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DAITQVPIPANEPVHSYAPHSPERSRLKSELIALAQQPIDLPHVIGGKHRMGDGERIDVVQPHRHAERLG TLTNAVHADATAAIEAAMAAKNGWAAMPFDERAGVFLRAADLLAGPWREKIAAATMLGQSKSAYQAEIDA PCELVDFWRFNVAFARQILDQQPVSAKGEWNRTDHRPLEGFVYAITPFNFTAIAANLPTAPALMGNTVVW KPSVTQTLAAYLTMQALEAAGLPPGVINLVTGDGLAVSDVALTDPRLAGIHFTGSTATFQHLWQQVGANI ASYQSYPRLVGETGGKDFVVAHSSARPEVVATALIRGAFEYQGQKCSAASRAFIPHSVWQQMGDTFLDTA AGLKYGDITDLSNFGGALIDRRAFIKNVDAIERAKGAAGVTIAVGGEYDDSVGYFVRPTVLLSDDPTDES FATEYFGPVLSLHVYPDDQYERILDVIDTGSRYALTGAVIADDRNAVLTAQNRLRFAAGNFYINDKPTGA VVGRQPFGGSRGSGTNDKAGSPQNLLRWTSTRTIKETFVPATDHTYPHMESD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4253 | rocA | - | 100% (543) | pyrroline-5-carboxylate dehydrogenase, RocA |
| M. marinum M | MMAR_3556 | - | 2e-35 | 30.80% (461) | aldehyde dehydrogenase NAD dependent |
| M. marinum M | MMAR_2875 | - | 4e-34 | 28.18% (511) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1219 | rocA | 0.0 | 84.90% (543) | pyrroline-5-carboxylate dehydrogenase ROCA |
| M. gilvum PYR-GCK | Mflv_0667 | - | 2e-38 | 28.97% (497) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv1187 | rocA | 0.0 | 84.90% (543) | pyrroline-5-carboxylate dehydrogenase ROCA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 9e-22 | 28.53% (375) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1330 | - | 0.0 | 74.59% (543) | pyrroline-5-carboxylate dehydrogenase RocA |
| M. avium 104 | MAV_1331 | pruA | 0.0 | 84.80% (546) | 1-pyrroline-5-carboxylate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5119 | pruA | 0.0 | 80.63% (542) | 1-pyrroline-5-carboxylate dehydrogenase |
| M. thermoresistible (build 8) | TH_3100 | - | 6e-35 | 29.55% (484) | PUTATIVE aldehyde dehydrogenase (NAD) family protein |
| M. ulcerans Agy99 | MUL_0932 | rocA | 0.0 | 99.63% (543) | pyrroline-5-carboxylate dehydrogenase, RocA |
| M. vanbaalenii PYR-1 | Mvan_4526 | - | 0.0 | 80.22% (541) | delta-1-pyrroline-5-carboxylate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4253|M.marinum_M -----------------MDAIT---QVPIPANEPVHSYAPHSPERSRLKS
MUL_0932|M.ulcerans_Agy99 MSDRLIDSCLPAGMLAGMDAIT---QVPIPANEPVHSYAPHSPERSRLKS
Mb1219|M.bovis_AF2122/97 -----------------MDAIT---QVPVPANEPVHDYAPKSPERTRLRT
Rv1187|M.tuberculosis_H37Rv -----------------MDAIT---QVPVPANEPVHDYAPKSPERTRLRT
MAV_1331|M.avium_104 --------MAAARILGSMDAITGISEVPVPANEPVHDYAPHSAERARLRA
Mvan_4526|M.vanbaalenii_PYR-1 -----------------MDAIS---DVPLPSNEPVHEYAPGSPERHRLEN
MSMEG_5119|M.smegmatis_MC2_155 -----------------MDAIT---DVPTPANEPIHDYAPGSQERTRLTT
MAB_1330|M.abscessus_ATCC_1997 -----------------MDAIT---TVPAPSNEPVLTYAPNTPERDRLTT
Mflv_0667|M.gilvum_PYR-GCK --------------------------------------------------
TH_3100|M.thermoresistible__bu ---------------------------------------------MTASP
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
MMAR_4253|M.marinum_M ELIALAQQPIDLPHVIGGKHRMGDGERIDVVQPHRHAERLGTLTNAVHAD
MUL_0932|M.ulcerans_Agy99 ELIALAQQPIDLPHVIGGKHRMGDGERIDVVQPHRHAERLGTLTNAVHAD
Mb1219|M.bovis_AF2122/97 ELASLADHPIDLPHVIGGRHRMGDGERIDVVQPHRHAARLGTLTNATHAD
Rv1187|M.tuberculosis_H37Rv ELASLADHPIDLPHVIGGRHRMGDGERIDVVQPHRHAARLGTLTNATHAD
MAV_1331|M.avium_104 ELAALAGHPIDLPHVIGGRHRMGDGERIDVVQPHRHAAKLGTLTNAVHAD
Mvan_4526|M.vanbaalenii_PYR-1 MLADLAADPIELPHVIGGTHRMGAGPSVEVVQPHRHSARLGICTNADHAD
MSMEG_5119|M.smegmatis_MC2_155 ALHDLASTHIDLPHVIGGEHRMGSGARIDVVQPHRHSAKLGTLTNAEHAD
MAB_1330|M.abscessus_ATCC_1997 ALGELTASPIDLPHVIGGARRMSDGERIDVVQPHNHRSVLGTVTNAGHRE
Mflv_0667|M.gilvum_PYR-GCK --------MINANLIINGREETSDR-TIDVVSPADIRVLLGSVPDAAPGQ
TH_3100|M.thermoresistible__bu VATSVQFNPETRLYIDGELRESRTGKTVDNINPA-TEEVLGTATDVGADD
MLBr_02573|M.leprae_Br4923 -------------------------MSIATINPATGETVK-TFTPTTQDE
: :.* . . :
MMAR_4253|M.marinum_M ATAAIEAAMAAKN--GWAAMPFDERAGVFLRAADLLAGPWREKIAAATML
MUL_0932|M.ulcerans_Agy99 ATAAIEAAMAAKN--GWAAMPFDERAGVFLRAADLLAGPWREKIAAATML
Mb1219|M.bovis_AF2122/97 AAAAVEAAMSAKS--DWAALPFDERAAVFLRAADLLAGPWREKIAAATML
Rv1187|M.tuberculosis_H37Rv AAAAVEAAMSAKS--DWAALPFDERAAVFLRAADLLAGPWREKIAAATML
MAV_1331|M.avium_104 ATAAVDAAMAAKS--DWAAMPFDERAAVFLRAADLLAGPWREKIAAATML
Mvan_4526|M.vanbaalenii_PYR-1 AAAAVEAAVAAKP--GWENTPFDERAAVFLRAADLMAGPWREKIAAATML
MSMEG_5119|M.smegmatis_MC2_155 ASAAIEAAIAAKQ--DWAALPFDQRAAVFLRAADLLSGPWREKVAAATML
MAB_1330|M.abscessus_ATCC_1997 AHDAVEAAIAAKN--YWATLPFDDRAAVFLRAADLLSGPWRAILNAATML
Mflv_0667|M.gilvum_PYR-GCK VDEAVAAAAMAFP--EWSSRPLEERQGALLAAAGTIH---DMIEEYAPIL
TH_3100|M.thermoresistible__bu MEQAIAAARRAFDTTDWSTN-HEFRRRCLLQLHDALQEEKEDIRAELIAE
MLBr_02573|M.leprae_Br4923 VEDAIARAYARFD--NYRHTTFTQRAKWANATADLLEAEANQSAALMTLE
*: * : * . :
MMAR_4253|M.marinum_M GQSKSAYQAEIDAPCELVD-FWRFNVAFARQILDQQPVSAKGEWNRTDH-
MUL_0932|M.ulcerans_Agy99 GQSKSAYQAEIDAPCELVD-FWRFNVAFTRQILDQQPVSAKGEWNRTDH-
Mb1219|M.bovis_AF2122/97 GQSKSVYQAEIDAVCELID-FWRFNVAFARQILEQQPISGPGEWNRIDY-
Rv1187|M.tuberculosis_H37Rv GQSKSVYQAEIDAVCELID-FWRFNVAFARQILEQQPISGPGEWNRIDY-
MAV_1331|M.avium_104 GQSKSAYQAEIDSPCEQID-FWRFNVAFARQILAQQPISGPGEWNRSDY-
Mvan_4526|M.vanbaalenii_PYR-1 GQSKTAYQAEIDAPCELVD-FWRFNVAFARQILAQQPLNSKGVWNRTDY-
MSMEG_5119|M.smegmatis_MC2_155 GQSKSAYQAEIDAPCELID-FWRFNVAFARQILAQQPISSPGVWNRTDH-
MAB_1330|M.abscessus_ATCC_1997 GQSKTAYQAEIDSACELAD-FWRFNVQFARQILAEQPNSGGGAWNRLEY-
Mflv_0667|M.gilvum_PYR-GCK SRENGKILEESHVDLEFASGICGYTAGISAEILADQQIRDTGGTTLIRR-
TH_3100|M.thermoresistible__bu VGATVGMTFIAQLEWPLAD-AIRWPANYISEFAWERPLPDAALMGAPYHR
MLBr_02573|M.leprae_Br4923 MGKTLQSAKDEAMKCAKGF---RYYAEKAETLLADEPAEAAAVGASKALA
. : . : :. .
MMAR_4253|M.marinum_M ---RPLEGFVYAITPFNFTAIAANLPTAPALMG-NTVVWKPSVTQTLAAY
MUL_0932|M.ulcerans_Agy99 ---RPLEGFVYAITPFNFTAIAANLPTAPALMG-NTVVWKPSVTQTLAAY
Mb1219|M.bovis_AF2122/97 ---RPLDGFVYAITPFNFTSIAGNLPTAPALMG-NTVIWKPSITQTLAAY
Rv1187|M.tuberculosis_H37Rv ---RPLDGFVYAITPFNFTSIAGNLPTAPALMG-NTVIWKPSITQTLAAY
MAV_1331|M.avium_104 ---RPLDGFVYAITPFNFTSIAGNLPTAPALMG-NTVVWKPSITQTLSAY
Mvan_4526|M.vanbaalenii_PYR-1 ---RPLEGFVYAITPFNFTAIAGNLPTAPALMG-NTVVWKPSPTQMFAAY
MSMEG_5119|M.smegmatis_MC2_155 ---RPLEGFVYAITPFNFTAIAGNLPTAPALMG-NTVVWKPSPTQTFAAY
MAB_1330|M.abscessus_ATCC_1997 ---RPLEGFVYAITPFNFTAIAGNLPTAPALLG-NTVVWKPSVTQAFAAH
Mflv_0667|M.gilvum_PYR-GCK ---RPIG-PVAAITPWNFPVVLAFMKLAPALVAGNTVVLKPAANSPLVLA
TH_3100|M.thermoresistible__bu KVVKEPVGVVGAITQWNFPFEIISNKLGQALATGNSVVLKPAMETPWSAL
MLBr_02573|M.leprae_Br4923 R--YQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCAL
* *: :**. . ** * : * :
MMAR_4253|M.marinum_M LTMQAL-EAAGLPPGVINLVTGDGLAVSDVALTDPRLAGIHFTGSTATFQ
MUL_0932|M.ulcerans_Agy99 LTMQAL-EAAGLPPGVINLVTGDGLAVSDVALTDPRLAGIHFTGSTATFQ
Mb1219|M.bovis_AF2122/97 LTMQLL-EAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFG
Rv1187|M.tuberculosis_H37Rv LTMQLL-EAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFG
MAV_1331|M.avium_104 LTMQLL-EAAGLPPGVINLVTGDGFAVSDVALADRRLAGIHFTGSTATFQ
Mvan_4526|M.vanbaalenii_PYR-1 LTMQLL-EAAGLPPGVINLLAGDGLAVSDVLLSDRRLAGIHFTGSTATFQ
MSMEG_5119|M.smegmatis_MC2_155 LTMQLL-EAAGLPPGVINLVTGDGIAVSEVALKDPRLAGIHFTGSTATFQ
MAB_1330|M.abscessus_ATCC_1997 FTLELL-EAAGLPPGVINLLNGDGIAVSDVALADPRLAGIHFTGSTRTFQ
Mflv_0667|M.gilvum_PYR-GCK EVVRAL-QQH-FPPGVLNMVTG-GDAVGEALVAHPRIRKIGFTGGIDTGR
TH_3100|M.thermoresistible__bu RWCRIIAEKTDIPPGVVNIVPTSDNSIAQVLATDPRVDMVSFTGSTAVGK
MLBr_02573|M.leprae_Br4923 YLADVI-ARGGFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQ
: :* . .: : .: . *: :**. .
MMAR_4253|M.marinum_M HLWQQVGANIASYQSYPRLVGETGGKD--FVVAHSSARPEVVATALIRGA
MUL_0932|M.ulcerans_Agy99 HLWQQVGANIASYQSYPRLVGETGGKD--FVVAHSSARPEVVATALIRGA
Mb1219|M.bovis_AF2122/97 HLWQWVGTNIGRYHSYPRLVGETGGKD--FVVAHASARPDVLRTALIRGA
Rv1187|M.tuberculosis_H37Rv HLWQWVGTNIGRYHSYPRLVGETGGKD--FVVAHASARPDVLRTALIRGA
MAV_1331|M.avium_104 RLWYQVGTNIGHYHCYPRLVGETGGKD--FIVAHASARPDVLRTALIRGA
Mvan_4526|M.vanbaalenii_PYR-1 HLWREVGTHIDRYDTYPRLVGETGGKD--FVVAHPSAQPDVLRTALIRGA
MSMEG_5119|M.smegmatis_MC2_155 HLWREVGANIDRYHTYPRLVGETGGKD--FVLAHSSAHPDVLRTALIRGA
MAB_1330|M.abscessus_ATCC_1997 HLWRQVGTNIDRYNTYPRLVGETGGKD--FVVAHASARPEILRTALIRGA
Mflv_0667|M.gilvum_PYR-GCK KVMAAAARDIK------RVTLELGGNDPAILLDDVDLSPETMR-QIVKGA
TH_3100|M.thermoresistible__bu LIQRLGADTMK------RTMLELGGKSAYLVREGADLEAALPG---CVGA
MLBr_02573|M.leprae_Br4923 AVGAIAGNEIKP------TVLELGGSDPFIVMPSADLDAAVAT--AVTGR
: . : * **.. :: . . *
MMAR_4253|M.marinum_M FEYQGQKCSAASRAFIPHSVWQQMGDTFLDTAAGLKYGDITDLSNFGGAL
MUL_0932|M.ulcerans_Agy99 FEYQGQKCSAASRAFIPHSVWQQMGDTFLDTAAGLKYGDITDLSNFGGAL
Mb1219|M.bovis_AF2122/97 FDYQGQKCSAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGAL
Rv1187|M.tuberculosis_H37Rv FDYQGQKCSAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGAL
MAV_1331|M.avium_104 FDYQGQKCSAASRAFIAQSVWRRMGDEFLAETAALRYGDVTDLTNFGGAL
Mvan_4526|M.vanbaalenii_PYR-1 FDYQGQKCSAASRAYIARSVWQKMGDDFLDTTEALPYGDVTELANFGGAL
MSMEG_5119|M.smegmatis_MC2_155 FDYQGQKCSAASRAFIPRSVWQKMGDDFLSATEALRYGDVADLTNYGGAV
MAB_1330|M.abscessus_ATCC_1997 FDYQGQKCSAASRAFVPRSVWDQMGDEFLDATSGLSYGDVTDLSNFGGAV
Mflv_0667|M.gilvum_PYR-GCK FGTTGQVCFGLKRIYVPTRIHDRFVEAFSAAVDEIVVGPGDDPRVTMGPL
TH_3100|M.thermoresistible__bu LMHSGQGCALATRMLVPRSIYDQAAEVASATFGSLAVGDPADPNTFCGPL
MLBr_02573|M.leprae_Br4923 VQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPL
. ** * .* : . : : * : *.:
MMAR_4253|M.marinum_M IDRRAFIKNVDAIERAKGAAGVTIAVGGEYDDS---VGYFVRPTVLLSDD
MUL_0932|M.ulcerans_Agy99 IDRRAFIKNVDAIERAKGAAGVTIAVGGEYDDS---VGYFVRPTALLSDD
Mb1219|M.bovis_AF2122/97 IDQRAFVKNVDAIERAKGAAAVTVAVGGEYDDS---EGYFVRPTVLLSDD
Rv1187|M.tuberculosis_H37Rv IDQRAFVKNVDAIERAKGAAAVTVAVGGEYDDS---EGYFVRPTVLLSDD
MAV_1331|M.avium_104 IDRRAFVKNVDAIERAKGAPHVTLAVGGEYDDS---EGYFVRPTVLLSDD
Mvan_4526|M.vanbaalenii_PYR-1 IDERAFVKNVTAIERAKSAAGVTIAVGGEYDDS---EGYFVRPTVLLSDD
MSMEG_5119|M.smegmatis_MC2_155 IDDRAFAKNVKAIERAKSAPGVTIAAGGEYDDS---EGYFVRPTVLLSDD
MAB_1330|M.abscessus_ATCC_1997 IDEKSFARNAAAIDRAK-SAGVTIAAGGEYDDS---QGYFVRPTVLLSDD
Mflv_0667|M.gilvum_PYR-GCK NNAQQKNLVEKIVDDARSSGATVTTLGQRLDSAAWDHGHFMMPSVVTAAD
TH_3100|M.thermoresistible__bu VSARQRDRVLNYIEIAKREGGRITVGGGVPEGLD--RGYFVAPTVVADVE
MLBr_02573|M.leprae_Br4923 ATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP----GWFYPPTVITDIT
:: * * : * * *:.:
MMAR_4253|M.marinum_M PTDESFATEYFGPVLSLHVYPDDQYERILDVIDTGSRYALTGAVIADDRN
MUL_0932|M.ulcerans_Agy99 PTDESFATEYFGPVLSLHVYPDDQYERILDVIDTGSRYALTGAVIADDRN
Mb1219|M.bovis_AF2122/97 PTDESFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQ
Rv1187|M.tuberculosis_H37Rv PTDESFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQ
MAV_1331|M.avium_104 PADESFATEYFGPLLSVHVYPDDDYQRILDVVDTGSRYALTGAVIADDRA
Mvan_4526|M.vanbaalenii_PYR-1 PGDEAFSTEYFGPLLAVHVYPDEDYERILDVVDTSARYALTGAVIADDRA
MSMEG_5119|M.smegmatis_MC2_155 PTDDAFCTEYFGPILAVHVYPDDEYERIIDVVDTGAKYGLTGAVIADDRT
MAB_1330|M.abscessus_ATCC_1997 PTDEAFSTEYFGPILAVHVYPDDDYGRILDVVDTGSPYGLTGAVIADDRA
Mflv_0667|M.gilvum_PYR-GCK PRLAIVEEEQFGPVVPVLKY--DELDDVIRLVNQ-SQYGLAASIWTSDEE
TH_3100|M.thermoresistible__bu PHHTIFQEEIFGPVLSITPY--NGGDDAAVELANNSTYGLAGAVMGPDDR
MLBr_02573|M.leprae_Br4923 KDMALYTDEVFGPVASVYCA---TNIDDAIEIANATPFGLGSNAWTQNES
* ***: .: : : :.* . :
MMAR_4253|M.marinum_M AVLTAQNRLRFAAGNFYINDKPTGAVVGRQPFGGSRGSGTNDKAGSPQNL
MUL_0932|M.ulcerans_Agy99 AVLTAQNRLRFAAGNFYINDKPTGAVVGRQPFGGSRGSGTNDKAGSPQNL
Mb1219|M.bovis_AF2122/97 AVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNL
Rv1187|M.tuberculosis_H37Rv AVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNL
MAV_1331|M.avium_104 AVLAAQDRLRFAAGNFYVNDKPTGAVVGRQPFGGSRGSGTNDKAGSPLNL
Mvan_4526|M.vanbaalenii_PYR-1 AVLTAERRLRHAAGNFYVNDKPTGAVVGQQPFGGSRASGTNDKAGSALNL
MSMEG_5119|M.smegmatis_MC2_155 AVQQALDGLRYAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSAQNL
MAB_1330|M.abscessus_ATCC_1997 AIRQASDRLRYAAGNFYVNDKPTGAVVGQQPFGGGRASGTDDKAGSPLNL
Mflv_0667|M.gilvum_PYR-GCK RAFLLGR--RFDTGSVFINSHTFTSLDPRAPFGGAKASGLG-REFSPASL
TH_3100|M.thermoresistible__bu AMAVARR---IRTGSLMINN--SLYYGADAPFGGYKMSGIGRQNGHEG-F
MLBr_02573|M.leprae_Br4923 EQRHFIDN--IVAGQVFING--MTVSYPELPFGGIKRSGYG-RELSTHGI
:*.. :*. **** : ** . : :
MMAR_4253|M.marinum_M LRWTSTRTIKETFVPATDHTYPHMESD--
MUL_0932|M.ulcerans_Agy99 LRWTSTRTIKETFVPATDHTYPHMESD--
Mb1219|M.bovis_AF2122/97 LRWTSARSIKETFVAATDHIYPHMAVD--
Rv1187|M.tuberculosis_H37Rv LRWTSARSIKETFVAATDHIYPHMAVD--
MAV_1331|M.avium_104 LRWTSARTIKETFVPATDHTYPHMGAD--
Mvan_4526|M.vanbaalenii_PYR-1 LRWTSARSIKETFVPPTSHTYPHMEV---
MSMEG_5119|M.smegmatis_MC2_155 MRWTSARSIKETFVPPTNHTYPHMEA---
MAB_1330|M.abscessus_ATCC_1997 QRWLLPRSIKETFNAPTEYQYPHMEREDG
Mflv_0667|M.gilvum_PYR-GCK DSYTELQTISRRIGPPGPPLS--------
TH_3100|M.thermoresistible__bu EQYLETKTIAYPLEAGQ------------
MLBr_02573|M.leprae_Br4923 REFCNIKTVWIA-----------------
: :::