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TRNVGPGPAHRSETDSSAAPVAARPGRSFGARGHARPLAGLATVVVVGLIIALAVTLFRGDFTKTEPVTL ISDRVGLVMNPDAKVKMRGVQVGTVGRIETLPDGRAALHLDMDPGQLRLIPGNVTADIASSTVFGAKFVD LVPPGKPEGTLQPGQVLQGEHVTVEVNTVFQQLTRVLDKIDPAKLNETLGAISAAFGGRGEKMGQTVSDF EALLEKLEPSLPNLNRDIESMAVVSGAYGDAAPDLLKTIENTNRISDSIVDEQQNLDAFLVSSIGLADVG NDVIGGNREALSTTLDLLAPTTDLLNEYAPGLNCALEGMAWVKNQPPQSDPGVLVNVAFTLGIERYRYPQ NLPKVAAKGGPHCMGLPHIGFGQRSKYLVTDTNANPWQYGNQGILLNSDGLKQLLFGPLDGPPRNTAQIG MPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4794 | - | - | 100% (424) | virulence factor |
| M. smegmatis MC2 155 | MSMEG_2855 | - | e-125 | 55.78% (389) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_5900 | - | 7e-64 | 38.24% (387) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 6e-58 | 36.49% (370) | MCE-family protein MCE4A |
| M. gilvum PYR-GCK | Mflv_2508 | - | 1e-138 | 64.03% (392) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 7e-64 | 40.17% (356) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 2e-51 | 33.42% (368) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-65 | 39.50% (362) | MCE-family protein |
| M. marinum M | MMAR_4710 | - | 1e-153 | 64.00% (425) | MCE-family protein |
| M. avium 104 | MAV_0948 | - | 1e-136 | 58.56% (403) | virulence factor Mce family protein, putative |
| M. thermoresistible (build 8) | TH_4437 | - | 1e-170 | 74.37% (394) | PUTATIVE virulence factor |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 2e-62 | 39.72% (355) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_4150 | - | 1e-149 | 63.55% (428) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1966|M.tuberculosis_H37Rv -------------------------MRRGPGRHRLHDAWWTLILFAVIGV
MUL_3918|M.ulcerans_Agy99 ---------------------------MDDRKEGLHPAWHTLILVLLFVA
Mb3529c|M.bovis_AF2122/97 --------------------------MSGGGSRRTSVRVAAALLAGLMVG
MAB_4153c|M.abscessus_ATCC_199 --------------------------MSDTSTRR-AVRLAGTVLASVLVL
MSMEG_4794|M.smegmatis_MC2_155 MTRNVGPGPAHRSETDSSAAPVAARPGRSFGARGHARPLAGLATVVVVGL
TH_4437|M.thermoresistible__bu ------------------------------MSRSYARPLAGLATVVVIGL
Mflv_2508|M.gilvum_PYR-GCK MN------------------------------KNLVRPLAGLGMVVALLV
Mvan_4150|M.vanbaalenii_PYR-1 MSSNLGPGPLHRSETTSGAAPLAASSGRHFGVSNVVRPLAGLGLVVALLV
MMAR_4710|M.marinum_M MSRNLGPNPMHRSETASAAAPVAASPGRHFGVSSYARPLAGLATVLVIAL
MAV_0948|M.avium_104 MTQNVPAG-----RGAIAGRPPRPGHAHPPAGRNYLPPLLGLATILIIGL
MLBr_02589|M.leprae_Br4923 ----------------------MTSSTKINASRKPPYKLAGVGLLVVAVV
Rv1966|M.tuberculosis_H37Rv AVLVTAVSFTGSLRSTVPVTLAADRSGLVMDSGAKVMMRGVQVGRVAQIG
MUL_3918|M.ulcerans_Agy99 AMWVTYALFMGSLRSVVPVTLTSERSGLVMETNAKVKLRGVQVGRVASIV
Mb3529c|M.bovis_AF2122/97 SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
MAB_4153c|M.abscessus_ATCC_199 LTVLTYLAYNDAFADTKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSIS
MSMEG_4794|M.smegmatis_MC2_155 IIALAVTLFRGDFTKTEPVTLISDRVGLVMNPDAKVKMRGVQVGTVGRIE
TH_4437|M.thermoresistible__bu IIAVAIGLFQGSFRKSVPVTVIAERAGLVMNPDAKVKMRGVQVGQVDRIE
Mflv_2508|M.gilvum_PYR-GCK ILAVSIGLFAGKFTETVPVTVISDRAGLVMNPDAKVKMRGVQVGTVKSID
Mvan_4150|M.vanbaalenii_PYR-1 ILAVSIGLFAGKFTETVPVTVISNRAGLVMNPDAKVKMRGVQVGSVRSID
MMAR_4710|M.marinum_M IVAVAVGLFRGDFTQSVPVTVVSPRAGLVMNPDAKVKMRGVEVGKVAAID
MAV_0948|M.avium_104 IFAVAVGLFQGSFTETVPVTVISQRAGLVMNPDAKVKMRGVQVGKVASIE
MLBr_02589|M.leprae_Br4923 IFGLVYGQFRGNFTPKSKLTMLADRAGLVMDRGSKITYNGVKIGRVADIS
: : : :*: : * ****: ..*: .*:::* * *
Rv1966|M.tuberculosis_H37Rv RIE-WAQNGASLRLEIDPDQIRYIPANVEAQISATTAFGAKFVDLVMPQN
MUL_3918|M.ulcerans_Agy99 GGG-KGATPVALTLEIDSDQIRYIPANVQAEIRATTVFGAKFVDLIYPED
Mb3529c|M.bovis_AF2122/97 Y---SGN-QARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
MAB_4153c|M.abscessus_ATCC_199 Y---AND-QAKLELAVNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQK
MSMEG_4794|M.smegmatis_MC2_155 T---LPDGRAALHLDMDPGQLRLIPGNVTADIASSTVFGAKFVDLVPPGK
TH_4437|M.thermoresistible__bu N---RPDGTAVLHLAMDPSQLHLIPKNVIADIASTTVFGAKSVQLTMPPE
Mflv_2508|M.gilvum_PYR-GCK Y---RPDGTAALQLDMDPSQLPLIPENVNVDIASSTVFGAKFVQFEAPEN
Mvan_4150|M.vanbaalenii_PYR-1 Y---RPDGTAALQLEMDPSQLHLIPSNVNVDIASSTVFGAKFVQLEAPPN
MMAR_4710|M.marinum_M V---RSNGDAVLHLAMDPSQIRLIPSNVLVDIASTSVFGAKFVELVPPEQ
MAV_0948|M.avium_104 S---LPNGQAAIHLAMDPSQMHFIPSNVLVDIASSTVFGAKSIQLVEPAQ
MLBr_02589|M.leprae_Br4923 ETVRNGRPVAEFTLDVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEH
. : * : . : ** *. . * ..: **.* :.: *
Rv1966|M.tuberculosis_H37Rv PSRARLSAGAVLHSKNVSTEINTVFENVVDLLNMIDPLKLNAVLTAVADA
MUL_3918|M.ulcerans_Agy99 PSPQRLKAGQVLMSRNVTSEANTVFQNLVAVLDQIDPAKLNAALSALAEG
Mb3529c|M.bovis_AF2122/97 PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
MAB_4153c|M.abscessus_ATCC_199 PSDSSLRPGATVTAEAVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEG
MSMEG_4794|M.smegmatis_MC2_155 P-EGTLQPGQVLQGEHVTVEVNTVFQQLTRVLDKIDPAKLNETLGAISAA
TH_4437|M.thermoresistible__bu PSAERLQPGQVLRGDHVMIEINTIFQQLVDVLDHIDPVKLNETLGAIASA
Mflv_2508|M.gilvum_PYR-GCK P-VGELRTGQVLRGDHVTVEINTVFQQLVNVLDAVDPLKLNETLGALSQA
Mvan_4150|M.vanbaalenii_PYR-1 P-TGELKRGQVLAGDHVTVEINTVFQQLVNVLDAVDPAKLNETLGAIAQA
MMAR_4710|M.marinum_M PSSESLQPHQVLEGKHVTVEVNTVFQQLTSLLSAIDPAKLNETLGAIASA
MAV_0948|M.avium_104 PSAQRLRAGQTLQGQHVMVEINTVFQELVSVLSHIDPPKLNESLGALAQA
MLBr_02589|M.leprae_Br4923 PSQKRLTPQTVIDARSVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQS
* * : . * * **:*: : : :** : * * * . .
Rv1966|M.tuberculosis_H37Rv VRGQGERIGQATTDLNEVLEALNARGDTIGGNWRSLKNFTDTYDAAAQDI
MUL_3918|M.ulcerans_Agy99 LRGQGPLIGQATTDANQVLLELNPRYETVTADLRAVKDFNDTFSAAAQDI
Mb3529c|M.bovis_AF2122/97 LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
MAB_4153c|M.abscessus_ATCC_199 LRGNGDNFGQGLVELDQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDI
MSMEG_4794|M.smegmatis_MC2_155 FGGRGEKMGQTVSDFEALLEKLEPSLPNLNRDIESMAVVSGAYGDAAPDL
TH_4437|M.thermoresistible__bu FSGRGEQFGQTLTDFEALLARLEPSLPAFSRDLELSAQVSAAYADAAPNL
Mflv_2508|M.gilvum_PYR-GCK FSGRGEKFGQTLTDFNALLAELEPSLPNLSRDIEAAVPTLEAYGDAAPDL
Mvan_4150|M.vanbaalenii_PYR-1 FNGRGEKFGQTLTDFNALLAKIEPSLPNLSHDIEAAVPALTAYADAGPDL
MMAR_4710|M.marinum_M VNGRGHKIGQMLSDLDSFLAKQDPSLPALSHDLAVLPVVSNAYADAAQDL
MAV_0948|M.avium_104 FSGRGPQLGQSLSDLDSFLARLEPSLPAFRHDLSVLPTVSNAYADAAPDL
MLBr_02589|M.leprae_Br4923 LAGLGERFGQSIVNGNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDF
. * * :* : :. : : :. ::
Rv1966|M.tuberculosis_H37Rv LTILNAASTTSATVVNHSTQLDALLLNAIGLSNAGTNLLGSSRDNLVGAA
MUL_3918|M.ulcerans_Agy99 LDTLNALSTTSTTITGHSTQLDALLLATIGLSNTGISLLAPNQANLIKAI
Mb3529c|M.bovis_AF2122/97 NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
MAB_4153c|M.abscessus_ATCC_199 VRILDNLPALSRTVVDQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAAL
MSMEG_4794|M.smegmatis_MC2_155 LKTIENTNRISDSIVDEQQNLDAFLVSSIGLADVGNDVIGGNREALSTTL
TH_4437|M.thermoresistible__bu LRTMQNSITLSDGIVDEQDNLDAFLVSAIGLADVGNDVLGGNREAFSEVL
Mflv_2508|M.gilvum_PYR-GCK VSIFENTTTLGNSIVDEQENLDQFLISSIGLADLGNEVVGGNREALTNVL
Mvan_4150|M.vanbaalenii_PYR-1 VSIIENTTTLGNSIVDEQDNLDEFLVSSIGLADLGNEVVGGNRQALTTTL
MMAR_4710|M.marinum_M VNTAENAIRISKSIVDEQQNLDAFLISSIGLADVGNDVVGGNRQALTDVL
MAV_0948|M.avium_104 VKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDVLSTNRQPLTNVL
MLBr_02589|M.leprae_Br4923 FDFLNNSIVTSRTINQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGA
. : .. :*. *: ::*:.: . . .. :
Rv1966|M.tuberculosis_H37Rv DILAPTTSLLFKYNPEYTCFLQGAKWYLDNGGYAAWGGADGRTLQLDVAL
MUL_3918|M.ulcerans_Agy99 NALEPTTNLLYKYSPEYTCLLEGAKYLLDHGGYEAPGG-NGRSLVLDAAL
Mb3529c|M.bovis_AF2122/97 NRLRAPLKVTSDYSPVFGCLFKGIARGVK--EFAPLIGVRKAGLFTSSSF
MAB_4153c|M.abscessus_ATCC_199 QRLRAPATLLGRYSPEIPCTLQAISKALV--TFTPLIGGVRPGLFLTNSF
MSMEG_4794|M.smegmatis_MC2_155 DLLAPTTDLLNEYAPGLNCALEGMAWVKN--QPP----QSDPGVLVNVAF
TH_4437|M.thermoresistible__bu ELLVPTTNLLNEYAPAINCSLLGMEYVMN--QPP----LMDPGVLVNVAF
Mflv_2508|M.gilvum_PYR-GCK DVLVPTTQLLHDYRKSLWCGIGGLVPFAQ--SPP----QFS-GIFVSAGL
Mvan_4150|M.vanbaalenii_PYR-1 DLLVPTTDLLYSYRKSLWCGIGGLVPFAK--SPP----QFS-GIFVSSGL
MMAR_4710|M.marinum_M DLLVPTSDLLYEYRQALWCGISGSLVNLH--APP----LPEPMIKVLVYL
MAV_0948|M.avium_104 HLLVPTTDLTNEYAPALTCSFGGLITIAH--GPP----LSEPSINISASL
MLBr_02589|M.leprae_Br4923 ADLVPTAQLLDTYSPAIFCTLRNYHDIEP--KVTSFLGGNGYSINDHVEL
* .. : * * : : :
Rv1966|M.tuberculosis_H37Rv LFGNDPYVYP-DNLPVVAAKGGPGGRPGCGPLPDATHNFPVRQLVTNTGW
MUL_3918|M.ulcerans_Agy99 ALGDDPYRFP-DNLPIIGAKGGPGGKPGCGSLPIVDNNWPVRNLVTNTGF
Mb3529c|M.bovis_AF2122/97 VLGAPSYTYP-ESLPIVNASGG--PNCR--GLPDIPTKQTGGSFYRAPFL
MAB_4153c|M.abscessus_ATCC_199 PLGAPVYTYP-DSLPIVNASGG--PNCR--GLPNIPTKMQNGSWFRSPFL
MSMEG_4794|M.smegmatis_MC2_155 TLGIERYRYP-QNLPKVAAKGG--PHC--MGLPHIGFGQ------RSKYL
TH_4437|M.thermoresistible__bu TLGIDRYRYP-SNLPKVGAKGG--PHC--MGLPFIGFGN------RSKYL
Mflv_2508|M.gilvum_PYR-GCK TLGVERYRYP-RDLPKVAAKSGGRDYCAELGLPEMPAEF------VPPMI
Mvan_4150|M.vanbaalenii_PYR-1 TLGVERYRYP-RDLPKVAASSGGRDYCAELGLPEMPAEF------VPPLI
MMAR_4710|M.marinum_M GFGAERYRYP-SNLPKVAATGG--PQC--YDLPLVPFDK------APPFV
MAV_0948|M.avium_104 TWGGERYRYP-TNLPKVAATGG--PKC--MGLPTLPFNT------NPPQF
MLBr_02589|M.leprae_Br4923 LSGLGFLLNPTSAISIIGAGVLSQGLLAPLGLAGVVNGAANPYIYPENLP
* * :. : * *.
Rv1966|M.tuberculosis_H37Rv GTGLDIRPNPGI-GHPCWANYFPVTRAVPEPPSIRQCIPGPAIGPNPAAG
MUL_3918|M.ulcerans_Agy99 GTGMDWRPNPGI-GFPGWANYFPVTRGTPEPPSIRNLFGGPAPGPIPYPG
Mb3529c|M.bovis_AF2122/97 VTDNALIP-----------YQPFTELQVDAPSTLQFLFNGAFAERDDF--
MAB_4153c|M.abscessus_ATCC_199 VTDNAYIP-----------YKPLEELQVNAPDTLQYLYNGAFAKRSEF--
MSMEG_4794|M.smegmatis_MC2_155 VTDTNANP-----------WQYGNQGILLNSDGLKQLLFGPLDGPPRNTA
TH_4437|M.thermoresistible__bu VTDVNANP-----------WQYGNQGIVLNSDGLKQLLFGPLDGPPRNTA
Mflv_2508|M.gilvum_PYR-GCK VGDVGANP-----------AQYGNSGILLNSEGLKNWLFGPLDGPPRNTA
Mvan_4150|M.vanbaalenii_PYR-1 VGDVGSNP-----------AQYGNAGILLNSEGLKNWLFGPLDGPPRNTA
MMAR_4710|M.marinum_M VADVGANP-----------MQYGNPQLLLNSDALKQLLYGPIDGPPRNTM
MAV_0948|M.avium_104 ITDIGANP-----------VGYGNPQLLINSDLLKQLLYGPIAGPPRNSA
MLBr_02589|M.leprae_Br4923 RVNARGGPGGAPGCWQHITRDLWPTPELVMDTGNSIAPYNHLDSGSPYAI
. * .
Rv1966|M.tuberculosis_H37Rv EQP-----------------------------------------------
MUL_3918|M.ulcerans_Agy99 APPYGAELYAPDGTPLWPGLPPAPPPGAPRESGPTPGSEPFVVPASAQAQ
Mb3529c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4794|M.smegmatis_MC2_155 QIGMPG--------------------------------------------
TH_4437|M.thermoresistible__bu QIGQPG--------------------------------------------
Mflv_2508|M.gilvum_PYR-GCK QIGQPG--------------------------------------------
Mvan_4150|M.vanbaalenii_PYR-1 QIGMPG--------------------------------------------
MMAR_4710|M.marinum_M QIGQPG--------------------------------------------
MAV_0948|M.avium_104 QVGMPG--------------------------------------------
MLBr_02589|M.leprae_Br4923 EYVWGRQVGDNTINP-----------------------------------
Rv1966|M.tuberculosis_H37Rv -----------------
MUL_3918|M.ulcerans_Agy99 PTPLPPAPLPQEVAPSP
Mb3529c|M.bovis_AF2122/97 -----------------
MAB_4153c|M.abscessus_ATCC_199 -----------------
MSMEG_4794|M.smegmatis_MC2_155 -----------------
TH_4437|M.thermoresistible__bu -----------------
Mflv_2508|M.gilvum_PYR-GCK -----------------
Mvan_4150|M.vanbaalenii_PYR-1 -----------------
MMAR_4710|M.marinum_M -----------------
MAV_0948|M.avium_104 -----------------
MLBr_02589|M.leprae_Br4923 -----------------