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M. marinum M MMAR_4722 (plcB_6)

annotation: membrane-associated phospholipase C 2 PlcB_6
coordinates: 5772382 - 5773938
length: 518 

MTWADAVDKMSRREFLAKLAAATSTGALMSLAGPVIEKAYGAGPCSGHLTDIEHIVLLMQENRSFDHYFG
TLSDVEGFDTPTPLFAQKGWNPRTQAPDPASTTLPFRLDTTRPPLLNGACVNDPDHGWATLHDSWNGGAN
DNWLPAQARTRSAANIPATLGYHTRDDLPIHFLLADTFTVCDHYFCSVIGPTFPNRLYWVSAWLDPDGAN
GGPLVETIPTPPIGKFSWPIMPQHLSDAGVSWKIYYDKRLGPAVNSYVGYGEIVRWFTQAQDPRSDLVRF
GATPRYPRDFATDVKANRLPQVSWLIPNFLESEHPAMPNAGGAIAFMDVLRILLSNPAVWEKTALIVSYD
ENGGFFDHVVPPTPPDGTPGEYLTVPDIDKVRGSGGIRGPIGLGYRVPGLVISPFSRGGLVAHDVFDHTS
QLRLIETRFGVPVPNLTAWRRSVTGDMTSAFNFGVPPNPSRPNLNQSKRVLPQLAQCGLGVEAVAGIFEL
NPPYRVPYPQAMPAQETTPARGIPSGLC

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_4722plcB_6-100% (518)membrane-associated phospholipase C 2 PlcB_6
M. marinum MMMAR_1485plcB_20.067.24% (525) membrane-associated phospholipase C 2 PlcB_2
M. marinum MMMAR_0284plcB_30.067.88% (523) membrane-associated phospholipase C 2 PlcB_3

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1784cplcD0.070.20% (510) phospholipase C 4 PLCD
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv2350cplcB0.068.48% (514) membrane-associated phospholipase C
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0555-1e-10041.15% (503) non-hemolytic phospholipase C
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2799plcB0.065.69% (513) membrane-associated phospholipase C 2 PlcB
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Rv2350c|M.tuberculosis_H37Rv        ---------MTRRQFFAKAAAATTAGAFMSLAGPIIEKAYG-AGPCPGHL
MUL_2799|M.ulcerans_Agy99           ---------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGHL
Mb1784c|M.bovis_AF2122/97           -MSQSHIGGVSRREFLAKVAAGG-AGALMSFAGPVIEKAYG-AGPCSGHL
MMAR_4722|M.marinum_M               MTWADAVDKMSRREFLAKLAAATSTGALMSLAGPVIEKAYG-AGPCSGHL
MAB_0555|M.abscessus_ATCC_1997      ------MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGSL
                                             ::**.:::. *.    .* :*:  . :::. . ..* .* *

Rv2350c|M.tuberculosis_H37Rv        TDIEHIVLLMQENRSFDHYFGTLSDTRGFDDTTPPVVFAQSGWNPMTQAV
MUL_2799|M.ulcerans_Agy99           TDIEHFVFMLQENRSFDHYFGSLSGINGFD--TPSSAFQQKGWNPQTQSI
Mb1784c|M.bovis_AF2122/97           TDIEHFVFFMQENRSFDHYFGTLSGTDGFN--TVSPLFQQKGWNPMTQAL
MMAR_4722|M.marinum_M               TDIEHIVLLMQENRSFDHYFGTLSDVEGFD--TPTPLFAQKGWNPRTQAP
MAB_0555|M.abscessus_ATCC_1997      RDVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDPQ
                                     *:**.*.:: **********:**.  **:  *       ..    .:. 

Rv2350c|M.tuberculosis_H37Rv        DPAGVTLPYRFDTTRGPLVAGECVNDPDHSWIGMHNSWNGGANDNWLPAQ
MUL_2799|M.ulcerans_Agy99           DPAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGAQ
Mb1784c|M.bovis_AF2122/97           DATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQ
MMAR_4722|M.marinum_M               DPASTTLPFRLDTTRPPLLNGACVNDPDHGWATLHDSWNGGANDNWLPAQ
MAB_0555|M.abscessus_ATCC_1997      NPDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAAH
                                    :. .  :*:::**:  ..        ..* *   * ::* *  ***: *:

Rv2350c|M.tuberculosis_H37Rv        VPFSPLQGNVPVTMGFYTRRDLPIHYLLADTFTVCDGYFCSLLGGTTPNR
MUL_2799|M.ulcerans_Agy99           AQAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPNR
Mb1784c|M.bovis_AF2122/97           AKTRSAA-HTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNR
MMAR_4722|M.marinum_M               ARTRSAA-NIPATLGYHTRDDLPIHFLLADTFTVCDHYFCSVIGPTFPNR
MAB_0555|M.abscessus_ATCC_1997      RKADGEH--YPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPNR
                                              * .:*:: * * *:*: **::**:** :..*::* * ***

Rv2350c|M.tuberculosis_H37Rv        LYWMSAWIDPDGTDGGPVLIEPNIQPLQHYSWRIMPENLEDAGVSWKVYQ
MUL_2799|M.ulcerans_Agy99           LYWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVYQ
Mb1784c|M.bovis_AF2122/97           LYWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYR
MMAR_4722|M.marinum_M               LYWVSAWLDPDGANGGPLVETIPTPPIGKFSWPIMPQHLSDAGVSWKIYY
MAB_0555|M.abscessus_ATCC_1997      MMWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVYA
                                    : *::. :**:. .*** :          :.*   .:.*. **:**::* 

Rv2350c|M.tuberculosis_H37Rv        NKLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGISPTYPLDFAADVRN
MUL_2799|M.ulcerans_Agy99           NKLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADVAS
Mb1784c|M.bovis_AF2122/97           NKTLGPIS-SVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLA
MMAR_4722|M.marinum_M               DKRLGPAVNSYVGYGEIVRWFTQAQDPRSDLVRFGATPRYPRDFATDVKA
MAB_0555|M.abscessus_ATCC_1997      EE----DDYGGCNVLKLFSRFQRSR-PGEPLYDKGIAPVRATQFEDDARA
                                    ::              :.  * ::  * . :   * :*  . .*  *.  

Rv2350c|M.tuberculosis_H37Rv        NRLPKVSWVLPGFLLSEHPAFPVN--VGAVAIVDALRILLSNPAVWEKTA
MUL_2799|M.ulcerans_Agy99           NRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEKTA
Mb1784c|M.bovis_AF2122/97           NRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEKTA
MMAR_4722|M.marinum_M               NRLPQVSWLIPNFLESEHPAMPNAG--GAIAFMDVLRILLSNPAVWEKTA
MAB_0555|M.abscessus_ATCC_1997      GRLPAVSWLIMTSTASEHPDYRPAD--GAAYIASKIDAIAANPEVWAKTV
                                    .*** ***::     ****        *.  : . :  : :** ** **.

Rv2350c|M.tuberculosis_H37Rv        LIVNYDENGGFFDHVVPPTPPPGTPGEFVTVPDIDSVPGSGGIRGPIGLG
MUL_2799|M.ulcerans_Agy99           LIVSFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPIGLG
Mb1784c|M.bovis_AF2122/97           LIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLG
MMAR_4722|M.marinum_M               LIVSYDENGGFFDHVVPPTPPDGTPGEYLTVPDIDKVRGSGGIRGPIGLG
MAB_0555|M.abscessus_ATCC_1997      FILNYDENDGLFDHVVPPTPPPGTPGEWVKG-------------VPIGGG
                                    :*:.:***.*:****.*.*.* *****::.               *** *

Rv2350c|M.tuberculosis_H37Rv        FRVPCLVISPYSRGPLMVHDTFDHTSTLKLIRARFGVPVPNLTAWRDATV
MUL_2799|M.ulcerans_Agy99           YRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRGVT
Mb1784c|M.bovis_AF2122/97           FRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVT
MMAR_4722|M.marinum_M               YRVPGLVISPFSRGGLVAHDVFDHTSQLRLIETRFGVPVPNLTAWRRSVT
MAB_0555|M.abscessus_ATCC_1997      FRVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRRKTF
                                    :*** :****:* *  :. : ***** *:::.   **  **:: **  . 

Rv2350c|M.tuberculosis_H37Rv        GDMTSTFNFAAPPNPSKPNLDHPRLNALPKLPQC-VPNAVLGTVTKTAIP
MUL_2799|M.ulcerans_Agy99           GDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQC-VPDTVT-VFTKTVPP
Mb1784c|M.bovis_AF2122/97           GDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQC-VPNAALGTINR-GIP
MMAR_4722|M.marinum_M               GDMTSAFNFGVPPNPSRPNLNQ-SKRVLPQLAQCGLGVEAVAGIFELNPP
MAB_0555|M.abscessus_ATCC_1997      GNLLSAFGFDSP------------VRPAPELPDTAAVVAAADRTDTRPPP
                                    *:: *:*.*  *             .  .   :      .         *

Rv2350c|M.tuberculosis_H37Rv        YRVPFPQSMPTQE-TAPTRGIPSGLC
MUL_2799|M.ulcerans_Agy99           YRVPFPQVMPSQE-TSPTRGIPSGPC
Mb1784c|M.bovis_AF2122/97           YRVPDPQIMPTQE-TTPTRGIPSGPC
MMAR_4722|M.marinum_M               YRVPYPQAMPAQE-TTPARGIPSGLC
MAB_0555|M.abscessus_ATCC_1997      VIPPAPQTSPVQEPGSRPRRYPRR--
                                       * **  * **  : .*  *