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SRNLGPNPMHRSETASAAAPVAASPGRHFGVSSYARPLAGLATVLVIALIVAVAVGLFRGDFTQSVPVTV VSPRAGLVMNPDAKVKMRGVEVGKVAAIDVRSNGDAVLHLAMDPSQIRLIPSNVLVDIASTSVFGAKFVE LVPPEQPSSESLQPHQVLEGKHVTVEVNTVFQQLTSLLSAIDPAKLNETLGAIASAVNGRGHKIGQMLSD LDSFLAKQDPSLPALSHDLAVLPVVSNAYADAAQDLVNTAENAIRISKSIVDEQQNLDAFLISSIGLADV GNDVVGGNRQALTDVLDLLVPTSDLLYEYRQALWCGISGSLVNLHAPPLPEPMIKVLVYLGFGAERYRYP SNLPKVAATGGPQCYDLPLVPFDKAPPFVVADVGANPMQYGNPQLLLNSDALKQLLYGPIDGPPRNTMQI GQPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4710 | - | - | 100% (425) | MCE-family protein |
| M. marinum M | MMAR_4051 | mce3A_1 | 4e-59 | 39.18% (342) | MCE-family protein Mce3A_1 |
| M. marinum M | MMAR_2882 | mce3A | 1e-58 | 40.73% (329) | MCE-family protein Mce3A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 2e-57 | 38.12% (362) | MCE-family protein MCE4A |
| M. gilvum PYR-GCK | Mflv_4538 | - | 1e-134 | 60.41% (389) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 4e-58 | 40.18% (326) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 5e-52 | 34.24% (368) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 5e-62 | 38.74% (382) | MCE-family protein |
| M. avium 104 | MAV_0948 | - | 1e-151 | 67.09% (392) | virulence factor Mce family protein, putative |
| M. smegmatis MC2 155 | MSMEG_4794 | - | 1e-153 | 64.00% (425) | virulence factor |
| M. thermoresistible (build 8) | TH_4437 | - | 1e-141 | 63.27% (392) | PUTATIVE virulence factor |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 2e-59 | 39.18% (342) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_4150 | - | 1e-147 | 62.70% (429) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1966|M.tuberculosis_H37Rv -------------------------MRRGPGRHRLHDAWWTLILFAVIGV
MUL_3918|M.ulcerans_Agy99 ---------------------------MDDRKEGLHPAWHTLILVLLFVA
Mb3529c|M.bovis_AF2122/97 --------------------------MSGGGSRRTSVRVAAALLAGLMVG
MAB_4153c|M.abscessus_ATCC_199 --------------------------MSDTSTRR-AVRLAGTVLASVLVL
MSMEG_4794|M.smegmatis_MC2_155 MTRNVGPGPAHRSETDSSAAPVAARPGRSFGARGHARPLAGLATVVVVGL
TH_4437|M.thermoresistible__bu ------------------------------MSRSYARPLAGLATVVVIGL
Mvan_4150|M.vanbaalenii_PYR-1 MSSNLGPGPLHRSETTSGAAPLAASSGRHFGVSNVVRPLAGLGLVVALLV
MMAR_4710|M.marinum_M MSRNLGPNPMHRSETASAAAPVAASPGRHFGVSSYARPLAGLATVLVIAL
MAV_0948|M.avium_104 MTQNVPAG-----RGAIAGRPPRPGHAHPPAGRNYLPPLLGLATILIIGL
Mflv_4538|M.gilvum_PYR-GCK ------------------------------MTTRPGRPLIGLATVLALAA
MLBr_02589|M.leprae_Br4923 ----------------------MTSSTKINASRKPPYKLAGVGLLVVAVV
Rv1966|M.tuberculosis_H37Rv AVLVTAVSFTGSLRSTVPVTLAADRSGLVMDSGAKVMMRGVQVGRVAQIG
MUL_3918|M.ulcerans_Agy99 AMWVTYALFMGSLRSVVPVTLTSERSGLVMETNAKVKLRGVQVGRVASIV
Mb3529c|M.bovis_AF2122/97 SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
MAB_4153c|M.abscessus_ATCC_199 LTVLTYLAYNDAFADTKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSIS
MSMEG_4794|M.smegmatis_MC2_155 IIALAVTLFRGDFTKTEPVTLISDRVGLVMNPDAKVKMRGVQVGTVGRIE
TH_4437|M.thermoresistible__bu IIAVAIGLFQGSFRKSVPVTVIAERAGLVMNPDAKVKMRGVQVGQVDRIE
Mvan_4150|M.vanbaalenii_PYR-1 ILAVSIGLFAGKFTETVPVTVISNRAGLVMNPDAKVKMRGVQVGSVRSID
MMAR_4710|M.marinum_M IVAVAVGLFRGDFTQSVPVTVVSPRAGLVMNPDAKVKMRGVEVGKVAAID
MAV_0948|M.avium_104 IFAVAVGLFQGSFTETVPVTVISQRAGLVMNPDAKVKMRGVQVGKVASIE
Mflv_4538|M.gilvum_PYR-GCK VIAVAVGLFRGSFTSTVPVTVLSQRAGLVMDADAKVKWHGAQVGSVESIE
MLBr_02589|M.leprae_Br4923 IFGLVYGQFRGNFTPKSKLTMLADRAGLVMDRGSKITYNGVKIGRVADIS
: : : :*: : * ****: ..*: .* ::* * *
Rv1966|M.tuberculosis_H37Rv RIE-WAQNGASLRLEIDPDQIRYIPANVEAQISATTAFGAKFVDLVMPQN
MUL_3918|M.ulcerans_Agy99 GGG-KGATPVALTLEIDSDQIRYIPANVQAEIRATTVFGAKFVDLIYPED
Mb3529c|M.bovis_AF2122/97 Y---SGN-QARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
MAB_4153c|M.abscessus_ATCC_199 Y---AND-QAKLELAVNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQK
MSMEG_4794|M.smegmatis_MC2_155 T---LPDGRAALHLDMDPGQLRLIPGNVTADIASSTVFGAKFVDLVPPGK
TH_4437|M.thermoresistible__bu N---RPDGTAVLHLAMDPSQLHLIPKNVIADIASTTVFGAKSVQLTMPPE
Mvan_4150|M.vanbaalenii_PYR-1 Y---RPDGTAALQLEMDPSQLHLIPSNVNVDIASSTVFGAKFVQLEAPPN
MMAR_4710|M.marinum_M V---RSNGDAVLHLAMDPSQIRLIPSNVLVDIASTSVFGAKFVELVPPEQ
MAV_0948|M.avium_104 S---LPNGQAAIHLAMDPSQMHFIPSNVLVDIASSTVFGAKSIQLVEPAQ
Mflv_4538|M.gilvum_PYR-GCK S---LPDGRASIQLAMDPSYMGIIPSDVRVDIASSTVFGSKYVELVPPAE
MLBr_02589|M.leprae_Br4923 ETVRNGRPVAEFTLDVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEH
. : * : . : ** :. . * ..: **.* :.: *
Rv1966|M.tuberculosis_H37Rv PSRARLSAGAVLHSKNVSTEINTVFENVVDLLNMIDPLKLNAVLTAVADA
MUL_3918|M.ulcerans_Agy99 PSPQRLKAGQVLMSRNVTSEANTVFQNLVAVLDQIDPAKLNAALSALAEG
Mb3529c|M.bovis_AF2122/97 PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
MAB_4153c|M.abscessus_ATCC_199 PSDSSLRPGATVTAEAVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEG
MSMEG_4794|M.smegmatis_MC2_155 P-EGTLQPGQVLQGEHVTVEVNTVFQQLTRVLDKIDPAKLNETLGAISAA
TH_4437|M.thermoresistible__bu PSAERLQPGQVLRGDHVMIEINTIFQQLVDVLDHIDPVKLNETLGAIASA
Mvan_4150|M.vanbaalenii_PYR-1 P-TGELKRGQVLAGDHVTVEINTVFQQLVNVLDAVDPAKLNETLGAIAQA
MMAR_4710|M.marinum_M PSSESLQPHQVLEGKHVTVEVNTVFQQLTSLLSAIDPAKLNETLGAIASA
MAV_0948|M.avium_104 PSAQRLRAGQTLQGQHVMVEINTVFQELVSVLSHIDPPKLNESLGALAQA
Mflv_4538|M.gilvum_PYR-GCK PSTQALRAGQVLTADHVTVEINTVFEQLSHVLGKIEPAKLNQTLGALGTA
MLBr_02589|M.leprae_Br4923 PSQKRLTPQTVIDARSVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQS
* * : . * * **:*: : : ::* : * * * . .
Rv1966|M.tuberculosis_H37Rv VRGQGERIGQATTDLNEVLEALNARGDTIGGNWRSLKNFTDTYDAAAQDI
MUL_3918|M.ulcerans_Agy99 LRGQGPLIGQATTDANQVLLELNPRYETVTADLRAVKDFNDTFSAAAQDI
Mb3529c|M.bovis_AF2122/97 LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
MAB_4153c|M.abscessus_ATCC_199 LRGNGDNFGQGLVELDQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDI
MSMEG_4794|M.smegmatis_MC2_155 FGGRGEKMGQTVSDFEALLEKLEPSLPNLNRDIESMAVVSGAYGDAAPDL
TH_4437|M.thermoresistible__bu FSGRGEQFGQTLTDFEALLARLEPSLPAFSRDLELSAQVSAAYADAAPNL
Mvan_4150|M.vanbaalenii_PYR-1 FNGRGEKFGQTLTDFNALLAKIEPSLPNLSHDIEAAVPALTAYADAGPDL
MMAR_4710|M.marinum_M VNGRGHKIGQMLSDLDSFLAKQDPSLPALSHDLAVLPVVSNAYADAAQDL
MAV_0948|M.avium_104 FSGRGPQLGQSLSDLDSFLARLEPSLPAFRHDLSVLPTVSNAYADAAPDL
Mflv_4538|M.gilvum_PYR-GCK LDGRGDQIGQTMVDFDAFLAQIEPSLPALERELALAPTVVGTYAEVAPQL
MLBr_02589|M.leprae_Br4923 LAGLGERFGQSIVNGNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDF
. * * :* : :. : : . ::
Rv1966|M.tuberculosis_H37Rv LTILNAASTTSATVVNHSTQLDALLLNAIGLSNAGTNLLGSSRDNLVGAA
MUL_3918|M.ulcerans_Agy99 LDTLNALSTTSTTITGHSTQLDALLLATIGLSNTGISLLAPNQANLIKAI
Mb3529c|M.bovis_AF2122/97 NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
MAB_4153c|M.abscessus_ATCC_199 VRILDNLPALSRTVVDQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAAL
MSMEG_4794|M.smegmatis_MC2_155 LKTIENTNRISDSIVDEQQNLDAFLVSSIGLADVGNDVIGGNREALSTTL
TH_4437|M.thermoresistible__bu LRTMQNSITLSDGIVDEQDNLDAFLVSAIGLADVGNDVLGGNREAFSEVL
Mvan_4150|M.vanbaalenii_PYR-1 VSIIENTTTLGNSIVDEQDNLDEFLVSSIGLADLGNEVVGGNRQALTTTL
MMAR_4710|M.marinum_M VNTAENAIRISKSIVDEQQNLDAFLISSIGLADVGNDVVGGNRQALTDVL
MAV_0948|M.avium_104 VKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDVLSTNRQPLTNVL
Mflv_4538|M.gilvum_PYR-GCK VDTLDAATTISDTLVAEQGNLDSLLVSVIGLSDIGNEVVGGNRQAITDVM
MLBr_02589|M.leprae_Br4923 FDFLNNSIVTSRTINQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGA
. : .. :*. *: :*:.: . . .. :
Rv1966|M.tuberculosis_H37Rv DILAPTTSLLFKYNPEYTCFLQ----------------------------
MUL_3918|M.ulcerans_Agy99 NALEPTTNLLYKYSPEYTCLLE----------------------------
Mb3529c|M.bovis_AF2122/97 NRLRAPLKVTSDYSPVFGCLFK----------------------------
MAB_4153c|M.abscessus_ATCC_199 QRLRAPATLLGRYSPEIPCTLQ----------------------------
MSMEG_4794|M.smegmatis_MC2_155 DLLAPTTDLLNEYAPGLNCALE----------------------------
TH_4437|M.thermoresistible__bu ELLVPTTNLLNEYAPAINCSLL----------------------------
Mvan_4150|M.vanbaalenii_PYR-1 DLLVPTTDLLYSYRKSLWCGIG----------------------------
MMAR_4710|M.marinum_M DLLVPTSDLLYEYRQALWCGIS----------------------------
MAV_0948|M.avium_104 HLLVPTTDLTNEYAPALTCSFG----------------------------
Mflv_4538|M.gilvum_PYR-GCK ELLIPTTDLLNQYHQALNCGIG----------------------------
MLBr_02589|M.leprae_Br4923 ADLVPTAQLLDTYSPAIFCTLRNYHDIEPKVTSFLGGNGYSINDHVELLS
* .. : * * :
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGADGRTLQLDVALLFG------NDPYVYPDNLPVV
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPGG-NGRSLVLDAALALG------DDPYRFPDNLPII
Mb3529c|M.bovis_AF2122/97 GIARGVK--EFAPLIGVRKAGLFTSSSFVLG------APSYTYPESLPIV
MAB_4153c|M.abscessus_ATCC_199 AISKALV--TFTPLIGGVRPGLFLTNSFPLG------APVYTYPDSLPIV
MSMEG_4794|M.smegmatis_MC2_155 GMAWVKN--QPP----QSDPGVLVNVAFTLG------IERYRYPQNLPKV
TH_4437|M.thermoresistible__bu GMEYVMN--QPP----LMDPGVLVNVAFTLG------IDRYRYPSNLPKV
Mvan_4150|M.vanbaalenii_PYR-1 GLVPFAK--SPP----QFS-GIFVSSGLTLG------VERYRYPRDLPKV
MMAR_4710|M.marinum_M GSLVNLH--APP----LPEPMIKVLVYLGFG------AERYRYPSNLPKV
MAV_0948|M.avium_104 GLITIAH--GPP----LSEPSINISASLTWG------GERYRYPTNLPKV
Mflv_4538|M.gilvum_PYR-GCK GAVQLAK--APG----TPVPGGLLLQTVVLG------QERYRYPQNLPKV
MLBr_02589|M.leprae_Br4923 GLGFLLNPTSAISIIGAGVLSQGLLAPLGLAGVVNGAANPYIYPENLPRV
. . . * :* .** :
Rv1966|M.tuberculosis_H37Rv AAKGGPGGRPGCG--PLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHP
MUL_3918|M.ulcerans_Agy99 GAKGGPGGKPGCG--SLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFP
Mb3529c|M.bovis_AF2122/97 NASGG----PNCR--GLPDIPTKQTGGSFYRAPFLVTDNALIP-------
MAB_4153c|M.abscessus_ATCC_199 NASGG----PNCR--GLPNIPTKMQNGSWFRSPFLVTDNAYIP-------
MSMEG_4794|M.smegmatis_MC2_155 AAKGG----PHC--MGLPHIGFGQ------RSKYLVTDTNANP-------
TH_4437|M.thermoresistible__bu GAKGG----PHC--MGLPFIGFGN------RSKYLVTDVNANP-------
Mvan_4150|M.vanbaalenii_PYR-1 AASSGG--RDYCAELGLPEMPAEF------VPPLIVGDVGSNP-------
MMAR_4710|M.marinum_M AATGG----PQC--YDLPLVPFDK------APPFVVADVGANP-------
MAV_0948|M.avium_104 AATGG----PKC--MGLPTLPFNT------NPPQFITDIGANP-------
Mflv_4538|M.gilvum_PYR-GCK AAKGG----PQC--TDLPRVPFEK------HPPFVITDVNANP-------
MLBr_02589|M.leprae_Br4923 NARGGPGGAPGCWQHITRDLWPTP-------ELVMDTGNSIAP-------
* .* * . *
Rv1966|M.tuberculosis_H37Rv CWANYFPVTRAVPEPPSIRQCIPGPAIGPNPAAGEQP-------------
MUL_3918|M.ulcerans_Agy99 GWANYFPVTRGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELYAPDGTPL
Mb3529c|M.bovis_AF2122/97 ---YQPFTELQVDAPSTLQFLFNGAFAERDDF------------------
MAB_4153c|M.abscessus_ATCC_199 ---YKPLEELQVNAPDTLQYLYNGAFAKRSEF------------------
MSMEG_4794|M.smegmatis_MC2_155 ---WQYGNQGILLNSDGLKQLLFGPLDGPPRNTAQIGMPG----------
TH_4437|M.thermoresistible__bu ---WQYGNQGIVLNSDGLKQLLFGPLDGPPRNTAQIGQPG----------
Mvan_4150|M.vanbaalenii_PYR-1 ---AQYGNAGILLNSEGLKNWLFGPLDGPPRNTAQIGMPG----------
MMAR_4710|M.marinum_M ---MQYGNPQLLLNSDALKQLLYGPIDGPPRNTMQIGQPG----------
MAV_0948|M.avium_104 ---VGYGNPQLLINSDLLKQLLYGPIAGPPRNSAQVGMPG----------
Mflv_4538|M.gilvum_PYR-GCK ---AQYGNQGIILNSDGLKQMLFGPIDGPPRNGGQIGHPG----------
MLBr_02589|M.leprae_Br4923 ------YNHLDSGSPYAIEYVWGRQVGDNTINP-----------------
. :.
Rv1966|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3918|M.ulcerans_Agy99 WPGLPPAPPPGAPRESGPTPGSEPFVVPASAQAQPTPLPPAPLPQEVAPS
Mb3529c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4794|M.smegmatis_MC2_155 --------------------------------------------------
TH_4437|M.thermoresistible__bu --------------------------------------------------
Mvan_4150|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4710|M.marinum_M --------------------------------------------------
MAV_0948|M.avium_104 --------------------------------------------------
Mflv_4538|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
Rv1966|M.tuberculosis_H37Rv -
MUL_3918|M.ulcerans_Agy99 P
Mb3529c|M.bovis_AF2122/97 -
MAB_4153c|M.abscessus_ATCC_199 -
MSMEG_4794|M.smegmatis_MC2_155 -
TH_4437|M.thermoresistible__bu -
Mvan_4150|M.vanbaalenii_PYR-1 -
MMAR_4710|M.marinum_M -
MAV_0948|M.avium_104 -
Mflv_4538|M.gilvum_PYR-GCK -
MLBr_02589|M.leprae_Br4923 -