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MDAITQVPVPANEPVHDYAPKSPERTRLRTELASLADHPIDLPHVIGGRHRMGDGERIDVVQPHRHAARL GTLTNATHADAAAAVEAAMSAKSDWAALPFDERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEID AVCELIDFWRFNVAFARQILEQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPALMGNTVI WKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQWVGTN IGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFIAHSVWQRMGDELLAK AAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTVAVGGEYDDSEGYFVRPTVLLSDDPTDE SFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTG AVVGRQPFGGARGSGTNDKAGSPLNLLRWTSARSIKETFVAATDHIYPHMAVD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1219 | rocA | - | 100% (543) | pyrroline-5-carboxylate dehydrogenase ROCA |
| M. bovis AF2122 / 97 | Mb1760 | gabD2 | 4e-28 | 28.36% (469) | succinic semialdehyde dehydrogenase |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 1e-25 | 28.02% (464) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0667 | - | 3e-38 | 28.63% (496) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv1187 | rocA | 0.0 | 100.00% (543) | pyrroline-5-carboxylate dehydrogenase ROCA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-20 | 25.17% (441) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1330 | - | 0.0 | 74.81% (540) | pyrroline-5-carboxylate dehydrogenase RocA |
| M. marinum M | MMAR_4253 | rocA | 0.0 | 84.90% (543) | pyrroline-5-carboxylate dehydrogenase, RocA |
| M. avium 104 | MAV_1331 | pruA | 0.0 | 88.46% (546) | 1-pyrroline-5-carboxylate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5119 | pruA | 0.0 | 80.93% (540) | 1-pyrroline-5-carboxylate dehydrogenase |
| M. thermoresistible (build 8) | TH_4242 | - | 5e-30 | 31.87% (364) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0932 | rocA | 0.0 | 84.53% (543) | pyrroline-5-carboxylate dehydrogenase, RocA |
| M. vanbaalenii PYR-1 | Mvan_4526 | - | 0.0 | 80.07% (542) | delta-1-pyrroline-5-carboxylate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1219|M.bovis_AF2122/97 -----------------MDAIT---QVPVPANEPVHDYAPKSPERTRLRT
Rv1187|M.tuberculosis_H37Rv -----------------MDAIT---QVPVPANEPVHDYAPKSPERTRLRT
MAV_1331|M.avium_104 --------MAAARILGSMDAITGISEVPVPANEPVHDYAPHSAERARLRA
MMAR_4253|M.marinum_M -----------------MDAIT---QVPIPANEPVHSYAPHSPERSRLKS
MUL_0932|M.ulcerans_Agy99 MSDRLIDSCLPAGMLAGMDAIT---QVPIPANEPVHSYAPHSPERSRLKS
MSMEG_5119|M.smegmatis_MC2_155 -----------------MDAIT---DVPTPANEPIHDYAPGSQERTRLTT
Mvan_4526|M.vanbaalenii_PYR-1 -----------------MDAIS---DVPLPSNEPVHEYAPGSPERHRLEN
MAB_1330|M.abscessus_ATCC_1997 -----------------MDAIT---TVPAPSNEPVLTYAPNTPERDRLTT
Mflv_0667|M.gilvum_PYR-GCK --------------------------------------------------
TH_4242|M.thermoresistible__bu --------------------------------------------------
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mb1219|M.bovis_AF2122/97 ELASLADHPIDLPHVIGGRHRMGDGERIDVVQPHRHAARLGTLTNATHAD
Rv1187|M.tuberculosis_H37Rv ELASLADHPIDLPHVIGGRHRMGDGERIDVVQPHRHAARLGTLTNATHAD
MAV_1331|M.avium_104 ELAALAGHPIDLPHVIGGRHRMGDGERIDVVQPHRHAAKLGTLTNAVHAD
MMAR_4253|M.marinum_M ELIALAQQPIDLPHVIGGKHRMGDGERIDVVQPHRHAERLGTLTNAVHAD
MUL_0932|M.ulcerans_Agy99 ELIALAQQPIDLPHVIGGKHRMGDGERIDVVQPHRHAERLGTLTNAVHAD
MSMEG_5119|M.smegmatis_MC2_155 ALHDLASTHIDLPHVIGGEHRMGSGARIDVVQPHRHSAKLGTLTNAEHAD
Mvan_4526|M.vanbaalenii_PYR-1 MLADLAADPIELPHVIGGTHRMGAGPSVEVVQPHRHSARLGICTNADHAD
MAB_1330|M.abscessus_ATCC_1997 ALGELTASPIDLPHVIGGARRMSDGERIDVVQPHNHRSVLGTVTNAGHRE
Mflv_0667|M.gilvum_PYR-GCK --------MINANLIINGREETSD-RTIDVVSPADIRVLLGSVPDAAPGQ
TH_4242|M.thermoresistible__bu -MTRSHALVETYGHYINGEWVDPD-SGRYEDVDPATGETFAAAPDASTAQ
MLBr_02573|M.leprae_Br4923 --------------------------MSIATINPATGETVKTFTPTTQDE
. . : :
Mb1219|M.bovis_AF2122/97 AAAAVEAAMSAKS--DWAALPFDERAAVFLRAADLLAGPWREKIAAATML
Rv1187|M.tuberculosis_H37Rv AAAAVEAAMSAKS--DWAALPFDERAAVFLRAADLLAGPWREKIAAATML
MAV_1331|M.avium_104 ATAAVDAAMAAKS--DWAAMPFDERAAVFLRAADLLAGPWREKIAAATML
MMAR_4253|M.marinum_M ATAAIEAAMAAKN--GWAAMPFDERAGVFLRAADLLAGPWREKIAAATML
MUL_0932|M.ulcerans_Agy99 ATAAIEAAMAAKN--GWAAMPFDERAGVFLRAADLLAGPWREKIAAATML
MSMEG_5119|M.smegmatis_MC2_155 ASAAIEAAIAAKQ--DWAALPFDQRAAVFLRAADLLSGPWREKVAAATML
Mvan_4526|M.vanbaalenii_PYR-1 AAAAVEAAVAAKP--GWENTPFDERAAVFLRAADLMAGPWREKIAAATML
MAB_1330|M.abscessus_ATCC_1997 AHDAVEAAIAAKN--YWATLPFDDRAAVFLRAADLLSGPWRAILNAATML
Mflv_0667|M.gilvum_PYR-GCK VDEAVAAAAMAFP--EWSSRPLEERQGALLAAAGTIH-DMIEEYAPILSR
TH_4242|M.thermoresistible__bu VDRAIAAAREAFDSGRWTGLTPEERAKCLQQLGAALL-EHADDFFALAQL
MLBr_02573|M.leprae_Br4923 VEDAIARAYARFD--NYRHTTFTQRAKWANATADLLEAEANQSAALMTLE
. *: * : . :* . :
Mb1219|M.bovis_AF2122/97 GQSKSVYQAEIDAVCELIDFWRFNVAFARQILEQQPISGPGEWNRIDYRP
Rv1187|M.tuberculosis_H37Rv GQSKSVYQAEIDAVCELIDFWRFNVAFARQILEQQPISGPGEWNRIDYRP
MAV_1331|M.avium_104 GQSKSAYQAEIDSPCEQIDFWRFNVAFARQILAQQPISGPGEWNRSDYRP
MMAR_4253|M.marinum_M GQSKSAYQAEIDAPCELVDFWRFNVAFARQILDQQPVSAKGEWNRTDHRP
MUL_0932|M.ulcerans_Agy99 GQSKSAYQAEIDAPCELVDFWRFNVAFTRQILDQQPVSAKGEWNRTDHRP
MSMEG_5119|M.smegmatis_MC2_155 GQSKSAYQAEIDAPCELIDFWRFNVAFARQILAQQPISSPGVWNRTDHRP
Mvan_4526|M.vanbaalenii_PYR-1 GQSKTAYQAEIDAPCELVDFWRFNVAFARQILAQQPLNSKGVWNRTDYRP
MAB_1330|M.abscessus_ATCC_1997 GQSKTAYQAEIDSACELADFWRFNVQFARQILAEQPNSGGGAWNRLEYRP
Mflv_0667|M.gilvum_PYR-GCK ENGKILEESHVDLEFASGICGYTAGISAEILAD-QQIRDTGGTTLIRRRP
TH_4242|M.thermoresistible__bu EWGCSANERMFHVEGPAVMTTHAGELALEPVEQPIDAWGAGGTTLLRYEP
MLBr_02573|M.leprae_Br4923 MGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALARYQ
* .
Mb1219|M.bovis_AF2122/97 LDGFVYAITPFNFTSIAGNLPTAPALMG-NTVIWKPSITQTLAAYLTMQL
Rv1187|M.tuberculosis_H37Rv LDGFVYAITPFNFTSIAGNLPTAPALMG-NTVIWKPSITQTLAAYLTMQL
MAV_1331|M.avium_104 LDGFVYAITPFNFTSIAGNLPTAPALMG-NTVVWKPSITQTLSAYLTMQL
MMAR_4253|M.marinum_M LEGFVYAITPFNFTAIAANLPTAPALMG-NTVVWKPSVTQTLAAYLTMQA
MUL_0932|M.ulcerans_Agy99 LEGFVYAITPFNFTAIAANLPTAPALMG-NTVVWKPSVTQTLAAYLTMQA
MSMEG_5119|M.smegmatis_MC2_155 LEGFVYAITPFNFTAIAGNLPTAPALMG-NTVVWKPSPTQTFAAYLTMQL
Mvan_4526|M.vanbaalenii_PYR-1 LEGFVYAITPFNFTAIAGNLPTAPALMG-NTVVWKPSPTQMFAAYLTMQL
MAB_1330|M.abscessus_ATCC_1997 LEGFVYAITPFNFTAIAGNLPTAPALLG-NTVVWKPSVTQAFAAHFTLEL
Mflv_0667|M.gilvum_PYR-GCK IG-PVAAITPWNFPVVLAFMKLAPALVAGNTVVLKPAANSPLVLAEVVRA
TH_4242|M.thermoresistible__bu LG-VVSVLTPWNFPHTLNAMKIGSALAAGNTVVLKPSPLTPLAGFALARM
MLBr_02573|M.leprae_Br4923 PLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLADV
* .: *:**. ..** . *. : * :
Mb1219|M.bovis_AF2122/97 LEAAG-LPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQW
Rv1187|M.tuberculosis_H37Rv LEAAG-LPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQW
MAV_1331|M.avium_104 LEAAG-LPPGVINLVTGDGFAVSDVALADRRLAGIHFTGSTATFQRLWYQ
MMAR_4253|M.marinum_M LEAAG-LPPGVINLVTGDGLAVSDVALTDPRLAGIHFTGSTATFQHLWQQ
MUL_0932|M.ulcerans_Agy99 LEAAG-LPPGVINLVTGDGLAVSDVALTDPRLAGIHFTGSTATFQHLWQQ
MSMEG_5119|M.smegmatis_MC2_155 LEAAG-LPPGVINLVTGDGIAVSEVALKDPRLAGIHFTGSTATFQHLWRE
Mvan_4526|M.vanbaalenii_PYR-1 LEAAG-LPPGVINLLAGDGLAVSDVLLSDRRLAGIHFTGSTATFQHLWRE
MAB_1330|M.abscessus_ATCC_1997 LEAAG-LPPGVINLLNGDGIAVSDVALADPRLAGIHFTGSTRTFQHLWRQ
Mflv_0667|M.gilvum_PYR-GCK LQQH--FPPGVLNMVTGGDAVG-EALVAHPRIRKIGFTGGIDTGRKVMAA
TH_4242|M.thermoresistible__bu IDEHTDIPPGVVNVVTPSGLDGSKMLTTDPRIDMVSFTGSSAVGREVMAG
MLBr_02573|M.leprae_Br4923 IARGG-FPEDCFQTLLIS-ANGVEAILRDPRVAAATLTGSEPAGQAVGAI
: :* . .: : . . . *: :**. . :
Mb1219|M.bovis_AF2122/97 VGTNIGRYHSYPRLVGETGGKD--FVVAHASARPDVLRTALIRGAFDYQG
Rv1187|M.tuberculosis_H37Rv VGTNIGRYHSYPRLVGETGGKD--FVVAHASARPDVLRTALIRGAFDYQG
MAV_1331|M.avium_104 VGTNIGHYHCYPRLVGETGGKD--FIVAHASARPDVLRTALIRGAFDYQG
MMAR_4253|M.marinum_M VGANIASYQSYPRLVGETGGKD--FVVAHSSARPEVVATALIRGAFEYQG
MUL_0932|M.ulcerans_Agy99 VGANIASYQSYPRLVGETGGKD--FVVAHSSARPEVVATALIRGAFEYQG
MSMEG_5119|M.smegmatis_MC2_155 VGANIDRYHTYPRLVGETGGKD--FVLAHSSAHPDVLRTALIRGAFDYQG
Mvan_4526|M.vanbaalenii_PYR-1 VGTHIDRYDTYPRLVGETGGKD--FVVAHPSAQPDVLRTALIRGAFDYQG
MAB_1330|M.abscessus_ATCC_1997 VGTNIDRYNTYPRLVGETGGKD--FVVAHASARPEILRTALIRGAFDYQG
Mflv_0667|M.gilvum_PYR-GCK AARDIK------RVTLELGGNDPAILLDDVDLSPETMRQIVKGAFGTTG-
TH_4242|M.thermoresistible__bu AAGGMK------RILLECGGKSASIVLDDLEVTDELLETILFECLTMHAG
MLBr_02573|M.leprae_Br4923 AGNEIKP------TVLELGGSDPFIVMPSADLDAAVATAVTGR--VQNNG
.. : * **.. ::: .
Mb1219|M.bovis_AF2122/97 QKCSAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRA
Rv1187|M.tuberculosis_H37Rv QKCSAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRA
MAV_1331|M.avium_104 QKCSAASRAFIAQSVWRRMGDEFLAETAALRYGDVTDLTNFGGALIDRRA
MMAR_4253|M.marinum_M QKCSAASRAFIPHSVWQQMGDTFLDTAAGLKYGDITDLSNFGGALIDRRA
MUL_0932|M.ulcerans_Agy99 QKCSAASRAFIPHSVWQQMGDTFLDTAAGLKYGDITDLSNFGGALIDRRA
MSMEG_5119|M.smegmatis_MC2_155 QKCSAASRAFIPRSVWQKMGDDFLSATEALRYGDVADLTNYGGAVIDDRA
Mvan_4526|M.vanbaalenii_PYR-1 QKCSAASRAYIARSVWQKMGDDFLDTTEALPYGDVTELANFGGALIDERA
MAB_1330|M.abscessus_ATCC_1997 QKCSAASRAFVPRSVWDQMGDEFLDATSGLSYGDVTDLSNFGGAVIDEKS
Mflv_0667|M.gilvum_PYR-GCK QVCFGLKRIYVPTRIHDRFVEAFSAAVDEIVVGPGDDPRVTMGPLNNAQQ
TH_4242|M.thermoresistible__bu QACILNSRLVVPEAMHDDVVARLGELARKVVVGNPVDPAVQMGPLISRAH
MLBr_02573|M.leprae_Br4923 QSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESG
* * .* : . : : * : *.:
Mb1219|M.bovis_AF2122/97 FVKNVDAIERAKGAAAVTVAVGGEYD---DSEGYFVRPTVLLSDDPTDES
Rv1187|M.tuberculosis_H37Rv FVKNVDAIERAKGAAAVTVAVGGEYD---DSEGYFVRPTVLLSDDPTDES
MAV_1331|M.avium_104 FVKNVDAIERAKGAPHVTLAVGGEYD---DSEGYFVRPTVLLSDDPADES
MMAR_4253|M.marinum_M FIKNVDAIERAKGAAGVTIAVGGEYD---DSVGYFVRPTVLLSDDPTDES
MUL_0932|M.ulcerans_Agy99 FIKNVDAIERAKGAAGVTIAVGGEYD---DSVGYFVRPTALLSDDPTDES
MSMEG_5119|M.smegmatis_MC2_155 FAKNVKAIERAKSAPGVTIAAGGEYD---DSEGYFVRPTVLLSDDPTDDA
Mvan_4526|M.vanbaalenii_PYR-1 FVKNVTAIERAKSAAGVTIAVGGEYD---DSEGYFVRPTVLLSDDPGDEA
MAB_1330|M.abscessus_ATCC_1997 FARNAAAIDRAK-SAGVTIAAGGEYD---DSQGYFVRPTVLLSDDPTDEA
Mflv_0667|M.gilvum_PYR-GCK KNLVEKIVDDARSSGATVTTLGQRLDSAAWDHGHFMMPSVVTAADPRLAI
TH_4242|M.thermoresistible__bu LERVEGFVERAVADGATVVAGGSRP--AHLDRGFFYEPTILTDVAPDDFI
MLBr_02573|M.leprae_Br4923 RAQVEQQVDAAAAAGAVIRCGGKRPD----RPGWFYPPTVITDITKDMAL
:: * . * . * * *: :
Mb1219|M.bovis_AF2122/97 FVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQAVLTA
Rv1187|M.tuberculosis_H37Rv FVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQAVLTA
MAV_1331|M.avium_104 FATEYFGPLLSVHVYPDDDYQRILDVVDTGSRYALTGAVIADDRAAVLAA
MMAR_4253|M.marinum_M FATEYFGPVLSLHVYPDDQYERILDVIDTGSRYALTGAVIADDRNAVLTA
MUL_0932|M.ulcerans_Agy99 FATEYFGPVLSLHVYPDDQYERILDVIDTGSRYALTGAVIADDRNAVLTA
MSMEG_5119|M.smegmatis_MC2_155 FCTEYFGPILAVHVYPDDEYERIIDVVDTGAKYGLTGAVIADDRTAVQQA
Mvan_4526|M.vanbaalenii_PYR-1 FSTEYFGPLLAVHVYPDEDYERILDVVDTSARYALTGAVIADDRAAVLTA
MAB_1330|M.abscessus_ATCC_1997 FSTEYFGPILAVHVYPDDDYGRILDVVDTGSPYGLTGAVIADDRAAIRQA
Mflv_0667|M.gilvum_PYR-GCK VEEEQFGPVVPVLKYDEL--DDVIRLVNQ-SQYGLAASIWTSDEERAFLL
TH_4242|M.thermoresistible__bu AQEEVFGPVLTVLRCRDD--DEAVDIANN-SRYGLGGAVYAADVDRALGV
MLBr_02573|M.leprae_Br4923 YTDEVFGPVASVYCATNI--DDAIEIANA-TPFGLGSNAWTQNESEQRHF
* ***: .: : : : : : :.* . : :
Mb1219|M.bovis_AF2122/97 LDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNLLRWTS
Rv1187|M.tuberculosis_H37Rv LDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNLLRWTS
MAV_1331|M.avium_104 QDRLRFAAGNFYVNDKPTGAVVGRQPFGGSRGSGTNDKAGSPLNLLRWTS
MMAR_4253|M.marinum_M QNRLRFAAGNFYINDKPTGAVVGRQPFGGSRGSGTNDKAGSPQNLLRWTS
MUL_0932|M.ulcerans_Agy99 QNRLRFAAGNFYINDKPTGAVVGRQPFGGSRGSGTNDKAGSPQNLLRWTS
MSMEG_5119|M.smegmatis_MC2_155 LDGLRYAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSAQNLMRWTS
Mvan_4526|M.vanbaalenii_PYR-1 ERRLRHAAGNFYVNDKPTGAVVGQQPFGGSRASGTNDKAGSALNLLRWTS
MAB_1330|M.abscessus_ATCC_1997 SDRLRYAAGNFYVNDKPTGAVVGQQPFGGGRASGTDDKAGSPLNLQRWLL
Mflv_0667|M.gilvum_PYR-GCK GR--RFDTGSVFINSHTFTSLDPRAPFGGAKASGLGREFS-PASLDSYTE
TH_4242|M.thermoresistible__bu AR--RIRSGQVSIN----GCIAGDAPFGGFGQSGIGREGG-LLGLRSYME
MLBr_02573|M.leprae_Br4923 IDN--IVAGQVFING--MTVSYPELPFGGIKRSGYGRELS-THGIREFCN
:*.. :* **** ** . : . .: :
Mb1219|M.bovis_AF2122/97 ARSIKETFVAATDHIYPHMAVD--
Rv1187|M.tuberculosis_H37Rv ARSIKETFVAATDHIYPHMAVD--
MAV_1331|M.avium_104 ARTIKETFVPATDHTYPHMGAD--
MMAR_4253|M.marinum_M TRTIKETFVPATDHTYPHMESD--
MUL_0932|M.ulcerans_Agy99 TRTIKETFVPATDHTYPHMESD--
MSMEG_5119|M.smegmatis_MC2_155 ARSIKETFVPPTNHTYPHMEA---
Mvan_4526|M.vanbaalenii_PYR-1 ARSIKETFVPPTSHTYPHMEV---
MAB_1330|M.abscessus_ATCC_1997 PRSIKETFNAPTEYQYPHMEREDG
Mflv_0667|M.gilvum_PYR-GCK LQTISRRIGPPGPPLS--------
TH_4242|M.thermoresistible__bu PKAIGVPA----------------
MLBr_02573|M.leprae_Br4923 IKTVWIA-----------------
:::