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VTQNVPAGRGAIAGRPPRPGHAHPPAGRNYLPPLLGLATILIIGLIFAVAVGLFQGSFTETVPVTVISQR AGLVMNPDAKVKMRGVQVGKVASIESLPNGQAAIHLAMDPSQMHFIPSNVLVDIASSTVFGAKSIQLVEP AQPSAQRLRAGQTLQGQHVMVEINTVFQELVSVLSHIDPPKLNESLGALAQAFSGRGPQLGQSLSDLDSF LARLEPSLPAFRHDLSVLPTVSNAYADAAPDLVKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDV LSTNRQPLTNVLHLLVPTTDLTNEYAPALTCSFGGLITIAHGPPLSEPSINISASLTWGGERYRYPTNLP KVAATGGPKCMGLPTLPFNTNPPQFITDIGANPVGYGNPQLLINSDLLKQLLYGPIAGPPRNSAQVGMPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0948 | - | - | 100% (420) | virulence factor Mce family protein, putative |
| M. avium 104 | MAV_2061 | - | 4e-63 | 36.91% (363) | virulence factor Mce family protein |
| M. avium 104 | MAV_0657 | - | 3e-60 | 39.52% (334) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 4e-61 | 39.88% (341) | MCE-family protein MCE4A |
| M. gilvum PYR-GCK | Mflv_4538 | - | 1e-132 | 60.05% (388) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3499c | mce4A | 4e-61 | 39.88% (341) | MCE-family protein MCE4A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 2e-49 | 31.99% (372) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 5e-64 | 39.70% (335) | MCE-family protein |
| M. marinum M | MMAR_4710 | - | 1e-151 | 67.09% (392) | MCE-family protein |
| M. smegmatis MC2 155 | MSMEG_4794 | - | 1e-135 | 58.56% (403) | virulence factor |
| M. thermoresistible (build 8) | TH_4437 | - | 1e-145 | 62.85% (393) | PUTATIVE virulence factor |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 5e-65 | 40.28% (355) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_2851 | - | 1e-133 | 60.31% (388) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3529c|M.bovis_AF2122/97 --------------------------MSGGGSRRTSVRVAAALLAGLMVG
Rv3499c|M.tuberculosis_H37Rv --------------------------MSGGGSRRTSVRVAAALLAGLMVG
MAB_4153c|M.abscessus_ATCC_199 --------------------------MSDTSTRR-AVRLAGTVLASVLVL
MSMEG_4794|M.smegmatis_MC2_155 MTRNVGPGPAHRSETDSSAAPVAARPGRSFGARGHARPLAGLATVVVVGL
TH_4437|M.thermoresistible__bu ------------------------------MSRSYARPLAGLATVVVIGL
MMAR_4710|M.marinum_M MSRNLGPNPMHRSETASAAAPVAASPGRHFGVSSYARPLAGLATVLVIAL
MAV_0948|M.avium_104 MTQNVPAG-----RGAIAGRPPRPGHAHPPAGRNYLPPLLGLATILIIGL
Mflv_4538|M.gilvum_PYR-GCK ------------------------------MTTRPGRPLIGLATVLALAA
Mvan_2851|M.vanbaalenii_PYR-1 ----------------------------MAIDSSVRRPLIGLATVLAVAA
MUL_3918|M.ulcerans_Agy99 ---------------------------MDDRKEGLHPAWHTLILVLLFVA
MLBr_02589|M.leprae_Br4923 ----------------------MTSSTKINASRKPPYKLAGVGLLVVAVV
Mb3529c|M.bovis_AF2122/97 SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
Rv3499c|M.tuberculosis_H37Rv SAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDIS
MAB_4153c|M.abscessus_ATCC_199 LTVLTYLAYNDAFADTKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSIS
MSMEG_4794|M.smegmatis_MC2_155 IIALAVTLFRGDFTKTEPVTLISDRVGLVMNPDAKVKMRGVQVGTVGRIE
TH_4437|M.thermoresistible__bu IIAVAIGLFQGSFRKSVPVTVIAERAGLVMNPDAKVKMRGVQVGQVDRIE
MMAR_4710|M.marinum_M IVAVAVGLFRGDFTQSVPVTVVSPRAGLVMNPDAKVKMRGVEVGKVAAID
MAV_0948|M.avium_104 IFAVAVGLFQGSFTETVPVTVISQRAGLVMNPDAKVKMRGVQVGKVASIE
Mflv_4538|M.gilvum_PYR-GCK VIAVAVGLFRGSFTSTVPVTVLSQRAGLVMDADAKVKWHGAQVGSVESIE
Mvan_2851|M.vanbaalenii_PYR-1 VIAVAVGLFRGSFTKTVPVTVLSQRAGLVMNADAKVKLHGAQVGSVHSIE
MUL_3918|M.ulcerans_Agy99 AMWVTYALFMGSLRSVVPVTLTSERSGLVMETNAKVKLRGVQVGRVASIV
MLBr_02589|M.leprae_Br4923 IFGLVYGQFRGNFTPKSKLTMLADRAGLVMDRGSKITYNGVKIGRVADIS
:. : : :*: : * ****: ..*:. .* ::* * *
Mb3529c|M.bovis_AF2122/97 YSG-NQAR---LKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
Rv3499c|M.tuberculosis_H37Rv YSG-NQAR---LKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKT
MAB_4153c|M.abscessus_ATCC_199 YAN-DQAK---LELAVNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQK
MSMEG_4794|M.smegmatis_MC2_155 TLP-DGR--AALHLDMDPGQLRLIPGNVTADIASSTVFGAKFVDLVPPGK
TH_4437|M.thermoresistible__bu NRP-DGT--AVLHLAMDPSQLHLIPKNVIADIASTTVFGAKSVQLTMPPE
MMAR_4710|M.marinum_M VRS-NGD--AVLHLAMDPSQIRLIPSNVLVDIASTSVFGAKFVELVPPEQ
MAV_0948|M.avium_104 SLP-NGQ--AAIHLAMDPSQMHFIPSNVLVDIASSTVFGAKSIQLVEPAQ
Mflv_4538|M.gilvum_PYR-GCK SLP-DGR--ASIQLAMDPSYMGIIPSDVRVDIASSTVFGSKYVELVPPAE
Mvan_2851|M.vanbaalenii_PYR-1 ALP-DGR--AAIHLAMDPSYMDIIPSDVRVDIASSTVFGSKFVELVPPAD
MUL_3918|M.ulcerans_Agy99 GGG-KGATPVALTLEIDSDQIRYIPANVQAEIRATTVFGAKFVDLIYPED
MLBr_02589|M.leprae_Br4923 ETVRNGRPVAEFTLDVYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEH
. : * : . : ** :. . * ..::**.* :.: *
Mb3529c|M.bovis_AF2122/97 PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
Rv3499c|M.tuberculosis_H37Rv PSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEG
MAB_4153c|M.abscessus_ATCC_199 PSDSSLRPGATVTAEAVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEG
MSMEG_4794|M.smegmatis_MC2_155 P-EGTLQPGQVLQGEHVTVEVNTVFQQLTRVLDKIDPAKLNETLGAISAA
TH_4437|M.thermoresistible__bu PSAERLQPGQVLRGDHVMIEINTIFQQLVDVLDHIDPVKLNETLGAIASA
MMAR_4710|M.marinum_M PSSESLQPHQVLEGKHVTVEVNTVFQQLTSLLSAIDPAKLNETLGAIASA
MAV_0948|M.avium_104 PSAQRLRAGQTLQGQHVMVEINTVFQELVSVLSHIDPPKLNESLGALAQA
Mflv_4538|M.gilvum_PYR-GCK PSTQALRAGQVLTADHVTVEINTVFEQLSHVLGKIEPAKLNQTLGALGTA
Mvan_2851|M.vanbaalenii_PYR-1 PSAQPLQPGQVLDAEHVTVEINTVFEQLSSVLAKIEPAKLNQTLGALATA
MUL_3918|M.ulcerans_Agy99 PSPQRLKAGQVLMSRNVTSEANTVFQNLVAVLDQIDPAKLNAALSALAEG
MLBr_02589|M.leprae_Br4923 PSQKRLTPQTVIDARSVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQS
* * . : . * * **:*: : : ::* : * :* * . .
Mb3529c|M.bovis_AF2122/97 LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
Rv3499c|M.tuberculosis_H37Rv LRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDL
MAB_4153c|M.abscessus_ATCC_199 LRGNGDNFGQGLVELDQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDI
MSMEG_4794|M.smegmatis_MC2_155 FGGRGEKMGQTVSDFEALLEKLEPSLPNLNRDIESMAVVSGAYGDAAPDL
TH_4437|M.thermoresistible__bu FSGRGEQFGQTLTDFEALLARLEPSLPAFSRDLELSAQVSAAYADAAPNL
MMAR_4710|M.marinum_M VNGRGHKIGQMLSDLDSFLAKQDPSLPALSHDLAVLPVVSNAYADAAQDL
MAV_0948|M.avium_104 FSGRGPQLGQSLSDLDSFLARLEPSLPAFRHDLSVLPTVSNAYADAAPDL
Mflv_4538|M.gilvum_PYR-GCK LDGRGDQIGQTMVDFDAFLAQIEPSLPALERELALAPTVVGTYAEVAPQL
Mvan_2851|M.vanbaalenii_PYR-1 FDGRGDQLGQMMADVDGLLAEIEPSLPVMEHELAVAPQVIGTYADVAQEL
MUL_3918|M.ulcerans_Agy99 LRGQGPLIGQATTDANQVLLELNPRYETVTADLRAVKDFNDTFSAAAQDI
MLBr_02589|M.leprae_Br4923 LAGLGERFGQSIVNGNSVLDDVNSQLPQARHDIQQLASLGDTYANSASDF
. * * :* : :. :: . :. * ::
Mb3529c|M.bovis_AF2122/97 NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
Rv3499c|M.tuberculosis_H37Rv NTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAI
MAB_4153c|M.abscessus_ATCC_199 VRILDNLPALSRTVVDQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAAL
MSMEG_4794|M.smegmatis_MC2_155 LKTIENTNRISDSIVDEQQNLDAFLVSSIGLADVGNDVIGGNREALSTTL
TH_4437|M.thermoresistible__bu LRTMQNSITLSDGIVDEQDNLDAFLVSAIGLADVGNDVLGGNREAFSEVL
MMAR_4710|M.marinum_M VNTAENAIRISKSIVDEQQNLDAFLISSIGLADVGNDVVGGNRQALTDVL
MAV_0948|M.avium_104 VKTAANATRISKTLVDEQHNLDALLISAIGLADIGNDVLSTNRQPLTNVL
Mflv_4538|M.gilvum_PYR-GCK VDTLDAATTISDTLVAEQGNLDSLLVSVIGLSDIGNEVVGGNRQAITDVM
Mvan_2851|M.vanbaalenii_PYR-1 VDTVEAVTTISQTVIDEQDNLDSLLVSVIGLSDNGIEVVGGNRQAITDVM
MUL_3918|M.ulcerans_Agy99 LDTLNALSTTSTTITGHSTQLDALLLATIGLSNTGISLLAPNQANLIKAI
MLBr_02589|M.leprae_Br4923 FDFLNNSIVTSRTINQQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGA
. : .. :*. *:: :*:.: . . .. :
Mb3529c|M.bovis_AF2122/97 NRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIGVRKAG---------
Rv3499c|M.tuberculosis_H37Rv NRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIGVRKAG---------
MAB_4153c|M.abscessus_ATCC_199 QRLRAPATLLGRYSPEIPCTLQAISKALVTFTPLIGGVRPG---------
MSMEG_4794|M.smegmatis_MC2_155 DLLAPTTDLLNEYAPGLNCALEGMAWVKNQPPQSDPG-------------
TH_4437|M.thermoresistible__bu ELLVPTTNLLNEYAPAINCSLLGMEYVMNQPPLMDPG-------------
MMAR_4710|M.marinum_M DLLVPTSDLLYEYRQALWCGISGSLVNLHAPPLPEPM-------------
MAV_0948|M.avium_104 HLLVPTTDLTNEYAPALTCSFGGLITIAHGPPLSEPS-------------
Mflv_4538|M.gilvum_PYR-GCK ELLIPTTDLLNQYHQALNCGIGGAVQLAKAPGTPVPG-------------
Mvan_2851|M.vanbaalenii_PYR-1 ELLVPTTDLLNRYHTALNCGLGGAVQLAKAPGTPVPG-------------
MUL_3918|M.ulcerans_Agy99 NALEPTTNLLYKYSPEYTCLLEGAKYLLDHGGYEAPGGNGRS--------
MLBr_02589|M.leprae_Br4923 ADLVPTAQLLDTYSPAIFCTLRNYHDIEPKVTSFLGGNGYSINDHVELLS
* .. : * * :
Mb3529c|M.bovis_AF2122/97 ---------------------------LFTSSSFVLGAPSYTYPESLPIV
Rv3499c|M.tuberculosis_H37Rv ---------------------------LFTSSSFVLGAPSYTYPESLPIV
MAB_4153c|M.abscessus_ATCC_199 ---------------------------LFLTNSFPLGAPVYTYPDSLPIV
MSMEG_4794|M.smegmatis_MC2_155 ---------------------------VLVNVAFTLGIERYRYPQNLPKV
TH_4437|M.thermoresistible__bu ---------------------------VLVNVAFTLGIDRYRYPSNLPKV
MMAR_4710|M.marinum_M ---------------------------IKVLVYLGFGAERYRYPSNLPKV
MAV_0948|M.avium_104 ---------------------------INISASLTWGGERYRYPTNLPKV
Mflv_4538|M.gilvum_PYR-GCK ---------------------------GLLLQTVVLGQERYRYPQNLPKV
Mvan_2851|M.vanbaalenii_PYR-1 ---------------------------GLLLQTIVLGQERYRYPQNLPKV
MUL_3918|M.ulcerans_Agy99 ---------------------------LVLDAALALGDDPYRFPDNLPII
MLBr_02589|M.leprae_Br4923 GLGFLLNPTSAISIIGAGVLSQGLLAPLGLAGVVNGAANPYIYPENLPRV
. . * :* .** :
Mb3529c|M.bovis_AF2122/97 NASGGPN----CRGLPDIPTKQTGGSFYRAPFLVTDNALI----------
Rv3499c|M.tuberculosis_H37Rv NASGGPN----CRGLPDIPTKQTGGSFYRAPFLVTDNALI----------
MAB_4153c|M.abscessus_ATCC_199 NASGGPN----CRGLPNIPTKMQNGSWFRSPFLVTDNAYI----------
MSMEG_4794|M.smegmatis_MC2_155 AAKGGPH----CMGLPHIGFGQ------RSKYLVTD---TNAN-------
TH_4437|M.thermoresistible__bu GAKGGPH----CMGLPFIGFGN------RSKYLVTD---VNAN-------
MMAR_4710|M.marinum_M AATGGPQ----CYDLPLVPFDK------APPFVVAD---VGAN-------
MAV_0948|M.avium_104 AATGGPK----CMGLPTLPFNT------NPPQFITD---IGAN-------
Mflv_4538|M.gilvum_PYR-GCK AAKGGPQ----CTDLPRVPFEK------HPPFVITD---VNAN-------
Mvan_2851|M.vanbaalenii_PYR-1 AAKGGPQ----CTDLPKVGFEK------HPPFVITD---VNAN-------
MUL_3918|M.ulcerans_Agy99 GAKGGPGGKPGCGSLPIVDNNW------PVRNLVTN---TGFGTGMDWRP
MLBr_02589|M.leprae_Br4923 NARGGPGGAPGCWQHITRDLWP-------TPELVMDTG------------
* *** * .: :
Mb3529c|M.bovis_AF2122/97 -------------PYQPFTELQVDAPSTLQFLFNGAFAER------DDF-
Rv3499c|M.tuberculosis_H37Rv -------------PYQPFTELQVDAPSTLQFLFNGAFAER------DDF-
MAB_4153c|M.abscessus_ATCC_199 -------------PYKPLEELQVNAPDTLQYLYNGAFAKR------SEF-
MSMEG_4794|M.smegmatis_MC2_155 -------------PWQYGNQGILLNSDGLKQLLFGPLDGP--PRNTAQIG
TH_4437|M.thermoresistible__bu -------------PWQYGNQGIVLNSDGLKQLLFGPLDGP--PRNTAQIG
MMAR_4710|M.marinum_M -------------PMQYGNPQLLLNSDALKQLLYGPIDGP--PRNTMQIG
MAV_0948|M.avium_104 -------------PVGYGNPQLLINSDLLKQLLYGPIAGP--PRNSAQVG
Mflv_4538|M.gilvum_PYR-GCK -------------PAQYGNQGIILNSDGLKQMLFGPIDGP--PRNGGQIG
Mvan_2851|M.vanbaalenii_PYR-1 -------------PAQYGNQGIVLNSDGLKQLLFGPIDGP--PRNTPQIG
MUL_3918|M.ulcerans_Agy99 NPGIGFPGWANYFPVTRGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELY
MLBr_02589|M.leprae_Br4923 ------------NSIAPYNHLDSGSPYAIEYVWGRQVGDN-------TIN
. : . .
Mb3529c|M.bovis_AF2122/97 --------------------------------------------------
Rv3499c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4794|M.smegmatis_MC2_155 MPG-----------------------------------------------
TH_4437|M.thermoresistible__bu QPG-----------------------------------------------
MMAR_4710|M.marinum_M QPG-----------------------------------------------
MAV_0948|M.avium_104 MPG-----------------------------------------------
Mflv_4538|M.gilvum_PYR-GCK HPG-----------------------------------------------
Mvan_2851|M.vanbaalenii_PYR-1 QPG-----------------------------------------------
MUL_3918|M.ulcerans_Agy99 APDGTPLWPGLPPAPPPGAPRESGPTPGSEPFVVPASAQAQPTPLPPAPL
MLBr_02589|M.leprae_Br4923 P-------------------------------------------------
Mb3529c|M.bovis_AF2122/97 --------
Rv3499c|M.tuberculosis_H37Rv --------
MAB_4153c|M.abscessus_ATCC_199 --------
MSMEG_4794|M.smegmatis_MC2_155 --------
TH_4437|M.thermoresistible__bu --------
MMAR_4710|M.marinum_M --------
MAV_0948|M.avium_104 --------
Mflv_4538|M.gilvum_PYR-GCK --------
Mvan_2851|M.vanbaalenii_PYR-1 --------
MUL_3918|M.ulcerans_Agy99 PQEVAPSP
MLBr_02589|M.leprae_Br4923 --------