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MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLAADRSGLVMDSGAKVMMRGVQVGR VAQIGRIEWAQNGASLRLEIDPDQIRYIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKN VSTEINTVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEALNARGDTIGGNWRSL KNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLDALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPT TSLLFKYNPEYTCFLQGAKWYLDNGGYAAWGGADGRTLQLDVALLFGNDPYVYPDNLPVVAAKGGPGGRP GCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRAVPEPPSIRQCIPGPAIGPNPA AGEQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1966 | mce3A | - | 100% (425) | MCE-FAMILY PROTEIN MCE3A |
| M. tuberculosis H37Rv | Rv0589 | mce2A | 2e-58 | 36.51% (378) | MCE-family protein MCE2A |
| M. tuberculosis H37Rv | Rv0169 | mce1A | 2e-54 | 32.26% (403) | MCE-family protein MCE1A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0604 | mce2A | 2e-58 | 36.51% (378) | MCE-family protein MCE2A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 1e-147 | 63.44% (413) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02589 | mce1A | 6e-57 | 34.41% (401) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-55 | 36.63% (344) | MCE-family protein |
| M. marinum M | MMAR_2882 | mce3A | 0.0 | 79.95% (419) | MCE-family protein Mce3A |
| M. avium 104 | MAV_2532 | - | 1e-126 | 59.16% (382) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-145 | 61.15% (417) | virulence factor |
| M. thermoresistible (build 8) | TH_2548 | - | 1e-149 | 63.33% (409) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-144 | 62.02% (416) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_0363 | - | 1e-175 | 70.71% (420) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
MMAR_2882|M.marinum_M ---MGRGPGKHRLHDAWWTVILFAAIVAAILVTTVSFTGTLRPHVAVTLT
Mvan_0363|M.vanbaalenii_PYR-1 ---MTVRAGENRLHSCWWALILVAALSVFVAATAAAFTGIFRSYVPVTLT
TH_2548|M.thermoresistible__bu -------------------VILVAAVTVFIVVTSAFFRGAFTATVPVTLS
Mflv_2101|M.gilvum_PYR-GCK -----MDD--DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKSTVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
Mb0604|M.bovis_AF2122/97 -MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTPKTELTMV
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
MAB_4153c|M.abscessus_ATCC_199 -----MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
:*:
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEW-AQNGASLRLEIDPDQIR
MMAR_2882|M.marinum_M SERSGLVMDAGAKVMLRGVQVGRVRQID-----SNHGASLELEIDPDQIR
Mvan_0363|M.vanbaalenii_PYR-1 SDRAGLVMENGARVKMRGVQVGRVAEIRG----GTGPAELLLEIDPEQIA
TH_2548|M.thermoresistible__bu AERSGIILEPNAKVKMRGVEVGKVAHVEA----TGGAAQVRLELFPEQLA
Mflv_2101|M.gilvum_PYR-GCK SDRAGLVMETNAKVKLRGVQVGRVSDISVTGR-QDPTVALQLEIDPDQVQ
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGK-GATPVALTLEIDSDQIR
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSGD-----PVTLRLELYPEQLQ
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIRGGAS-G---VSLQLEIEPDQIR
Mb0604|M.bovis_AF2122/97 ASRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLDVNPRYIS
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNAKDLR
: *:*:::: ..:: .*:::*:* : . . * : . :
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
MMAR_2882|M.marinum_M YIPANVEAQISATTAFGAKFVDLVIPPTPSRARLAAGAVLHSKNVSTEIN
Mvan_0363|M.vanbaalenii_PYR-1 RIPANVQAQISVTTAFGSKFVDLVPPEHPSTDRLAAGAVLMSTNVSTEVN
TH_2548|M.thermoresistible__bu RIPANVMAEIDSTTAFGAKFVNLVYPDNPSEERLTAGAVLHADRVATEVN
Mflv_2101|M.gilvum_PYR-GCK YIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSRNVTTEVN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
Mb0604|M.bovis_AF2122/97 LIPVNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVGSVTTEFN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
** *. . * :* ** * * : * * : . .: *: * *
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
MMAR_2882|M.marinum_M TVFENVVDLLNMIDPLKLNAVLSAVAEGVRGQGERIGQATTDLNQVLQAL
Mvan_0363|M.vanbaalenii_PYR-1 TVFENIVDLLDMVDPAKLNAVLSAIADAVRGQGPRMGEATTGLNEVLTAL
TH_2548|M.thermoresistible__bu TVFENVVELIGMIDPAKLNAVLSATAEAVRGQGERIGEATTALSEVLQAV
Mflv_2101|M.gilvum_PYR-GCK TVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDANQVLLAL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
Mb0604|M.bovis_AF2122/97 TLFETITSIAEKVDPIELNATLSAVAQAPDGLGGKFGESIVNGNQILAQL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
*:*:.:. : :*. :** .*:* .:. * * :*.. . .. * :
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
MMAR_2882|M.marinum_M NARRDTLRQNWRSLRDFSNTYDAAARDILTILDAASTTSTTVVDHARSLD
Mvan_0363|M.vanbaalenii_PYR-1 NARSDTIRGDWRSFKGFNDTYNAVAEDIVAILDGASTTSSTVVAHSAQLD
TH_2548|M.thermoresistible__bu NDRSGLIREDWRAFKAFNDTYAAVAEDLLTVLDAASVTSETLVDHSAALD
Mflv_2101|M.gilvum_PYR-GCK NPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVVNQAKELD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
Mb0604|M.bovis_AF2122/97 NPRLPQLGYDVRRLADLGEVYVDASPDLWSFLQNALTTARTLTSQQRDLD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
* : : : . : : :: *: . : *: : *.
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
MMAR_2882|M.marinum_M SLLLNVIGLADTGTNLLANNRESLTTSINILEPTTNLLFKYNPEYTCLLQ
Mvan_0363|M.vanbaalenii_PYR-1 TLLLNVTGFAESGTNLLTTSKDSLVDAVNTLAPTTALLHKYDPIYTCWLQ
TH_2548|M.thermoresistible__bu ALLLSVTGFGRAGSGLLEESRDDLVTAARVLEPTTALLHRYSPSYTCLLQ
Mflv_2101|M.gilvum_PYR-GCK ALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSPSYTCLLL
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
Mb0604|M.bovis_AF2122/97 AALLAATGAGNTGEDVFARGGPYLARAAADLVPTATLLDTYSPELFCMIR
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
** . * . * : * . : ..: ** *.* * :
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGADGRT-----------------------------
MMAR_2882|M.marinum_M GTKWYLDNGGYAAWGGADGRT-----------------------------
Mvan_0363|M.vanbaalenii_PYR-1 GATWFLENGGWDVWGGANGKS-----------------------------
TH_2548|M.thermoresistible__bu GAQLLLENGAYDVYGGADGRS-----------------------------
Mflv_2101|M.gilvum_PYR-GCK GAKHLLDEGGYEAPG-GNGRT-----------------------------
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPG-GNGRS-----------------------------
MAV_2532|M.avium_104 GSKYDAEFFGDVAGG-HNGYS-----------------------------
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFG-GNGRS-----------------------------
Mb0604|M.bovis_AF2122/97 NFHDAAPKVADAVGGNGYS-------------------------------
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNPTSAISIIGAGVLSQ
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIGGVRPG-------------------------------
* .
Rv1966|M.tuberculosis_H37Rv -----LQLDVALLFGNDPYVYPDNLPVVAAKGGP--GGRPGCGPLPDATH
MMAR_2882|M.marinum_M -----LQLDVALLLGNDPYVFPDNLPLVAARGGP--GGAPGCGSLPDATK
Mvan_0363|M.vanbaalenii_PYR-1 -----IQLDIALLAGNDPYRFPDNLPRIAAKGGP--GGAPGCGSLPDATK
TH_2548|M.thermoresistible__bu -----LIFDVGLLPGNDLYEYPRHLPVVAAKGGP--GGRPGCGSLPDVAE
Mflv_2101|M.gilvum_PYR-GCK -----LVLDTSLSFGDDPYQYPRHLPIIGAKGGP--GGKPGCGSLPKVAE
MUL_3918|M.ulcerans_Agy99 -----LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCGSLPIVDN
MAV_2532|M.avium_104 -----VTLDVALLLGDEAYRYPDNLPINGAKGGP--GGQPGCGSLPDVSK
MSMEG_0346|M.smegmatis_MC2_155 -----AIFDIGLLLGNDPYHYPDDLPIVGAKGGP--GGKPGCGSLPDVAK
Mb0604|M.bovis_AF2122/97 -----LAAAGTILGAPNPYVYPDNLPRVNAHGGP--GGRPGCWQTITREL
MLBr_02589|M.leprae_Br4923 GLLAPLGLAGVVNGAANPYIYPENLPRVNARGGP--GGAPGCWQHITRDL
MAB_4153c|M.abscessus_ATCC_199 -----LFLTNSFPLGAPVYTYPDSLPIVNASGGPNCRGLPNIPTKMQNGS
. . * :* ** * *** * *.
Rv1966|M.tuberculosis_H37Rv NFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRAVPEPPSIRQCI
MMAR_2882|M.marinum_M NFPVRQLVTDTGWGTGLDIRPNPGIGHPCWADYLPVTRAVPQPPSVRPCL
Mvan_0363|M.vanbaalenii_PYR-1 NFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRAVPEQPSIRQCI
TH_2548|M.thermoresistible__bu NFPVRKLITDTGWGTGLDIRPNPGIGSPCFANWFPVTRAVPEPPSIRTCL
Mflv_2101|M.gilvum_PYR-GCK NWPVRNLVTNTGFGSGLDWRPNPGIAFPTYANYLPVTRAVPEPPSVRNLF
MUL_3918|M.ulcerans_Agy99 NWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLF
MAV_2532|M.avium_104 NFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLPVTRGTPQPPSLR-HP
MSMEG_0346|M.smegmatis_MC2_155 NFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFPVTRGIPQPPIIRNLG
Mb0604|M.bovis_AF2122/97 WP-APYLVMDTG------------------ASLAPYNHVELGQPMFTEYV
MLBr_02589|M.leprae_Br4923 WP-TPELVMDTG------------------NSIAPYNHLDSGSPYAIEYV
MAB_4153c|M.abscessus_ATCC_199 WFRSPFLVTDNAY-----------------IPYKPLEELQVNAPDTLQYL
*: :.. * . *
Rv1966|M.tuberculosis_H37Rv PGPAIG--PNP----------------------AAGEQP-----------
MMAR_2882|M.marinum_M PGPAIG--PNPGGPPYGAALYGPGGVPLWPGVPPAPTEP-----------
Mvan_0363|M.vanbaalenii_PYR-1 PGPAIGPVPYPGAPPYGAALYGPGGTPLWPGLPPAPPPP-----------
TH_2548|M.thermoresistible__bu PGPAIGPVPYPGAPPYGAPMYGPGGVPLWPGVPPAGPEP-----------
Mflv_2101|M.gilvum_PYR-GCK GGPAIGPIPYPGAPAYGAQLYAPDGTPLWPGLPPAPPPG--APRDPGPRP
MUL_3918|M.ulcerans_Agy99 GGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPAPPPG--APRESGPTP
MAV_2532|M.avium_104 GGTAPGPMPYPGAPPYGAPQYAPDGTPLYPGLPPAPPPG--RPRDAGPPP
MSMEG_0346|M.smegmatis_MC2_155 GGPAPGPIPYPGAPPYGADLYADDGTPLWPGLPPAPPPSDQPPPDPNNPP
Mb0604|M.bovis_AF2122/97 WGRQYGENTINP--------------------------------------
MLBr_02589|M.leprae_Br4923 WGRQVGDNTINP--------------------------------------
MAB_4153c|M.abscessus_ATCC_199 YNGAFAKRSEF---------------------------------------
. . .
Rv1966|M.tuberculosis_H37Rv -------------------------------------
MMAR_2882|M.marinum_M ---APIPEPLAPQQETETPSP----------------
Mvan_0363|M.vanbaalenii_PYR-1 ---TQEGAPAP--------------------------
TH_2548|M.thermoresistible__bu ---GPAQPDSNGQTPP---------------------
Mflv_2101|M.gilvum_PYR-GCK -GSEPFVVPHPSQMQPTAVPYPFVPPPVPAQPGPPR-
MUL_3918|M.ulcerans_Agy99 -GSEPFVVPASAQAQPTPLP----PAPLPQEVAPSP-
MAV_2532|M.avium_104 AGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVPGP
MSMEG_0346|M.smegmatis_MC2_155 PGAEPFVPPAPAAMTPTQ-------------------
Mb0604|M.bovis_AF2122/97 -------------------------------------
MLBr_02589|M.leprae_Br4923 -------------------------------------
MAB_4153c|M.abscessus_ATCC_199 -------------------------------------