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PVHAEELNMHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDEGPIDGPPIVLLHGEPTWSYLY RTMITPLTDAGNRVLAPDLIGFGRSDKPSRIEDYSYQRHVDWVVSWFEHLNLSDVTLFVQDWGSLIGLRI AAEQPDRVGRLVVANGFLPTAQRRTPPAFYAWRAFARYSPVLPAGRIVSVGTVRRVSSKVRAGYDAPFPD KTYQAGARAFPQLVPTSPADPAIPANRKAWEALGRWEKPFLAIFGARDPILGHADSPLIKHIPGAAGQPH ARINASHFIQEDRGPELAERILSWQQALL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2130 | - | - | 100% (310) | haloalkane dehalogenase |
| M. avium 104 | MAV_0357 | - | 7e-76 | 48.66% (298) | haloalkane dehalogenase |
| M. avium 104 | MAV_5163 | - | 1e-14 | 30.23% (172) | hydrolase, alpha/beta fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2318 | - | 1e-148 | 82.94% (299) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4004 | - | 4e-35 | 57.72% (123) | haloalkane dehalogenase |
| M. tuberculosis H37Rv | Rv2296 | - | 1e-148 | 82.94% (299) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-05 | 29.47% (95) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 5e-15 | 30.07% (143) | epoxide hydrolase EphA |
| M. marinum M | MMAR_3472 | - | 1e-142 | 79.12% (297) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6314 | - | 3e-75 | 48.32% (298) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_1615 | linB | 1e-19 | 30.95% (294) | POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE |
| M. ulcerans Agy99 | MUL_3052 | - | 2e-28 | 31.79% (302) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 7e-94 | 55.93% (295) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2318|M.bovis_AF2122/97 ---------MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDE
Rv2296|M.tuberculosis_H37Rv ---------MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDE
MAV_2130|M.avium_104 MPVHAEELNMHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDE
MMAR_3472|M.marinum_M ---------MDVVRTPDARFQNLVGYPFAAHYVDVAATDTPHLRMHYIDE
Mflv_4004|M.gilvum_PYR-GCK ---------MDVLRTPYERFTDLPGFPFDPHYVEVGG-----LRMHYLDE
Mvan_2384|M.vanbaalenii_PYR-1 ---------MDILRTPDERFADLPDFPFAPHYVEVDG-----LRMHYLDE
MSMEG_6314|M.smegmatis_MC2_155 ---------MQTLRTPDERFAQLPEFPYAPMYCDIDDGEGGRLRVAWVED
MUL_3052|M.ulcerans_Agy99 ---------MGRQFTPD-FTPDPKLYPFASRWFDSSRG-----RLHYIDE
TH_1615|M.thermoresistible__bu --------------MPGSKPYG------EPRFREIKNK-----RMAYIDE
MAB_0528c|M.abscessus_ATCC_199 ----------------------MTDAAVDIRERDIATNG---VHLRIVEA
MLBr_00862|M.leprae_Br4923 ------------------MPATQSIHKVPHQFVESPDG----VRLAIYQS
: :: :
Mb2318|M.bovis_AF2122/97 GPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSD--K
Rv2296|M.tuberculosis_H37Rv GPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSD--K
MAV_2130|M.avium_104 GPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPDLIGFGRSD--K
MMAR_3472|M.marinum_M GPADGPPIVLLHGEPTWSYLYRTMIPPLAAGGYRVLAPDLIGFGRSD--K
Mflv_4004|M.gilvum_PYR-GCK GPAGGDVVLLLHGEPSWSYLYRTMIPVLVDAGLRAVAIDLVGFGRSD--K
Mvan_2384|M.vanbaalenii_PYR-1 GPADGPVVLLLHGEPSWSYLYRRMIPVLVDAGLRAVAIDLVGFGRSD--K
MSMEG_6314|M.smegmatis_MC2_155 GPAHAEPVLLLHGEPSWSFLYRKMIPILVAAGHRVICPDLVGFGRSD--K
MUL_3052|M.ulcerans_Agy99 --SDGPPILLCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSE--H
TH_1615|M.thermoresistible__bu G--EGDAIVFQHGNPTSSYLWRNVLP-HLEGLGRLVACDLIGMGGSEKLS
MAB_0528c|M.abscessus_ATCC_199 GEPGQPAVILSHGFPELAYSWRHQIPALAAAGYHVIAPDQRGYGRSS--M
MLBr_00862|M.leprae_Br4923 GQPEGPAIVLVHGFPDSHVLWDGVVP-LLAKRFRIVRYDNRGVGQSS--V
::: ** * : : : : * * * *.
Mb2318|M.bovis_AF2122/97 PTRIEDYTYLRHVEWVTS-WFENLDLHDVTLFVQDWGSLIGLRIAAEH--
Rv2296|M.tuberculosis_H37Rv PTRIEDYTYLRHVEWVTS-WFENLDLHDVTLFVQDWGSLIGLRIAAEH--
MAV_2130|M.avium_104 PSRIEDYSYQRHVDWVVS-WFEHLNLSDVTLFVQDWGSLIGLRIAAEQ--
MMAR_3472|M.marinum_M PTRIADYTYLRHVEWVKS-WFEELRLAEATLFVQDWGSLIGLRVAAEH--
Mflv_4004|M.gilvum_PYR-GCK PADRADYTYQAHVDWTWG-AVAALGLADITLVCQD---------------
Mvan_2384|M.vanbaalenii_PYR-1 PTRREDYTYQAHVDWTWA-AIEAIGLTGITLVCQDWGGLIGLRLVGEH--
MSMEG_6314|M.smegmatis_MC2_155 PTRIEDHTYARHVEWMRSLVFDALDLRKVTLVGQDWGGLIGLRLAAEH--
MUL_3052|M.ulcerans_Agy99 PGTFG-YKVDEHAQVVGE-FVDHLGLDNYLTMGQDWGGPISMAVAVER--
TH_1615|M.thermoresistible__bu PSGPDRYHYGEHRDYLFALWEELELGDRVVLVLHDWGSVLGFDWANHH--
MAB_0528c|M.abscessus_ATCC_199 PAHIDDYNIEALSDDLLG-ILDDVGAGKATFVGHDWGAVVTWHTALAV--
MLBr_00862|M.leprae_Br4923 PKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGA
* : : . :*
Mb2318|M.bovis_AF2122/97 GDRIARLVVANG-----FLPAA-----QGRTPLPF-------YVWR----
Rv2296|M.tuberculosis_H37Rv GDRIARLVVANG-----FLPAA-----QGRTPLPF-------YVWR----
MAV_2130|M.avium_104 PDRVGRLVVANG-----FLPTA-----QRRTPPAF-------YAWR----
MMAR_3472|M.marinum_M GDAIARLVVANG-----FLPTA-----RGRTPTAF-------HIWR----
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 PDRFARVVAANT-----TLPTG-----DQRPGEAF-------LAWQ----
MSMEG_6314|M.smegmatis_MC2_155 PDRFANIVVANT-----GLPTG-----DIPMPDIW-------WQFR----
MUL_3052|M.ulcerans_Agy99 AERVRGIVLGNT-----WFWPA-----DTLTMKAF-------STVMSSLP
TH_1615|M.thermoresistible__bu RDRVQGIAHMES-----IVTPLTWADWEDPARSVF-------QGLRTP-E
MAB_0528c|M.abscessus_ATCC_199 PERVSGVVGLSV-----PFTRRSQVPPTQAWNKLFGDNFFYILYFQEPGV
MLBr_00862|M.leprae_Br4923 SDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVL
Mb2318|M.bovis_AF2122/97 -AFARYSPVLPAGRLVNFGTVHRVPA------------------------
Rv2296|M.tuberculosis_H37Rv -AFARYSPVLPAGRLVNFGTVHRVPA------------------------
MAV_2130|M.avium_104 -AFARYSPVLPAGRIVSVGTVRRVSS------------------------
MMAR_3472|M.marinum_M -AFARYSPVLPAGRLVAAGTVRKVPP------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 -RFSQETPDFAVGHIVNGGCVSTLAP------------------------
MSMEG_6314|M.smegmatis_MC2_155 -NAIQKAPKVDVGRFVASGCRRPLSD------------------------
MUL_3052|M.ulcerans_Agy99 MQYAILHHNFFVERLIPAGTTHRPSS------------------------
TH_1615|M.thermoresistible__bu GERMVLEENIFVEAMLPRGVHRTLSD------------------------
MAB_0528c|M.abscessus_ATCC_199 ADADLNRDPATTMRRMMAGMARIDGA------------------------
MLBr_00862|M.leprae_Br4923 FSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTY
Mb2318|M.bovis_AF2122/97 ----------------------------GVRAGYDAPFPDK-TYQAGARA
Rv2296|M.tuberculosis_H37Rv ----------------------------GVRAGYDAPFPDK-TYQAGARA
MAV_2130|M.avium_104 ----------------------------KVRAGYDAPFPDK-TYQAGARA
MMAR_3472|M.marinum_M ----------------------------AVRAGYDAPFPDK-SYQAGARA
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 ----------------------------EVIAAYDAPFPDD-SYKAGARQ
MSMEG_6314|M.smegmatis_MC2_155 ----------------------------GVIAAYDAPFPDD-SYCAGPRA
MUL_3052|M.ulcerans_Agy99 ----------------------------AVMEHYRGVQPTA-SARVGVAE
TH_1615|M.thermoresistible__bu ----------------------------EEMAHYREPFRDRGEGRRPTLT
MAB_0528c|M.abscessus_ATCC_199 ----------------------------TMIAPGPAGFVERMPDPGELPE
MLBr_00862|M.leprae_Br4923 PANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRL
Mb2318|M.bovis_AF2122/97 FPRLVPTSPDDPAVPAN----------------RAAWEALGRW-------
Rv2296|M.tuberculosis_H37Rv FPRLVPTSPDDPAVPAN----------------RAAWEALGRW-------
MAV_2130|M.avium_104 FPQLVPTSPADPAIPAN----------------RKAWEALGRW-------
MMAR_3472|M.marinum_M FPQLVPISPDDPAVAAN----------------RAAWDALGRW-------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 FPTLVPTSPDDPAAPAN----------------RAAWEVLRTF-------
MSMEG_6314|M.smegmatis_MC2_155 MPGLVPTSPDDPAAEAN----------------RAAWKVLRAS-------
MUL_3052|M.ulcerans_Agy99 MPKQILAARPLLARLAS----------------EVPAQLG----------
TH_1615|M.thermoresistible__bu WPRNVPIDGEPADVAAI----------------VADYAVWLAEG------
MAB_0528c|M.abscessus_ATCC_199 WLSQDELDHYITEFARTGFTGGLNWYRNFDRNWALTERLAGANV------
MLBr_00862|M.leprae_Br4923 WRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDT
Mb2318|M.bovis_AF2122/97 -DKPFLAIFGYRDPILGQADGPLIK----------HIPGAAGQPHARIKA
Rv2296|M.tuberculosis_H37Rv -DKPFLAIFGYRDPILGQADGPLIK----------HIPGAAGQPHARIKA
MAV_2130|M.avium_104 -EKPFLAIFGARDPILGHADSPLIK----------HIPGAAGQPHARINA
MMAR_3472|M.marinum_M -EKPFLAIFGERDPLLGRADRPLIK----------HIPGAAGQPHARINA
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 -DRPFLCAFSDSDPITRGADAPLRK----------FIPGAQGRPEVTIAG
MSMEG_6314|M.smegmatis_MC2_155 -KTPMLVAFSDGDPITGGMAPIFKK----------EMRGAHGIEHPVISG
MUL_3052|M.ulcerans_Agy99 -TKPALLVWGMKDFAFR-PEPMLAR----------MRAVFADHILVELPE
TH_1615|M.thermoresistible__bu -DVPKLFVNAEPGAIVRGRVRDFVR----------SWP---NQTEITVAG
MAB_0528c|M.abscessus_ATCC_199 -VVPSLFIAGAADPVLGFTDHAGSA----------KYR-TDNRGDLLIDG
MLBr_00862|M.leprae_Br4923 FGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVAS
Mb2318|M.bovis_AF2122/97 S-HFIQEDSGTELAERMLSWQQAT--------------------------
Rv2296|M.tuberculosis_H37Rv S-HFIQEDSGTELAERMLSWQQAT--------------------------
MAV_2130|M.avium_104 S-HFIQEDRGPELAERILSWQQALL-------------------------
MMAR_3472|M.marinum_M N-HFIQEDSGPELAERIISWQ-----------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 GGHFLQEDKGPELAAVVVDFIAANPV------------------------
MSMEG_6314|M.smegmatis_MC2_155 AGHFLQEDAGEDLASAVVEFLRDR--------------------------
MUL_3052|M.ulcerans_Agy99 AKHLIQEDAPDEIAAAIIARFG----------------------------
TH_1615|M.thermoresistible__bu R-HYIQEDSPDEIGAAIADFVRKLRG------------------------
MAB_0528c|M.abscessus_ATCC_199 AGHWIQQERPLEVNAALLAFLREVVH------------------------
MLBr_00862|M.leprae_Br4923 GGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTP
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MMAR_3472|M.marinum_M --------------------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6314|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSL
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MMAR_3472|M.marinum_M --------------------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6314|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPT
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MMAR_3472|M.marinum_M --------------------------------------------------
Mflv_4004|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6314|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYA
Mb2318|M.bovis_AF2122/97 ---------------------
Rv2296|M.tuberculosis_H37Rv ---------------------
MAV_2130|M.avium_104 ---------------------
MMAR_3472|M.marinum_M ---------------------
Mflv_4004|M.gilvum_PYR-GCK ---------------------
Mvan_2384|M.vanbaalenii_PYR-1 ---------------------
MSMEG_6314|M.smegmatis_MC2_155 ---------------------
MUL_3052|M.ulcerans_Agy99 ---------------------
TH_1615|M.thermoresistible__bu ---------------------
MAB_0528c|M.abscessus_ATCC_199 ---------------------
MLBr_00862|M.leprae_Br4923 LYGISRVLPQVLRSTARIRVI