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M. marinum M MMAR_3566 (plcB)

annotation: membrane-associated phospholipase C 2 PlcB
coordinates: 4384117 - 4385682
length: 521 

LVSKHPVDGMSRREFMAKLAAASSAGAMMSLAGPVIEKAYGAGPCSGHLTDIEHFVFMLQENRSFDHYFG
SLSGINGFDTPSSAFQQKGWNPQTQSIDPAGVTIPYRFDTTRGPLLNGACVNDPGHQWIDMHRAFNNGAN
DNWLGAQAQAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPNRLYWMSAWIDPNGE
QGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVYQNKLLGALNNTVIGYDGMLNDFVQARDPRSNMAR
YGIAPTYPLDFVADVASNRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEKTALIV
SFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPIGLGYRVPCFVISPYSRGPLMVHDIFD
HTSQLRLLEQRFGVPVPNLTTWRRGVTGDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVTVFT
KTVPPYRVPFPQVMPSQETSPTRGIPSGPC*

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3566plcB-100% (521)membrane-associated phospholipase C 2 PlcB
M. marinum MMMAR_3823plcB_10.080.19% (520) membrane-associated phospholipase C 2 PlcB_1
M. marinum MMMAR_0284plcB_30.070.80% (524) membrane-associated phospholipase C 2 PlcB_3

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1784cplcD0.069.36% (519) phospholipase C 4 PLCD
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv2350cplcB0.073.93% (514) membrane-associated phospholipase C
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0555-5e-8836.98% (503) non-hemolytic phospholipase C
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2799plcB0.099.61% (511) membrane-associated phospholipase C 2 PlcB
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3566|M.marinum_M               MLVSKHPVDGMSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGH
MUL_2799|M.ulcerans_Agy99           ----------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYG-AGPCSGH
Rv2350c|M.tuberculosis_H37Rv        ----------MTRRQFFAKAAAATTAGAFMSLAGPIIEKAYG-AGPCPGH
Mb1784c|M.bovis_AF2122/97           --MSQSHIGGVSRREFLAKVAAGG-AGALMSFAGPVIEKAYG-AGPCSGH
MAB_0555|M.abscessus_ATCC_1997      -------MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGS
                                              ::**.:::. *.    .* :*:  . :::. . ..* .* 

MMAR_3566|M.marinum_M               LTDIEHFVFMLQENRSFDHYFGSLSGINGFD--TPSSAFQQKGWNPQTQS
MUL_2799|M.ulcerans_Agy99           LTDIEHFVFMLQENRSFDHYFGSLSGINGFD--TPSSAFQQKGWNPQTQS
Rv2350c|M.tuberculosis_H37Rv        LTDIEHIVLLMQENRSFDHYFGTLSDTRGFDDTTPPVVFAQSGWNPMTQA
Mb1784c|M.bovis_AF2122/97           LTDIEHFVFFMQENRSFDHYFGTLSGTDGFN--TVSPLFQQKGWNPMTQA
MAB_0555|M.abscessus_ATCC_1997      LRDVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDP
                                    * *:**.*.:: **********:**.  **:  *       ..    .:.

MMAR_3566|M.marinum_M               IDPAGVTIPYRFDTTRGPLLNGACVNDPGHQWIDMHRAFNNGANDNWLGA
MUL_2799|M.ulcerans_Agy99           IDPAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGA
Rv2350c|M.tuberculosis_H37Rv        VDPAGVTLPYRFDTTRGPLVAGECVNDPDHSWIGMHNSWNGGANDNWLPA
Mb1784c|M.bovis_AF2122/97           LDATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPA
MAB_0555|M.abscessus_ATCC_1997      QNPDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAA
                                     :. *  :*:::**: ...        ..* *   * ::* *  ***: *

MMAR_3566|M.marinum_M               QAQAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPN
MUL_2799|M.ulcerans_Agy99           QAQAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPN
Rv2350c|M.tuberculosis_H37Rv        QVPFSPLQGNVPVTMGFYTRRDLPIHYLLADTFTVCDGYFCSLLGGTTPN
Mb1784c|M.bovis_AF2122/97           QAKTRSAA-HTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPN
MAB_0555|M.abscessus_ATCC_1997      HRKADGEH--YPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPN
                                    :          * .**:* * * *:*: **::**:** :..*::* * **

MMAR_3566|M.marinum_M               RLYWMSAWIDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVY
MUL_2799|M.ulcerans_Agy99           RLYWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVY
Rv2350c|M.tuberculosis_H37Rv        RLYWMSAWIDPDGTDGGPVLIEPNIQPLQHYSWRIMPENLEDAGVSWKVY
Mb1784c|M.bovis_AF2122/97           RLYWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVY
MAB_0555|M.abscessus_ATCC_1997      RMMWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVY
                                    *: *::. :**:. .*** : .. ..    :.*   .:.*. **:**:**

MMAR_3566|M.marinum_M               QN-KLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADV
MUL_2799|M.ulcerans_Agy99           QN-KLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADV
Rv2350c|M.tuberculosis_H37Rv        QN-KLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGISPTYPLDFAADV
Mb1784c|M.bovis_AF2122/97           RN-KTLGPIS-SVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADV
MAB_0555|M.abscessus_ATCC_1997      AEEDDYGGCN-----VLKLFSRFQRSR-PGEPLYDKGIAPVRATQFEDDA
                                     : .  *  .        :.. * ::  * . :   *::*  . .*  *.

MMAR_3566|M.marinum_M               ASNRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEK
MUL_2799|M.ulcerans_Agy99           ASNRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEK
Rv2350c|M.tuberculosis_H37Rv        RNNRLPKVSWVLPGFLLSEHPAFPVN--VGAVAIVDALRILLSNPAVWEK
Mb1784c|M.bovis_AF2122/97           LANRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEK
MAB_0555|M.abscessus_ATCC_1997      RAGRLPAVSWLIMTSTASEHPDYRPA--DGAAYIASKIDAIAANPEVWAK
                                      .*** ***::     ****        *.  *.. :  : :** ** *

MMAR_3566|M.marinum_M               TALIVSFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPIG
MUL_2799|M.ulcerans_Agy99           TALIVSFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPIG
Rv2350c|M.tuberculosis_H37Rv        TALIVNYDENGGFFDHVVPPTPPPGTPGEFVTVPDIDSVPGSGGIRGPIG
Mb1784c|M.bovis_AF2122/97           TALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIG
MAB_0555|M.abscessus_ATCC_1997      TVFILNYDENDGLFDHVVPPTPPPGTPGEWVKG-------------VPIG
                                    *.:*:.:***.*:****.*.*.* *****::.               ***

MMAR_3566|M.marinum_M               LGYRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRG
MUL_2799|M.ulcerans_Agy99           LGYRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRG
Rv2350c|M.tuberculosis_H37Rv        LGFRVPCLVISPYSRGPLMVHDTFDHTSTLKLIRARFGVPVPNLTAWRDA
Mb1784c|M.bovis_AF2122/97           LGFRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRS
MAB_0555|M.abscessus_ATCC_1997      GGFRVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRRK
                                     *:***.:****:* *  :. : ***** *:::.   **  **:: **  

MMAR_3566|M.marinum_M               VTGDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVT-VFTKTVP
MUL_2799|M.ulcerans_Agy99           VTGDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVT-VFTKTVP
Rv2350c|M.tuberculosis_H37Rv        TVGDMTSTFNFAAPPNPSKPNLDHPRLNALPKLPQCVPNAVLGTVTKTAI
Mb1784c|M.bovis_AF2122/97           VTGDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINR-GI
MAB_0555|M.abscessus_ATCC_1997      TFGNLLSAFGFDSPVRPAPELPDTAAVVAAADRTDTRP-----------P
                                    . *:: *:*.*  * ..:    * . : * .   :  *            

MMAR_3566|M.marinum_M               PYRVPFPQVMPSQE-TSPTRGIPSGPC
MUL_2799|M.ulcerans_Agy99           PYRVPFPQVMPSQE-TSPTRGIPSGPC
Rv2350c|M.tuberculosis_H37Rv        PYRVPFPQSMPTQE-TAPTRGIPSGLC
Mb1784c|M.bovis_AF2122/97           PYRVPDPQIMPTQE-TTPTRGIPSGPC
MAB_0555|M.abscessus_ATCC_1997      PVIPPAPQTSPVQEPGSRPRRYPRR--
                                    *   * **  * **  : .*  *