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VAAARILGSMDAITGISEVPVPANEPVHDYAPHSAERARLRAELAALAGHPIDLPHVIGGRHRMGDGERI DVVQPHRHAAKLGTLTNAVHADATAAVDAAMAAKSDWAAMPFDERAAVFLRAADLLAGPWREKIAAATML GQSKSAYQAEIDSPCEQIDFWRFNVAFARQILAQQPISGPGEWNRSDYRPLDGFVYAITPFNFTSIAGNL PTAPALMGNTVVWKPSITQTLSAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADRRLAGIHFTGSTA TFQRLWYQVGTNIGHYHCYPRLVGETGGKDFIVAHASARPDVLRTALIRGAFDYQGQKCSAASRAFIAQS VWRRMGDEFLAETAALRYGDVTDLTNFGGALIDRRAFVKNVDAIERAKGAPHVTLAVGGEYDDSEGYFVR PTVLLSDDPADESFATEYFGPLLSVHVYPDDDYQRILDVVDTGSRYALTGAVIADDRAAVLAAQDRLRFA AGNFYVNDKPTGAVVGRQPFGGSRGSGTNDKAGSPLNLLRWTSARTIKETFVPATDHTYPHMGAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1331 | pruA | - | 100% (555) | 1-pyrroline-5-carboxylate dehydrogenase |
| M. avium 104 | MAV_2608 | - | 8e-33 | 31.25% (448) | aldehyde dehydrogenase family protein |
| M. avium 104 | MAV_1944 | - | 3e-31 | 31.16% (475) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1219 | rocA | 0.0 | 88.46% (546) | pyrroline-5-carboxylate dehydrogenase ROCA |
| M. gilvum PYR-GCK | Mflv_0667 | - | 1e-37 | 29.12% (498) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv1187 | rocA | 0.0 | 88.46% (546) | pyrroline-5-carboxylate dehydrogenase ROCA |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 7e-19 | 25.75% (369) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1330 | - | 0.0 | 75.14% (543) | pyrroline-5-carboxylate dehydrogenase RocA |
| M. marinum M | MMAR_4253 | rocA | 0.0 | 84.80% (546) | pyrroline-5-carboxylate dehydrogenase, RocA |
| M. smegmatis MC2 155 | MSMEG_5119 | pruA | 0.0 | 81.10% (545) | 1-pyrroline-5-carboxylate dehydrogenase |
| M. thermoresistible (build 8) | TH_3080 | - | 3e-31 | 30.00% (500) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0932 | rocA | 0.0 | 83.88% (552) | pyrroline-5-carboxylate dehydrogenase, RocA |
| M. vanbaalenii PYR-1 | Mvan_4526 | - | 0.0 | 80.85% (543) | delta-1-pyrroline-5-carboxylate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1219|M.bovis_AF2122/97 -----------------MDAIT---QVPVPANEPVHDYAPKSPERTRLRT
Rv1187|M.tuberculosis_H37Rv -----------------MDAIT---QVPVPANEPVHDYAPKSPERTRLRT
MAV_1331|M.avium_104 --------MAAARILGSMDAITGISEVPVPANEPVHDYAPHSAERARLRA
MMAR_4253|M.marinum_M -----------------MDAIT---QVPIPANEPVHSYAPHSPERSRLKS
MUL_0932|M.ulcerans_Agy99 MSDRLIDSCLPAGMLAGMDAIT---QVPIPANEPVHSYAPHSPERSRLKS
Mvan_4526|M.vanbaalenii_PYR-1 -----------------MDAIS---DVPLPSNEPVHEYAPGSPERHRLEN
MSMEG_5119|M.smegmatis_MC2_155 -----------------MDAIT---DVPTPANEPIHDYAPGSQERTRLTT
MAB_1330|M.abscessus_ATCC_1997 -----------------MDAIT---TVPAPSNEPVLTYAPNTPERDRLTT
Mflv_0667|M.gilvum_PYR-GCK --------------------------------------------------
TH_3080|M.thermoresistible__bu --------------------------------------------------
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mb1219|M.bovis_AF2122/97 ELASLADHPIDLPHVIGGRHRMG-DGERIDVVQPHRHAARLGTLTNATHA
Rv1187|M.tuberculosis_H37Rv ELASLADHPIDLPHVIGGRHRMG-DGERIDVVQPHRHAARLGTLTNATHA
MAV_1331|M.avium_104 ELAALAGHPIDLPHVIGGRHRMG-DGERIDVVQPHRHAAKLGTLTNAVHA
MMAR_4253|M.marinum_M ELIALAQQPIDLPHVIGGKHRMG-DGERIDVVQPHRHAERLGTLTNAVHA
MUL_0932|M.ulcerans_Agy99 ELIALAQQPIDLPHVIGGKHRMG-DGERIDVVQPHRHAERLGTLTNAVHA
Mvan_4526|M.vanbaalenii_PYR-1 MLADLAADPIELPHVIGGTHRMG-AGPSVEVVQPHRHSARLGICTNADHA
MSMEG_5119|M.smegmatis_MC2_155 ALHDLASTHIDLPHVIGGEHRMG-SGARIDVVQPHRHSAKLGTLTNAEHA
MAB_1330|M.abscessus_ATCC_1997 ALGELTASPIDLPHVIGGARRMS-DGERIDVVQPHNHRSVLGTVTNAGHR
Mflv_0667|M.gilvum_PYR-GCK --------MINANLIINGREET--SDRTIDVVSPADIRVLLGSVPDAAPG
TH_3080|M.thermoresistible__bu --------VHPEELFIGGEWATPSSAQRIEVISP-HTEEPVAAVAAACPD
MLBr_02573|M.leprae_Br4923 --------------------------MSIATINP-ATGETVKTFTPTTQD
: .:.* : . :
Mb1219|M.bovis_AF2122/97 DAAAAVEAAMSAKS--DWAALPFDERAAVFLRAADLLAGPWREKIAAATM
Rv1187|M.tuberculosis_H37Rv DAAAAVEAAMSAKS--DWAALPFDERAAVFLRAADLLAGPWREKIAAATM
MAV_1331|M.avium_104 DATAAVDAAMAAKS--DWAAMPFDERAAVFLRAADLLAGPWREKIAAATM
MMAR_4253|M.marinum_M DATAAIEAAMAAKN--GWAAMPFDERAGVFLRAADLLAGPWREKIAAATM
MUL_0932|M.ulcerans_Agy99 DATAAIEAAMAAKN--GWAAMPFDERAGVFLRAADLLAGPWREKIAAATM
Mvan_4526|M.vanbaalenii_PYR-1 DAAAAVEAAVAAKP--GWENTPFDERAAVFLRAADLMAGPWREKIAAATM
MSMEG_5119|M.smegmatis_MC2_155 DASAAIEAAIAAKQ--DWAALPFDQRAAVFLRAADLLSGPWREKVAAATM
MAB_1330|M.abscessus_ATCC_1997 EAHDAVEAAIAAKN--YWATLPFDDRAAVFLRAADLLSGPWRAILNAATM
Mflv_0667|M.gilvum_PYR-GCK QVDEAVAAAAMAFP--EWSSRPLEERQGALLAAAGTIH-DMIEEYAPILS
TH_3080|M.thermoresistible__bu DVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYG-ERRSELAELIT
MLBr_02573|M.leprae_Br4923 EVEDAIARAYARFD--NYRHTTFTQRAKWANATADLLEAEANQSAALMTL
:. *: * : :* *
Mb1219|M.bovis_AF2122/97 LGQSKSVYQAEIDAVCELIDFWRFNVAFARQILEQQPISGPGEWNRIDYR
Rv1187|M.tuberculosis_H37Rv LGQSKSVYQAEIDAVCELIDFWRFNVAFARQILEQQPISGPGEWNRIDYR
MAV_1331|M.avium_104 LGQSKSAYQAEIDSPCEQIDFWRFNVAFARQILAQQPISGPGEWNRSDYR
MMAR_4253|M.marinum_M LGQSKSAYQAEIDAPCELVDFWRFNVAFARQILDQQPVSAKGEWNRTDHR
MUL_0932|M.ulcerans_Agy99 LGQSKSAYQAEIDAPCELVDFWRFNVAFTRQILDQQPVSAKGEWNRTDHR
Mvan_4526|M.vanbaalenii_PYR-1 LGQSKTAYQAEIDAPCELVDFWRFNVAFARQILAQQPLNSKGVWNRTDYR
MSMEG_5119|M.smegmatis_MC2_155 LGQSKSAYQAEIDAPCELIDFWRFNVAFARQILAQQPISSPGVWNRTDHR
MAB_1330|M.abscessus_ATCC_1997 LGQSKTAYQAEIDSACELADFWRFNVQFARQILAEQPNSGGGAWNRLEYR
Mflv_0667|M.gilvum_PYR-GCK RENGKILEESHVDLEFASGICGYTAGISAEILADQQIRD--TGGTTLIRR
TH_3080|M.thermoresistible__bu AQIGAPISFAQRAQVGLPWTMMSAFCTLAENHPWQQTRAGMYGADVHVRR
MLBr_02573|M.leprae_Br4923 EMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALARY
. :
Mb1219|M.bovis_AF2122/97 PLDGFVYAITPFNFTSIAGNLPTAPALMG-NTVIWKPSITQTLAAYLTMQ
Rv1187|M.tuberculosis_H37Rv PLDGFVYAITPFNFTSIAGNLPTAPALMG-NTVIWKPSITQTLAAYLTMQ
MAV_1331|M.avium_104 PLDGFVYAITPFNFTSIAGNLPTAPALMG-NTVVWKPSITQTLSAYLTMQ
MMAR_4253|M.marinum_M PLEGFVYAITPFNFTAIAANLPTAPALMG-NTVVWKPSVTQTLAAYLTMQ
MUL_0932|M.ulcerans_Agy99 PLEGFVYAITPFNFTAIAANLPTAPALMG-NTVVWKPSVTQTLAAYLTMQ
Mvan_4526|M.vanbaalenii_PYR-1 PLEGFVYAITPFNFTAIAGNLPTAPALMG-NTVVWKPSPTQMFAAYLTMQ
MSMEG_5119|M.smegmatis_MC2_155 PLEGFVYAITPFNFTAIAGNLPTAPALMG-NTVVWKPSPTQTFAAYLTMQ
MAB_1330|M.abscessus_ATCC_1997 PLEGFVYAITPFNFTAIAGNLPTAPALLG-NTVVWKPSVTQAFAAHFTLE
Mflv_0667|M.gilvum_PYR-GCK RPIGPVAAITPWNFPVVLAFMKLAPALVAGNTVVLKPAANSPLVLAEVVR
TH_3080|M.thermoresistible__bu EPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLDALLLAE
MLBr_02573|M.leprae_Br4923 QPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLAD
* * *: *:*:. ***:. . : * :
Mb1219|M.bovis_AF2122/97 LLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQW
Rv1187|M.tuberculosis_H37Rv LLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQW
MAV_1331|M.avium_104 LLEAAGLPPGVINLVTGDGFAVSDVALADRRLAGIHFTGSTATFQRLWYQ
MMAR_4253|M.marinum_M ALEAAGLPPGVINLVTGDGLAVSDVALTDPRLAGIHFTGSTATFQHLWQQ
MUL_0932|M.ulcerans_Agy99 ALEAAGLPPGVINLVTGDGLAVSDVALTDPRLAGIHFTGSTATFQHLWQQ
Mvan_4526|M.vanbaalenii_PYR-1 LLEAAGLPPGVINLLAGDGLAVSDVLLSDRRLAGIHFTGSTATFQHLWRE
MSMEG_5119|M.smegmatis_MC2_155 LLEAAGLPPGVINLVTGDGIAVSEVALKDPRLAGIHFTGSTATFQHLWRE
MAB_1330|M.abscessus_ATCC_1997 LLEAAGLPPGVINLLNGDGIAVSDVALADPRLAGIHFTGSTRTFQHLWRQ
Mflv_0667|M.gilvum_PYR-GCK ALQQH-FPPGVLNMVTG-GDAVGEALVAHPRIRKIGFTGGIDTGRKVMAA
TH_3080|M.thermoresistible__bu LIADSGIPSGVVNVLPG-PAGVGERLVRHPGVDKVSFTGSTAAGRAVAAA
MLBr_02573|M.leprae_Br4923 VIARGGFPEDCFQTLLISANGV-EAILRDPRVAAATLTGSEPAGQAVGAI
: :* . .: : .* : : . : :**. : :
Mb1219|M.bovis_AF2122/97 VGTNIGRYHSYPRLVGETGGKDFVVAHASARP-DVLRTALIRGAFDYQGQ
Rv1187|M.tuberculosis_H37Rv VGTNIGRYHSYPRLVGETGGKDFVVAHASARP-DVLRTALIRGAFDYQGQ
MAV_1331|M.avium_104 VGTNIGHYHCYPRLVGETGGKDFIVAHASARP-DVLRTALIRGAFDYQGQ
MMAR_4253|M.marinum_M VGANIASYQSYPRLVGETGGKDFVVAHSSARP-EVVATALIRGAFEYQGQ
MUL_0932|M.ulcerans_Agy99 VGANIASYQSYPRLVGETGGKDFVVAHSSARP-EVVATALIRGAFEYQGQ
Mvan_4526|M.vanbaalenii_PYR-1 VGTHIDRYDTYPRLVGETGGKDFVVAHPSAQP-DVLRTALIRGAFDYQGQ
MSMEG_5119|M.smegmatis_MC2_155 VGANIDRYHTYPRLVGETGGKDFVLAHSSAHP-DVLRTALIRGAFDYQGQ
MAB_1330|M.abscessus_ATCC_1997 VGTNIDRYNTYPRLVGETGGKDFVVAHASARP-EILRTALIRGAFDYQGQ
Mflv_0667|M.gilvum_PYR-GCK AARDIK------RVTLELGGNDPAILLDDVDLSPETMRQIVKGAFGTTGQ
TH_3080|M.thermoresistible__bu AAAGLK------RVSLELGGKSAAVVLSDADP-AAVATAVRSASLSNSGQ
MLBr_02573|M.leprae_Br4923 AGNEIKP------TVLELGGSDPFIVMPSADLDAAVATAVT-GRVQNNGQ
.. : * **.. : .. : . . **
Mb1219|M.bovis_AF2122/97 KCSAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAF
Rv1187|M.tuberculosis_H37Rv KCSAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAF
MAV_1331|M.avium_104 KCSAASRAFIAQSVWRRMGDEFLAETAALRYGDVTDLTNFGGALIDRRAF
MMAR_4253|M.marinum_M KCSAASRAFIPHSVWQQMGDTFLDTAAGLKYGDITDLSNFGGALIDRRAF
MUL_0932|M.ulcerans_Agy99 KCSAASRAFIPHSVWQQMGDTFLDTAAGLKYGDITDLSNFGGALIDRRAF
Mvan_4526|M.vanbaalenii_PYR-1 KCSAASRAYIARSVWQKMGDDFLDTTEALPYGDVTELANFGGALIDERAF
MSMEG_5119|M.smegmatis_MC2_155 KCSAASRAFIPRSVWQKMGDDFLSATEALRYGDVADLTNYGGAVIDDRAF
MAB_1330|M.abscessus_ATCC_1997 KCSAASRAFVPRSVWDQMGDEFLDATSGLSYGDVTDLSNFGGAVIDEKSF
Mflv_0667|M.gilvum_PYR-GCK VCFGLKRIYVPTRIHDRFVEAFSAAVDEIVVGPGDDPRVTMGPLNNAQQK
TH_3080|M.thermoresistible__bu ICNALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVARRQQ
MLBr_02573|M.leprae_Br4923 SCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGR
* . .* .: : : : * : *.:
Mb1219|M.bovis_AF2122/97 VKNVDAIERAKGAAAVTVAVGGEYD---DSEGYFVRPTVLLSDDPTDESF
Rv1187|M.tuberculosis_H37Rv VKNVDAIERAKGAAAVTVAVGGEYD---DSEGYFVRPTVLLSDDPTDESF
MAV_1331|M.avium_104 VKNVDAIERAKGAPHVTLAVGGEYD---DSEGYFVRPTVLLSDDPADESF
MMAR_4253|M.marinum_M IKNVDAIERAKGAAGVTIAVGGEYD---DSVGYFVRPTVLLSDDPTDESF
MUL_0932|M.ulcerans_Agy99 IKNVDAIERAKGAAGVTIAVGGEYD---DSVGYFVRPTALLSDDPTDESF
Mvan_4526|M.vanbaalenii_PYR-1 VKNVTAIERAKSAAGVTIAVGGEYD---DSEGYFVRPTVLLSDDPGDEAF
MSMEG_5119|M.smegmatis_MC2_155 AKNVKAIERAKSAPGVTIAAGGEYD---DSEGYFVRPTVLLSDDPTDDAF
MAB_1330|M.abscessus_ATCC_1997 ARNAAAIDRAK-SAGVTIAAGGEYD---DSQGYFVRPTVLLSDDPTDEAF
Mflv_0667|M.gilvum_PYR-GCK NLVEKIVDDARSSGATVTTLGQRLDSAAWDHGHFMMPSVVTAADPRLAIV
TH_3080|M.thermoresistible__bu ERVRGYIEAGCAEGARLVTGGPGLP-AGVDRGWYVQPTLFADADNSMRIA
MLBr_02573|M.leprae_Br4923 AQVEQQVDAAAAAGAVIRCGGKRPD----RPGWFYPPTVITDITKDMALY
:: . * * : *: .
Mb1219|M.bovis_AF2122/97 VIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQAVLTAL
Rv1187|M.tuberculosis_H37Rv VIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQAVLTAL
MAV_1331|M.avium_104 ATEYFGPLLSVHVYPDDDYQRILDVVDTGSRYALTGAVIADDRAAVLAAQ
MMAR_4253|M.marinum_M ATEYFGPVLSLHVYPDDQYERILDVIDTGSRYALTGAVIADDRNAVLTAQ
MUL_0932|M.ulcerans_Agy99 ATEYFGPVLSLHVYPDDQYERILDVIDTGSRYALTGAVIADDRNAVLTAQ
Mvan_4526|M.vanbaalenii_PYR-1 STEYFGPLLAVHVYPDEDYERILDVVDTSARYALTGAVIADDRAAVLTAE
MSMEG_5119|M.smegmatis_MC2_155 CTEYFGPILAVHVYPDDEYERIIDVVDTGAKYGLTGAVIADDRTAVQQAL
MAB_1330|M.abscessus_ATCC_1997 STEYFGPILAVHVYPDDDYGRILDVVDTGSPYGLTGAVIADDRAAIRQAS
Mflv_0667|M.gilvum_PYR-GCK EEEQFGPVVPVLKYDEL--DDVIRLVNQ-SQYGLAASIWTSDEERAFLLG
TH_3080|M.thermoresistible__bu REEIFGPVLTVIPYPDE--DAAVAIAND-SDYGLAGSVFTADTERGLAIA
MLBr_02573|M.leprae_Br4923 TDEVFGPVAS--VYCATNIDDAIEIANA-TPFGLGSNAWTQNESEQRHFI
* ***: . * : : : : :.* . : :
Mb1219|M.bovis_AF2122/97 DRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNLLRWTSA
Rv1187|M.tuberculosis_H37Rv DRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNLLRWTSA
MAV_1331|M.avium_104 DRLRFAAGNFYVNDKPTGAVVGRQPFGGSRGSGTNDKAGSPLNLLRWTSA
MMAR_4253|M.marinum_M NRLRFAAGNFYINDKPTGAVVGRQPFGGSRGSGTNDKAGSPQNLLRWTST
MUL_0932|M.ulcerans_Agy99 NRLRFAAGNFYINDKPTGAVVGRQPFGGSRGSGTNDKAGSPQNLLRWTST
Mvan_4526|M.vanbaalenii_PYR-1 RRLRHAAGNFYVNDKPTGAVVGQQPFGGSRASGTNDKAGSALNLLRWTSA
MSMEG_5119|M.smegmatis_MC2_155 DGLRYAAGNFYINDKPTGAVVGQQPFGGSRASGTNDKAGSAQNLMRWTSA
MAB_1330|M.abscessus_ATCC_1997 DRLRYAAGNFYVNDKPTGAVVGQQPFGGGRASGTDDKAGSPLNLQRWLLP
Mflv_0667|M.gilvum_PYR-GCK R--RFDTGSVFINSHTFTSLDPRAPFGGAKASGLGREFS-PASLDSYTEL
TH_3080|M.thermoresistible__bu A--RIRTGTFGVNQG--YTMDPFAPFGGVKGSGYGRELG-PEGIDAYTDV
MLBr_02573|M.leprae_Br4923 DN--IVAGQVFINGMT--VSYPELPFGGIKRSGYGRELS-THGIREFCNI
:* . :* **** : ** . : . . .: :
Mb1219|M.bovis_AF2122/97 RSIKETFVAATDHIYPHMAVD--
Rv1187|M.tuberculosis_H37Rv RSIKETFVAATDHIYPHMAVD--
MAV_1331|M.avium_104 RTIKETFVPATDHTYPHMGAD--
MMAR_4253|M.marinum_M RTIKETFVPATDHTYPHMESD--
MUL_0932|M.ulcerans_Agy99 RTIKETFVPATDHTYPHMESD--
Mvan_4526|M.vanbaalenii_PYR-1 RSIKETFVPPTSHTYPHMEV---
MSMEG_5119|M.smegmatis_MC2_155 RSIKETFVPPTNHTYPHMEA---
MAB_1330|M.abscessus_ATCC_1997 RSIKETFNAPTEYQYPHMEREDG
Mflv_0667|M.gilvum_PYR-GCK QTISRRIGPPGPPLS--------
TH_3080|M.thermoresistible__bu KSIS--VAPASTT----------
MLBr_02573|M.leprae_Br4923 KTVWIA-----------------
:::