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TTRPGRPLIGLATVLALAAVIAVAVGLFRGSFTSTVPVTVLSQRAGLVMDADAKVKWHGAQVGSVESIES LPDGRASIQLAMDPSYMGIIPSDVRVDIASSTVFGSKYVELVPPAEPSTQALRAGQVLTADHVTVEINTV FEQLSHVLGKIEPAKLNQTLGALGTALDGRGDQIGQTMVDFDAFLAQIEPSLPALERELALAPTVVGTYA EVAPQLVDTLDAATTISDTLVAEQGNLDSLLVSVIGLSDIGNEVVGGNRQAITDVMELLIPTTDLLNQYH QALNCGIGGAVQLAKAPGTPVPGGLLLQTVVLGQERYRYPQNLPKVAAKGGPQCTDLPRVPFEKHPPFVI TDVNANPAQYGNQGIILNSDGLKQMLFGPIDGPPRNGGQIGHPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4538 | - | - | 100% (395) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4160 | - | e-125 | 56.56% (389) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2508 | - | e-124 | 56.60% (394) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 3e-55 | 37.43% (342) | MCE-family protein MCE4A |
| M. tuberculosis H37Rv | Rv3499c | mce4A | 3e-55 | 37.43% (342) | MCE-family protein MCE4A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 5e-47 | 30.29% (373) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 6e-64 | 39.38% (353) | MCE-family protein |
| M. marinum M | MMAR_4710 | - | 1e-134 | 60.41% (389) | MCE-family protein |
| M. avium 104 | MAV_0948 | - | 1e-132 | 60.05% (388) | virulence factor Mce family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2855 | - | 1e-169 | 72.66% (395) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2722 | - | 1e-167 | 73.16% (395) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 5e-61 | 39.88% (341) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_2851 | - | 0.0 | 84.83% (389) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3529c|M.bovis_AF2122/97 --------------------------MSGGGSRRTSVRVAAALLAGLMVG
Rv3499c|M.tuberculosis_H37Rv --------------------------MSGGGSRRTSVRVAAALLAGLMVG
MAB_4153c|M.abscessus_ATCC_199 --------------------------MSDTSTRR-AVRLAGTVLASVLVL
Mflv_4538|M.gilvum_PYR-GCK ------------------------------MTTRPGRPLIGLATVLALAA
Mvan_2851|M.vanbaalenii_PYR-1 ----------------------------MAIDSSVRRPLIGLATVLAVAA
MSMEG_2855|M.smegmatis_MC2_155 ------------------------------MRTDVRRPLLGVATAVVILA
TH_2722|M.thermoresistible__bu ----------MDNTGMDNTGMDNAGMGSAGMSTEWKRRLAGFATASVIVL
MMAR_4710|M.marinum_M MSRNLGPNPMHRSETASAAAPVAASPGRHFGVSSYARPLAGLATVLVIAL
MAV_0948|M.avium_104 MTQNVPAG-----RGAIAGRPPRPGHAHPPAGRNYLPPLLGLATILIIGL
MUL_3918|M.ulcerans_Agy99 ---------------------------MDDRKEGLHPAWHTLILVLLFVA
MLBr_02589|M.leprae_Br4923 ----------------------MTSSTKINASRKPPYKLAGVGLLVVAVV
Mb3529c|M.bovis_AF2122/97 SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
Rv3499c|M.tuberculosis_H37Rv SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
MAB_4153c|M.abscessus_ATCC_199 LTVLTYLAYNDAFADTKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSIS
Mflv_4538|M.gilvum_PYR-GCK VIAVAVGLFRGSFTSTVPVTVLSQRAGLVMDADAKVKWHGAQVGSVESIE
Mvan_2851|M.vanbaalenii_PYR-1 VIAVAVGLFRGSFTKTVPVTVLSQRAGLVMNADAKVKLHGAQVGSVHSIE
MSMEG_2855|M.smegmatis_MC2_155 VVALSVSLFRGSFIKSVPITVLTQRAGLVMNPDAKVKLHGAQVGRVQAIE
TH_2722|M.thermoresistible__bu LVAMAIGFFRGSFTRTVPVTVLSERAGLVMNPDAKVKLHGAQVGSVRSID
MMAR_4710|M.marinum_M IVAVAVGLFRGDFTQSVPVTVVSPRAGLVMNPDAKVKMRGVEVGKVAAID
MAV_0948|M.avium_104 IFAVAVGLFQGSFTETVPVTVISQRAGLVMNPDAKVKMRGVQVGKVASIE
MUL_3918|M.ulcerans_Agy99 AMWVTYALFMGSLRSVVPVTLTSERSGLVMETNAKVKLRGVQVGRVASIV
MLBr_02589|M.leprae_Br4923 IFGLVYGQFRGNFTPKSKLTMLADRAGLVMDRGSKITYNGVKIGRVADIS
: : : :*: : *:****: ..*:. .* ::* * *
Mb3529c|M.bovis_AF2122/97 YSG-NQAR---LKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
Rv3499c|M.tuberculosis_H37Rv YSG-NQAR---LKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
MAB_4153c|M.abscessus_ATCC_199 YAN-DQAK---LELAVNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQK
Mflv_4538|M.gilvum_PYR-GCK SLP-DGR--ASIQLAMDPSYMGIIPSDVRVDIASSTVFGSKYVELVPPAE
Mvan_2851|M.vanbaalenii_PYR-1 ALP-DGR--AAIHLAMDPSYMDIIPSDVRVDIASSTVFGSKFVELVPPAD
MSMEG_2855|M.smegmatis_MC2_155 SLP-DGR--AALHLAMEPAYLDLIPANVGVDIAAPTVFGAKSIELVPPPN
TH_2722|M.thermoresistible__bu TLP-DGR--AAIQLAMNPAYLHLIPANVRVDISSPTVFGAKAVELVPPHR
MMAR_4710|M.marinum_M VRS-NGD--AVLHLAMDPSQIRLIPSNVLVDIASTSVFGAKFVELVPPEQ
MAV_0948|M.avium_104 SLP-NGQ--AAIHLAMDPSQMHFIPSNVLVDIASSTVFGAKSIQLVEPAQ
MUL_3918|M.ulcerans_Agy99 GGG-KGATPVALTLEIDSDQIRYIPANVQAEIRATTVFGAKFVDLIYPED
MLBr_02589|M.leprae_Br4923 ETVRNGRPVAEFTLDVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEH
. : * : . : **::. . * . ::**.* :.: *
Mb3529c|M.bovis_AF2122/97 PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
Rv3499c|M.tuberculosis_H37Rv PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
MAB_4153c|M.abscessus_ATCC_199 PSDSSLRPGATVTAEAVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEG
Mflv_4538|M.gilvum_PYR-GCK PSTQALRAGQVLTADHVTVEINTVFEQLSHVLGKIEPAKLNQTLGALGTA
Mvan_2851|M.vanbaalenii_PYR-1 PSAQPLQPGQVLDAEHVTVEINTVFEQLSSVLAKIEPAKLNQTLGALATA
MSMEG_2855|M.smegmatis_MC2_155 PDPQPLRAGQVLSADHVTVEINTIFEKLSTVLSKIEPHKLNQTLGALSVA
TH_2722|M.thermoresistible__bu PDPEPLRPGQVLTADHVTVEINTVFEQLSSVLAKIEPQKLNQTLEALSAA
MMAR_4710|M.marinum_M PSSESLQPHQVLEGKHVTVEVNTVFQQLTSLLSAIDPAKLNETLGAIASA
MAV_0948|M.avium_104 PSAQRLRAGQTLQGQHVMVEINTVFQELVSVLSHIDPPKLNESLGALAQA
MUL_3918|M.ulcerans_Agy99 PSPQRLKAGQVLMSRNVTSEANTVFQNLVAVLDQIDPAKLNAALSALAEG
MLBr_02589|M.leprae_Br4923 PSQKRLTPQTVIDARSVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQS
*. . * . : . * * **:*: : : ::* : * :* * . .
Mb3529c|M.bovis_AF2122/97 LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
Rv3499c|M.tuberculosis_H37Rv LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
MAB_4153c|M.abscessus_ATCC_199 LRGNGDNFGQGLVELDQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDI
Mflv_4538|M.gilvum_PYR-GCK LDGRGDQIGQTMVDFDAFLAQIEPSLPALERELALAPTVVGTYAEVAPQL
Mvan_2851|M.vanbaalenii_PYR-1 FDGRGDQLGQMMADVDGLLAEIEPSLPVMEHELAVAPQVIGTYADVAQEL
MSMEG_2855|M.smegmatis_MC2_155 VDGRGDQIGQMLTEFDAFLTKIDPSLPTLDHELAVAPHVLDAYADVAPEL
TH_2722|M.thermoresistible__bu LDGRGERIGQMLTDFDEFLARVEPSLPTLEHELALAPQVVEAYADVAPAL
MMAR_4710|M.marinum_M VNGRGHKIGQMLSDLDSFLAKQDPSLPALSHDLAVLPVVSNAYADAAQDL
MAV_0948|M.avium_104 FSGRGPQLGQSLSDLDSFLARLEPSLPAFRHDLSVLPTVSNAYADAAPDL
MUL_3918|M.ulcerans_Agy99 LRGQGPLIGQATTDANQVLLELNPRYETVTADLRAVKDFNDTFSAAAQDI
MLBr_02589|M.leprae_Br4923 LAGLGERFGQSIVNGNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDF
. * * :* : :. :: . :. * :
Mb3529c|M.bovis_AF2122/97 NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
Rv3499c|M.tuberculosis_H37Rv NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
MAB_4153c|M.abscessus_ATCC_199 VRILDNLPALSRTVVDQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAAL
Mflv_4538|M.gilvum_PYR-GCK VDTLDAATTISDTLVAEQGNLDSLLVSVIGLSDIGNEVVGGNRQAITDVM
Mvan_2851|M.vanbaalenii_PYR-1 VDTVEAVTTISQTVIDEQDNLDSLLVSVIGLSDNGIEVVGGNRQAITDVM
MSMEG_2855|M.smegmatis_MC2_155 LTTVDAATTVSRTIVEERHNVDGLLLSMIGLSDIGIDVVGANRQAITDAA
TH_2722|M.thermoresistible__bu METATAATTTGRTIVDEQTNLDKLLLHVSGLADIGIDVIGTNRAAITDVA
MMAR_4710|M.marinum_M VNTAENAIRISKSIVDEQQNLDAFLISSIGLADVGNDVVGGNRQALTDVL
MAV_0948|M.avium_104 VKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDVLSTNRQPLTNVL
MUL_3918|M.ulcerans_Agy99 LDTLNALSTTSTTITGHSTQLDALLLATIGLSNTGISLLAPNQANLIKAI
MLBr_02589|M.leprae_Br4923 FDFLNNSIVTSRTINQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGA
. :: . ::. *: *:.: . . .. :
Mb3529c|M.bovis_AF2122/97 NRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIGVRKAG---------
Rv3499c|M.tuberculosis_H37Rv NRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIGVRKAG---------
MAB_4153c|M.abscessus_ATCC_199 QRLRAPATLLGRYSPEIPCTLQAISKALVTFTPLIGGVRPG---------
Mflv_4538|M.gilvum_PYR-GCK ELLIPTTDLLNQYHQALNCGIGGAVQLAKAPGTPVPGG------------
Mvan_2851|M.vanbaalenii_PYR-1 ELLVPTTDLLNRYHTALNCGLGGAVQLAKAPGTPVPGG------------
MSMEG_2855|M.smegmatis_MC2_155 HLLAPTTDLTNEYHQALTCGLGGAVQLAKAPGSPVPGG------------
TH_2722|M.thermoresistible__bu RLLVPTTDLLNRYHEALTCGLGGAAQLAKAPGSPVPGG------------
MMAR_4710|M.marinum_M DLLVPTSDLLYEYRQALWCGISGSLVNLHAPPLPEPMI------------
MAV_0948|M.avium_104 HLLVPTTDLTNEYAPALTCSFGGLITIAHGPPLSEPSI------------
MUL_3918|M.ulcerans_Agy99 NALEPTTNLLYKYSPEYTCLLEGAKYLLDHGGYEAPGGNGRS--------
MLBr_02589|M.leprae_Br4923 ADLVPTAQLLDTYSPAIFCTLRNYHDIEPKVTSFLGGNGYSINDHVELLS
* .. : * * :
Mb3529c|M.bovis_AF2122/97 ---------------------------LFTSSSFVLGAPSYTYPESLPIV
Rv3499c|M.tuberculosis_H37Rv ---------------------------LFTSSSFVLGAPSYTYPESLPIV
MAB_4153c|M.abscessus_ATCC_199 ---------------------------LFLTNSFPLGAPVYTYPDSLPIV
Mflv_4538|M.gilvum_PYR-GCK ----------------------------LLLQTVVLGQERYRYPQNLPKV
Mvan_2851|M.vanbaalenii_PYR-1 ----------------------------LLLQTIVLGQERYRYPQNLPKV
MSMEG_2855|M.smegmatis_MC2_155 ----------------------------LLLQTVVLGQERYRYPDNLPKV
TH_2722|M.thermoresistible__bu ----------------------------LLLQTIVLGQERYRYPANLPKV
MMAR_4710|M.marinum_M ----------------------------KVLVYLGFGAERYRYPSNLPKV
MAV_0948|M.avium_104 ----------------------------NISASLTWGGERYRYPTNLPKV
MUL_3918|M.ulcerans_Agy99 ---------------------------LVLDAALALGDDPYRFPDNLPII
MLBr_02589|M.leprae_Br4923 GLGFLLNPTSAISIIGAGVLSQGLLAPLGLAGVVNGAANPYIYPENLPRV
. . * :* .** :
Mb3529c|M.bovis_AF2122/97 NASGGPN----CRGLPDIPTKQTGGSFYRAPFLVTDNALI----------
Rv3499c|M.tuberculosis_H37Rv NASGGPN----CRGLPDIPTKQTGGSFYRAPFLVTDNALI----------
MAB_4153c|M.abscessus_ATCC_199 NASGGPN----CRGLPNIPTKMQNGSWFRSPFLVTDNAYI----------
Mflv_4538|M.gilvum_PYR-GCK AAKGGPQ----CTDLPRVPFEKH------PPFVITD---VNAN-------
Mvan_2851|M.vanbaalenii_PYR-1 AAKGGPQ----CTDLPKVGFEKH------PPFVITD---VNAN-------
MSMEG_2855|M.smegmatis_MC2_155 AAKGGPQ----CTDLPKVPFQKH------PPFVITD---VNAN-------
TH_2722|M.thermoresistible__bu AAKGGPQ----CTDLPKVPFQKS------PPFVITD---INAN-------
MMAR_4710|M.marinum_M AATGGPQ----CYDLPLVPFDKA------PPFVVAD---VGAN-------
MAV_0948|M.avium_104 AATGGPK----CMGLPTLPFNTN------PPQFITD---IGAN-------
MUL_3918|M.ulcerans_Agy99 GAKGGPGGKPGCGSLPIVDNNWP------VRNLVTN---TGFGTGMDWRP
MLBr_02589|M.leprae_Br4923 NARGGPGGAPGCWQHITRDLWPT-------PELVMDTG------------
* *** * .: :
Mb3529c|M.bovis_AF2122/97 -------------PYQPFTELQVDAPSTLQFLFNGAFAER------DDF-
Rv3499c|M.tuberculosis_H37Rv -------------PYQPFTELQVDAPSTLQFLFNGAFAER------DDF-
MAB_4153c|M.abscessus_ATCC_199 -------------PYKPLEELQVNAPDTLQYLYNGAFAKR------SEF-
Mflv_4538|M.gilvum_PYR-GCK -------------PAQYGNQGIILNSDGLKQMLFGPIDGP--PRNGGQIG
Mvan_2851|M.vanbaalenii_PYR-1 -------------PAQYGNQGIVLNSDGLKQLLFGPIDGP--PRNTPQIG
MSMEG_2855|M.smegmatis_MC2_155 -------------PAQYGNEGILLNSDGLKQMLYGPIAGP--PRNSAQIG
TH_2722|M.thermoresistible__bu -------------PAQYGNQGILLNSDGLKQMLYGPIDGP--PRNTAQIG
MMAR_4710|M.marinum_M -------------PMQYGNPQLLLNSDALKQLLYGPIDGP--PRNTMQIG
MAV_0948|M.avium_104 -------------PVGYGNPQLLINSDLLKQLLYGPIAGP--PRNSAQVG
MUL_3918|M.ulcerans_Agy99 NPGIGFPGWANYFPVTRGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELY
MLBr_02589|M.leprae_Br4923 ------------NSIAPYNHLDSGSPYAIEYVWGRQVGDN-------TIN
. : . .
Mb3529c|M.bovis_AF2122/97 --------------------------------------------------
Rv3499c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4538|M.gilvum_PYR-GCK HPG-----------------------------------------------
Mvan_2851|M.vanbaalenii_PYR-1 QPG-----------------------------------------------
MSMEG_2855|M.smegmatis_MC2_155 QPG-----------------------------------------------
TH_2722|M.thermoresistible__bu QPG-----------------------------------------------
MMAR_4710|M.marinum_M QPG-----------------------------------------------
MAV_0948|M.avium_104 MPG-----------------------------------------------
MUL_3918|M.ulcerans_Agy99 APDGTPLWPGLPPAPPPGAPRESGPTPGSEPFVVPASAQAQPTPLPPAPL
MLBr_02589|M.leprae_Br4923 P-------------------------------------------------
Mb3529c|M.bovis_AF2122/97 --------
Rv3499c|M.tuberculosis_H37Rv --------
MAB_4153c|M.abscessus_ATCC_199 --------
Mflv_4538|M.gilvum_PYR-GCK --------
Mvan_2851|M.vanbaalenii_PYR-1 --------
MSMEG_2855|M.smegmatis_MC2_155 --------
TH_2722|M.thermoresistible__bu --------
MMAR_4710|M.marinum_M --------
MAV_0948|M.avium_104 --------
MUL_3918|M.ulcerans_Agy99 PQEVAPSP
MLBr_02589|M.leprae_Br4923 --------