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MRIPRLLGVILMIFTTGLLLAPPSGAQPPFRLASYVTDNADALTSSGRAKVTTAVNQLYTERHVRLWVVY VDDFSGQSATNWAQRTMQTSELGDYDAILAVATVARSYAFLVPSTVDGITSSQVESLRRNKIEPKLRDGD WAGAAVAAADGLNKSPRPSGGIPLLVVLSVLAVAVAIFWIVMRYRASRRRTNALAAARRVDPTDARALAA VPLDVLDELSRSMVVDVDNAVRTSSNELAVAIDEFGEQRTAPFSQAVSNAKAALSQAFSVRQQLDDSTPE TPAQRRDLLTRVIVSAANADRELESQTEAFEKLRDLVINAPARLDLLTQRYIELTTRIAPTEQRLVELHD EFGATALSSISANVASAHELLAFADSNISSARELSAKAVSGQQTGLVDAVRAAESALGQARSLLDAVDSA AGDIRHAVATMPSVLADIQAGIQHANEQLQKSPANKSAYAAELIAARDAAARAVDNARVTGAADPLSAFA QLTTADADLDRLLAAIAQEQANAEHLRRSLEQALFTAESRIRAVSDYIDTRRGSIGPEARTRLAEAGRRL DAAQSYRSTNPTEAIAQANAASTLAANAQSLANSDVQAAQRAYTRQGGNNTGAVLGGIIIGDLLSGGMRG GFGGWSPTSFGGSSGSSGDSSGGGFLGGGGRF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3652 | - | - | 100% (662) | hypothetical protein MMAR_3652 |
| M. marinum M | MMAR_2408 | pknF_1 | 3e-24 | 41.55% (142) | anchored-membrane serine/threonine-protein kinase PknF_1 |
| M. marinum M | MMAR_1195 | - | 4e-06 | 26.23% (244) | PE-PGRS family protein, PE_PGRS9_4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2374 | - | 0.0 | 72.81% (662) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_2720 | - | 0.0 | 56.87% (670) | hypothetical protein Mflv_2720 |
| M. tuberculosis H37Rv | Rv2345 | - | 0.0 | 72.81% (662) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1706c | - | 1e-169 | 50.82% (671) | hypothetical protein MAB_1706c |
| M. avium 104 | MAV_2041 | - | 0.0 | 69.32% (665) | hypothetical protein MAV_2041 |
| M. smegmatis MC2 155 | MSMEG_4484 | - | 0.0 | 57.68% (690) | putative transmembrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1486 | - | 2e-05 | 32.37% (139) | cell wall-associated hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3816 | - | 0.0 | 58.53% (668) | hypothetical protein Mvan_3816 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2374|M.bovis_AF2122/97 ---MRLVRLLG-MVLTILAAGL---LLGPPAGAQPPFRLSNYVTDNAGVL
Rv2345|M.tuberculosis_H37Rv ---MRLVRLLG-MVLTILAAGL---LLGPPAGAQPPFRLSNYVTDNAGVL
MMAR_3652|M.marinum_M ---MRIPRLLG-VILMIFTTGL---LLAPPSGAQPPFRLASYVTDNADAL
MAV_2041|M.avium_104 ---MRTARLLA-VLAALLTVGLSAGLLAPPAGAQPPLRLSDYLTDTAGVL
Mflv_2720|M.gilvum_PYR-GCK ---MRVARLLP-LLLALLTVGL---LGAPAASAEPPLRLPTYLTDRAGAL
Mvan_3816|M.vanbaalenii_PYR-1 MAVMRVARLLP-MLLAVLTLGL---LCAPGVAAEPPLRLPTYLTDNAGAL
MSMEG_4484|M.smegmatis_MC2_155 ---MRIGRLFS-LLLAILTTGL---LVAPAAAAEPPLRLATQITDQAGAL
MAB_1706c|M.abscessus_ATCC_199 ---MRLLRALAGLLGVLIAVCAPTLLLAPVASADPPFRIPGYVTDRAGAL
MUL_1486|M.ulcerans_Agy99 --------------------------------------------------
Mb2374|M.bovis_AF2122/97 TSSGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELG
Rv2345|M.tuberculosis_H37Rv TSSGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELG
MMAR_3652|M.marinum_M TSSGRAKVTTAVNQLYTERHVRLWVVYVDDFSGQSATNWAQRTMQTSELG
MAV_2041|M.avium_104 SDSGRKAITTAVDKLYTDRHIRLWVVYVDTFSGQTATRWAQDTLRTSDLG
Mflv_2720|M.gilvum_PYR-GCK DAAGESEVQTAIDQLYDDKRIRLWVVYVEDFSGQSAQTWAQTTFTRSDLG
Mvan_3816|M.vanbaalenii_PYR-1 DTAGTAEVQAAIDRLYNEERIRLWVVFVDDFSGQDAQTWTQTTFARSDLG
MSMEG_4484|M.smegmatis_MC2_155 SASQAASVQRALDRLYDDRRIKLWVVFVEDFSGQNYIGWAQNTMRLSDFG
MAB_1706c|M.abscessus_ATCC_199 KNP--AKVRAAVDQLYDQQHVRLWVVYVKDFEGTDPTAWADKTIKASNLG
MUL_1486|M.ulcerans_Agy99 ---------------------------MRRTRRSSASRSAARLVRPAIPS
: : : .
Mb2374|M.bovis_AF2122/97 NYDALLAVATTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSG
Rv2345|M.tuberculosis_H37Rv NYDALLAVATTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSG
MMAR_3652|M.marinum_M DYDAILAVATVARSYAFLVPSTVDGITSSQVESLRRNKIEPKLRDGDWAG
MAV_2041|M.avium_104 DYDALLAVATTDRAYAFLVPPTIRGVNQSRVDALRHNKIEPALHDGDWSG
Mflv_2720|M.gilvum_PYR-GCK DQDVILAVATVDRAYALITPRGG--AVRADIDEVRTQQVEPRLRAGDWAG
Mvan_3816|M.vanbaalenii_PYR-1 NQDVILAVATVDRAYALIAPKGG--AVRVDIDKVRTQQVEPLLRTGDWAG
MSMEG_4484|M.smegmatis_MC2_155 DDDALLAVATVDRAFAFQVPDTL--VDTARADDIRRNSIGPSLRREDWAG
MAB_1706c|M.abscessus_ATCC_199 DRDALLAVATEERSYAFQVASGIKNVSDSEIENLRTNTIEPALRTSDWDG
MUL_1486|M.ulcerans_Agy99 VVSVALLVTVPAVANADSR--------TDSIAALIADVARANQRLDDLSA
.. * *:. * : . : * .
Mb2374|M.bovis_AF2122/97 AAVAAANGLN-----RSPSSSSRVVLLVTVGIIVIVVAVLLVVMRHRNRR
Rv2345|M.tuberculosis_H37Rv AAVAAANGLN-----RSPSSSSRVVLLVTVGIIVIVVAVLLVVMRHRNRR
MMAR_3652|M.marinum_M AAVAAADGLN-----KSPRPSGGIPLLVVLSVLAVAVAIFWIVMRYRASR
MAV_2041|M.avium_104 AAVAAATGLD-----TAPGSSGRVILLATLAALLVAVMGLLLVMRYRGRR
Mflv_2720|M.gilvum_PYR-GCK AAVAAAQGL----AGSGGGSVSWFGVIVALALIALALTILVLWQRRRRRK
Mvan_3816|M.vanbaalenii_PYR-1 AAVAAAEGL----AGSGGGSVSWTGVLVVLAVIALALAALVLWQRRRRRK
MSMEG_4484|M.smegmatis_MC2_155 AAIAAADQLNTEPASATGGGVSWPALLIVLGIIAVLIGILWIWSRRRRAK
MAB_1706c|M.abscessus_ATCC_199 AAIKTATGLES--AASSSASIPWKPVLGALAFGAVLVGAFMLFSWFRTRS
MUL_1486|M.ulcerans_Agy99 AVELEQEGVN---------------------------KAMVAVETARDEA
*. : : *
Mb2374|M.bovis_AF2122/97 RRADELAAARRVDPTNVMALAAVPLQALDDLSRSMVVDVDNAVRTSTNEL
Rv2345|M.tuberculosis_H37Rv RRADELAAARRVDPTNVMALAAVPLQALDDLSRSMVVDVDNAVRTSTNEL
MMAR_3652|M.marinum_M RRTNALAAARRVDPTDARALAAVPLDVLDELSRSMVVDVDNAVRTSSNEL
MAV_2041|M.avium_104 RRAAALAAARRLDPTDLDALAALPLPTLDDLSRALVVDVDNALRTSANEL
Mflv_2720|M.gilvum_PYR-GCK RREAEFAAAQRVDPSDPEALAAVPLDALDDLSRKIVVDVDNEVRTSESEL
Mvan_3816|M.vanbaalenii_PYR-1 RREAEFAAAQRVDPSDANALAAVPLDALDELSRKIVVDVDNELRTSESEL
MSMEG_4484|M.smegmatis_MC2_155 RRKAEFEAAKRVDPTDPDALASVPLEALDALSREIVVDVDNAVRTSQAEL
MAB_1706c|M.abscessus_ATCC_199 RRRAEIEAAKGIDPSDAEALAKQPVTALDGLSKSIVVNVDNAVRTSEAEL
MUL_1486|M.ulcerans_Agy99 AAAEHELEASQQAVKDANAAIAAAQHRFDTFAAATYMNGPSDS-------
* .: * . :* :: :: .
Mb2374|M.bovis_AF2122/97 ALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPETPAQRREL
Rv2345|M.tuberculosis_H37Rv ALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDDNTPETPAQRREL
MMAR_3652|M.marinum_M AVAIDEFGEQRTAPFSQAVSNAKAALSQAFSVRQQLDDSTPETPAQRRDL
MAV_2041|M.avium_104 DLAVAEFGDQRTQPFTQAVTNAKAALSQAFTVRQQLDDGMPETPAQRREL
Mflv_2720|M.gilvum_PYR-GCK ALAVEEFGAQDTAAFTRAVEGAKTTLAQALNVRHILDDAVPETPMQRRDL
Mvan_3816|M.vanbaalenii_PYR-1 ALAVEEFGEQDTAPFSRAVANARTTLAQALNVRQILDDAVPETPMQRRDL
MSMEG_4484|M.smegmatis_MC2_155 ELAVEEFGAKRTEPFTTAVANARKALAQAFNVRQILDDDVPETPLQQRDL
MAB_1706c|M.abscessus_ATCC_199 ALAVEEFGTESTAPFQQAVDSAKKALAQAFSVRKQLDDAIPETPLEQRRL
MUL_1486|M.ulcerans_Agy99 -----YLTATSPDEIIAAATAAKTLAASAQTVMANLERARTRQVNKE---
: . : *. *: :.* .* *: .. :.
Mb2374|M.bovis_AF2122/97 LTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRI
Rv2345|M.tuberculosis_H37Rv LTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVELTTRI
MMAR_3652|M.marinum_M LTRVIVSAANADRELESQTEAFEKLRDLVINAPARLDLLTQRYIELTTRI
MAV_2041|M.avium_104 LTQVIVSAARADRELESQTEAFEGLRDLVINAPSRLDGLTQQYVELTARI
Mflv_2720|M.gilvum_PYR-GCK LTRVIVAAAKADQELEAQREAFAALRDLVINAPSRLDTLTQQMIDLTTRI
Mvan_3816|M.vanbaalenii_PYR-1 LTRVIVAAAKADRELEAQREAFAQLRDLLINAPSRLDTLTQQMVDLTARL
MSMEG_4484|M.smegmatis_MC2_155 LTRVIVSAARADRELEAQSAAFEQLRDLVINAPARLDLMTQQMVDLSARI
MAB_1706c|M.abscessus_ATCC_199 LIDVITTAARADRTLEDQSSAFDALRNLVINAPAKLDTLTQQVVAVTARL
MUL_1486|M.ulcerans_Agy99 -SASRLAEQKADKAAEDAKTSQDAAVTALTDTQRKFDQQREEVNRLAAER
: .**: : : :: ::* :. :::.
Mb2374|M.bovis_AF2122/97 GPTQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQA
Rv2345|M.tuberculosis_H37Rv GPTQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQA
MMAR_3652|M.marinum_M APTEQRLVELHDEFGATALSSISANVASAHELLAFADSNISSARELSAKA
MAV_2041|M.avium_104 GPAEQQLAALHNEFSAAALTSVSGNVTAAKERLAFADRNIGTARELAGQA
Mflv_2720|M.gilvum_PYR-GCK TPAEQTLQQLKSQFAASALVSVSDNIDEARSRLAYADQSITTARTLVSRP
Mvan_3816|M.vanbaalenii_PYR-1 TPAEQTLEQLKSQFAETALVSVSDNIDEARQRLAFADQSITTARGLVSRP
MSMEG_4484|M.smegmatis_MC2_155 ETSQQTLAALHTQFDARALESVAGNVDTARERLAFADRNITTARGLVSRP
MAB_1706c|M.abscessus_ATCC_199 PESERILGQLRTEFDAAALASIGDNVAEATERVRFADSRITHGRELAARA
MUL_1486|M.ulcerans_Agy99 DEAEAKLQAAR-----LVAWSSAGAEGPPPGAMWDPGARPGNGRRWDGWD
:: * : . * . . : .. .*
Mb2374|M.bovis_AF2122/97 VSGRQAGLVDAVRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADI
Rv2345|M.tuberculosis_H37Rv VSGRQAGLVDAVRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADI
MMAR_3652|M.marinum_M VSGQQTGLVDAVRAAESALGQARSLLDAVDSAAGDIRHAVATMPSVLADI
MAV_2041|M.avium_104 VSGQQGRLVDAVRAAESALGQARSLLDAVDHAAGDIRHAIDQLPSAMADI
Mflv_2720|M.gilvum_PYR-GCK AH-RQGGLVDAIHSAEAALGQARTLLDAVDSASTDINRAVTGLPAVIADI
Mvan_3816|M.vanbaalenii_PYR-1 AD-RQGGLVDAIHAAEAALGQARTLLDAVDSASTDINRAVTGLPAVIADI
MSMEG_4484|M.smegmatis_MC2_155 AA-DQTGLVDAVRAAESALSQARTLLDAVDSASTDINRALAGLPAAVADI
MAB_1706c|M.abscessus_ATCC_199 LEGQQMSLVDAIRGAESALTQANALLDAIDNAANNIRHAIDSLAASIADT
MUL_1486|M.ulcerans_Agy99 PTLPQIPSANIPGDPIAVVNQVLGISATSAQVTANMGQNFLQQLGILKPT
* .: . :.: *. : : .: :: : . . :
Mb2374|M.bovis_AF2122/97 QTGIKRANQHLQQAQQPQTGRTGDLIAARDAAARALDRAR--GAADPLTA
Rv2345|M.tuberculosis_H37Rv QTGIKRANQHLQQAQQPQTGRTGDLIAARDAAARALDRAR--GAADPLTA
MMAR_3652|M.marinum_M QAGIQHANEQLQKSPANKSAYAAELIAARDAAARAVDNARVTGAADPLSA
MAV_2041|M.avium_104 ENDIKRAAELLAATRDTKSGHAAELAAARDAATRAVEGARAGAPDDPLGA
Mflv_2720|M.gilvum_PYR-GCK QNGINSAGAQLAQG---SVAVATELSDARDAAVQAVAEAQSSGETDPLGA
Mvan_3816|M.vanbaalenii_PYR-1 QNGINQAGAQLAQG---NVAVATELSTARDAAVQAVSQAQSTGNSDPLGA
MSMEG_4484|M.smegmatis_MC2_155 EAGIEQANDLLAQP---DTPQADKLATARDAAVQAAGEAKSNGTADPLGT
MAB_1706c|M.abscessus_ATCC_199 KSDIAQAEEFQKQG---RLPSSEELTKAHDAAVAAVADAERIGATDPLTA
MUL_1486|M.ulcerans_Agy99 DTGITNAATGATRIPRVYGRQASEYVIRRGMAQIGVPYSWGGGNAAGP--
. .* * : . :. * . : .
Mb2374|M.bovis_AF2122/97 FDQLTKVDADLDRLLATLAEEQATADRLNRSLEQALFTAESRVRAVSEYI
Rv2345|M.tuberculosis_H37Rv FDQLTKVDADLDRLLATLAEEQATADRLNRSLEQALFTAESRVRAVSEYI
MMAR_3652|M.marinum_M FAQLTTADADLDRLLAAIAQEQANAEHLRRSLEQALFTAESRIRAVSDYI
MAV_2041|M.avium_104 FGQLTKADAGLNAVLAAVAQERAAAERLARSLEQALFTAQSRVRAVSDYI
Mflv_2720|M.gilvum_PYR-GCK FTRLTQADADLDRLLAEVAEERETAARLSRTFDQALFNAQSRVRAVSDYI
Mvan_3816|M.vanbaalenii_PYR-1 FTRLTQADADLDRLLAEVAEERETAERLSRTFDQALFNAQSRVRAVSDYI
MSMEG_4484|M.smegmatis_MC2_155 FTRLTQADADLDQLLATVHEQREAAERLARTLEQAIFTAESRITAVSDYI
MAB_1706c|M.abscessus_ATCC_199 FTHLAAADAQLDKLLAAAQEERAAAERRARVLDQALVAARQRLDAVNQYI
MUL_1486|M.ulcerans_Agy99 ----------------------------SKGIDSGAGITGFDCSGLVLYS
: ::.. : .: *
Mb2374|M.bovis_AF2122/97 DTRRGSIGPEARTRLAEAKRQLEAAHDRKSSNPTEAIAYANAASTLAAHA
Rv2345|M.tuberculosis_H37Rv DTRRGSIGPEARTRLAEAKRQLEAAHDRKSSNPTEAIAYANAASTLAAHA
MMAR_3652|M.marinum_M DTRRGSIGPEARTRLAEAGRRLDAAQSYRSTNPTEAIAQANAASTLAANA
MAV_2041|M.avium_104 DTRRGSIGPEARTRLAEAQRHLHAAADRRATDPADAIAHANAASTLAAEA
Mflv_2720|M.gilvum_PYR-GCK DTRRGAIGPEARTRLAEAVRQLQAARDKQDTNLNEAIAHANGAAMLAAQA
Mvan_3816|M.vanbaalenii_PYR-1 DTRRGAIGPEARTRLAEAVRQLQAARDKRETNLNEAIAHANGAAMLAAQA
MSMEG_4484|M.smegmatis_MC2_155 ETRRGSIGPEARTRLAEATRQLEAARAKRSTNPNEAVAHANGASTLAAQA
MAB_1706c|M.abscessus_ATCC_199 GLHRGAVGARTRWNLDEAQRRLAAAEQSRASNPSDAILFANGAAELATQA
MUL_1486|M.ulcerans_Agy99 FAGVGIKLPHYSGSQYNLGRKIPTSQMRRGDVIFYGPGGSQHVTLYLGNG
* .. : *:: :: : . :: .: ..
Mb2374|M.bovis_AF2122/97 QSLANADVQSAQRAYT---RRGGNN--AGAILG---GIIIGDLLSGGTRG
Rv2345|M.tuberculosis_H37Rv QSLANADVQSAQRAYT---RRGGNN--AGAILG---GIIIGDLLSGGTRG
MMAR_3652|M.marinum_M QSLANSDVQAAQRAYT---RQGGNN--TGAVLG---GIIIGDLLSGGMRG
MAV_2041|M.avium_104 QSLANGDVQAARRAYP---RGGGGD--MGAMLG---GIIIGDLLSSGMRG
Mflv_2720|M.gilvum_PYR-GCK QSLANSDVTAAQRHFNGPYGGGGGGGQMGAVIG---GILIGNVLSGVLRG
Mvan_3816|M.vanbaalenii_PYR-1 QSLANSDVTAAQRHFSGPYGGGGGG-QMGAVIG---GILIGNVLSGALRG
MSMEG_4484|M.smegmatis_MC2_155 QSLANDDVRAAQRSYTSHHGGGGAD--MGAVLG---GIIIGNVLRGGFGG
MAB_1706c|M.abscessus_ATCC_199 QYSAQQEVQSAQRYYG---NGYGGYSVAGDVAGNVAGAVIGGILRGMLSG
MUL_1486|M.ulcerans_Agy99 QMLEAPDIGLKVRVAP------------VRTSG------MTPFVVRYIEY
* :: * * : .:
Mb2374|M.bovis_AF2122/97 GLG-GWIPTSFGGSSNAPGSS---------------PDGGFLGGGGRF
Rv2345|M.tuberculosis_H37Rv GLG-GWIPTSFGGSSNAPGSS---------------PDGGFLGGGGRF
MMAR_3652|M.marinum_M GFG-GWSPTSFGGSSGSSGDS---------------SGGGFLGGGGRF
MAV_2041|M.avium_104 GFG-GWSPASFGGSTSSSG-------------------GGVLGGGGRF
Mflv_2720|M.gilvum_PYR-GCK GLGGGGFGGGFG--GGGFGGG---------------GGGGFSGGGGRF
Mvan_3816|M.vanbaalenii_PYR-1 GFGGGGFGGGFG--GGGFGGG---------------GGG-FSGGGGRF
MSMEG_4484|M.smegmatis_MC2_155 GGGYGGYGGGFGGFGGGFGGGRSSGRPTSYGGSSHSSGRNYGGGGGRF
MAB_1706c|M.abscessus_ATCC_199 GAGHHSSWSGSGSSSYGGSSR--------------SSGSSFRGGGGRF
MUL_1486|M.ulcerans_Agy99 ------------------------------------------------