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INANLIINGREETSDRTIDVVSPADIRVLLGSVPDAAPGQVDEAVAAAAMAFPEWSSRPLEERQGALLAA AGTIHDMIEEYAPILSRENGKILEESHVDLEFASGICGYTAGISAEILADQQIRDTGGTTLIRRRPIGPV AAITPWNFPVVLAFMKLAPALVAGNTVVLKPAANSPLVLAEVVRALQQHFPPGVLNMVTGGDAVGEALVA HPRIRKIGFTGGIDTGRKVMAAAARDIKRVTLELGGNDPAILLDDVDLSPETMRQIVKGAFGTTGQVCFG LKRIYVPTRIHDRFVEAFSAAVDEIVVGPGDDPRVTMGPLNNAQQKNLVEKIVDDARSSGATVTTLGQRL DSAAWDHGHFMMPSVVTAADPRLAIVEEEQFGPVVPVLKYDELDDVIRLVNQSQYGLAASIWTSDEERAF LLGRRFDTGSVFINSHTFTSLDPRAPFGGAKASGLGREFSPASLDSYTELQTISRRIGPPGPPLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0667 | - | - | 100% (486) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0569 | - | 0.0 | 100.00% (486) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4389 | - | 1e-77 | 37.39% (476) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 3e-66 | 36.05% (466) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 3e-75 | 37.11% (477) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 3e-54 | 31.10% (463) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-73 | 35.15% (478) | aldehyde dehydrogenase |
| M. marinum M | MMAR_2875 | - | 5e-81 | 37.84% (481) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1340 | - | 4e-78 | 37.23% (462) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 5e-74 | 36.90% (477) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3068 | - | 2e-78 | 38.22% (450) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2877 | - | 3e-79 | 37.03% (478) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0486 | - | 0.0 | 99.38% (486) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0667|M.gilvum_PYR-GCK ------------MINAN-----LIINGREETSDRTIDVVSPADIRVLLGS
Mvan_0486|M.vanbaalenii_PYR-1 ------------MISAN-----LIINGREETSDRTIDVVSPADIRVLLGS
MMAR_2875|M.marinum_M ------------MTTVAVPHHAMLIGGESVDSDRRLSLVDPGDE-SPVAT
MUL_2877|M.ulcerans_Agy99 ------------MTTVAVPHHAMLIGGESVDSDRRLSLVDPGDE-SPVAT
Mb2883c|M.bovis_AF2122/97 ------------MSTT--------------------QLINPATE-EVLAS
Rv0223c|M.tuberculosis_H37Rv ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATG-EYVGK
MAB_4484|M.abscessus_ATCC_1997 --------------MTNYDKLFIGGVWTEPATDQVIEVISPATG-QKVGQ
MSMEG_0309|M.smegmatis_MC2_155 MTAMTQTAPAATAATTNWDKLFIGGQWVEPSSSEIIEVFSPATG-EKVGQ
TH_3068|M.thermoresistible__bu ----------VTMTETEPKGFWIDGGWAAPATSERIQLIEASTG-DPITT
MAV_1340|M.avium_104 --------MADPPALVQTYQLYIDGQWVEP-QDGRYDDLSPCTE-AVIAT
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATG-ETVKT
. :
Mflv_0667|M.gilvum_PYR-GCK VPDAAPGQVDEAVAAAAMAFP--E-WSSRPLEERQGALLAAAGTIHDMIE
Mvan_0486|M.vanbaalenii_PYR-1 VPDAAPGQVDEAVAAAAMAFP--E-WSSRPLEERQGALLAAAGTIHDMIE
MMAR_2875|M.marinum_M VACGDASHVDAAVAAAKASFEDGS-WSRATPQERAAVMRRIVAAADQVTD
MUL_2877|M.ulcerans_Agy99 VACGDASHVDAAVAAAKASFEDGS-WSRATPQERAAVMRRIVAAADQVTD
Mb2883c|M.bovis_AF2122/97 VDHTDANAVDDAVQRARAAQR--R-WARLAPAQRAAGLRAFAAAVQAHLD
Rv0223c|M.tuberculosis_H37Rv VPMAAAADVDAAVAAARAAFDNGP-WPSTPPHERAAVIAAAVKMLAERKD
MAB_4484|M.abscessus_ATCC_1997 CPLASPADVDAAVSAARRAFDNGP-WPRLTPHERQAVLQKAVSLLESRKD
MSMEG_0309|M.smegmatis_MC2_155 APLATKADVDAACAAARKAFDEGP-WPRMTPQEREAVLAKATALIEESAD
TH_3068|M.thermoresistible__bu VPAAGPADVDAAVGAARRAFDDPTGWAHWTAEQRRAAITSLADALTSRGE
MAV_1340|M.avium_104 APDASVAQVDDAIAAARRAFDSGP-WGRISAEQRARCLNQLGEALTKHAD
MLBr_02573|M.leprae_Br4923 FTPTTQDEVEDAIARAYARFDNYR---HTTFTQRAKWANATADLLEAEAN
*: * * . :* :
Mflv_0667|M.gilvum_PYR-GCK EYAPILSREN-GKILEESHVDLEFASGICGYTAGISAEILADQQIRDTG-
Mvan_0486|M.vanbaalenii_PYR-1 EYAPILSREN-GKILEESHVDLEFASGICGYTAGISAEILADQQIRDTG-
MMAR_2875|M.marinum_M ELIELEMACNGATIRLATGFHIGYALSHFSYFADLAESYAYQRPAPIETF
MUL_2877|M.ulcerans_Agy99 ELIELEMACNGATIRLATGFHIGHALSHFSYFADLAESYAYQRPAPIETF
Mb2883c|M.bovis_AF2122/97 ELAALEVANSGHPI-VSAEWEAGHVRDVLAFYAASPERLS-GRQIPVAG-
Rv0223c|M.tuberculosis_H37Rv LFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYG
MAB_4484|M.abscessus_ATCC_1997 EICKAIADETGAPPMVIETLQWMGGFGAIQYYANAADAVKWKELRNGAYG
MSMEG_0309|M.smegmatis_MC2_155 EFKTLLKLETGQPQTIVDMMQYGAAMSTLQFYASAADKFAWKDIRDGIYG
TH_3068|M.thermoresistible__bu AIAKAVSTQNGMPISISSVTEAVMPAMLLNYYAELAEQQPVEEKRTSFTG
MAV_1340|M.avium_104 DFFALSQTEWG--CIGNERIMQIDGAGFMSMHAAQLATQLVDQEVAGISA
MLBr_02573|M.leprae_Br4923 QSAALMTLEMGKTLQSAKDEAMKCAKG-FRYYAEKAETLLADEPAEAAAV
*
Mflv_0667|M.gilvum_PYR-GCK ---GTTLIRRRPIGPVAAITPWNFPVVLAFMKLAPALVAGNTVVLKPAAN
Mvan_0486|M.vanbaalenii_PYR-1 ---GTTLIRRRPIGPVAAITPWNFPVVLAFMKLAPALVAGNTVVLKPAAN
MMAR_2875|M.marinum_M PVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEH
MUL_2877|M.ulcerans_Agy99 PVLSQSVVHREPIGVVGAITPWNFPLLLTLWKVGPAIAAGNSVVVKPDEH
Mb2883c|M.bovis_AF2122/97 ---GVDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAEL
Rv0223c|M.tuberculosis_H37Rv ----QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAE
MAB_4484|M.abscessus_ATCC_1997 ----QTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAE
MSMEG_0309|M.smegmatis_MC2_155 ----QTLVLKEPVGVVGAVVAWNVPFFLAANKLGPALLAGCTIVLKPAAE
TH_3068|M.thermoresistible__bu G---TTLVRRTPVGVVAAIVPWNFPQTLTFFKLAPLLAAGCTAVIKPSPE
MAV_1340|M.avium_104 G---TTLLRHVPLGVVAVLTPWNFPHCLNVMKLNHALAAGNTVVLKPSPL
MLBr_02573|M.leprae_Br4923 G-ASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASN
: * * * .: .**.* : ** ::*
Mflv_0667|M.gilvum_PYR-GCK SPLVLAEVVR-ALQ-QHFPPGVLNMVTG-GDAVGEALVAHPRIRKIGFTG
Mvan_0486|M.vanbaalenii_PYR-1 SPLVLAEIIR-ALQ-QHFPPGVLNMVTG-GDAVGEALVAHPRIRKIGFTG
MMAR_2875|M.marinum_M TPLSILEFARIAER-SGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTG
MUL_2877|M.ulcerans_Agy99 TPLSILEFARIAER-SGLPPGVINVVPGEGPEAGARLASHPDVGKIAFTG
Mb2883c|M.bovis_AF2122/97 TPLTTMRLGELAVE-AGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTG
Rv0223c|M.tuberculosis_H37Rv TPLTANALAEVFAE-VGLPEGVLSVV-PGGIETGQALTSNPDIDMFTFTG
MAB_4484|M.abscessus_ATCC_1997 TPLSSFILAEVFAE-AGVPEGVLSVV-PGGAETGRALTNNPDVDVFSFTG
MSMEG_0309|M.smegmatis_MC2_155 TPLTTNLMAQKFLE-AGLPEGVLSVV-PGGPETGRALTDNPALDKFTFTG
TH_3068|M.thermoresistible__bu TVLDSYLLAEAIEE-SDIPAGVVNIV-PGGRETGAYLVEHPGVDKVAFTG
MAV_1340|M.avium_104 TPLAGLALARLIDEHTDIPPGVVNVVTPSGVEAAKLLTTDPRIDMVSFTG
MLBr_02573|M.leprae_Br4923 VPQCALYLADVIAR-GGFPEDCFQTLLISANGVEAILR-DPRVAAATLTG
. . . . .. : . . : .* : :**
Mflv_0667|M.gilvum_PYR-GCK GIDTGRKVMAAAARDIKRVTLELGGNDPAILLDDVDLSP-ETMRQIVKGA
Mvan_0486|M.vanbaalenii_PYR-1 GIDTGRKVMAAAARDIKRVTLELGGNDPAILLDDVDLSP-ETMRQIVKGA
MMAR_2875|M.marinum_M STAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEM-AVEG-VLYGC
MUL_2877|M.ulcerans_Agy99 STAVGREIMRLASGTVKQVTLELGGKGPTIVLDDADLEM-AVEG-VLYGC
Mb2883c|M.bovis_AF2122/97 STEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLER-AATT-APAGV
Rv0223c|M.tuberculosis_H37Rv SSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLA--AAIPMMVFSG
MAB_4484|M.abscessus_ATCC_1997 STAVGKEIAEIAAKNLKKVTLELGGKSAAIVLEDADLA--AALPMLVFSG
MSMEG_0309|M.smegmatis_MC2_155 SSAVGKEIGKIAAEKLKPCTLELGGKSAAIILEDADLD--STLPMLLFSG
TH_3068|M.thermoresistible__bu STAAGRAIGEACGRLIRPVTLELGGKSASIILDDADLP--ALLEQFFAAT
MAV_1340|M.avium_104 SSAVGRQVMSAAGDTIKRILLELGGKSASIVLDDANVTDEMLEQMLFQSC
MLBr_02573|M.leprae_Br4923 SEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLD--AAVATAVTGR
. .*: : .. :: *****... *:: . :: .
Mflv_0667|M.gilvum_PYR-GCK FGTTGQVCFGLKRIYVPTRIHDRFVEAFSAAVDEIVVGPGDDPRVTMGPL
Mvan_0486|M.vanbaalenii_PYR-1 FGTTGQVCFGLKRIYVPTRIHDRFVEAFSAAVDEIVVGPGDDPRVTMGPL
MMAR_2875|M.marinum_M FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
MUL_2877|M.ulcerans_Agy99 FAYSGQVCESGTRALVPTTLYQEFVDRLVKRAATIVVGPTRDWDTDLGPV
Mb2883c|M.bovis_AF2122/97 FDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPL
Rv0223c|M.tuberculosis_H37Rv VMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPL
MAB_4484|M.abscessus_ATCC_1997 LMNAGQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPL
MSMEG_0309|M.smegmatis_MC2_155 LMNSGQACVGQTRILAPRSRYDEVVEKVAAGVAAMQVGVPDDPAAMVGPL
TH_3068|M.thermoresistible__bu LMNNGQTCYLGTRVLAPRSRYAETVDILTDFARSLKVGNALDAATQIGPL
MAV_1340|M.avium_104 SLHAGQACILHSRLLLPDSLHDDVVDRLAALARDVKVGDPTDPDVQMGPL
MLBr_02573|M.leprae_Br4923 VQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPL
** * .* : : . : ** . . :**:
Mflv_0667|M.gilvum_PYR-GCK NNAQQKNLVEKIVDDARSSGATVTTLGQRLDSAAWDHGHFMMPSVVTAAD
Mvan_0486|M.vanbaalenii_PYR-1 NNAQQKNLVEKIVDDARSSGATVTTLGQRLDSAAWDHGHFMMPSVVTAAD
MMAR_2875|M.marinum_M IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
MUL_2877|M.ulcerans_Agy99 IDAAQRTRILNYIRGAQTDGATVALGGEALTGGMFDKGFWVAPTILTGVH
Mb2883c|M.bovis_AF2122/97 VSRAHRDKVAGYVP----DDAPVAFRGTAPAG----RGFWFPPTVLTPKR
Rv0223c|M.tuberculosis_H37Rv ISEKQRTRVEGYIAKGIEEGARLVCGGGRPEG--LDNGFFIQPTVFADVD
MAB_4484|M.abscessus_ATCC_1997 ITEKQRTRVEGYIAKGIAEGARLAYGGKRPEG--LDGGYFVQPTIFADVD
MSMEG_0309|M.smegmatis_MC2_155 ISEKQRERVEGYIKKGIEEGARLVTGGGRPEG--LDSGWFVQPTVFADVD
TH_3068|M.thermoresistible__bu ATENQQRRVQGYIEKGRAEGGRITTGGGRPAD--LDRGWFVEPTVFADVA
MAV_1340|M.avium_104 ISAAQRDRVEAHIAGARSDGATLVTGGGRPAG--LDVGYYVEPTILSGVE
MLBr_02573|M.leprae_Br4923 ATESGRAQVEQQVDAAAAAGAVIRCGGKRPDR----PGWFYPPTVITDIT
: : : .. : * * : *::.:
Mflv_0667|M.gilvum_PYR-GCK PRLAIVEEEQFGPVVPVLKYDELDDVIRLVNQSQYGLAASIWTSDEERAF
Mvan_0486|M.vanbaalenii_PYR-1 PRLAIVEEEQFGPVVPVLKYDELDDVIRLVNQSQYGLAASIWTSDEERAF
MMAR_2875|M.marinum_M NDMAIAREEVFGPVLVVIGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
MUL_2877|M.ulcerans_Agy99 NDMAIAREEVFGPVLVVSGYDGDEQAIAIANDSDYGLAASIWTSDNARGL
Mb2883c|M.bovis_AF2122/97 GDRTVT-DEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRAL
Rv0223c|M.tuberculosis_H37Rv NKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGI
MAB_4484|M.abscessus_ATCC_1997 NSMTIAQEEIFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGL
MSMEG_0309|M.smegmatis_MC2_155 NSMTIAQEEIFGPVLVVIPFEDEDDAVRIANDSVYGLAGSVYTTDHAKGV
TH_3068|M.thermoresistible__bu NSHTIAREEIFGPVLTVIPYTDVDEAVAIANDSEFGLGGSVWTSDPERGV
MAV_1340|M.avium_104 PNSTVAQEEVFGPVLSVLRYRDDDDAVAIANNSRYGLSGAVWGDDVDRAV
MLBr_02573|M.leprae_Br4923 KDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQR
:: :* **** : :.: :.* : :**.. : : .
Mflv_0667|M.gilvum_PYR-GCK LLGRRFDTGSVFINSHTFTSLDPRAPFGGAKASGLGREFSPAS-LDSYTE
Mvan_0486|M.vanbaalenii_PYR-1 LLGRRFDTGSVFINSHTFTSLDPRAPFGGAKASGLGREFSPAS-LDSYTE
MMAR_2875|M.marinum_M AMAERIQSGSVWINDA--HQINCRLPFGGYKQSGVGRELGPDA-LDAYTE
MUL_2877|M.ulcerans_Agy99 AMAERIRSGSVWINDA--HQINCRLLFGGYKQSGVGRELGPDT-LDAYTE
Mb2883c|M.bovis_AF2122/97 RVARAVESGNLSVNSH--SSVRFNTPFGGFKQSGVGRELGPDA-PLQFTE
Rv0223c|M.tuberculosis_H37Rv KISQQIRTGTYGINWY---AFDPGSPFGGYKNSGIGRENGPEG-VEHFTQ
MAB_4484|M.abscessus_ATCC_1997 EVAAQIRTGTYGINWY---AFDPSCPFGGYKQSGIGRENGPEG-IEEYCE
MSMEG_0309|M.smegmatis_MC2_155 EIASKVRTGTYGINMY---AFDPGAPFGGYKNSGIGRECGPEG-IAGYCE
TH_3068|M.thermoresistible__bu QVARRVQTGSIGVNNY---TLDFRSPFGGVKASGLGRELGPEG-LAAYQQ
MAV_1340|M.avium_104 GVARRIRTGQIAVNGI---SP-AGAPFGGFRLSGLGREGGGIGGLHQYME
MLBr_02573|M.leprae_Br4923 HFIDNIVAGQVFINGMT--VSYPELPFGGIKRSGYGRELSTHG-IREFCN
. . :* :* *** : ** *** . : :
Mflv_0667|M.gilvum_PYR-GCK LQTISRRIGPPGPPLS-----------
Mvan_0486|M.vanbaalenii_PYR-1 LQTISRRIGPPGPPLS-----------
MMAR_2875|M.marinum_M VKTIHLDLSGGREAKPYDVLLGHPETG
MUL_2877|M.ulcerans_Agy99 VKTIHLDLSGGREAKPYDVLLGHPETG
Mb2883c|M.bovis_AF2122/97 TKNVFIAV--GEEM-------------
Rv0223c|M.tuberculosis_H37Rv QKSVLLPMGYTVA--------------
MAB_4484|M.abscessus_ATCC_1997 LKSVLLPMGYTLESI------------
MSMEG_0309|M.smegmatis_MC2_155 SKSVLLPFGYTPE--------------
TH_3068|M.thermoresistible__bu LTSIFLA--------------------
MAV_1340|M.avium_104 PMAIGVPA-------------------
MLBr_02573|M.leprae_Br4923 IKTVWIA--------------------
: