATCC_1997      YEVFLISRIREYWMASGRTR----------------ADNDEAVALGVART
MLBr_02620|M.leprae_Br4923          YEVFLVSRMVEARAESMSTQ--------------------EAVRIGTAST
                                    *****::*: *    :                        .:: :* * *

Mb1177|M.bovis_AF2122/97            GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP
Rv1146|M.tuberculosis_H37Rv         GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVP
MAV_1287|M.avium_104                GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVFADATLVRMVVVP
MUL_0989|M.ulcerans_Agy99           GRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAMAADATLVRMVLVP
Mflv_2131|M.gilvum_PYR-GCK          GRVVTAAALVMSISFAALIAAQVSFMRMFGGGLTLAVLVDATLVRMLLVP
Mvan_4573|M.vanbaalenii_PYR-1       GRVVTAAALLMSISFAALIAAKVAFMRMFGVGLTLAILADATLVRMLLVP
MSMEG_5178|M.smegmatis_MC2_155      GRVITAAALLMSISFAALIAAQVAFMRMFGLGLTLAVLVDATLVRMLLVP
MMAR_4810|M.marinum_M               GRVITAAALLMSISFAGLISAEVSFMRMFGVGLTIAVLVDATLVRVLLVP
TH_1538|M.thermoresistible__bu      ARVITAAALIMSISFAALIGAQVSFMRMIGLGLMVAVLVDATLVRLILVP
MAB_1287|M.abscessus_ATCC_1997      GRVVTAAALIMAIAFAALMAAQVSFMRMFGTGLTIAILVDATIIRMLLVP
MLBr_02620|M.leprae_Br4923          GRLITAAALVLAVVAGSFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVP
                                    .*::*****::::  ..:: :.: :*: :. **  *:  ***::*:.:**

Mb1177|M.bovis_AF2122/97            AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG
Rv1146|M.tuberculosis_H37Rv         AFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGG--LGKIAG
MAV_1287|M.avium_104                AFMHVMGRWNWWAPKPLAWLHDRFGISEAADEEPRLRACPRTRRIRRIAR
MUL_0989|M.ulcerans_Agy99           AFMHVMGRWNWWAPKPLVWLHQRFGISETGAVGGADAAATEA------AD
Mflv_2131|M.gilvum_PYR-GCK          AFMHLLGRWNWWAPPPLARLHARIGVSETVP-------------------
Mvan_4573|M.vanbaalenii_PYR-1       AFMHVLGRWNWWAPKPLARLHERIGFSETLDDSSDSPP----------RS
MSMEG_5178|M.smegmatis_MC2_155      AFMRVMGRWNWWAPAPLARLHERIGFSESGLPPDPKP-------------
MMAR_4810|M.marinum_M               AFMHVFGGLNWWAPKPLERWHSRSGADRSAGQTGPSDGAVGGNSSKFDSN
TH_1538|M.thermoresistible__bu      AFMHVMGRANWWAPAPLARWHDRFGIREAADAPDRPRSDPAPTPXXXDAS
MAB_1287|M.abscessus_ATCC_1997      SFMRLLGRFNWWAPKPLVTLHERIGFSD----------------------
MLBr_02620|M.leprae_Br4923          SVMKLLGDDCWWAPRWARLLQNRIGLGEIHLPDERRRPTVSGRPVRPPVT
                                    :.*:: *   ****      : * *                         

Mb1177|M.bovis_AF2122/97            RSDGQT---------IPAS-----------LTRNG---------------
Rv1146|M.tuberculosis_H37Rv         RSDGQT---------IPAS-----------LTRNG---------------
MAV_1287|M.avium_104                RRGRRTGAQHRLTAVRPTARRVWRSDPILRLIRGGRCTQA----------
MUL_0989|M.ulcerans_Agy99           RRDRPT---------IPAA-----------LSGRG---------------
Mflv_2131|M.gilvum_PYR-GCK          -QRV----------------------------------------------
Mvan_4573|M.vanbaalenii_PYR-1       RQHVATG-----------------------NEHG----------------
MSMEG_5178|M.smegmatis_MC2_155      -QPASVG-----------------------MTQSG---------------
MMAR_4810|M.marinum_M               RRVDDH------------------------VHRSPR--------------
TH_1538|M.thermoresistible__bu      VRKGPAPSSISRDPAVPAYVPDRP------RTRSACRCSR----------
MAB_1287|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_02620|M.leprae_Br4923          AASLAAPASRVPRGPTHPATLEPSQRARSGLASRPQIKRPQELPSGASTA
                                                                                      

Mb1177|M.bovis_AF2122/97            --------------------------------------------------
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                --------------------------------------------------
MUL_0989|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2131|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4573|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5178|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_4810|M.marinum_M               --------------------------------------------------
TH_1538|M.thermoresistible__bu      --------------------------------------------------
MAB_1287|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_02620|M.leprae_Br4923          RIQMRPSQSVEATTTRLSVPGNAPTTAAVSSSQGVQAVPLAATRHPLPTP
                                                                                      

Mb1177|M.bovis_AF2122/97            --------------------------------------------------
Rv1146|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1287|M.avium_104                --------------------------------------------------
MUL_0989|M.ulcerans_Agy99           --------------------------------------------------
Mflv_2131|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4573|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5178|M.smegmatis_MC2_155      --------------------------------------------------
MMAR_4810|M.marinum_M               --------------------------------------------------
TH_1538|M.thermoresistible__bu      --------------------------------------------------
MAB_1287|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_02620|M.leprae_Br4923          SPASGQTRAMPVPANRSSDNASETAEPTTALPIMRPQDNDSEVATEKLNA
                                                                                      

Mb1177|M.bovis_AF2122/97            ------------------------------
Rv1146|M.tuberculosis_H37Rv         ------------------------------
MAV_1287|M.avium_104                ------------------------------
MUL_0989|M.ulcerans_Agy99           ------------------------------
Mflv_2131|M.gilvum_PYR-GCK          ------------------------------
Mvan_4573|M.vanbaalenii_PYR-1       ------------------------------
MSMEG_5178|M.smegmatis_MC2_155      ------------------------------
MMAR_4810|M.marinum_M               ------------------------------
TH_1538|M.thermoresistible__bu      ------------------------------
MAB_1287|M.abscessus_ATCC_1997      ------------------------------
MLBr_02620|M.leprae_Br4923          LGQGDNSRQHRRATGGGISAQDLLRREGRL