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MSSDIVGYGVSAQANDGTLVELLRRLPATTEVELAQREIDPGSSVLDLGAGVGRIANPLAKLGYRVTAVD DSAALLDEVRGARTVCARIEELELGQRFDAVLLASSLINYPGTELRRAVLATVAGHLEPAGKALIQWRSP SWFASMQQGGSHRFVDGPLTRTMDVKSDRDGVLEGTVSFELDGQLWRQPVRAQRLTCAQIRDELHSAGMQ LETSEPEKAEWLVASPHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4482 | - | - | 100% (228) | methyltransferase |
| M. marinum M | MMAR_1596 | - | 2e-54 | 51.64% (213) | hypothetical protein MMAR_1596 |
| M. marinum M | MMAR_1164 | - | 1e-07 | 29.82% (114) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3374 | - | 3e-05 | 36.00% (100) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4890 | - | 3e-08 | 26.97% (152) | methyltransferase type 12 |
| M. tuberculosis H37Rv | Rv3342 | - | 3e-05 | 36.00% (100) | methyltransferase (methylase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2548c | - | 3e-09 | 30.70% (114) | hypothetical protein MAB_2548c |
| M. avium 104 | MAV_4332 | - | 1e-07 | 31.07% (103) | SAM-dependent methyltransferases |
| M. smegmatis MC2 155 | MSMEG_3430 | - | 7e-08 | 29.82% (114) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1247 | - | 2e-07 | 28.07% (114) | SAM-dependent methyltransferase |
| M. ulcerans Agy99 | MUL_2851 | - | 7e-08 | 29.82% (114) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1534 | - | 2e-08 | 30.70% (114) | methyltransferase type 12 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4332|M.avium_104 MVEQSIWMQKVAADPGHSHWYIERFRAMARAGDDLAGEARFVDAMAPRGA
Mvan_1534|M.vanbaalenii_PYR-1 MVETSIWMQKVAADPGHSRWYIERFRAMARAGDDLAGEARLVDAMAPRGA
MUL_2851|M.ulcerans_Agy99 MVEQSIWMQKVAADPGHSRWYIERFRAMARAGEDLVGEARLVDSIAPRGA
MSMEG_3430|M.smegmatis_MC2_155 MVEQSLWMQKVAADPGHSQWYIERFRSLARAGEDLFGEARLVDAMAPRNA
TH_1247|M.thermoresistible__bu MVEKSLWMRKVEADPGHSQWYIERFRAMARAGEDLVGEARLVDAMAPRNA
MAB_2548c|M.abscessus_ATCC_199 MVEQSLWMQKVAADPNHSQWYIDRFRSMARDGADLAGEARLVDALVPRGA
Mflv_4890|M.gilvum_PYR-GCK MAETSLWMQKVAADPGHSRWYIERFRAMARAGDDLFGEARLIDAMVPRGA
Mb3374|M.bovis_AF2122/97 ---------MTCSRRDMSLSFGSAVGAYERGRPSYPPEA--IDWLLPAAA
Rv3342|M.tuberculosis_H37Rv ---------MTCSRRDMSLSFGSAVGAYERGRPSYPPEA--IDWLLPAAA
MMAR_4482|M.marinum_M -------MSSDIVGYGVSAQANDGTLVELLRRLPATTEVELAQREIDPGS
. * . *. : :
MAV_4332|M.avium_104 R-ILDAGCGPGRLGSYLAAAGHQVVGVDVDPALIEAAEHDHPGPRWLVGD
Mvan_1534|M.vanbaalenii_PYR-1 R-ILDAGCGPGRVGGYLAAAGHQVVGVDVDPALIEAAEQDYPGPRWLVGD
MUL_2851|M.ulcerans_Agy99 H-ILDAGCGPGRLGRHLAAAGHRVVGVDVDPALIEAAEQDYPGPQWLVGD
MSMEG_3430|M.smegmatis_MC2_155 H-ILDAGCGPGRLGGYLAGVGHRVVGVDVDPALIAAAEEDYPGPRWLVGD
TH_1247|M.thermoresistible__bu H-ILDAGCGPGRLGGYLSAAGHRVVGVDVDPALIEAAEQDYPGPQYLVGD
MAB_2548c|M.abscessus_ATCC_199 R-ILDAGCGAGRVGGFLAAAGHHVVGVDVDPALIEAAEHDHPGPRWLVGD
Mflv_4890|M.gilvum_PYR-GCK R-ILDAGCGPGRLGGYLAAAGHHVVGVDVDPVLIDAAEKDHPGATWLVGD
Mb3374|M.bovis_AF2122/97 RRVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDVLRAALPQTVALLGT
Rv3342|M.tuberculosis_H37Rv RRVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDVLRAALPQTVALLGT
MMAR_4482|M.marinum_M S-VLDLGAGVGRIANPLAKLGYRVTAVDDSAALLDEVR----GARTVCAR
:** *.* *:: * * *..** . :: . . : .
MAV_4332|M.avium_104 LAELDL------------------PARGITDPFDVIVSAGNV-MTFLAPS
Mvan_1534|M.vanbaalenii_PYR-1 LAELDL------------------PARGITEPFDLIVSAGNV-MTFLAPS
MUL_2851|M.ulcerans_Agy99 LAELDL------------------PARGIAEPFDVIVSAGNV-MTFLAPS
MSMEG_3430|M.smegmatis_MC2_155 LAELDL------------------PARGIAEPFDIIVSAGNV-MTFLAPS
TH_1247|M.thermoresistible__bu LAELDL------------------PARGIPDPFDVIVMAGNV-MAFLAPS
MAB_2548c|M.abscessus_ATCC_199 LAELDL------------------PSRGISEPFDVIVSAGNV-MAFLAPS
Mflv_4890|M.gilvum_PYR-GCK LAELDL------------------PARGIAEPFDVIVSAGNV-MTFLAPS
Mb3374|M.bovis_AF2122/97 AEEIPLDDNSVDAVLVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRD
Rv3342|M.tuberculosis_H37Rv AEEIPLDDNSVDAVLVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRD
MMAR_4482|M.marinum_M IEELELG-----------------------QRFDAVLLASSL-INYPGTE
*: * : : .. : : : .
MAV_4332|M.avium_104 TRVLVLSRLRAHLAADGRAAIG-------FGAYR--EYEFTD------FL
Mvan_1534|M.vanbaalenii_PYR-1 TRVQVLARLRAHLRDDGRAVIG-------FGAGR--EYEYPQ------FL
MUL_2851|M.ulcerans_Agy99 TRARVLGRLRAHLCSDGRAVIG-------FGAGR--DYAFAD------FL
MSMEG_3430|M.smegmatis_MC2_155 TRAQVLSRLRAHLTDNGRAVIG-------FGAGR--DYGFEE------FL
TH_1247|M.thermoresistible__bu TRTTVLSRLRAHLAEDGRAAIG-------FGAGR--DYDFDE------FL
MAB_2548c|M.abscessus_ATCC_199 TRRQVLRRLRSHLADPGRAVIG-------FGAGR--DYEFSE------FL
Mflv_4890|M.gilvum_PYR-GCK TRGEVLRRLRTHLAAEGRAVIG-------FGADR--DYDFAE------FL
Mb3374|M.bovis_AF2122/97 ERLGWVRELGEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTN------YL
Rv3342|M.tuberculosis_H37Rv ERLGWVRELGEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTN------YL
MMAR_4482|M.marinum_M LRRAVLATVAGHLEPAGKALIQWRSPSWFASMQQGGSHRFVDGPLTRTMD
* : : : * . : . : :
MAV_4332|M.avium_104 NDAADAGFAP-----------------DLLLSSWDLRPFTEDSD------
Mvan_1534|M.vanbaalenii_PYR-1 DDAAAGGLTP-----------------DLLLSTWDVRPFTDDSD------
MUL_2851|M.ulcerans_Agy99 DDAQAAGLVP-----------------DLLLSTWDLRPFTDDCD------
MSMEG_3430|M.smegmatis_MC2_155 ADAKGAGFTP-----------------DQLLSTWDVRPFSEDSD------
TH_1247|M.thermoresistible__bu ADAATAGLTP-----------------DLLLSTWDLRPFTEDSE------
MAB_2548c|M.abscessus_ATCC_199 SDADAAGLVP-----------------DLLLSTWDLRPFTDKSD------
Mflv_4890|M.gilvum_PYR-GCK DDAAGAGFVP-----------------DLLLSTWDLRPWREDSG------
Mb3374|M.bovis_AF2122/97 TPQALIDLVASRSYCITSPAQVRTKTLDRVRQLLATHPALANSNGLALP-
Rv3342|M.tuberculosis_H37Rv TPQALIDLVASRSYCITSPAQVRTKTLDRVRQLLATHPALANSNGLALP-
MMAR_4482|M.marinum_M VKSDRDGVLEGTVSFELDGQLWRQPVRAQRLTCAQIRDELHSAGMQLETS
.. : ..
MAV_4332|M.avium_104 ------FLVAVLRPA----
Mvan_1534|M.vanbaalenii_PYR-1 ------FLVAVLRPA----
MUL_2851|M.ulcerans_Agy99 ------FLVALLRPA----
MSMEG_3430|M.smegmatis_MC2_155 ------FLVAILRRA----
TH_1247|M.thermoresistible__bu ------FLVALLRRA----
MAB_2548c|M.abscessus_ATCC_199 ------FLVALLRRDDAPS
Mflv_4890|M.gilvum_PYR-GCK ------FLVAVLRRM----
Mb3374|M.bovis_AF2122/97 ------YVTVCVRATLA--
Rv3342|M.tuberculosis_H37Rv ------YVTVCVRATLA--
MMAR_4482|M.marinum_M EPEKAEWLVASPHR-----
::.. :