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MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLTSERSGLVMETNAKVKLRGVQVGRVA SIVGGGKGATPVALTLEIDSDQIRYIPANVQAEIRATTVFGAKFVDLVYPQDPSPQRLKAGQVLMSRNVT SEANTVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLELNPRYETVTADLRAVKD FNDTFSAAAQDILDTLNALSTTSTTITSHSTQLDALLLATIGLSNTGISLLAPNQANLIKAINALEPTTN LLYKYSPEYTCLLEGAKYLLDHGGYEAPGGNGRSLVLDAALALGDDPYRFPDNLPIIGAKGGPGGKPGCG SLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLFGGPAPGPIPYPGA PPYGAELYAPDGTPLWPGLPPAPPPGAPRESGPTPGSEPFVVPAPAQAQPTPLPPAPLPQEVAPSP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4051 | mce3A_1 | - | 100% (486) | MCE-family protein Mce3A_1 |
| M. marinum M | MMAR_2882 | mce3A | e-156 | 61.15% (471) | MCE-family protein Mce3A |
| M. marinum M | MMAR_4883 | mce2A | 8e-61 | 37.54% (357) | MCE-family protein Mce2A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0604 | mce2A | 5e-62 | 37.50% (360) | MCE-family protein MCE2A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 0.0 | 74.80% (488) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-145 | 62.50% (416) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 4e-58 | 34.96% (389) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-56 | 38.94% (339) | MCE-family protein |
| M. avium 104 | MAV_2532 | - | 1e-159 | 62.78% (446) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-173 | 62.85% (471) | virulence factor |
| M. thermoresistible (build 8) | TH_2690 | - | 1e-149 | 61.21% (428) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 0.0 | 99.18% (486) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_4604 | - | 0.0 | 76.95% (486) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4051|M.marinum_M -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
Mvan_4604|M.vanbaalenii_PYR-1 -----MEGHEEGLHPAWWTLILVILTVVALWLTYSLFFGTFRAHETVTLT
Mflv_2101|M.gilvum_PYR-GCK -----MDD--DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKSTVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
TH_2690|M.thermoresistible__bu -------------------LLLIASIVCLVVVCSVLFVGAHKSYAPVLLT
Mb0604|M.bovis_AF2122/97 -MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTPKTELTMV
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
MAB_4153c|M.abscessus_ATCC_199 -----MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
: :
MMAR_4051|M.marinum_M SERSGLVMETNAKVKLRGVQVGRVASIVGGGKG-ATPVALTLEIDSDQIR
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGKG-ATPVALTLEIDSDQIR
Mvan_4604|M.vanbaalenii_PYR-1 SERSGLVMETGAKVKLRGVQVGRVSAIQGGSQ----PVALKLEIDKDKIK
Mflv_2101|M.gilvum_PYR-GCK SDRAGLVMETNAKVKLRGVQVGRVSDISVTGRQ-DPTVALQLEIDPDQVQ
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSGDP-----VTLRLELYPEQLQ
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEWA-QNGASLRLEIDPDQIR
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIR---GG-ASGVSLQLEIEPDQIR
TH_2690|M.thermoresistible__bu SERSGLVMERGAKVKLRGVEVGRVAQITGGSE----PVKLQLDIEPAKLR
Mb0604|M.bovis_AF2122/97 ASRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLDVNPRYIS
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNAKDLR
: *:**:*: ..*: .*:::*:* * . : * : :
MMAR_4051|M.marinum_M YIPANVQAEIRATTVFGAKFVDLVYPQDPSPQRLKAGQVLMSRNVTSEAN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
Mvan_4604|M.vanbaalenii_PYR-1 FIPANIEGQIRATTVFGAKFVDLVYPEDPKGQ-LQAGQVIESRNVTVEAN
Mflv_2101|M.gilvum_PYR-GCK YIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSRNVTTEVN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
TH_2690|M.thermoresistible__bu FIPANVEAEIEATTAFGAKFVNLIVPDDPSPQRLSPGDVLTSRNVSTEVN
Mb0604|M.bovis_AF2122/97 LIPVNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVGSVTTEFN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
** * * .:* ** * * : *. * : . .: *: * *
MMAR_4051|M.marinum_M TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
Mvan_4604|M.vanbaalenii_PYR-1 TVFQNVVDIIKRIDVAKLNSTLSALADGVRGQGERIGQATTDANQVLLEL
Mflv_2101|M.gilvum_PYR-GCK TVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDANQVLLAL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
TH_2690|M.thermoresistible__bu TVFQNLVGVLDQIDVSKLNATLSALADGLQGQGARIGEATTSAKEVLVAM
Mb0604|M.bovis_AF2122/97 TLFETITSIAEKVDPIELNATLSAVAQAPDGLGGKFGESIVNGNQILAQL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
*:*:.:. : :* :** .*:* .:. * * :*.. .. .. * :
MMAR_4051|M.marinum_M NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITSHSTQLD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
Mvan_4604|M.vanbaalenii_PYR-1 NPRNETIAENWRALRDFNDTYSVAAQDILTTLDALSTTSTTITNRATQLD
Mflv_2101|M.gilvum_PYR-GCK NPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVVNQAKELD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
TH_2690|M.thermoresistible__bu NPRMDTVRENFRSLEGFGDAYAAAADDILDVLDAAATTGTTITERTGDLE
Mb0604|M.bovis_AF2122/97 NPRLPQLGYDVRRLADLGEVYVDASPDLWSFLQNALTTARTLTSQQRDLD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
*.: : : . : :: :: *: . . *: . *.
MMAR_4051|M.marinum_M ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
Mvan_4604|M.vanbaalenii_PYR-1 ALLMATTGLSNSGISLLAPNQANLIKAINVLEPTTNLLHKYSPSYTCLLT
Mflv_2101|M.gilvum_PYR-GCK ALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSPSYTCLLL
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
TH_2690|M.thermoresistible__bu DVLLSAVGFGQSGVDLLAPNSDNIVRAIRALQPTTDVLEKYHPTYTCLLQ
Mb0604|M.bovis_AF2122/97 AALLAATGAGNTGEDVFARGGPYLARAAADLVPTATLLDTYSPELFCMIR
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
*: . * .. * :. : . : ..: :* * * * :
MMAR_4051|M.marinum_M GAKYLLDHGGYEAPGG-NGRS-----------------------------
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPGG-NGRS-----------------------------
Mvan_4604|M.vanbaalenii_PYR-1 GAKTLLDTGGYDAPGG-NGRT-----------------------------
Mflv_2101|M.gilvum_PYR-GCK GAKHLLDEGGYEAPGG-NGRT-----------------------------
MAV_2532|M.avium_104 GSKYDAEFFGDVAGGH-NGYS-----------------------------
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGADGRT-----------------------------
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFGG-NGRS-----------------------------
TH_2690|M.thermoresistible__bu GSVFLLNNMAYDSMGGANGKS-----------------------------
Mb0604|M.bovis_AF2122/97 NFHDAAPKVADAVGGNGYS-------------------------------
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNPTSAISIIGAGVLSQ
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIGGVRPG-------------------------------
* .
MMAR_4051|M.marinum_M -----LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCGSLPIVDN
MUL_3918|M.ulcerans_Agy99 -----LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCGSLPIVDN
Mvan_4604|M.vanbaalenii_PYR-1 -----LVLDVGLTLGDDPYHYPDNLPVIGAKGGP--GGKPSCGSLPDVAK
Mflv_2101|M.gilvum_PYR-GCK -----LVLDTSLSFGDDPYQYPRHLPIIGAKGGP--GGKPGCGSLPKVAE
MAV_2532|M.avium_104 -----VTLDVALLLGDEAYRYPDNLPINGAKGGP--GGQPGCGSLPDVSK
Rv1966|M.tuberculosis_H37Rv -----LQLDVALLFGNDPYVYPDNLPVVAAKGGP--GGRPGCGPLPDATH
MSMEG_0346|M.smegmatis_MC2_155 -----AIFDIGLLLGNDPYHYPDDLPIVGAKGGP--GGKPGCGSLPDVAK
TH_2690|M.thermoresistible__bu -----LIVDAGLLLGDDPYRYPQHLPRIAAKGGP--GGKPSCGSLPDATK
Mb0604|M.bovis_AF2122/97 -----LAAAGTILGAPNPYVYPDNLPRVNAHGGP--GGRPGCWQTITREL
MLBr_02589|M.leprae_Br4923 GLLAPLGLAGVVNGAANPYIYPENLPRVNARGGP--GGAPGCWQHITRDL
MAB_4153c|M.abscessus_ATCC_199 -----LFLTNSFPLGAPVYTYPDSLPIVNASGGPNCRGLPNIPTKMQNGS
. . * :* ** * *** * *.
MMAR_4051|M.marinum_M NWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLF
MUL_3918|M.ulcerans_Agy99 NWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLF
Mvan_4604|M.vanbaalenii_PYR-1 NWPVRNLVTNTGFGTGIDWRPNPGIGFPAWANYLPTTRAVPEPPSIRNLF
Mflv_2101|M.gilvum_PYR-GCK NWPVRNLVTNTGFGSGLDWRPNPGIAFPTYANYLPVTRAVPEPPSVRNLF
MAV_2532|M.avium_104 NFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLPVTRGTPQPPSLR-HP
Rv1966|M.tuberculosis_H37Rv NFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRAVPEPPSIRQCI
MSMEG_0346|M.smegmatis_MC2_155 NFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFPVTRGIPQPPIIRNLG
TH_2690|M.thermoresistible__bu KFPVRYLVTDTGFGTGLDIRPNPGIGFPGLANYFPVTKAMPEPPRIY-HP
Mb0604|M.bovis_AF2122/97 WP-APYLVMDTG------------------ASLAPYNHVELGQPMFTEYV
MLBr_02589|M.leprae_Br4923 WP-TPELVMDTG------------------NSIAPYNHLDSGSPYAIEYV
MAB_4153c|M.abscessus_ATCC_199 WFRSPFLVTDNAY-----------------IPYKPLEELQVNAPDTLQYL
** :.. * . *
MMAR_4051|M.marinum_M GGPAPGPIP-YPGAPPYGAELYAPDGTPLWPGLPPAPPPG--APRESGPT
MUL_3918|M.ulcerans_Agy99 GGPAPGPIP-YPGAPPYGAELYAPDGTPLWPGLPPAPPPG--APRESGPT
Mvan_4604|M.vanbaalenii_PYR-1 GGPAIGPIP-YPGAPAYGADLYAPDGTPLWPGLPPAPPPM--APRDPGPT
Mflv_2101|M.gilvum_PYR-GCK GGPAIGPIP-YPGAPAYGAQLYAPDGTPLWPGLPPAPPPG--APRDPGPR
MAV_2532|M.avium_104 GGTAPGPMP-YPGAPPYGAPQYAPDGTPLYPGLPPAPPPG--RPRDAGPP
Rv1966|M.tuberculosis_H37Rv PGPAIGPNP-AAGEQP----------------------------------
MSMEG_0346|M.smegmatis_MC2_155 GGPAPGPIP-YPGAPPYGADLYADDGTPLWPGLPPAPPPSDQPPPDPNNP
TH_2690|M.thermoresistible__bu GGPAPGPEPPYPGGPPHGAPLYGPDGTPLWP---PAP-------------
Mb0604|M.bovis_AF2122/97 WGRQYGENTINP--------------------------------------
MLBr_02589|M.leprae_Br4923 WGRQVGDNTINP--------------------------------------
MAB_4153c|M.abscessus_ATCC_199 YNGAFAKRSEF---------------------------------------
. . .
MMAR_4051|M.marinum_M P-GSEPFVVPAPAQAQPTPLP----PAPLPQEV-APSP
MUL_3918|M.ulcerans_Agy99 P-GSEPFVVPASAQAQPTPLP----PAPLPQEV-APSP
Mvan_4604|M.vanbaalenii_PYR-1 P-GSEPFIVQHPAQMQPTPLP----PVPLPREA-APSP
Mflv_2101|M.gilvum_PYR-GCK P-GSEPFVVPHPSQMQPTAVPYPFVPPPVPAQP-GPPR
MAV_2532|M.avium_104 PAGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVPGP
Rv1966|M.tuberculosis_H37Rv --------------------------------------
MSMEG_0346|M.smegmatis_MC2_155 PPGAEPFVPPAPAAMTPTQ-------------------
TH_2690|M.thermoresistible__bu --------------------------------------
Mb0604|M.bovis_AF2122/97 --------------------------------------
MLBr_02589|M.leprae_Br4923 --------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------